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{{Infobox_gene}}
{{PBB_Controls
'''Cytoplasmic protein NCK2''' (also known as '''NCK-beta''' and '''Grb4''') is a [[protein]] that in humans is encoded by the ''NCK2'' [[gene]].<ref name="pmid9737977" /><ref name="pmid16752908">{{cite journal | vauthors = Liu J, Li M, Ran X, Fan JS, Song J | title = Structural insight into the binding diversity between the human Nck2 SH3 domains and proline-rich proteins | journal = Biochemistry | volume = 45 | issue = 23 | pages = 7171–84 | date = Jun 2006 | pmid = 16752908 | pmc = | doi = 10.1021/bi060091y }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NCK2 NCK adaptor protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8440| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_NCK2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1u5s.
| PDB = {{PDB2|1u5s}}, {{PDB2|1wx6}}, {{PDB2|1z3k}}, {{PDB2|2b86}}, {{PDB2|2cia}}, {{PDB2|2frw}}, {{PDB2|2fry}}
| Name = NCK adaptor protein 2
| HGNCid = 7665
| Symbol = NCK2
| AltSymbols =; GRB4; NCKbeta
| OMIM = 604930
| ECnumber = 
| Homologene = 20794
| MGIid = 1306821
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008093 |text = cytoskeletal adaptor activity}} {{GNF_GO|id=GO:0030159 |text = receptor signaling complex scaffold activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0007172 |text = signal complex assembly}} {{GNF_GO|id=GO:0007176 |text = regulation of epidermal growth factor receptor activity}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0030838 |text = positive regulation of actin filament polymerization}} {{GNF_GO|id=GO:0042102 |text = positive regulation of T cell proliferation}} {{GNF_GO|id=GO:0042110 |text = T cell activation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8440
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_001004720
    | Hs_RefseqmRNA = NM_001004720
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 17974
    | Mm_Ensembl = ENSMUSG00000066877
    | Mm_RefseqmRNA = XM_973478
    | Mm_RefseqProtein = XP_978572
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 43390297
    | Mm_GenLoc_end = 43515060
    | Mm_Uniprot = 
  }}
}}
'''NCK adaptor protein 2''', also known as '''NCK2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NCK2 NCK adaptor protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8440| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
NCK belongs to family of [[Signal transducing adaptor protein|adaptor protein]]s,There are two mammalian NCK genes, [[NCK1]] and NCK2. NCK1 is located in chromosome 3 and NCK2 is located in chromosome 2. The protein contains three [[SH3 domain]]s and one [[SH2 domain]]. The protein has no known [[catalysis|catalyti]]c function but has been shown to bind and recruit various proteins involved in the regulation of [[receptor protein tyrosine kinase]]s. It is through these regulatory activities that this protein is believed to be involved in [[cytoskeleton|cytoskeletal]] reorganization. Alternate [[transcriptional]] [[RNA splicing|splice variants]], encoding different [[isoform]]s, have been characterized.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.<ref name="entrez">{{cite web | title = Entrez Gene: NCK2 NCK adaptor protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8440| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
NCK2 has been shown to [[Protein-protein interaction|interact]] with:
{{div col|colwidth=20em}}
