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{{Infobox_gene}}
{{PBB_Controls
'''Multiple PDZ domain protein''' is a [[protein]] that in humans is encoded by the ''MPDZ'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MPDZ multiple PDZ domain protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8777| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image = PBB_Protein_MPDZ_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2fcf.
| PDB = {{PDB2|2fcf}}, {{PDB2|2fne}}, {{PDB2|2iwn}}, {{PDB2|2iwo}}, {{PDB2|2iwp}}, {{PDB2|2iwq}}, {{PDB2|2o2t}}, {{PDB2|2opg}}
| Name = Multiple PDZ domain protein
| HGNCid = 7208
| Symbol = MPDZ
| AltSymbols =; DKFZp781P216; FLJ25909; FLJ34626; FLJ90240; MUPP1
| OMIM = 603785
| ECnumber = 
| Homologene = 2841
| MGIid = 1343489
| GeneAtlas_image1 = PBB_GE_MPDZ_205079_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_MPDZ_213306_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005923 |text = tight junction}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0019717 |text = synaptosome}} {{GNF_GO|id=GO:0045202 |text = synapse}}
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8777
    | Hs_Ensembl = ENSG00000107186
    | Hs_RefseqProtein = NP_003820
    | Hs_RefseqmRNA = NM_003829
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 9
    | Hs_GenLoc_start = 13095703
    | Hs_GenLoc_end = 13240357
    | Hs_Uniprot = O75970
    | Mm_EntrezGene = 17475
    | Mm_Ensembl = ENSMUSG00000028402
    | Mm_RefseqmRNA = NM_010820
    | Mm_RefseqProtein = NP_034950
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 80749736
    | Mm_GenLoc_end = 80914038
    | Mm_Uniprot = Q8VBX6
  }}
}}
'''Multiple PDZ domain protein''', also known as '''MPDZ''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MPDZ multiple PDZ domain protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8777| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
MPDZ has been shown to [[Protein-protein interaction|interact]] with:
{{PBB_Summary
* [[5-HT2C receptor]],<ref name = pmid11150294>{{cite journal | vauthors = Becamel C, Figge A, Poliak S, Dumuis A, Peles E, Bockaert J, Lubbert H, Ullmer C | title = Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1 | journal = J. Biol. Chem. | volume = 276 | issue = 16 | pages = 12974–82 | date = April 2001 | pmid = 11150294 | doi = 10.1074/jbc.M008089200 }}</ref><ref name = pmid9537516>{{cite journal | vauthors = Ullmer C, Schmuck K, Figge A, Lübbert H | title = Cloning and characterization of MUPP1, a novel PDZ domain protein | journal = FEBS Lett. | volume = 424 | issue = 1-2 | pages = 63–8 | date = March 1998 | pmid = 9537516 | doi =  10.1016/s0014-5793(98)00141-0}}</ref>
| section_title =  
* [[CD117]],<ref name = pmid11018522>{{cite journal | vauthors = Mancini A, Koch A, Stefan M, Niemann H, Tamura T | title = The direct association of the multiple PDZ domain containing proteins (MUPP-1) with the human c-Kit C-terminus is regulated by tyrosine kinase activity | journal = FEBS Lett. | volume = 482 | issue = 1-2 | pages = 54–8 | date = September 2000 | pmid = 11018522 | doi = 10.1016/s0014-5793(00)02036-6}}</ref> and
| summary_text =  
* [[PLEKHA1]].<ref name = pmid11802782>{{cite journal | vauthors = Kimber WA, Trinkle-Mulcahy L, Cheung PC, Deak M, Marsden LJ, Kieloch A, Watt S, Javier RT, Gray A, Downes CP, Lucocq JM, Alessi DR | title = Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo | journal = Biochem. J. | volume = 361 | issue = Pt 3 | pages = 525–36 | date = February 2002 | pmid = 11802782 | pmc = 1222335 | doi = 10.1042/0264-6021:3610525}}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist|35em}}
==Further reading==
 
