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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Protein BEX3''' is a [[protein]] that in humans is encoded by the ''NGFRAP1'' [[gene]].<ref name="pmid10764727">{{cite journal | vauthors = Mukai J, Hachiya T, Shoji-Hoshino S, Kimura MT, Nadano D, Suvanto P, Hanaoka T, Li Y, Irie S, Greene LA, Sato TA | title = NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR | journal = J. Biol. Chem. | volume = 275 | issue = 23 | pages = 17566–70  | date = Jul 2000 | pmid = 10764727 | pmc =  | doi = 10.1074/jbc.C000140200 }}</ref><ref name="pmid2171551">{{cite journal | vauthors = Rapp G, Freudenstein J, Klaudiny J, Mucha J, Wempe F, Zimmer M, Scheit KH | title = Characterization of three abundant mRNAs from human ovarian granulosa cells | journal = DNA Cell Biol. | volume = 9 | issue = 7 | pages = 479–85  | date = Dec 1990 | pmid = 2171551 | pmc = | doi = 10.1089/dna.1990.9.479 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27018| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Nerve growth factor receptor (TNFRSF16) associated protein 1
| HGNCid = 13388
| Symbol = NGFRAP1
| AltSymbols =; BEX3; Bex; DXS6984E; HGR74; NADE
| OMIM = 300361
| ECnumber = 
| Homologene = 7642
| MGIid = 1338016
| GeneAtlas_image1 = PBB_GE_NGFRAP1_217963_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0005123 |text = death receptor binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process = {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0008150 |text = biological_process}} {{GNF_GO|id=GO:0008625 |text = induction of apoptosis via death domain receptors}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 27018
    | Hs_Ensembl = ENSG00000166681
    | Hs_RefseqProtein = NP_055195
    | Hs_RefseqmRNA = NM_014380
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 102517910
    | Hs_GenLoc_end = 102519661
    | Hs_Uniprot = Q00994
    | Mm_EntrezGene = 12070
    | Mm_Ensembl = ENSMUSG00000046432
    | Mm_RefseqmRNA = XM_975991
    | Mm_RefseqProtein = XP_981085
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 131616691
    | Mm_GenLoc_end = 131618322
    | Mm_Uniprot = Q9WTZ9
  }}
}}
'''Nerve growth factor receptor (TNFRSF16) associated protein 1''', also known as '''NGFRAP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27018| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
NGFRAP1 has been shown to [[Protein-protein interaction|interact]] with [[YWHAE]]<ref name=pmid11278287>{{cite journal | vauthors = Kimura MT, Irie S, Shoji-Hoshino S, Mukai J, Nadano D, Oshimura M, Sato TA | title = 14-3-3 is involved in p75 neurotrophin receptor-mediated signal transduction | journal = J. Biol. Chem. | volume = 276 | issue = 20 | pages = 17291–300 | date = May 2001 | pmid = 11278287 | doi = 10.1074/jbc.M005453200 }}</ref> and [[Low affinity nerve growth factor receptor]].<ref name=pmid10764727 />
{{PBB_Summary
== References ==
| section_title =  
{{reflist}}
| summary_text =  
}}


