MGEA5: Difference between revisions

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{{Infobox_gene}}
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'''Bifunctional protein NCOAT''' is a [[protein]] that in humans is encoded by the ''MGEA5'' [[gene]].<ref name="pmid9811929">{{cite journal |vauthors=Heckel D, Comtesse N, Brass N, Blin N, Zang KD, Meese E | title = Novel immunogenic antigen homologous to hyaluronidase in meningioma | journal = Hum Mol Genet | volume = 7 | issue = 12 | pages = 1859–72 |date=Dec 1998 | pmid = 9811929 | pmc =  | doi = 10.1093/hmg/7.12.1859 }}</ref><ref name="pmid16356930">{{cite journal |vauthors=Toleman CA, Paterson AJ, Kudlow JE | title = The histone acetyltransferase NCOAT contains a zinc finger-like motif involved in substrate recognition | journal = J Biol Chem | volume = 281 | issue = 7 | pages = 3918–25 |date=Feb 2006 | pmid = 16356930 | pmc =  | doi = 10.1074/jbc.M510485200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MGEA5 meningioma expressed antigen 5 (hyaluronidase)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10724| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =  
| Name = Meningioma expressed antigen 5 (hyaluronidase)
| HGNCid = 7056
| Symbol = MGEA5
| AltSymbols =; FLJ11229; FLJ23355; KIAA0679; MEA5; NCOAT
| OMIM = 604039
| ECnumber =
| Homologene = 8154
| MGIid = 1932139
  | GeneAtlas_image1 = PBB_GE_MGEA5_200899_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_MGEA5_200898_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004402 |text = histone acetyltransferase activity}} {{GNF_GO|id=GO:0004415 |text = hyalurononglucosaminidase activity}} {{GNF_GO|id=GO:0004563 |text = beta-N-acetylhexosaminidase activity}} {{GNF_GO|id=GO:0008415 |text = acyltransferase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0016798 |text = hydrolase activity, acting on glycosyl bonds}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
  | Process = {{GNF_GO|id=GO:0006516 |text = glycoprotein catabolic process}} {{GNF_GO|id=GO:0008152 |text = metabolic process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10724
    | Hs_Ensembl = ENSG00000198408
    | Hs_RefseqProtein = NP_036347
    | Hs_RefseqmRNA = NM_012215
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 10
    | Hs_GenLoc_start = 103534199
    | Hs_GenLoc_end = 103568165
    | Hs_Uniprot = O60502
    | Mm_EntrezGene = 76055
    | Mm_Ensembl = ENSMUSG00000025220
    | Mm_RefseqmRNA = NM_023799
    | Mm_RefseqProtein = NP_076288
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 19
    | Mm_GenLoc_start = 45803572
    | Mm_GenLoc_end = 45837090
    | Mm_Uniprot = Q05CX1
  }}
}}
'''Meningioma expressed antigen 5 (hyaluronidase)''', also known as '''MGEA5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MGEA5 meningioma expressed antigen 5 (hyaluronidase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10724| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi=  }}
*{{cite journal  | author=Nakajima D |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=10.1093/dnares/9.3.99 |name-list-format=vanc| author2=Okazaki N  | author3=Yamakawa H  | display-authors=3  | last4=Kikuno  | first4=R  | last5=Ohara  | first5=O  | last6=Nagase  | first6=T }}
*{{cite journal  | author=Ishikawa K, Nagase T, Suyama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 3 |pages= 169-76 |year= 1998 |pmid= 9734811 |doi=  }}
*{{cite journal  | author=Ishikawa K |title=Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro |journal=DNA Res. |volume=5 |issue= 3 |pages= 169–76 |year= 1998 |pmid= 9734811 |doi=10.1093/dnares/5.3.169 |name-list-format=vanc| author2=Nagase T  | author3=Suyama M  | display-authors=3  | last4=Miyajima  | first4=N | last5=Tanaka  | first5=A  | last6=Kotani  | first6=H  | last7=Nomura  | first7=N  | last8=Ohara  | first8=O  }}
*{{cite journal  | author=Heckel D, Comtesse N, Brass N, ''et al.'' |title=Novel immunogenic antigen homologous to hyaluronidase in meningioma. |journal=Hum. Mol. Genet. |volume=7 |issue= 12 |pages= 1859-72 |year= 1998 |pmid= 9811929 |doi=  }}