{{refbegin | 2}}
== Further reading ==
{{PBB_Further_reading
{{refbegin|35em}}
| citations =
* {{cite journal | vauthors = Ullmer C, Schmuck K, Figge A, Lübbert H | title = Cloning and characterization of MUPP1, a novel PDZ domain protein | journal = FEBS Lett. | volume = 424 | issue = 1–2 | pages = 63–8 | year = 1998 | pmid = 9537516 | doi = 10.1016/S0014-5793(98)00141-0 }}
*{{cite journal | author=Ullmer C, Schmuck K, Figge A, Lübbert H |title=Cloning and characterization of MUPP1, a novel PDZ domain protein. |journal=FEBS Lett. |volume=424 |issue= 1-2 |pages= 63-8 |year= 1998 |pmid= 9537516 |doi= }}
* {{cite journal | vauthors = Barritt DS, Pearn MT, Zisch AH, Lee SS, Javier RT, Pasquale EB, Stallcup WB | title = The multi-PDZ domain protein MUPP1 is a cytoplasmic ligand for the membrane-spanning proteoglycan NG2 | journal = J. Cell. Biochem. | volume = 79 | issue = 2 | pages = 213–24 | year = 2000 | pmid = 10967549 | pmc = 3501957 | doi = 10.1002/1097-4644(20001101)79:2<213::AID-JCB50>3.0.CO;2-G }}
*{{cite journal | author=Barritt DS, Pearn MT, Zisch AH, ''et al.'' |title=The multi-PDZ domain protein MUPP1 is a cytoplasmic ligand for the membrane-spanning proteoglycan NG2. |journal=J. Cell. Biochem. |volume=79 |issue= 2 |pages= 213-24 |year= 2000 |pmid= 10967549 |doi= }}
* {{cite journal | vauthors = Lee SS, Glaunsinger B, Mantovani F, Banks L, Javier RT | title = Multi-PDZ Domain Protein MUPP1 Is a Cellular Target for both Adenovirus E4-ORF1 and High-Risk Papillomavirus Type 18 E6 Oncoproteins | journal = J. Virol. | volume = 74 | issue = 20 | pages = 9680–93 | year = 2000 | pmid = 11000240 | pmc = 112400 | doi = 10.1128/JVI.74.20.9680-9693.2000 }}
*{{cite journal  | author=Lee SS, Glaunsinger B, Mantovani F, ''et al.'' |title=Multi-PDZ domain protein MUPP1 is a cellular target for both adenovirus E4-ORF1 and high-risk papillomavirus type 18 E6 oncoproteins. |journal=J. Virol. |volume=74 |issue= 20 |pages= 9680-93 |year= 2000 |pmid= 11000240 |doi= }}
* {{cite journal | vauthors = Mancini A, Koch A, Stefan M, Niemann H, Tamura T | title = The direct association of the multiple PDZ domain containing proteins (MUPP-1) with the human c-Kit C-terminus is regulated by tyrosine kinase activity | journal = FEBS Lett. | volume = 482 | issue = 1–2 | pages = 54–8 | year = 2000 | pmid = 11018522 | doi = 10.1016/S0014-5793(00)02036-6 }}
*{{cite journal  | author=Mancini A, Koch A, Stefan M, ''et al.'' |title=The direct association of the multiple PDZ domain containing proteins (MUPP-1) with the human c-Kit C-terminus is regulated by tyrosine kinase activity. |journal=FEBS Lett. |volume=482 |issue= 1-2 |pages= 54-8 |year= 2000 |pmid= 11018522 |doi= }}
* {{cite journal | vauthors = Becamel C, Figge A, Poliak S, Dumuis A, Peles E, Bockaert J, Lubbert H, Ullmer C | title = Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1 | journal = J. Biol. Chem. | volume = 276 | issue = 16 | pages = 12974–82 | year = 2001 | pmid = 11150294 | doi = 10.1074/jbc.M008089200 }}
*{{cite journal | author=Becamel C, Figge A, Poliak S, ''et al.'' |title=Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1. |journal=J. Biol. Chem. |volume=276 |issue= 16 |pages= 12974-82 |year= 2001 |pmid= 11150294 |doi= 10.1074/jbc.M008089200 }}
* {{cite journal | vauthors = Vassilev A, Kaneko KJ, Shu H, Zhao Y, DePamphilis ML | title = TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm | journal = Genes Dev. | volume = 15 | issue = 10 | pages = 1229–41 | year = 2001 | pmid = 11358867 | pmc = 313800 | doi = 10.1101/gad.888601 }}
*{{cite journal | author=Vassilev A, Kaneko KJ, Shu H, ''et al.'' |title=TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm. |journal=Genes Dev. |volume=15 |issue= 10 |pages= 1229-41 |year= 2001 |pmid= 11358867 |doi= 10.1101/gad.888601 }}
* {{cite journal | vauthors = Hamazaki Y, Itoh M, Sasaki H, Furuse M, Tsukita S | title = Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion molecule | journal = J. Biol. Chem. | volume = 277 | issue = 1 | pages = 455–61 | year = 2002 | pmid = 11689568 | doi = 10.1074/jbc.M109005200 }}
*{{cite journal | author=Hamazaki Y, Itoh M, Sasaki H, ''et al.'' |title=Multi-PDZ domain protein 1 (MUPP1) is concentrated at tight junctions through its possible interaction with claudin-1 and junctional adhesion molecule. |journal=J. Biol. Chem. |volume=277 |issue= 1 |pages= 455-61 |year= 2002 |pmid= 11689568 |doi= 10.1074/jbc.M109005200 }}
* {{cite journal | vauthors = Kimber WA, Trinkle-Mulcahy L, Cheung PC, Deak M, Marsden LJ, Kieloch A, Watt S, Javier RT, Gray A, Downes CP, Lucocq JM, Alessi DR | title = Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo | journal = Biochem. J. | volume = 361 | issue = Pt 3 | pages = 525–36 | year = 2002 | pmid = 11802782 | pmc = 1222335 | doi = 10.1042/0264-6021:3610525 }}
*{{cite journal | author=Kimber WA, Trinkle-Mulcahy L, Cheung PC, ''et al.'' |title=Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo. |journal=Biochem. J. |volume=361 |issue= Pt 3 |pages= 525-36 |year= 2002 |pmid= 11802782 |doi= }}
* {{cite journal | vauthors = Poliak S, Matlis S, Ullmer C, Scherer SS, Peles E | title = Distinct claudins and associated PDZ proteins form different autotypic tight junctions in myelinating Schwann cells | journal = J. Cell Biol. | volume = 159 | issue = 2 | pages = 361–72 | year = 2002 | pmid = 12403818 | pmc = 2173042 | doi = 10.1083/jcb.200207050 }}