* [[Epidermal growth factor receptor]],<ref name = pmid9737977>{{cite journal | vauthors = Chen M, She H, Davis EM, Spicer CM, Kim L, Ren R, Le Beau MM, Li W | title = Identification of Nck family genes, chromosomal localization, expression, and signaling specificity | journal = The Journal of Biological Chemistry | volume = 273 | issue = 39 | pages = 25171–8 | date = Sep 1998 | pmid = 9737977 | doi =  10.1074/jbc.273.39.25171}}</ref><ref name = pmid9843575/><ref name = pmid10026169>{{cite journal | vauthors = Braverman LE, Quilliam LA | title = Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck | journal = The Journal of Biological Chemistry | volume = 274 | issue = 9 | pages = 5542–9 | date = Feb 1999 | pmid = 10026169 | doi =  10.1074/jbc.274.9.5542}}</ref>
* [[LIMS1]],<ref name = pmid10022929>{{cite journal | vauthors = Tu Y, Li F, Goicoechea S, Wu C | title = The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells | journal = Molecular and Cellular Biology | volume = 19 | issue = 3 | pages = 2425–34 | date = Mar 1999 | pmid = 10022929 | pmc = 84035 | doi =  10.1128/mcb.19.3.2425}}</ref><ref name = pmid9843575>{{cite journal | vauthors = Tu Y, Li F, Wu C | title = Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways | journal = Molecular Biology of the Cell | volume = 9 | issue = 12 | pages = 3367–82 | date = Dec 1998 | pmid = 9843575 | pmc = 25640 | doi =  10.1091/mbc.9.12.3367}}</ref>
* [[PDGFRB]],<ref name = pmid9737977/><ref name = pmid10026169/><ref name = pmid11027258>{{cite journal | vauthors = Chen M, She H, Kim A, Woodley DT, Li W | title = Nckbeta adapter regulates actin polymerization in NIH 3T3 fibroblasts in response to platelet-derived growth factor bb | journal = Molecular and Cellular Biology | volume = 20 | issue = 21 | pages = 7867–80 | date = Nov 2000 | pmid = 11027258 | pmc = 86398 | doi =  10.1128/mcb.20.21.7867-7880.2000}}</ref>
* [[PTK2]],<ref name = pmid11950595>{{cite journal | vauthors = Goicoechea SM, Tu Y, Hua Y, Chen K, Shen TL, Guan JL, Wu C | title = Nck-2 interacts with focal adhesion kinase and modulates cell motility | journal = The International Journal of Biochemistry & Cell Biology | volume = 34 | issue = 7 | pages = 791–805 | date = Jul 2002 | pmid = 11950595 | doi =  10.1016/s1357-2725(02)00002-x}}</ref>
* [[T-cell surface glycoprotein CD3 epsilon chain]]<ref name = pmid12110186>{{cite journal | vauthors = Gil D, Schamel WW, Montoya M, Sánchez-Madrid F, Alarcón B | title = Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation | journal = Cell | volume = 109 | issue = 7 | pages = 901–12 | date = Jun 2002 | pmid = 12110186 | doi =  10.1016/S0092-8674(02)00799-7}}</ref>  and
* [[TrkB]].<ref name = pmid12074588>{{cite journal | vauthors = Suzuki S, Mizutani M, Suzuki K, Yamada M, Kojima M, Hatanaka H, Koizumi S | title = Brain-derived neurotrophic factor promotes interaction of the Nck2 adaptor protein with the TrkB tyrosine kinase receptor | journal = Biochemical and Biophysical Research Communications | volume = 294 | issue = 5 | pages = 1087–92 | date = Jun 2002 | pmid = 12074588 | doi = 10.1016/S0006-291X(02)00606-X }}</ref>
{{Div col end}}
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Li W, Hu P, Skolnik EY, Ullrich A, Schlessinger J | title = The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptors | journal = Molecular and Cellular Biology | volume = 12 | issue = 12 | pages = 5824–33 | date = Dec 1992 | pmid = 1333047 | pmc = 360522 | doi = 10.1128/MCB.12.12.5824 }}
| citations =
* {{cite journal | vauthors = Tu Y, Li F, Wu C | title = Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways | journal = Molecular Biology of the Cell | volume = 9 | issue = 12 | pages = 3367–82 | date = Dec 1998 | pmid = 9843575 | pmc = 25640 | doi = 10.1091/mbc.9.12.3367 }}
*{{cite journal | author=Li W, Hu P, Skolnik EY, ''et al.'' |title=The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptors. |journal=Mol. Cell. Biol. |volume=12 |issue= 12 |pages= 5824-33 |year= 1992 |pmid= 1333047 |doi= }}