*{{cite journal  | author=Gao Y |title=Dynamic O-glycosylation of nuclear and cytosolic proteins: cloning and characterization of a neutral, cytosolic beta-N-acetylglucosaminidase from human brain |journal=J. Biol. Chem. |volume=276 |issue= 13 |pages= 9838–45 |year= 2001 |pmid= 11148210 |doi= 10.1074/jbc.M010420200  |name-list-format=vanc| author2=Wells L | author3=Comer FI  | display-authors=3  | last4=Parker  | first4=GJ  | last5=Hart  | first5=GW }}
*{{cite journal  | author=Gao Y, Wells L, Comer FI, ''et al.'' |title=Dynamic O-glycosylation of nuclear and cytosolic proteins: cloning and characterization of a neutral, cytosolic beta-N-acetylglucosaminidase from human brain. |journal=J. Biol. Chem. |volume=276 |issue= 13 |pages= 9838-45 |year= 2001 |pmid= 11148210 |doi= 10.1074/jbc.M010420200 }}
*{{cite journal  |vauthors=Comtesse N, Maldener E, Meese E |title=Identification of a nuclear variant of MGEA5, a cytoplasmic hyaluronidase and a beta-N-acetylglucosaminidase |journal=Biochem. Biophys. Res. Commun. |volume=283 |issue= 3 |pages= 634–40 |year= 2001 |pmid= 11341771 |doi= 10.1006/bbrc.2001.4815 }}
*{{cite journal  | author=Comtesse N, Maldener E, Meese E |title=Identification of a nuclear variant of MGEA5, a cytoplasmic hyaluronidase and a beta-N-acetylglucosaminidase. |journal=Biochem. Biophys. Res. Commun. |volume=283 |issue= 3 |pages= 634-40 |year= 2001 |pmid= 11341771 |doi= 10.1006/bbrc.2001.4815 }}
*{{cite journal  | author=Wells L |title=Dynamic O-glycosylation of nuclear and cytosolic proteins: further characterization of the nucleocytoplasmic beta-N-acetylglucosaminidase, O-GlcNAcase |journal=J. Biol. Chem. |volume=277 |issue= 3 |pages= 1755–61 |year= 2002 |pmid= 11788610 |doi= 10.1074/jbc.M109656200 |name-list-format=vanc| author2=Gao Y | author3=Mahoney JA  | display-authors=3  | last4=Vosseller  | first4=K  | last5=Chen  | first5=C  | last6=Rosen  | first6=A  | last7=Hart  | first7=GW  }}
*{{cite journal  | author=Wells L, Gao Y, Mahoney JA, ''et al.'' |title=Dynamic O-glycosylation of nuclear and cytosolic proteins: further characterization of the nucleocytoplasmic beta-N-acetylglucosaminidase, O-GlcNAcase. |journal=J. Biol. Chem. |volume=277 |issue= 3 |pages= 1755-61 |year= 2002 |pmid= 11788610 |doi=  }}
*{{cite journal  |vauthors=Farook VS, Bogardus C, Prochazka M |title=Analysis of MGEA5 on 10q24.1-q24.3 encoding the beta-O-linked N-acetylglucosaminidase as a candidate gene for type 2 diabetes mellitus in Pima Indians |journal=Mol. Genet. Metab. |volume=77 |issue= 1–2 |pages= 189–93 |year= 2003 |pmid= 12359146 |doi=10.1016/S1096-7192(02)00127-0  }}
*{{cite journal  | author=Farook VS, Bogardus C, Prochazka M |title=Analysis of MGEA5 on 10q24.1-q24.3 encoding the beta-O-linked N-acetylglucosaminidase as a candidate gene for type 2 diabetes mellitus in Pima Indians. |journal=Mol. Genet. Metab. |volume=77 |issue= 1-2 |pages= 189-93 |year= 2003 |pmid= 12359146 |doi= }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285  |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Beausoleil SA |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446  |name-list-format=vanc| author2=Jedrychowski M  | author3=Schwartz D  | display-authors=3  | last4=Elias  | first4=JE  | last5=Villén  | first5=J  | last6=Li  | first6=J  | last7=Cohn  | first7=MA  | last8=Cantley  | first8=LC  | last9=Gygi  | first9=SP }}
*{{cite journal  | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal  | author=Ballif BA |title=Phosphoproteomic analysis of the developing mouse brain |journal=Mol. Cell. Proteomics |volume=3 |issue= 11 |pages= 1093–101 |year= 2005 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200  |name-list-format=vanc| author2=Villén J  | author3=Beausoleil SA  | display-authors=3  | last4=Schwartz  | first4=D  | last5=Gygi  | first5=SP }}