==References==
== Further reading ==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Auffray C, Behar G, Bois F, Bouchier C, Da Silva C, Devignes MD, Duprat S, Houlgatte R, Jumeau MN, Lamy B | title = [IMAGE: molecular integration of the analysis of the human genome and its expression] | journal = C. R. Acad. Sci. III, Sci. Vie | volume = 318 | issue = 2 | pages = 263–72 | year = 1995 | pmid = 7757816 | doi =  }}
| citations =
* {{cite journal | vauthors = Ye X, Mehlen P, Rabizadeh S, VanArsdale T, Zhang H, Shin H, Wang JJ, Leo E, Zapata J, Hauser CA, Reed JC, Bredesen DE | title = TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction | journal = J. Biol. Chem. | volume = 274 | issue = 42 | pages = 30202–8 | year = 1999 | pmid = 10514511 | doi = 10.1074/jbc.274.42.30202 }}
*{{cite journal  | author=Rapp G, Freudenstein J, Klaudiny J, ''et al.'' |title=Characterization of three abundant mRNAs from human ovarian granulosa cells. |journal=DNA Cell Biol. |volume=9 |issue= 7 |pages= 479-85 |year= 1990 |pmid= 2171551 |doi=  }}
* {{cite journal | vauthors = Irie S, Hachiya T, Rabizadeh S, Maruyama W, Mukai J, Li Y, Reed JC, Bredesen DE, Sato TA | title = Functional interaction of Fas-associated phosphatase-1 (FAP-1) with p75(NTR) and their effect on NF-kappaB activation | journal = FEBS Lett. | volume = 460 | issue = 2 | pages = 191–8 | year = 1999 | pmid = 10544233 | doi = 10.1016/S0014-5793(99)01324-1 }}
*{{cite journal | author=Auffray C, Behar G, Bois F, ''et al.'' |title=[IMAGE: molecular integration of the analysis of the human genome and its expression] |journal=C. R. Acad. Sci. III, Sci. Vie |volume=318 |issue= 2 |pages= 263-72 |year= 1995 |pmid= 7757816 |doi=  }}
* {{cite journal | vauthors = Bilderback TR, Gazula VR, Dobrowsky RT | title = Phosphoinositide 3-kinase regulates crosstalk between Trk A tyrosine kinase and p75(NTR)-dependent sphingolipid signaling pathways | journal = J. Neurochem. | volume = 76 | issue = 5 | pages = 1540–51 | year = 2001 | pmid = 11238738 | doi = 10.1046/j.1471-4159.2001.00171.x }}
*{{cite journal | author=Ye X, Mehlen P, Rabizadeh S, ''et al.'' |title=TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction. |journal=J. Biol. Chem. |volume=274 |issue= 42 |pages= 30202-8 |year= 1999 |pmid= 10514511 |doi= }}
* {{cite journal | vauthors = Kimura MT, Irie S, Shoji-Hoshino S, Mukai J, Nadano D, Oshimura M, Sato TA | title = 14-3-3 is involved in p75 neurotrophin receptor-mediated signal transduction | journal = J. Biol. Chem. | volume = 276 | issue = 20 | pages = 17291–300 | year = 2001 | pmid = 11278287 | doi = 10.1074/jbc.M005453200 }}
*{{cite journal | author=Irie S, Hachiya T, Rabizadeh S, ''et al.'' |title=Functional interaction of Fas-associated phosphatase-1 (FAP-1) with p75(NTR) and their effect on NF-kappaB activation. |journal=FEBS Lett. |volume=460 |issue= 2 |pages= 191-8 |year= 1999 |pmid= 10544233 |doi= }}
* {{cite journal | vauthors = Mukai J, Shoji S, Kimura MT, Okubo S, Sano H, Suvanto P, Li Y, Irie S, Sato TA | title = Structure-function analysis of NADE: identification of regions that mediate nerve growth factor-induced apoptosis | journal = J. Biol. Chem. | volume = 277 | issue = 16 | pages = 13973–82 | year = 2002 | pmid = 11830582 | doi = 10.1074/jbc.M106342200 }}
*{{cite journal  | author=Mukai J, Hachiya T, Shoji-Hoshino S, ''et al.'' |title=NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR. |journal=J. Biol. Chem. |volume=275 |issue= 23 |pages= 17566-70 |year= 2000 |pmid= 10764727 |doi= 10.1074/jbc.C000140200 }}
* {{cite journal | vauthors = Tong X, Xie D, Roth W, Reed J, Koeffler HP | title = NADE (p75NTR-associated cell death executor) suppresses cellular growth in vivo | journal = Int. J. Oncol. | volume = 22 | issue = 6 | pages = 1357–62 | year = 2003 | pmid = 12739005 | doi = 10.3892/ijo.22.6.1357 }}
