MYO9B: Difference between revisions

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{{Infobox_gene}}
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'''Myosin-IXb''' is a [[protein]] that in humans is encoded by the ''MYO9B'' [[gene]].<ref name="pmid9226381">{{cite journal |vauthors=Bahler M, Kehrer I, Gordon L, Stoffler HE, Olsen AS | title = Physical mapping of human myosin-IXB (MYO9B), the human orthologue of the rat myosin myr 5, to chromosome 19p13.1 | journal = Genomics | volume = 43 | issue = 1 | pages = 107–9 |date=Sep 1997 | pmid = 9226381 | pmc =  | doi = 10.1006/geno.1997.4776 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MYO9B myosin IXB| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4650| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Myosin IXB
| HGNCid = 7609
| Symbol = MYO9B
| AltSymbols =; CELIAC4; MYR5
| OMIM = 602129
| ECnumber =
| Homologene = 3058
| MGIid = 106624
  | GeneAtlas_image1 = PBB_GE_MYO9B_214780_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_MYO9B_217297_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000146 |text = microfilament motor activity}} {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0005096 |text = GTPase activator activity}} {{GNF_GO|id=GO:0005100 |text = Rho GTPase activator activity}} {{GNF_GO|id=GO:0005516 |text = calmodulin binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016887 |text = ATPase activity}} {{GNF_GO|id=GO:0019992 |text = diacylglycerol binding}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}} {{GNF_GO|id=GO:0043531 |text = ADP binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005938 |text = cell cortex}} {{GNF_GO|id=GO:0016459 |text = myosin complex}} {{GNF_GO|id=GO:0031941 |text = filamentous actin}} {{GNF_GO|id=GO:0048471 |text = perinuclear region of cytoplasm}}
| Process = {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0030048 |text = actin filament-based movement}} {{GNF_GO|id=GO:0032011 |text = ARF protein signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4650
    | Hs_Ensembl = ENSG00000099331
    | Hs_RefseqProtein = NP_004136
    | Hs_RefseqmRNA = NM_004145
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 17073466
    | Hs_GenLoc_end = 17185093
    | Hs_Uniprot = Q13459
    | Mm_EntrezGene = 17925
    | Mm_Ensembl = ENSMUSG00000004677
    | Mm_RefseqmRNA = NM_015742
    | Mm_RefseqProtein = NP_056557
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 74219286
    | Mm_GenLoc_end = 74289698
    | Mm_Uniprot = Q3TRQ0
  }}
}}
'''Myosin IXB''', also known as '''MYO9B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MYO9B myosin IXB| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4650| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Bement WM, Hasson T, Wirth JA, ''et al.'' |title=Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 14 |pages= 6549-53 |year= 1994 |pmid= 8022818 |doi=  }}
*{{cite journal   |vauthors=Bement WM, Hasson T, Wirth JA, etal |title=Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 14 |pages= 6549–53 |year= 1994 |pmid= 8022818 |doi=10.1073/pnas.91.14.6549  | pmc=44240 }}
*{{cite journal | author=Wirth JA, Jensen KA, Post PL, ''et al.'' |title=Human myosin-IXb, an unconventional myosin with a chimerin-like rho/rac GTPase-activating protein domain in its tail. |journal=J. Cell. Sci. |volume=109 ( Pt 3) |issue=  |pages= 653-61 |year= 1997 |pmid= 8907710 |doi=  }}
*{{cite journal   |vauthors=Wirth JA, Jensen KA, Post PL, etal |title=Human myosin-IXb, an unconventional myosin with a chimerin-like rho/rac GTPase-activating protein domain in its tail. |journal=J. Cell Sci. |volume=109 |issue=  3|pages= 653–61 |year= 1997 |pmid= 8907710 |doi=  }}
*{{cite journal  | author=Bähler M, Kehrer I, Gordon L, ''et al.'' |title=Physical mapping of human myosin-IXB (MYO9B), the human orthologue of the rat myosin myr 5, to chromosome 19p13.1. |journal=Genomics |volume=43 |issue= 1 |pages= 107-9 |year= 1997 |pmid= 9226381 |doi= 10.1006/geno.1997.4776 }}