* {{cite journal | vauthors = Tu Y, Li F, Goicoechea S, Wu C | title = The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells | journal = Molecular and Cellular Biology | volume = 19 | issue = 3 | pages = 2425–34 | date = Mar 1999 | pmid = 10022929 | pmc = 84035 | doi =  10.1128/mcb.19.3.2425}}
*{{cite journal | author=Chen M, She H, Davis EM, ''et al.'' |title=Identification of Nck family genes, chromosomal localization, expression, and signaling specificity. |journal=J. Biol. Chem. |volume=273 |issue= 39 |pages= 25171-8 |year= 1998 |pmid= 9737977 |doi= }}
* {{cite journal | vauthors = Braverman LE, Quilliam LA | title = Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck | journal = The Journal of Biological Chemistry | volume = 274 | issue = 9 | pages = 5542–9 | date = Feb 1999 | pmid = 10026169 | doi = 10.1074/jbc.274.9.5542 }}
*{{cite journal | author=Tu Y, Li F, Wu C |title=Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways. |journal=Mol. Biol. Cell |volume=9 |issue= 12 |pages= 3367-82 |year= 1999 |pmid= 9843575 |doi=  }}
* {{cite journal | vauthors = Coutinho S, Jahn T, Lewitzky M, Feller S, Hutzler P, Peschel C, Duyster J | title = Characterization of Ggrb4, an adapter protein interacting with Bcr-Abl | journal = Blood | volume = 96 | issue = 2 | pages = 618–24 | date = Jul 2000 | pmid = 10887126 | doi =  }}
*{{cite journal | author=Tu Y, Li F, Goicoechea S, Wu C |title=The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells. |journal=Mol. Cell. Biol. |volume=19 |issue= 3 |pages= 2425-34 |year= 1999 |pmid= 10022929 |doi= }}
* {{cite journal | vauthors = Chen M, She H, Kim A, Woodley DT, Li W | title = Nckbeta adapter regulates actin polymerization in NIH 3T3 fibroblasts in response to platelet-derived growth factor bb | journal = Molecular and Cellular Biology | volume = 20 | issue = 21 | pages = 7867–80 | date = Nov 2000 | pmid = 11027258 | pmc = 86398 | doi = 10.1128/MCB.20.21.7867-7880.2000 }}
*{{cite journal | author=Braverman LE, Quilliam LA |title=Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck. |journal=J. Biol. Chem. |volume=274 |issue= 9 |pages= 5542-9 |year= 1999 |pmid= 10026169 |doi=  }}
* {{cite journal | vauthors = Tu Y, Kucik DF, Wu C | title = Identification and kinetic analysis of the interaction between Nck-2 and DOCK180 | journal = FEBS Letters | volume = 491 | issue = 3 | pages = 193–9 | date = Mar 2001 | pmid = 11240126 | doi = 10.1016/S0014-5793(01)02195-0 }}
*{{cite journal | author=Coutinho S, Jahn T, Lewitzky M, ''et al.'' |title=Characterization of Ggrb4, an adapter protein interacting with Bcr-Abl. |journal=Blood |volume=96 |issue= 2 |pages= 618-24 |year= 2000 |pmid= 10887126 |doi= }}
* {{cite journal | vauthors = Jahn T, Seipel P, Coutinho S, Miething C, Peschel C, Duyster J | title = Grb4/Nckbeta acts as a nuclear repressor of v-Abl-induced transcription from c-jun/c-fos promoter elements | journal = The Journal of Biological Chemistry | volume = 276 | issue = 46 | pages = 43419–27 | date = Nov 2001 | pmid = 11514578 | doi = 10.1074/jbc.M107030200 }}
*{{cite journal | author=Chen M, She H, Kim A, ''et al.'' |title=Nckbeta adapter regulates actin polymerization in NIH 3T3 fibroblasts in response to platelet-derived growth factor bb. |journal=Mol. Cell. Biol. |volume=20 |issue= 21 |pages= 7867-80 |year= 2000 |pmid= 11027258 |doi= }}
* {{cite journal | vauthors = Cowan CA, Henkemeyer M | title = The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals | journal = Nature | volume = 413 | issue = 6852 | pages = 174–9 | date = Sep 2001 | pmid = 11557983 | doi = 10.1038/35093123 }}
*{{cite journal | author=Tu Y, Kucik DF, Wu C |title=Identification and kinetic analysis of the interaction between Nck-2 and DOCK180. |journal=FEBS Lett. |volume=491 |issue= 3 |pages= 193-9 |year= 2001 |pmid= 11240126 |doi= }}