*{{cite journal | author=Bilderback TR, Gazula VR, Dobrowsky RT |title=Phosphoinositide 3-kinase regulates crosstalk between Trk A tyrosine kinase and p75(NTR)-dependent sphingolipid signaling pathways. |journal=J. Neurochem. |volume=76 |issue= 5 |pages= 1540-51 |year= 2001 |pmid= 11238738 |doi= }}
* {{cite journal | vauthors = Yoon K, Jang HD, Lee SY | title = Direct interaction of Smac with NADE promotes TRAIL-induced apoptosis | journal = Biochem. Biophys. Res. Commun. | volume = 319 | issue = 2 | pages = 649–54 | year = 2004 | pmid = 15178455 | doi = 10.1016/j.bbrc.2004.05.043 }}
*{{cite journal | author=Kimura MT, Irie S, Shoji-Hoshino S, ''et al.'' |title=14-3-3 is involved in p75 neurotrophin receptor-mediated signal transduction. |journal=J. Biol. Chem. |volume=276 |issue= 20 |pages= 17291-300 |year= 2001 |pmid= 11278287 |doi= 10.1074/jbc.M005453200 }}
* {{cite journal | vauthors = Alvarez E, Zhou W, Witta SE, Freed CR | title = Characterization of the Bex gene family in humans, mice, and rats | journal = Gene | volume = 357 | issue = 1 | pages = 18–28 | year = 2005 | pmid = 15958283 | doi = 10.1016/j.gene.2005.05.012 }}
*{{cite journal | author=Mukai J, Shoji S, Kimura MT, ''et al.'' |title=Structure-function analysis of NADE: identification of regions that mediate nerve growth factor-induced apoptosis. |journal=J. Biol. Chem. |volume=277 |issue= 16 |pages= 13973-82 |year= 2002 |pmid= 11830582 |doi= 10.1074/jbc.M106342200 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Yu Y, Wang J, Yuan H, Qin F, Wang J, Zhang N, Li YY, Liu J, Lu H | title = Characterization of human dopamine responsive protein DRG-1 that binds to p75NTR-associated cell death executor NADE | journal = Brain Res. | volume = 1100 | issue = 1 | pages = 13–20 | year = 2006 | pmid = 16777077 | doi = 10.1016/j.brainres.2006.05.010 }}
*{{cite journal  | author=Tong X, Xie D, Roth W, ''et al.'' |title=NADE (p75NTR-associated cell death executor) suppresses cellular growth in vivo. |journal=Int. J. Oncol. |volume=22 |issue= 6 |pages= 1357-62 |year= 2003 |pmid= 12739005 |doi= }}
* {{cite journal | vauthors = Yasui S, Tsuzaki K, Ninomiya H, Floricel F, Asano Y, Maki H, Takamura A, Nanba E, Higaki K, Ohno K | title = The TSC1 gene product hamartin interacts with NADE | journal = Mol. Cell. Neurosci. | volume = 35 | issue = 1 | pages = 100–8 | year = 2007 | pmid = 17355907 | doi = 10.1016/j.mcn.2007.02.007 }}
*{{cite journal | author=Yoon K, Jang HD, Lee SY |title=Direct interaction of Smac with NADE promotes TRAIL-induced apoptosis. |journal=Biochem. Biophys. Res. Commun. |volume=319 |issue= 2 |pages= 649-54 |year= 2004 |pmid= 15178455 |doi= 10.1016/j.bbrc.2004.05.043 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Ross MT, Grafham DV, Coffey AJ, ''et al.'' |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325-37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 }}
*{{cite journal  | author=Alvarez E, Zhou W, Witta SE, Freed CR |title=Characterization of the Bex gene family in humans, mice, and rats. |journal=Gene |volume=357 |issue= 1 |pages= 18-28 |year= 2005 |pmid= 15958283 |doi= 10.1016/j.gene.2005.05.012 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Yu Y, Wang J, Yuan H, ''et al.'' |title=Characterization of human dopamine responsive protein DRG-1 that binds to p75NTR-associated cell death executor NADE. |journal=Brain Res. |volume=1100 |issue= 1 |pages= 13-20 |year= 2006 |pmid= 16777077 |doi= 10.1016/j.brainres.2006.05.010 }}
*{{cite journal | author=Yasui S, Tsuzaki K, Ninomiya H, ''et al.'' |title=The TSC1 gene product hamartin interacts with NADE. |journal=Mol. Cell. Neurosci. |volume=35 |issue= 1 |pages= 100-8 |year= 2007 |pmid= 17355907 |doi= 10.1016/j.mcn.2007.02.007 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
 