*{{cite journal  |vauthors=Post PL, Bokoch GM, Mooseker MS |title=Human myosin-IXb is a mechanochemically active motor and a GAP for rho. |journal=J. Cell Sci. |volume=111 |issue= 7|pages= 941–50 |year= 1998 |pmid= 9490638 |doi= }}
*{{cite journal | author=Post PL, Bokoch GM, Mooseker MS |title=Human myosin-IXb is a mechanochemically active motor and a GAP for rho. |journal=J. Cell. Sci. |volume=111 ( Pt 7) |issue= |pages= 941-50 |year= 1998 |pmid= 9490638 |doi=  }}
*{{cite journal   |vauthors=Grewal PK, Jones AM, Maconochie M, etal |title=Cloning of the murine unconventional myosin gene Myo9b and identification of alternative splicing. |journal=Gene |volume=240 |issue= 2 |pages= 389–98 |year= 2000 |pmid= 10580159 |doi=10.1016/S0378-1119(99)00459-X }}
*{{cite journal | author=Grewal PK, Jones AM, Maconochie M, ''et al.'' |title=Cloning of the murine unconventional myosin gene Myo9b and identification of alternative splicing. |journal=Gene |volume=240 |issue= 2 |pages= 389-98 |year= 2000 |pmid= 10580159 |doi= }}
*{{cite journal   |vauthors=Post PL, Tyska MJ, O'Connell CB, etal |title=Myosin-IXb is a single-headed and processive motor. |journal=J. Biol. Chem. |volume=277 |issue= 14 |pages= 11679–83 |year= 2002 |pmid= 11801597 |doi= 10.1074/jbc.M111173200 }}
*{{cite journal  | author=Post PL, Tyska MJ, O'Connell CB, ''et al.'' |title=Myosin-IXb is a single-headed and processive motor. |journal=J. Biol. Chem. |volume=277 |issue= 14 |pages= 11679-83 |year= 2002 |pmid= 11801597 |doi= 10.1074/jbc.M111173200 }}
*{{cite journal  |vauthors=Inoue A, Saito J, Ikebe R, Ikebe M |title=Myosin IXb is a single-headed minus-end-directed processive motor. |journal=Nat. Cell Biol. |volume=4 |issue= 4 |pages= 302–6 |year= 2002 |pmid= 11901422 |doi= 10.1038/ncb774 }}
*{{cite journal | author=Inoue A, Saito J, Ikebe R, Ikebe M |title=Myosin IXb is a single-headed minus-end-directed processive motor. |journal=Nat. Cell Biol. |volume=4 |issue= 4 |pages= 302-6 |year= 2002 |pmid= 11901422 |doi= 10.1038/ncb774 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Van Belzen MJ, Meijer JW, Sandkuijl LA, etal |title=A major non-HLA locus in celiac disease maps to chromosome 19. |journal=Gastroenterology |volume=125 |issue= 4 |pages= 1032–41 |year= 2003 |pmid= 14517787 |doi=10.1016/S0016-5085(03)01205-8 }}
*{{cite journal  | author=Van Belzen MJ, Meijer JW, Sandkuijl LA, ''et al.'' |title=A major non-HLA locus in celiac disease maps to chromosome 19. |journal=Gastroenterology |volume=125 |issue= 4 |pages= 1032-41 |year= 2003 |pmid= 14517787 |doi= }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  |vauthors=Saeki N, Tokuo H, Ikebe M |title=BIG1 is a binding partner of myosin IXb and regulates its Rho-GTPase activating protein activity. |journal=J. Biol. Chem. |volume=280 |issue= 11 |pages= 10128–34 |year= 2005 |pmid= 15644318 |doi= 10.1074/jbc.M413415200 }}
*{{cite journal  | author=Saeki N, Tokuo H, Ikebe M |title=BIG1 is a binding partner of myosin IXb and regulates its Rho-GTPase activating protein activity. |journal=J. Biol. Chem. |volume=280 |issue= 11 |pages= 10128-34 |year= 2005 |pmid= 15644318 |doi= 10.1074/jbc.M413415200 }}
*{{cite journal   |vauthors=Cheng J, Kapranov P, Drenkow J, etal |title=Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution. |journal=Science |volume=308 |issue= 5725 |pages= 1149–54 |year= 2005 |pmid= 15790807 |doi= 10.1126/science.1108625 }}
*{{cite journal | author=Cheng J, Kapranov P, Drenkow J, ''et al.'' |title=Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution. |journal=Science |volume=308 |issue= 5725 |pages= 1149-54 |year= 2005 |pmid= 15790807 |doi= 10.1126/science.1108625 }}
*{{cite journal   |vauthors=Monsuur AJ, de Bakker PI, Alizadeh BZ, etal |title=Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect. |journal=Nat. Genet. |volume=37 |issue= 12 |pages= 1341–4 |year= 2006 |pmid= 16282976 |doi= 10.1038/ng1680 }}
*{{cite journal | author=Monsuur AJ, de Bakker PI, Alizadeh BZ, ''et al.'' |title=Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect. |journal=Nat. Genet. |volume=37 |issue= 12 |pages= 1341-4 |year= 2006 |pmid= 16282976 |doi= 10.1038/ng1680 }}