* {{cite journal | vauthors = Goicoechea SM, Tu Y, Hua Y, Chen K, Shen TL, Guan JL, Wu C | title = Nck-2 interacts with focal adhesion kinase and modulates cell motility | journal = The International Journal of Biochemistry & Cell Biology | volume = 34 | issue = 7 | pages = 791–805 | date = Jul 2002 | pmid = 11950595 | doi = 10.1016/S1357-2725(02)00002-X }}
*{{cite journal | author=Jahn T, Seipel P, Coutinho S, ''et al.'' |title=Grb4/Nckbeta acts as a nuclear repressor of v-Abl-induced transcription from c-jun/c-fos promoter elements. |journal=J. Biol. Chem. |volume=276 |issue= 46 |pages= 43419-27 |year= 2001 |pmid= 11514578 |doi= 10.1074/jbc.M107030200 }}
* {{cite journal | vauthors = Suzuki S, Mizutani M, Suzuki K, Yamada M, Kojima M, Hatanaka H, Koizumi S | title = Brain-derived neurotrophic factor promotes interaction of the Nck2 adaptor protein with the TrkB tyrosine kinase receptor | journal = Biochemical and Biophysical Research Communications | volume = 294 | issue = 5 | pages = 1087–92 | date = Jun 2002 | pmid = 12074588 | doi = 10.1016/S0006-291X(02)00606-X }}
*{{cite journal | author=Cowan CA, Henkemeyer M |title=The SH2/SH3 adaptor Grb4 transduces B-ephrin reverse signals. |journal=Nature |volume=413 |issue= 6852 |pages= 174-9 |year= 2001 |pmid= 11557983 |doi= 10.1038/35093123 }}
* {{cite journal | vauthors = Gil D, Schamel WW, Montoya M, Sánchez-Madrid F, Alarcón B | title = Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation | journal = Cell | volume = 109 | issue = 7 | pages = 901–12 | date = Jun 2002 | pmid = 12110186 | doi = 10.1016/S0092-8674(02)00799-7 }}
*{{cite journal | author=Goicoechea SM, Tu Y, Hua Y, ''et al.'' |title=Nck-2 interacts with focal adhesion kinase and modulates cell motility. |journal=Int. J. Biochem. Cell Biol. |volume=34 |issue= 7 |pages= 791-805 |year= 2002 |pmid= 11950595 |doi= }}
* {{cite journal | vauthors = Song J, Vranken W, Xu P, Gingras R, Noyce RS, Yu Z, Shen SH, Ni F | title = Solution structure and backbone dynamics of the functional cytoplasmic subdomain of human ephrin B2, a cell-surface ligand with bidirectional signaling properties | journal = Biochemistry | volume = 41 | issue = 36 | pages = 10942–9 | date = Sep 2002 | pmid = 12206665 | doi = 10.1021/bi025815u }}
*{{cite journal | author=Suzuki S, Mizutani M, Suzuki K, ''et al.'' |title=Brain-derived neurotrophic factor promotes interaction of the Nck2 adaptor protein with the TrkB tyrosine kinase receptor. |journal=Biochem. Biophys. Res. Commun. |volume=294 |issue= 5 |pages= 1087-92 |year= 2002 |pmid= 12074588 |doi= 10.1016/S0006-291X(02)00606-X }}
* {{cite journal | vauthors = Aspenström P | title = The WASP-binding protein WIRE has a role in the regulation of the actin filament system downstream of the platelet-derived growth factor receptor | journal = Experimental Cell Research | volume = 279 | issue = 1 | pages = 21–33 | date = Sep 2002 | pmid = 12213210 | doi = 10.1006/excr.2002.5576 }}
*{{cite journal | author=Gil D, Schamel WW, Montoya M, ''et al.'' |title=Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation. |journal=Cell |volume=109 |issue= 7 |pages= 901-12 |year= 2002 |pmid= 12110186 |doi= }}
* {{cite journal | vauthors = Hafizi S, Alindri F, Karlsson R, Dahlbäck B | title = Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin | journal = Biochemical and Biophysical Research Communications | volume = 299 | issue = 5 | pages = 793–800 | date = Dec 2002 | pmid = 12470648 | doi = 10.1016/S0006-291X(02)02718-3 }}
