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{{ | '''Neighbor of BRCA1 gene 1 protein''' is a [[protein]] that in humans is encoded by the ''NBR1'' [[gene]].<ref name="pmid8069304">{{cite journal |vauthors=Campbell IG, Nicolai HM, Foulkes WD, Senger G, Stamp GW, Allan G, Boyer C, Jones K, ((Bast RC Jr)), Solomon E | title = A novel gene encoding a B-box protein within the BRCA1 region at 17q21.1 | journal = Hum Mol Genet | volume = 3 | issue = 4 | pages = 589–594 |date=Sep 1994 | pmid = 8069304 | pmc = | doi =10.1093/hmg/3.4.589 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NBR1 neighbor of BRCA1 gene 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4077| accessdate = }}</ref> | ||
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| summary_text = The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential | | summary_text = The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential. This gene is located on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three alternatively spliced variants encoding the same protein have been identified for this gene.<ref name="entrez"/> One implied function lies in autophagy, where it acts a cargo receptor in selective autophagy.<ref>{{cite journal|last1=Kirkin|first1=Vladimir|title=A Role for Ubiquitin in Selective Autophagy|journal=Molecular Cell|date=2009|volume=34|doi= 10.1016/j.molcel.2009.04.026|pages=259–269}}</ref> | ||
}} | }} | ||
==Interactions== | |||
NBR1 has been shown to [[Protein-protein interaction|interact]] with [[FEZ1]].<ref name=pmid11856312>{{cite journal |last=Whitehouse |first=Caroline |authorlink= |author2=Chambers Julie |author3=Howe Kathy |author4=Cobourne Martyn |author5=Sharpe Paul |author6=Solomon Ellen |date=Jan 2002 |title=NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube |journal=Eur. J. Biochem. |volume=269 |issue=2 |pages=538–545 |publisher= |location = Germany| issn = 0014-2956| pmid = 11856312 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1046/j.0014-2956.2001.02681.x }}</ref> | |||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | author=Miki Y | *{{cite journal | author=Miki Y |title=A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1 |journal=Science |volume=266 |issue= 5182 |pages= 66–71 |year= 1994 |pmid= 7545954 |doi=10.1126/science.7545954 |name-list-format=vanc| author2=Swensen J | author3=Shattuck-Eidens D | display-authors=3 | last4=Futreal | first4=P. | last5=Harshman | first5=K | last6=Tavtigian | first6=S | last7=Liu | first7=Q | last8=Cochran | first8=C | last9=Bennett | first9=L. }} | ||
*{{cite journal | author=Harshman K |title=Comparison of the positional cloning methods used to isolate the BRCA1 gene |journal=Hum. Mol. Genet. |volume=4 |issue= 8 |pages= 1259–1266 |year= 1995 |pmid= 7581362 |doi=10.1093/hmg/4.8.1259 |name-list-format=vanc| author2=Bell R | author3=Rosenthal J | display-authors=3 | last4=Katcher | first4=Harold | last5=Mlkl | first5=Yoshio | last6=Swenson | first6=Jeff | last7=Gholami | first7=Zahra | last8=Frye | first8=Cheryl | last9=Ding | first9=Wei }} | |||
*{{cite journal | author= | *{{cite journal | author=Nomura N |title=Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1 |journal=DNA Res. |volume=1 |issue= 5 |pages= 223–229 |year= 1995 |pmid= 7584044 |doi=10.1093/dnares/1.5.223 |name-list-format=vanc| author2=Nagase T | author3=Miyajima N | display-authors=3 | last4=Sazuka | first4=T | last5=Tanaka | first5=A | last6=Sato | first6=S | last7=Seki | first7=N | last8=Kawarabayasi | first8=Y | last9=Ishikawa | first9=K }} | ||
*{{cite journal | author=Brown MA |title=Regulation of BRCA1 |journal=Nature |volume=372 |issue= 6508 |pages= 733–733 |year= 1995 |pmid= 7997258 |doi= 10.1038/372733a0 |name-list-format=vanc| author2=Nicolai H | author3=Xu CF | display-authors=3 | last4=Griffiths | first4=Beatrice L. | last5=Jones | first5=Karen A. | last6=Solomon | first6=Ellen | last7=Hosking | first7=Louise | last8=Trowsdale | first8=John | last9=Black | first9=Donald M. }} | |||
*{{cite journal | author= | *{{cite journal | author=Brown MA |title=The 5' end of the BRCA1 gene lies within a duplicated region of human chromosome 17q21 |journal=Oncogene |volume=12 |issue= 12 |pages= 2507–13 |year= 1996 |pmid= 8700509 |doi= |name-list-format=vanc| author2=Xu CF | author3=Nicolai H | display-authors=3 | last4=Griffiths | first4=B | last5=Chambers | first5=JA | last6=Black | first6=D | last7=Solomon | first7=E }} | ||
