MOAP1: Difference between revisions

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{{Infobox_gene}}
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'''Modulator of apoptosis 1''' is a [[protein]] that in humans is encoded by the ''MOAP1'' [[gene]].<ref name="pmid11060313">{{cite journal |vauthors=Tan KO, Tan KM, Chan SL, Yee KS, Bevort M, Ang KC, Yu VC | title = MAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domains | journal = J Biol Chem | volume = 276 | issue = 4 | pages = 2802–7 |date=May 2001 | pmid = 11060313 | pmc =  | doi = 10.1074/jbc.M008955200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MOAP1 modulator of apoptosis 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64112| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Modulator of apoptosis 1
| HGNCid = 16658
| Symbol = MOAP1
| AltSymbols =; MAP-1; PNMA4
| OMIM = 609485
| ECnumber =
| Homologene = 11154
| MGIid = 1915555
| GeneAtlas_image1 = PBB_GE_MOAP1_212508_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
  | Process = {{GNF_GO|id=GO:0006915 |text = apoptosis}}  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 64112
    | Hs_Ensembl = ENSG00000165943
    | Hs_RefseqProtein = NP_071434
    | Hs_RefseqmRNA = NM_022151
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 14
    | Hs_GenLoc_start = 92718295
    | Hs_GenLoc_end = 92721002
    | Hs_Uniprot = Q96BY2
    | Mm_EntrezGene = 64113
    | Mm_Ensembl = ENSMUSG00000041716
    | Mm_RefseqmRNA = NM_022323
    | Mm_RefseqProtein = NP_071718
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 12
    | Mm_GenLoc_start = 103143124
    | Mm_GenLoc_end = 103159722
    | Mm_Uniprot = Q9ERH6
  }}
}}
'''Modulator of apoptosis 1''', also known as '''MOAP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MOAP1 modulator of apoptosis 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64112| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene was identified by its interaction with apoptosis regulator BAX protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with BAX. When overexpressed, this gene has been shown to mediate caspase-dependent apoptosis.<ref name="entrez">{{cite web | title = Entrez Gene: MOAP1 modulator of apoptosis 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64112| accessdate = }}</ref>
| summary_text = The protein encoded by this gene was identified by its interaction with apoptosis regulator BAX protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with BAX. When overexpressed, this gene has been shown to mediate caspase-dependent apoptosis.<ref name="entrez"/>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Tan KO, Tan KM, Chan SL, ''et al.'' |title=MAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domains. |journal=J. Biol. Chem. |volume=276 |issue= 4 |pages= 2802-7 |year= 2001 |pmid= 11060313 |doi= 10.1074/jbc.M008955200 }}
*{{cite journal  |vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948 }}
*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
*{{cite journal   |vauthors=Simpson JC, Wellenreuther R, Poustka A, etal |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 | pmc=1083732 }}
*{{cite journal | author=Simpson JC, Wellenreuther R, Poustka A, ''et al.'' |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287-92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Wiemann S, Arlt D, Huber W, etal |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 | pmc=528930 }}
*{{cite journal | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal   |vauthors=Baksh S, Tommasi S, Fenton S, etal |title=The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to Bax conformational change and cell death. |journal=Mol. Cell |volume=18 |issue= 6 |pages= 637–50 |year= 2005 |pmid= 15949439 |doi= 10.1016/j.molcel.2005.05.010 }}
*{{cite journal | author=Baksh S, Tommasi S, Fenton S, ''et al.'' |title=The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to Bax conformational change and cell death. |journal=Mol. Cell |volume=18 |issue= 6 |pages= 637-50 |year= 2005 |pmid= 15949439 |doi= 10.1016/j.molcel.2005.05.010 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Vos MD, Dallol A, Eckfeld K, etal |title=The RASSF1A tumor suppressor activates Bax via MOAP-1. |journal=J. Biol. Chem. |volume=281 |issue= 8 |pages= 4557–63 |year= 2006 |pmid= 16344548 |doi= 10.1074/jbc.M512128200 }}
*{{cite journal | author=Vos MD, Dallol A, Eckfeld K, ''et al.'' |title=The RASSF1A tumor suppressor activates Bax via MOAP-1. |journal=J. Biol. Chem. |volume=281 |issue= 8 |pages= 4557-63 |year= 2006 |pmid= 16344548 |doi= 10.1074/jbc.M512128200 }}
*{{cite journal   |vauthors=Mehrle A, Rosenfelder H, Schupp I, etal |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 | pmc=1347501 }}
*{{cite journal | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
*{{cite journal   |vauthors=Lim J, Hao T, Shaw C, etal |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal  |vauthors=Fu NY, Sukumaran SK, Yu VC |title=Inhibition of ubiquitin-mediated degradation of MOAP-1 by apoptotic stimuli promotes Bax function in mitochondria. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 24 |pages= 10051–6 |year= 2007 |pmid= 17535899 |doi= 10.1073/pnas.0700007104 | pmc=1877986 }}
*{{cite journal  | author=Fu NY, Sukumaran SK, Yu VC |title=Inhibition of ubiquitin-mediated degradation of MOAP-1 by apoptotic stimuli promotes Bax function in mitochondria. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 24 |pages= 10051-6 |year= 2007 |pmid= 17535899 |doi= 10.1073/pnas.0700007104 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 06:42, 4 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Modulator of apoptosis 1 is a protein that in humans is encoded by the MOAP1 gene.[1][2]

The protein encoded by this gene was identified by its interaction with apoptosis regulator BAX protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with BAX. When overexpressed, this gene has been shown to mediate caspase-dependent apoptosis.[2]

References

  1. ↑ Tan KO, Tan KM, Chan SL, Yee KS, Bevort M, Ang KC, Yu VC (May 2001). "MAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domains". J Biol Chem. 276 (4): 2802–7. doi:10.1074/jbc.M008955200. PMID 11060313.
  2. ↑ 2.0 2.1 "Entrez Gene: MOAP1 modulator of apoptosis 1".

Further reading



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