*{{cite journal  | author=Ballif BA, Villén J, Beausoleil SA, ''et al.'' |title=Phosphoproteomic analysis of the developing mouse brain. |journal=Mol. Cell Proteomics |volume=3 |issue= 11 |pages= 1093-101 |year= 2005 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200 }}
*{{cite journal  |vauthors=Toleman C, Paterson AJ, Whisenhunt TR, Kudlow JE |title=Characterization of the histone acetyltransferase (HAT) domain of a bifunctional protein with activable O-GlcNAcase and HAT activities |journal=J. Biol. Chem. |volume=279 |issue= 51 |pages= 53665–73 |year= 2005 |pmid= 15485860 |doi= 10.1074/jbc.M410406200 }}
*{{cite journal | author=Toleman C, Paterson AJ, Whisenhunt TR, Kudlow JE |title=Characterization of the histone acetyltransferase (HAT) domain of a bifunctional protein with activable O-GlcNAcase and HAT activities. |journal=J. Biol. Chem. |volume=279 |issue= 51 |pages= 53665-73 |year= 2005 |pmid= 15485860 |doi= 10.1074/jbc.M410406200 }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Whisenhunt TR |title=Disrupting the enzyme complex regulating O-GlcNAcylation blocks signaling and development |journal=Glycobiology |volume=16 |issue= 6 |pages= 551–63 |year= 2006 |pmid= 16505006 |doi= 10.1093/glycob/cwj096  |name-list-format=vanc| author2=Yang X  | author3=Bowe DB  | display-authors=3  | last4=Paterson  | first4=AJ  | last5=Van Tine  | first5=BA  | last6=Kudlow  | first6=JE }}
*{{cite journal  | author=Toleman CA, Paterson AJ, Kudlow JE |title=The histone acetyltransferase NCOAT contains a zinc finger-like motif involved in substrate recognition. |journal=J. Biol. Chem. |volume=281 |issue= 7 |pages= 3918-25 |year= 2006 |pmid= 16356930 |doi= 10.1074/jbc.M510485200 }}
*{{cite journal  |vauthors=Toleman C, Paterson AJ, Kudlow JE |title=Location and characterization of the O-GlcNAcase active site |journal=Biochim. Biophys. Acta |volume=1760 |issue= 5 |pages= 829–39 |year= 2006 |pmid= 16517082 |doi= 10.1016/j.bbagen.2006.01.017 }}
*{{cite journal | author=Whisenhunt TR, Yang X, Bowe DB, ''et al.'' |title=Disrupting the enzyme complex regulating O-GlcNAcylation blocks signaling and development. |journal=Glycobiology |volume=16 |issue= 6 |pages= 551-63 |year= 2006 |pmid= 16505006 |doi= 10.1093/glycob/cwj096 }}
*{{cite journal  | author=Cameron EA |title=MGEA5-14 polymorphism and type 2 diabetes in Mexico City |journal=Am. J. Hum. Biol. |volume=19 |issue= 4 |pages= 593–6 |year= 2007 |pmid= 17546623 |doi= 10.1002/ajhb.20639  |name-list-format=vanc| author2=Martinez-Marignac VL  | author3=Chan A  | display-authors=3  | last4=Valladares  | first4=A.  | last5=Simmonds  | first5=L.V.  | last6=Wacher  | first6=N.  | last7=Kumate  | first7=J.  | last8=McKeigue  | first8=P.  | last9=Shriver  | first9=M.D. }}
*{{cite journal  | author=Toleman C, Paterson AJ, Kudlow JE |title=Location and characterization of the O-GlcNAcase active site. |journal=Biochim. Biophys. Acta |volume=1760 |issue= 5 |pages= 829-39 |year= 2006 |pmid= 16517082 |doi= 10.1016/j.bbagen.2006.01.017 }}
*{{cite journal | author=Cameron EA, Martinez-Marignac VL, Chan A, ''et al.'' |title=MGEA5-14 polymorphism and type 2 diabetes in Mexico City. |journal=Am. J. Hum. Biol. |volume=19 |issue= 4 |pages= 593-6 |year= 2007 |pmid= 17546623 |doi= 10.1002/ajhb.20639 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 06:28, 4 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Bifunctional protein NCOAT is a protein that in humans is encoded by the MGEA5 gene.[1][2][3]


References

  1. ↑ Heckel D, Comtesse N, Brass N, Blin N, Zang KD, Meese E (Dec 1998). "Novel immunogenic antigen homologous to hyaluronidase in meningioma". Hum Mol Genet. 7 (12): 1859–72. doi:10.1093/hmg/7.12.1859. PMID 9811929.
  2. ↑ Toleman CA, Paterson AJ, Kudlow JE (Feb 2006). "The histone acetyltransferase NCOAT contains a zinc finger-like motif involved in substrate recognition". J Biol Chem. 281 (7): 3918–25. doi:10.1074/jbc.M510485200. PMID 16356930.
  3. ↑ "Entrez Gene: MGEA5 meningioma expressed antigen 5 (hyaluronidase)".

Further reading



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