*{{cite journal |vauthors=Dimitrov S, Brennerova M, Forejt J |title=Expression profiles and intergenic structure of head-to-head oriented Brca1 and Nbr1 genes |journal=Gene |volume=262 |issue= 1–2 |pages= 89–98 |year= 2001 |pmid= 11179671 |doi=10.1016/S0378-1119(00)00549-7 }} | |||
*{{cite journal | author=Whitehouse C |title=NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube |journal=Eur. J. Biochem. |volume=269 |issue= 2 |pages= 538–545 |year= 2002 |pmid= 11856312 |doi=10.1046/j.0014-2956.2001.02681.x |name-list-format=vanc| author2=Chambers J | author3=Howe K | display-authors=3 | last4=Cobourne | first4=Martyn | last5=Sharpe | first5=Paul | last6=Solomon | first6=Ellen }} | |||
*{{cite journal | author=Wistow G |title=Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium |journal=Mol. Vis. |volume=8 |issue= |pages= 185–95 |year= 2002 |pmid= 12107412 |doi= |name-list-format=vanc| author2=Bernstein SL | author3=Ray S | display-authors=3 | last4=Wyatt | first4=MK | last5=Behal | first5=A | last6=Touchman | first6=JW | last7=Bouffard | first7=G | last8=Smith | first8=D | last9=Peterson | first9=K }} | |||
*{{cite journal | author= | *{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }} | ||
*{{cite journal | author=Lamark T |title=Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins |journal=J. Biol. Chem. |volume=278 |issue= 36 |pages= 34568–34581 |year= 2003 |pmid= 12813044 |doi= 10.1074/jbc.M303221200 |name-list-format=vanc| author2=Perander M | author3=Outzen H | display-authors=3 | last4=Kristiansen | first4=K | last5=Øvervatn | first5=A | last6=Michaelsen | first6=E | last7=Bjørkøy | first7=G | last8=Johansen | first8=T }} | |||
*{{cite journal | | *{{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–45 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki }} | ||
*{{cite journal | author= | *{{cite journal | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–2127 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-format=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }} | ||
*{{cite journal | author=Lange S |title=The kinase domain of titin controls muscle gene expression and protein turnover |journal=Science |volume=308 |issue= 5728 |pages= 1599–1603 |year= 2005 |pmid= 15802564 |doi= 10.1126/science.1110463 |name-list-format=vanc| author2=Xiang F | author3=Yakovenko A | display-authors=3 | last4=Vihola | first4=A | last5=Hackman | first5=P | last6=Rostkova | first6=E | last7=Kristensen | first7=J | last8=Brandmeier | first8=B | last9=Franzen | first9=G }} | |||
*{{cite journal | author= | *{{cite journal | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–1178 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |name-list-format=vanc| author2=Venkatesan K | author3=Hao T | display-authors=3 | last4=Hirozane-Kishikawa | first4=Tomoko | last5=Dricot | first5=Amélie | last6=Li | first6=Ning | last7=Berriz | first7=Gabriel F. | last8=Gibbons | first8=Francis D. | last9=Dreze | first9=Matija }} | ||
}} | }} | ||
{{refend}} | {{refend}} | ||
{{PDB Gallery|geneid=4077}} | |||
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[[Category:Human proteins]] | |||
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Revision as of 12:35, 5 September 2017
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| External IDs | GeneCards: [1] | ||||||
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| Location (UCSC) | n/a | n/a | |||||
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Neighbor of BRCA1 gene 1 protein is a protein that in humans is encoded by the NBR1 gene.[1][2]
The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential. This gene is located on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three alternatively spliced variants encoding the same protein have been identified for this gene.[2] One implied function lies in autophagy, where it acts a cargo receptor in selective autophagy.[3]
Interactions
NBR1 has been shown to interact with FEZ1.[4]
References
- ↑ Campbell IG, Nicolai HM, Foulkes WD, Senger G, Stamp GW, Allan G, Boyer C, Jones K, Bast RC Jr, Solomon E (Sep 1994). "A novel gene encoding a B-box protein within the BRCA1 region at 17q21.1". Hum Mol Genet. 3 (4): 589–594. doi:10.1093/hmg/3.4.589. PMID 8069304.