*{{cite journal | author=Poliak S, Matlis S, Ullmer C, ''et al.'' |title=Distinct claudins and associated PDZ proteins form different autotypic tight junctions in myelinating Schwann cells. |journal=J. Cell Biol. |volume=159 |issue= 2 |pages= 361-72 |year= 2002 |pmid= 12403818 |doi= 10.1083/jcb.200207050 }}
* {{cite journal | vauthors = Griffon N, Jeanneteau F, Prieur F, Diaz J, Sokoloff P | title = CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors | journal = Brain Res. Mol. Brain Res. | volume = 117 | issue = 1 | pages = 47–57 | year = 2003 | pmid = 14499480 | doi = 10.1016/S0169-328X(03)00283-3 }}
*{{cite journal | author=Griffon N, Jeanneteau F, Prieur F, ''et al.'' |title=CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors. |journal=Brain Res. Mol. Brain Res. |volume=117 |issue= 1 |pages= 47-57 |year= 2003 |pmid= 14499480 |doi= }}
* {{cite journal | vauthors = Krapivinsky G, Medina I, Krapivinsky L, Gapon S, Clapham DE | title = SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation | journal = Neuron | volume = 43 | issue = 4 | pages = 563–74 | year = 2004 | pmid = 15312654 | doi = 10.1016/j.neuron.2004.08.003 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = van de Pavert SA, Kantardzhieva A, Malysheva A, Meuleman J, Versteeg I, Levelt C, Klooster J, Geiger S, Seeliger MW, Rashbass P, Le Bivic A, Wijnholds J | title = Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure | journal = J. Cell Sci. | volume = 117 | issue = Pt 18 | pages = 4169–77 | year = 2005 | pmid = 15316081 | doi = 10.1242/jcs.01301 }}
*{{cite journal | author=Humphray SJ, Oliver K, Hunt AR, ''et al.'' |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369-74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 }}
* {{cite journal | vauthors = Coyne CB, Voelker T, Pichla SL, Bergelson JM | title = The coxsackievirus and adenovirus receptor interacts with the multi-PDZ domain protein-1 (MUPP-1) within the tight junction | journal = J. Biol. Chem. | volume = 279 | issue = 46 | pages = 48079–84 | year = 2005 | pmid = 15364909 | doi = 10.1074/jbc.M409061200 }}
*{{cite journal | author=Krapivinsky G, Medina I, Krapivinsky L, ''et al.'' |title=SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation. |journal=Neuron |volume=43 |issue= 4 |pages= 563-74 |year= 2004 |pmid= 15312654 |doi= 10.1016/j.neuron.2004.08.003 }}
* {{cite journal | vauthors = Okuhira K, Fitzgerald ML, Sarracino DA, Manning JJ, Bell SA, Goss JL, Freeman MW | title = Purification of ATP-binding cassette transporter A1 and associated binding proteins reveals the importance of beta1-syntrophin in cholesterol efflux | journal = J. Biol. Chem. | volume = 280 | issue = 47 | pages = 39653–64 | year = 2006 | pmid = 16192269 | doi = 10.1074/jbc.M510187200 }}
*{{cite journal | author=van de Pavert SA, Kantardzhieva A, Malysheva A, ''et al.'' |title=Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure. |journal=J. Cell. Sci. |volume=117 |issue= Pt 18 |pages= 4169-77 |year= 2005 |pmid= 15316081 |doi= 10.1242/jcs.01301 }}
* {{cite journal | vauthors = Heydecke D, Meyer D, Ackermann F, Wilhelm B, Gudermann T, Boekhoff I | title = The multi PDZ domain protein MUPP1 as a putative scaffolding protein for organizing signaling complexes in the acrosome of mammalian spermatozoa | journal = J. Androl. | volume = 27 | issue = 3 | pages = 390–404 | year = 2006 | pmid = 16452527 | doi = 10.2164/jandrol.05166 }}
*{{cite journal | author=Coyne CB, Voelker T, Pichla SL, Bergelson JM |title=The coxsackievirus and adenovirus receptor interacts with the multi-PDZ domain protein-1 (MUPP-1) within the tight junction. |journal=J. Biol. Chem. |volume=279 |issue= 46 |pages= 48079-84 |year= 2005 |pmid= 15364909 |doi= 10.1074/jbc.M409061200 }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | year = 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Okuhira K, Fitzgerald ML, Sarracino DA, ''et al.'' |title=Purification of ATP-binding cassette transporter A1 and associated binding proteins reveals the importance of beta1-syntrophin in cholesterol efflux. |journal=J. Biol. Chem. |volume=280 |issue= 47 |pages= 39653-64 |year= 2006 |pmid= 16192269 |doi= 10.1074/jbc.M510187200 }}
* {{cite journal | vauthors = Szafranski K, Schindler S, Taudien S, Hiller M, Huse K, Jahn N, Schreiber S, Backofen R, Platzer M | title = Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns | journal = Genome Biology | volume = 8 | issue = 8 | pages = R154 | year = 2007 | pmid = 17672918 | pmc = 2374985 | doi = 10.1186/gb-2007-8-8-r154 }}
*{{cite journal | author=Heydecke D, Meyer D, Ackermann F, ''et al.'' |title=The multi PDZ domain protein MUPP1 as a putative scaffolding protein for organizing signaling complexes in the acrosome of mammalian spermatozoa. |journal=J. Androl. |volume=27 |issue= 3 |pages= 390-404 |year= 2006 |pmid= 16452527 |doi= 10.2164/jandrol.05166 }}
*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | author=Szafranski K, Schindler S, Taudien S, ''et al.'' |title=Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns. |journal= |volume=8 |issue= 8 |pages= R154 |year=  |pmid= 17672918 |doi= 10.1186/gb-2007-8-8-r154 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=8777}}
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{{gene-9-stub}}