{{WikiDoc Sources}}
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Revision as of 02:18, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Protein BEX3 is a protein that in humans is encoded by the NGFRAP1 gene.[1][2][3]

Interactions

NGFRAP1 has been shown to interact with YWHAE[4] and Low affinity nerve growth factor receptor.[1]

References

  1. ↑ 1.0 1.1 Mukai J, Hachiya T, Shoji-Hoshino S, Kimura MT, Nadano D, Suvanto P, Hanaoka T, Li Y, Irie S, Greene LA, Sato TA (Jul 2000). "NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR". J. Biol. Chem. 275 (23): 17566–70. doi:10.1074/jbc.C000140200. PMID 10764727.
  2. ↑ Rapp G, Freudenstein J, Klaudiny J, Mucha J, Wempe F, Zimmer M, Scheit KH (Dec 1990). "Characterization of three abundant mRNAs from human ovarian granulosa cells". DNA Cell Biol. 9 (7): 479–85. doi:10.1089/dna.1990.9.479. PMID 2171551.
  3. ↑ "Entrez Gene: NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1".
  4. ↑ Kimura MT, Irie S, Shoji-Hoshino S, Mukai J, Nadano D, Oshimura M, Sato TA (May 2001). "14-3-3 is involved in p75 neurotrophin receptor-mediated signal transduction". J. Biol. Chem. 276 (20): 17291–300. doi:10.1074/jbc.M005453200. PMID 11278287.

Further reading

  • Auffray C, Behar G, Bois F, Bouchier C, Da Silva C, Devignes MD, Duprat S, Houlgatte R, Jumeau MN, Lamy B (1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". C. R. Acad. Sci. III, Sci. Vie. 318 (2): 263–72. PMID 7757816.
  • Ye X, Mehlen P, Rabizadeh S, VanArsdale T, Zhang H, Shin H, Wang JJ, Leo E, Zapata J, Hauser CA, Reed JC, Bredesen DE (1999). "TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction". J. Biol. Chem. 274 (42): 30202–8. doi:10.1074/jbc.274.42.30202. PMID 10514511.
  • Irie S, Hachiya T, Rabizadeh S, Maruyama W, Mukai J, Li Y, Reed JC, Bredesen DE, Sato TA (1999). "Functional interaction of Fas-associated phosphatase-1 (FAP-1) with p75(NTR) and their effect on NF-kappaB activation". FEBS Lett. 460 (2): 191–8. doi:10.1016/S0014-5793(99)01324-1. PMID 10544233.
  • Bilderback TR, Gazula VR, Dobrowsky RT (2001). "Phosphoinositide 3-kinase regulates crosstalk between Trk A tyrosine kinase and p75(NTR)-dependent sphingolipid signaling pathways". J. Neurochem. 76 (5): 1540–51. doi:10.1046/j.1471-4159.2001.00171.x. PMID 11238738.
  • Kimura MT, Irie S, Shoji-Hoshino S, Mukai J, Nadano D, Oshimura M, Sato TA (2001). "14-3-3 is involved in p75 neurotrophin receptor-mediated signal transduction". J. Biol. Chem. 276 (20): 17291–300. doi:10.1074/jbc.M005453200. PMID 11278287.
  • Mukai J, Shoji S, Kimura MT, Okubo S, Sano H, Suvanto P, Li Y, Irie S, Sato TA (2002). "Structure-function analysis of NADE: identification of regions that mediate nerve growth factor-induced apoptosis". J. Biol. Chem. 277 (16): 13973–82. doi:10.1074/jbc.M106342200. PMID 11830582.
  • Tong X, Xie D, Roth W, Reed J, Koeffler HP (2003). "NADE (p75NTR-associated cell death executor) suppresses cellular growth in vivo". Int. J. Oncol. 22 (6): 1357–62. doi:10.3892/ijo.22.6.1357. PMID 12739005.
  • Yoon K, Jang HD, Lee SY (2004). "Direct interaction of Smac with NADE promotes TRAIL-induced apoptosis". Biochem. Biophys. Res. Commun. 319 (2): 649–54. doi:10.1016/j.bbrc.2004.05.043. PMID 15178455.
  • Alvarez E, Zhou W, Witta SE, Freed CR (2005). "Characterization of the Bex gene family in humans, mice, and rats". Gene. 357 (1): 18–28. doi:10.1016/j.gene.2005.05.012. PMID 15958283.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Yu Y, Wang J, Yuan H, Qin F, Wang J, Zhang N, Li YY, Liu J, Lu H (2006). "Characterization of human dopamine responsive protein DRG-1 that binds to p75NTR-associated cell death executor NADE". Brain Res. 1100 (1): 13–20. doi:10.1016/j.brainres.2006.05.010. PMID 16777077.
  • Yasui S, Tsuzaki K, Ninomiya H, Floricel F, Asano Y, Maki H, Takamura A, Nanba E, Higaki K, Ohno K (2007). "The TSC1 gene product hamartin interacts with NADE". Mol. Cell. Neurosci. 35 (1): 100–8. doi:10.1016/j.mcn.2007.02.007. PMID 17355907.


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