*{{cite journal  |vauthors=Kambara T, Ikebe M |title=A unique ATP hydrolysis mechanism of single-headed processive myosin, myosin IX. |journal=J. Biol. Chem. |volume=281 |issue= 8 |pages= 4949–57 |year= 2006 |pmid= 16338935 |doi= 10.1074/jbc.M509141200 }}
*{{cite journal  | author=Kambara T, Ikebe M |title=A unique ATP hydrolysis mechanism of single-headed processive myosin, myosin IX. |journal=J. Biol. Chem. |volume=281 |issue= 8 |pages= 4949-57 |year= 2006 |pmid= 16338935 |doi= 10.1074/jbc.M509141200 }}
*{{cite journal   |vauthors=Nishikawa M, Nishikawa S, Inoue A, etal |title=A unique mechanism for the processive movement of single-headed myosin-IX. |journal=Biochem. Biophys. Res. Commun. |volume=343 |issue= 4 |pages= 1159–64 |year= 2006 |pmid= 16616011 |doi= 10.1016/j.bbrc.2006.03.057 }}
*{{cite journal | author=Nishikawa M, Nishikawa S, Inoue A, ''et al.'' |title=A unique mechanism for the processive movement of single-headed myosin-IX. |journal=Biochem. Biophys. Res. Commun. |volume=343 |issue= 4 |pages= 1159-64 |year= 2006 |pmid= 16616011 |doi= 10.1016/j.bbrc.2006.03.057 }}
*{{cite journal   |vauthors=Amundsen SS, Monsuur AJ, Wapenaar MC, etal |title=Association analysis of MYO9B gene polymorphisms with celiac disease in a Swedish/Norwegian cohort. |journal=Hum. Immunol. |volume=67 |issue= 4-5 |pages= 341–5 |year= 2006 |pmid= 16720215 |doi= 10.1016/j.humimm.2006.03.020 }}
*{{cite journal | author=Amundsen SS, Monsuur AJ, Wapenaar MC, ''et al.'' |title=Association analysis of MYO9B gene polymorphisms with celiac disease in a Swedish/Norwegian cohort. |journal=Hum. Immunol. |volume=67 |issue= 4-5 |pages= 341-5 |year= 2006 |pmid= 16720215 |doi= 10.1016/j.humimm.2006.03.020 }}
*{{cite journal   |vauthors=Giordano M, Marano C, Mellai M, etal |title=A family-based study does not confirm the association of MYO9B with celiac disease in the Italian population. |journal=Genes Immun. |volume=7 |issue= 7 |pages= 606–8 |year= 2007 |pmid= 16943798 |doi= 10.1038/sj.gene.6364331 }}
*{{cite journal | author=Giordano M, Marano C, Mellai M, ''et al.'' |title=A family-based study does not confirm the association of MYO9B with celiac disease in the Italian population. |journal=Genes Immun. |volume=7 |issue= 7 |pages= 606-8 |year= 2007 |pmid= 16943798 |doi= 10.1038/sj.gene.6364331 }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal   |vauthors=van Bodegraven AA, Curley CR, Hunt KA, etal |title=Genetic variation in myosin IXB is associated with ulcerative colitis. |journal=Gastroenterology |volume=131 |issue= 6 |pages= 1768–74 |year= 2007 |pmid= 17087940 |doi= 10.1053/j.gastro.2006.09.011 }}
*{{cite journal | author=van Bodegraven AA, Curley CR, Hunt KA, ''et al.'' |title=Genetic variation in myosin IXB is associated with ulcerative colitis. |journal=Gastroenterology |volume=131 |issue= 6 |pages= 1768-74 |year= 2007 |pmid= 17087940 |doi= 10.1053/j.gastro.2006.09.011 }}
*{{cite journal   |vauthors=Núñez C, Márquez A, Varadé J, etal |title=No evidence of association of the MYO9B polymorphisms with celiac disease in the Spanish population. |journal=Tissue Antigens |volume=68 |issue= 6 |pages= 489–92 |year= 2007 |pmid= 17176439 |doi= 10.1111/j.1399-0039.2006.00699.x }}
*{{cite journal | author=Núñez C, Márquez A, Varadé J, ''et al.'' |title=No evidence of association of the MYO9B polymorphisms with celiac disease in the Spanish population. |journal=Tissue Antigens |volume=68 |issue= 6 |pages= 489-92 |year= 2007 |pmid= 17176439 |doi= 10.1111/j.1399-0039.2006.00699.x }}
}}
}}
{{refend}}
{{refend}}


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{{gene-19-stub}}

Revision as of 20:22, 8 November 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Myosin-IXb is a protein that in humans is encoded by the MYO9B gene.[1][2]


References

  1. Bahler M, Kehrer I, Gordon L, Stoffler HE, Olsen AS (Sep 1997). "Physical mapping of human myosin-IXB (MYO9B), the human orthologue of the rat myosin myr 5, to chromosome 19p13.1". Genomics. 43 (1): 107–9. doi:10.1006/geno.1997.4776. PMID 9226381.
  2. "Entrez Gene: MYO9B myosin IXB".

Further reading