Latest revision as of 20:20, 8 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Multiple PDZ domain protein is a protein that in humans is encoded by the MPDZ gene.[1]

Interactions

MPDZ has been shown to interact with:

References

  1. ↑ "Entrez Gene: MPDZ multiple PDZ domain protein".
  2. ↑ Becamel C, Figge A, Poliak S, Dumuis A, Peles E, Bockaert J, Lubbert H, Ullmer C (April 2001). "Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1". J. Biol. Chem. 276 (16): 12974–82. doi:10.1074/jbc.M008089200. PMID 11150294.
  3. ↑ Ullmer C, Schmuck K, Figge A, Lübbert H (March 1998). "Cloning and characterization of MUPP1, a novel PDZ domain protein". FEBS Lett. 424 (1–2): 63–8. doi:10.1016/s0014-5793(98)00141-0. PMID 9537516.
  4. ↑ Mancini A, Koch A, Stefan M, Niemann H, Tamura T (September 2000). "The direct association of the multiple PDZ domain containing proteins (MUPP-1) with the human c-Kit C-terminus is regulated by tyrosine kinase activity". FEBS Lett. 482 (1–2): 54–8. doi:10.1016/s0014-5793(00)02036-6. PMID 11018522.
  5. ↑ Kimber WA, Trinkle-Mulcahy L, Cheung PC, Deak M, Marsden LJ, Kieloch A, Watt S, Javier RT, Gray A, Downes CP, Lucocq JM, Alessi DR (February 2002). "Evidence that the tandem-pleckstrin-homology-domain-containing protein TAPP1 interacts with Ptd(3,4)P2 and the multi-PDZ-domain-containing protein MUPP1 in vivo". Biochem. J. 361 (Pt 3): 525–36. doi:10.1042/0264-6021:3610525. PMC 1222335. PMID 11802782.

Further reading


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