*{{cite journal | author=Song J, Vranken W, Xu P, ''et al.'' |title=Solution structure and backbone dynamics of the functional cytoplasmic subdomain of human ephrin B2, a cell-surface ligand with bidirectional signaling properties. |journal=Biochemistry |volume=41 |issue= 36 |pages= 10942-9 |year= 2002 |pmid= 12206665 |doi= }}
* {{cite journal | vauthors = Velyvis A, Vaynberg J, Yang Y, Vinogradova O, Zhang Y, Wu C, Qin J | title = Structural and functional insights into PINCH LIM4 domain-mediated integrin signaling | journal = Nature Structural Biology | volume = 10 | issue = 7 | pages = 558–64 | date = Jul 2003 | pmid = 12794636 | doi = 10.1038/nsb938 }}
*{{cite journal | author=Aspenström P |title=The WASP-binding protein WIRE has a role in the regulation of the actin filament system downstream of the platelet-derived growth factor receptor. |journal=Exp. Cell Res. |volume=279 |issue= 1 |pages= 21-33 |year= 2002 |pmid= 12213210 |doi= }}
* {{cite journal | vauthors = Hu Y, Fang X, Dunham SM, Prada C, Stachowiak EK, Stachowiak MK | title = 90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signaling | journal = The Journal of Biological Chemistry | volume = 279 | issue = 28 | pages = 29325–35 | date = Jul 2004 | pmid = 15117958 | doi = 10.1074/jbc.M311144200 }}
*{{cite journal | author=Hafizi S, Alindri F, Karlsson R, Dahlbäck B |title=Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin. |journal=Biochem. Biophys. Res. Commun. |volume=299 |issue= 5 |pages= 793-800 |year= 2003 |pmid= 12470648 |doi= }}
* {{cite journal | vauthors = Ran X, Song J | title = Structural insight into the binding diversity between the Tyr-phosphorylated human ephrinBs and Nck2 SH2 domain | journal = The Journal of Biological Chemistry | volume = 280 | issue = 19 | pages = 19205–12 | date = May 2005 | pmid = 15764601 | doi = 10.1074/jbc.M500330200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Song J | title = Tyrosine phosphorylation of the well packed ephrinB cytoplasmic beta-hairpin for reverse signaling. Structural consequences and binding properties | journal = The Journal of Biological Chemistry | volume = 278 | issue = 27 | pages = 24714–20 | date = Jul 2003 | pmid = 12606549 | doi = 10.1074/jbc.M210625200 }}
*{{cite journal | author=Velyvis A, Vaynberg J, Yang Y, ''et al.'' |title=Structural and functional insights into PINCH LIM4 domain-mediated integrin signaling. |journal=Nat. Struct. Biol. |volume=10 |issue= 7 |pages= 558-64 |year= 2003 |pmid= 12794636 |doi= 10.1038/nsb938 }}
* {{cite journal | vauthors = Liu Z, Guo X, Jiang Y, Zhang H | title = NCK2 is significantly associated with opiates addiction in African-origin men | journal = TheScientificWorldJournal | volume = 2013 | pages = 748979 | year = 2013 | pmid = 23533358 | doi = 10.1155/2013/748979 | pmc=3603435}}
*{{cite journal | author=Hu Y, Fang X, Dunham SM, ''et al.'' |title=90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signaling. |journal=J. Biol. Chem. |volume=279 |issue= 28 |pages= 29325-35 |year= 2004 |pmid= 15117958 |doi= 10.1074/jbc.M311144200 }}
{{refend}}
}}
*{{cite journal | author=Liu J, Li M, Ran X, Fan JS, Song J. |title=Structural insight into the binding diversity between the human Nck2 SH3 domains and proline-rich proteins. |journal=Biochemistry. |volume=45 |issue= 23 |pages= 7171-84. |year= 2006 |pmid= 16752908 }}
*{{cite journal  | author=Ran X, Song J. |title=Structural insight into the binding diversity between the Tyr-phosphorylated human ephrinBs and Nck2 SH2 domain. |journal=J Biol Chem.  |volume=280 |issue= 19 |pages= 19205-12. |year= 2005 |pmid= 15764601 }}
*{{cite journal  | author= Song J. |title=Tyrosine phosphorylation of the well packed ephrinB cytoplasmic beta-hairpin for reverse signaling. Structural consequences and binding properties. |journal=J Biol Chem.  |volume=278 |issue= 27 |pages= 24714-20. |year= 2003 |pmid= 12606549 }}


