NRD1: Difference between revisions

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{{Infobox_gene}}
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'''Nardilysin''' is a [[protein]] that in humans is encoded by the ''NRD1'' [[gene]].<ref name="pmid9581555">{{cite journal |vauthors=Hospital V, Prat A, Joulie C, Cherif D, Day R, Cohen P | title = Human and rat testis express two mRNA species encoding variants of NRD convertase, a metalloendopeptidase of the insulinase family | journal = Biochem J | volume = 327 | issue =  3| pages = 773–9 |date=May 1998 | pmid = 9581555 | pmc = 1218856 | doi =  }}</ref><ref name="pmid9479496">{{cite journal |vauthors=Fumagalli P, Accarino M, Egeo A, Scartezzini P, Rappazzo G, Pizzuti A, Avvantaggiato V, Simeone A, Arrigo G, Zuffardi O, Ottolenghi S, Taramelli R | title = Human NRD convertase: a highly conserved metalloendopeptidase expressed at specific sites during development and in adult tissues | journal = Genomics | volume = 47 | issue = 2 | pages = 238–45 |date=Apr 1998 | pmid = 9479496 | pmc =  | doi = 10.1006/geno.1997.5078 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NRD1 nardilysin (N-arginine dibasic convertase)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4898| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Nardilysin (N-arginine dibasic convertase)
| HGNCid = 7995
| Symbol = NRD1
| AltSymbols =; hNRD1; hNRD2
  | OMIM = 602651
| ECnumber =
| Homologene = 68260
| MGIid = 1201386
| GeneAtlas_image1 = PBB_GE_NRD1_208709_s_at_tn.png
  | Function = {{GNF_GO|id=GO:0004222 |text = metalloendopeptidase activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016919 |text = nardilysin activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0048408 |text = epidermal growth factor binding}}
| Component = {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0009986 |text = cell surface}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0007528 |text = neuromuscular junction development}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0016477 |text = cell migration}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4898
    | Hs_Ensembl = ENSG00000078618
    | Hs_RefseqProtein = NP_002516
    | Hs_RefseqmRNA = NM_002525
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 52027451
    | Hs_GenLoc_end = 52117065
    | Hs_Uniprot = O43847
    | Mm_EntrezGene = 230598
    | Mm_Ensembl = ENSMUSG00000053510
    | Mm_RefseqmRNA = NM_146150
    | Mm_RefseqProtein = NP_666262
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 108498587
    | Mm_GenLoc_end = 108559709
    | Mm_Uniprot = Q8R1H1
  }}
}}
'''Nardilysin (N-arginine dibasic convertase)''', also known as '''NRD1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NRD1 nardilysin (N-arginine dibasic convertase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4898| accessdate = }}</ref>


