MGAT1: Difference between revisions

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{{Infobox_gene}}
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'''Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase''' is an [[enzyme]] that in humans is encoded by the ''MGAT1'' [[gene]].<ref name="pmid1827260">{{cite journal |vauthors=Hull E, Sarkar M, Spruijt MP, Hoppener JW, Dunn R, Schachter H | title = Organization and localization to chromosome 5 of the human UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I gene | journal = Biochem Biophys Res Commun | volume = 176 | issue = 2 | pages = 608–15 |date=Jun 1991 | pmid = 1827260 | pmc =  | doi =10.1016/S0006-291X(05)80227-X }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4245| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_MGAT1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1fo8.
| PDB = {{PDB2|1fo8}}, {{PDB2|1fo9}}, {{PDB2|1foa}}, {{PDB2|2am3}}, {{PDB2|2am4}}, {{PDB2|2am5}}, {{PDB2|2apc}}
| Name = Mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
| HGNCid = 7044
| Symbol = MGAT1
| AltSymbols =; GLCNAC-TI; GLCT1; GLYT1; GNT-1; GNT-I; MGAT
| OMIM = 160995
| ECnumber =
| Homologene = 1804
| MGIid = 96973
  | GeneAtlas_image1 = PBB_GE_MGAT1_201126_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003827 |text = alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity}} {{GNF_GO|id=GO:0016757 |text = transferase activity, transferring glycosyl groups}}
  | Component = {{GNF_GO|id=GO:0000139 |text = Golgi membrane}} {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0005975 |text = carbohydrate metabolic process}} {{GNF_GO|id=GO:0006023 |text = aminoglycan biosynthetic process}} {{GNF_GO|id=GO:0006487 |text = protein amino acid N-linked glycosylation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4245
    | Hs_Ensembl = ENSG00000131446
    | Hs_RefseqProtein = NP_002397
    | Hs_RefseqmRNA = NM_002406
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 180150154
    | Hs_GenLoc_end = 180175147
    | Hs_Uniprot = P26572
    | Mm_EntrezGene = 17308
    | Mm_Ensembl = ENSMUSG00000020346
    | Mm_RefseqmRNA = XM_979241
    | Mm_RefseqProtein = XP_984335
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 49087669
    | Mm_GenLoc_end = 49106453
    | Mm_Uniprot = Q5SW40
  }}
}}
'''Mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase''', also known as '''MGAT1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4245| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I is a medial-Golgi enzyme essential for the synthesis of hybrid and complex N-glycans.  The protein, encoded by a single exon, shows typical features of a type II transmembrane protein. The protein is believed to be essential for normal embryogenesis.<ref name="entrez">{{cite web | title = Entrez Gene: MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4245| accessdate = }}</ref>
| summary_text = There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I is a medial-Golgi enzyme essential for the synthesis of hybrid and complex N-glycans.  The protein, encoded by a single exon, shows typical features of a type II transmembrane protein. The protein is believed to be essential for normal embryogenesis.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Kumar R, Yang J, Eddy RL, ''et al.'' |title=Cloning and expression of the murine gene and chromosomal location of the human gene encoding N-acetylglucosaminyltransferase I. |journal=Glycobiology |volume=2 |issue= 4 |pages= 383-93 |year= 1992 |pmid= 1421759 |doi=  }}
*{{cite journal   |vauthors=Kumar R, Yang J, Eddy RL, etal |title=Cloning and expression of the murine gene and chromosomal location of the human gene encoding N-acetylglucosaminyltransferase I |journal=Glycobiology |volume=2 |issue= 4 |pages= 383–93 |year= 1992 |pmid= 1421759 |doi=10.1093/glycob/2.4.383 }}
*{{cite journal  | author=Kumar R, Yang J, Larsen RD, Stanley P |title=Cloning and expression of N-acetylglucosaminyltransferase I, the medial Golgi transferase that initiates complex N-linked carbohydrate formation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 24 |pages= 9948-52 |year= 1991 |pmid= 1702225 |doi= }}
*{{cite journal  |vauthors=Kumar R, Yang J, Larsen RD, Stanley P |title=Cloning and expression of N-acetylglucosaminyltransferase I, the medial Golgi transferase that initiates complex N-linked carbohydrate formation |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 24 |pages= 9948–52 |year= 1991 |pmid= 1702225 |doi=10.1073/pnas.87.24.9948  | pmc=55291 }}