{{refend}}
== External links ==
*[http://cmkb.cellmigration.org/report.cgi?report=orth_overview&gene_id=8440 Nck2] Info with links in the [http://www.cellmigration.org/index.shtml Cell Migration Gateway]
 
{{PDB Gallery|geneid=8440}}


{{protein-stub}}
[[Category:Human proteins]]
{{WikiDoc Sources}}

Latest revision as of 14:52, 1 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Cytoplasmic protein NCK2 (also known as NCK-beta and Grb4) is a protein that in humans is encoded by the NCK2 gene.[1][2][3]

Function

NCK belongs to family of adaptor proteins,There are two mammalian NCK genes, NCK1 and NCK2. NCK1 is located in chromosome 3 and NCK2 is located in chromosome 2. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[3]

Interactions

NCK2 has been shown to interact with:

References

  1. ↑ 1.0 1.1 1.2 Chen M, She H, Davis EM, Spicer CM, Kim L, Ren R, Le Beau MM, Li W (Sep 1998). "Identification of Nck family genes, chromosomal localization, expression, and signaling specificity". The Journal of Biological Chemistry. 273 (39): 25171–8. doi:10.1074/jbc.273.39.25171. PMID 9737977.
  2. ↑ Liu J, Li M, Ran X, Fan JS, Song J (Jun 2006). "Structural insight into the binding diversity between the human Nck2 SH3 domains and proline-rich proteins". Biochemistry. 45 (23): 7171–84. doi:10.1021/bi060091y. PMID 16752908.
  3. ↑ 3.0 3.1 "Entrez Gene: NCK2 NCK adaptor protein 2".
  4. ↑ 4.0 4.1 Tu Y, Li F, Wu C (Dec 1998). "Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways". Molecular Biology of the Cell. 9 (12): 3367–82. doi:10.1091/mbc.9.12.3367. PMC 25640. PMID 9843575.
  5. ↑ 5.0 5.1 Braverman LE, Quilliam LA (Feb 1999). "Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck". The Journal of Biological Chemistry. 274 (9): 5542–9. doi:10.1074/jbc.274.9.5542. PMID 10026169.
  6. ↑ Tu Y, Li F, Goicoechea S, Wu C (Mar 1999). "The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells". Molecular and Cellular Biology. 19 (3): 2425–34. doi:10.1128/mcb.19.3.2425. PMC 84035. PMID 10022929.
  7. ↑ Chen M, She H, Kim A, Woodley DT, Li W (Nov 2000). "Nckbeta adapter regulates actin polymerization in NIH 3T3 fibroblasts in response to platelet-derived growth factor bb". Molecular and Cellular Biology. 20 (21): 7867–80. doi:10.1128/mcb.20.21.7867-7880.2000. PMC 86398. PMID 11027258.
  8. ↑ Goicoechea SM, Tu Y, Hua Y, Chen K, Shen TL, Guan JL, Wu C (Jul 2002). "Nck-2 interacts with focal adhesion kinase and modulates cell motility". The International Journal of Biochemistry & Cell Biology. 34 (7): 791–805. doi:10.1016/s1357-2725(02)00002-x. PMID 11950595.
  9. ↑ Gil D, Schamel WW, Montoya M, Sánchez-Madrid F, Alarcón B (Jun 2002). "Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation". Cell. 109 (7): 901–12. doi:10.1016/S0092-8674(02)00799-7. PMID 12110186.
  10. ↑ Suzuki S, Mizutani M, Suzuki K, Yamada M, Kojima M, Hatanaka H, Koizumi S (Jun 2002). "Brain-derived neurotrophic factor promotes interaction of the Nck2 adaptor protein with the TrkB tyrosine kinase receptor". Biochemical and Biophysical Research Communications. 294 (5): 1087–92. doi:10.1016/S0006-291X(02)00606-X. PMID 12074588.

Further reading

External links

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