- ↑ 2.0 2.1 "Entrez Gene: NBR1 neighbor of BRCA1 gene 1".
- ↑ Kirkin, Vladimir (2009). "A Role for Ubiquitin in Selective Autophagy". Molecular Cell. 34: 259–269. doi:10.1016/j.molcel.2009.04.026.
- ↑ Whitehouse, Caroline; Chambers Julie; Howe Kathy; Cobourne Martyn; Sharpe Paul; Solomon Ellen (Jan 2002). "NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube". Eur. J. Biochem. Germany. 269 (2): 538–545. doi:10.1046/j.0014-2956.2001.02681.x. ISSN 0014-2956. PMID 11856312.
Further reading
- Miki Y, Swensen J, Shattuck-Eidens D, et al. (1994). "A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1". Science. 266 (5182): 66–71. doi:10.1126/science.7545954. PMID 7545954.
- Harshman K, Bell R, Rosenthal J, et al. (1995). "Comparison of the positional cloning methods used to isolate the BRCA1 gene". Hum. Mol. Genet. 4 (8): 1259–1266. doi:10.1093/hmg/4.8.1259. PMID 7581362.
- Nomura N, Nagase T, Miyajima N, et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–229. doi:10.1093/dnares/1.5.223. PMID 7584044.
- Brown MA, Nicolai H, Xu CF, et al. (1995). "Regulation of BRCA1". Nature. 372 (6508): 733–733. doi:10.1038/372733a0. PMID 7997258.
- Brown MA, Xu CF, Nicolai H, et al. (1996). "The 5' end of the BRCA1 gene lies within a duplicated region of human chromosome 17q21". Oncogene. 12 (12): 2507–13. PMID 8700509.
- Dimitrov S, Brennerova M, Forejt J (2001). "Expression profiles and intergenic structure of head-to-head oriented Brca1 and Nbr1 genes". Gene. 262 (1–2): 89–98. doi:10.1016/S0378-1119(00)00549-7. PMID 11179671.
- Whitehouse C, Chambers J, Howe K, et al. (2002). "NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube". Eur. J. Biochem. 269 (2): 538–545. doi:10.1046/j.0014-2956.2001.02681.x. PMID 11856312.
- Wistow G, Bernstein SL, Ray S, et al. (2002). "Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium". Mol. Vis. 8: 185–95. PMID 12107412.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Lamark T, Perander M, Outzen H, et al. (2003). "Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins". J. Biol. Chem. 278 (36): 34568–34581. doi:10.1074/jbc.M303221200. PMID 12813044.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Lange S, Xiang F, Yakovenko A, et al. (2005). "The kinase domain of titin controls muscle gene expression and protein turnover". Science. 308 (5728): 1599–1603. doi:10.1126/science.1110463. PMID 15802564.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514.
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