*{{cite journal  | author=Hull E, Sarkar M, Spruijt MP, ''et al.'' |title=Organization and localization to chromosome 5 of the human UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I gene. |journal=Biochem. Biophys. Res. Commun. |volume=176 |issue= 2 |pages= 608-15 |year= 1991 |pmid= 1827260 |doi=  }}
*{{cite journal   |vauthors=Tan J, D'Agostaro AF, Bendiak B, etal |title=The human UDP-N-acetylglucosamine: alpha-6-D-mannoside-beta-1,2- N-acetylglucosaminyltransferase II gene (MGAT2). Cloning of genomic DNA, localization to chromosome 14q21, expression in insect cells and purification of the recombinant protein |journal=Eur. J. Biochem. |volume=231 |issue= 2 |pages= 317–28 |year= 1995 |pmid= 7635144 |doi=10.1111/j.1432-1033.1995.tb20703.x }}
*{{cite journal | author=Tan J, D'Agostaro AF, Bendiak B, ''et al.'' |title=The human UDP-N-acetylglucosamine: alpha-6-D-mannoside-beta-1,2- N-acetylglucosaminyltransferase II gene (MGAT2). Cloning of genomic DNA, localization to chromosome 14q21, expression in insect cells and purification of the recombinant protein. |journal=Eur. J. Biochem. |volume=231 |issue= 2 |pages= 317-28 |year= 1995 |pmid= 7635144 |doi=  }}
*{{cite journal   |vauthors=Yip B, Chen SH, Mulder H, etal |title=Organization of the human beta-1,2-N-acetylglucosaminyltransferase I gene (MGAT1), which controls complex and hybrid N-glycan synthesis |journal=Biochem. J. |volume=321 |issue=  2|pages= 465–74 |year= 1997 |pmid= 9020882 |doi= | pmc=1218092 }}
*{{cite journal | author=Yip B, Chen SH, Mulder H, ''et al.'' |title=Organization of the human beta-1,2-N-acetylglucosaminyltransferase I gene (MGAT1), which controls complex and hybrid N-glycan synthesis. |journal=Biochem. J. |volume=321 ( Pt 2) |issue=  |pages= 465-74 |year= 1997 |pmid= 9020882 |doi=  }}
*{{cite journal   |vauthors=Yen CL, Stone SJ, Cases S, etal |title=Identification of a gene encoding MGAT1, a monoacylglycerol acyltransferase |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 13 |pages= 8512–7 |year= 2002 |pmid= 12077311 |doi= 10.1073/pnas.132274899 | pmc=124292 }}
*{{cite journal | author=Yen CL, Stone SJ, Cases S, ''et al.'' |title=Identification of a gene encoding MGAT1, a monoacylglycerol acyltransferase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 13 |pages= 8512-7 |year= 2002 |pmid= 12077311 |doi= 10.1073/pnas.132274899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Colland F, Jacq X, Trouplin V, etal |title=Functional proteomics mapping of a human signaling pathway |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 | pmc=442148 }}
*{{cite journal | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Otsuki T, Ota T, Nishikawa T, etal |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
*{{cite journal | author=Otsuki T, Ota T, Nishikawa T, ''et al.'' |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117-26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
*{{cite journal   |vauthors=Saribas AS, Johnson K, Liu L, etal |title=Refolding of human beta-1-2 GlcNAc transferase (GnT1) and the role of its unpaired Cys 121 |journal=Biochem. Biophys. Res. Commun. |volume=362 |issue= 2 |pages= 381–6 |year= 2007 |pmid= 17716624 |doi= 10.1016/j.bbrc.2007.07.199 }}
*{{cite journal | author=Saribas AS, Johnson K, Liu L, ''et al.'' |title=Refolding of human beta-1-2 GlcNAc transferase (GnT1) and the role of its unpaired Cys 121. |journal=Biochem. Biophys. Res. Commun. |volume=362 |issue= 2 |pages= 381-6 |year= 2007 |pmid= 17716624 |doi= 10.1016/j.bbrc.2007.07.199 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=4245}}
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Latest revision as of 06:27, 4 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase is an enzyme that in humans is encoded by the MGAT1 gene.[1][2]

There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I is a medial-Golgi enzyme essential for the synthesis of hybrid and complex N-glycans. The protein, encoded by a single exon, shows typical features of a type II transmembrane protein. The protein is believed to be essential for normal embryogenesis.[2]

References

  1. ↑ Hull E, Sarkar M, Spruijt MP, Hoppener JW, Dunn R, Schachter H (Jun 1991). "Organization and localization to chromosome 5 of the human UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I gene". Biochem Biophys Res Commun. 176 (2): 608–15. doi:10.1016/S0006-291X(05)80227-X. PMID 1827260.
  2. ↑ 2.0 2.1 "Entrez Gene: MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase".

Further reading



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