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==Interactions==
NRD1 has been shown to [[Protein-protein interaction|interact]] with [[Heparin-binding EGF-like growth factor]].<ref name=pmid11432822>{{cite journal |last=Nishi |first=E |authorlink= |author2=Prat A |author3=Hospital V |author4=Elenius K |author5=Klagsbrun M  |date=Jul 2001 |title=N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration |journal=EMBO J. |volume=20 |issue=13 |pages=3342–50 |publisher= |location = England| issn = 0261-4189| pmid = 11432822 |doi = 10.1093/emboj/20.13.3342 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=125525 }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Seidah NG, Prat A |title=Precursor convertases in the secretory pathway, cytosol and extracellular milieu. |journal=Essays Biochem. |volume=38 |issue=  |pages= 79-94 |year= 2003 |pmid= 12463163 |doi=  }}
*{{cite journal  |vauthors=Seidah NG, Prat A |title=Precursor convertases in the secretory pathway, cytosol and extracellular milieu. |journal=Essays Biochem. |volume=38 |issue=  |pages= 79–94 |year= 2003 |pmid= 12463163 |doi=  }}
*{{cite journal  | author=Hospital V, Prat A |title=Nardilysin, a basic residues specific metallopeptidase that mediates cell migration and proliferation. |journal=Protein Pept. Lett. |volume=11 |issue= 5 |pages= 501-8 |year= 2005 |pmid= 15544571 |doi=  }}
*{{cite journal  |vauthors=Hospital V, Prat A |title=Nardilysin, a basic residues specific metallopeptidase that mediates cell migration and proliferation. |journal=Protein Pept. Lett. |volume=11 |issue= 5 |pages= 501–8 |year= 2005 |pmid= 15544571 |doi=10.2174/0929866043406508 }}
*{{cite journal  | author=Fumagalli P, Accarino M, Egeo A, ''et al.'' |title=Human NRD convertase: a highly conserved metalloendopeptidase expressed at specific sites during development and in adult tissues. |journal=Genomics |volume=47 |issue= 2 |pages= 238-45 |year= 1998 |pmid= 9479496 |doi= 10.1006/geno.1997.5078 }}
*{{cite journal  |vauthors=Winter AG, Pierotti AR |title=Gene expression of the dibasic-pair cleaving enzyme NRD convertase (N-arginine dibasic convertase) is differentially regulated in the GH3 pituitary and Mat-Lu prostate cell lines. |journal=Biochem. J. |volume=351 |issue=  3|pages= 755–64 |year= 2001 |pmid= 11042131 |doi= 10.1042/0264-6021:3510755| pmc=1221416 }}
*{{cite journal  | author=Hospital V, Prat A, Joulie C, ''et al.'' |title=Human and rat testis express two mRNA species encoding variants of NRD convertase, a metalloendopeptidase of the insulinase family. |journal=Biochem. J. |volume=327 ( Pt 3) |issue=  |pages= 773-9 |year= 1998 |pmid= 9581555 |doi= }}
*{{cite journal   |vauthors=Nishi E, Prat A, Hospital V, etal |title=N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration. |journal=EMBO J. |volume=20 |issue= 13 |pages= 3342–50 |year= 2001 |pmid= 11432822 |doi= 10.1093/emboj/20.13.3342 | pmc=125525 }}
*{{cite journal  | author=Winter AG, Pierotti AR |title=Gene expression of the dibasic-pair cleaving enzyme NRD convertase (N-arginine dibasic convertase) is differentially regulated in the GH3 pituitary and Mat-Lu prostate cell lines. |journal=Biochem. J. |volume=351 Pt 3 |issue=  |pages= 755-64 |year= 2001 |pmid= 11042131 |doi=  }}
*{{cite journal  |vauthors=Ma Z, Csuhai E, Chow KM, Hersh LB |title=Expression of the acidic stretch of nardilysin as a functional binding domain. |journal=Biochemistry |volume=40 |issue= 31 |pages= 9447–52 |year= 2001 |pmid= 11478915 |doi=10.1021/bi010538x }}
*{{cite journal | author=Nishi E, Prat A, Hospital V, ''et al.'' |title=N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration. |journal=EMBO J. |volume=20 |issue= 13 |pages= 3342-50 |year= 2001 |pmid= 11432822 |doi= 10.1093/emboj/20.13.3342 }}
*{{cite journal   |vauthors=Hospital V, Nishi E, Klagsbrun M, etal |title=The metalloendopeptidase nardilysin (NRDc) is potently inhibited by heparin-binding epidermal growth factor-like growth factor (HB-EGF). |journal=Biochem. J. |volume=367 |issue= Pt 1 |pages= 229–38 |year= 2003 |pmid= 12095415 |doi= 10.1042/BJ20020822 | pmc=1222870 }}
*{{cite journal  | author=Ma Z, Csuhai E, Chow KM, Hersh LB |title=Expression of the acidic stretch of nardilysin as a functional binding domain. |journal=Biochemistry |volume=40 |issue= 31 |pages= 9447-52 |year= 2001 |pmid= 11478915 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Hospital V, Nishi E, Klagsbrun M, ''et al.'' |title=The metalloendopeptidase nardilysin (NRDc) is potently inhibited by heparin-binding epidermal growth factor-like growth factor (HB-EGF). |journal=Biochem. J. |volume=367 |issue= Pt 1 |pages= 229-38 |year= 2003 |pmid= 12095415 |doi= 10.1042/BJ20020822 }}
*{{cite journal   |vauthors=Chow KM, Oakley O, Goodman J, etal |title=Nardilysin cleaves peptides at monobasic sites. |journal=Biochemistry |volume=42 |issue= 7 |pages= 2239–44 |year= 2003 |pmid= 12590613 |doi= 10.1021/bi027178d }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Chow KM, Oakley O, Goodman J, ''et al.'' |title=Nardilysin cleaves peptides at monobasic sites. |journal=Biochemistry |volume=42 |issue= 7 |pages= 2239-44 |year= 2003 |pmid= 12590613 |doi= 10.1021/bi027178d }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Gregory SG, Barlow KF, McLay KE, etal |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal   |vauthors=Nishi E, Hiraoka Y, Yoshida K, etal |title=Nardilysin enhances ectodomain shedding of heparin-binding epidermal growth factor-like growth factor through activation of tumor necrosis factor-alpha-converting enzyme. |journal=J. Biol. Chem. |volume=281 |issue= 41 |pages= 31164–72 |year= 2006 |pmid= 16923819 |doi= 10.1074/jbc.M601316200 }}
*{{cite journal | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal   |vauthors=Bernstein HG, Stricker R, Dobrowolny H, etal |title=Histochemical evidence for wide expression of the metalloendopeptidase nardilysin in human brain neurons. |journal=Neuroscience |volume=146 |issue= 4 |pages= 1513–23 |year= 2007 |pmid= 17442499 |doi= 10.1016/j.neuroscience.2007.02.057 }}
*{{cite journal | author=Nishi E, Hiraoka Y, Yoshida K, ''et al.'' |title=Nardilysin enhances ectodomain shedding of heparin-binding epidermal growth factor-like growth factor through activation of tumor necrosis factor-alpha-converting enzyme. |journal=J. Biol. Chem. |volume=281 |issue= 41 |pages= 31164-72 |year= 2006 |pmid= 16923819 |doi= 10.1074/jbc.M601316200 }}
*{{cite journal | author=Bernstein HG, Stricker R, Dobrowolny H, ''et al.'' |title=Histochemical evidence for wide expression of the metalloendopeptidase nardilysin in human brain neurons. |journal=Neuroscience |volume=146 |issue= 4 |pages= 1513-23 |year= 2007 |pmid= 17442499 |doi= 10.1016/j.neuroscience.2007.02.057 }}
}}
}}
{{refend}}
{{refend}}


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Revision as of 13:14, 5 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Nardilysin is a protein that in humans is encoded by the NRD1 gene.[1][2][3]


Interactions

NRD1 has been shown to interact with Heparin-binding EGF-like growth factor.[4]

References

  1. ↑ Hospital V, Prat A, Joulie C, Cherif D, Day R, Cohen P (May 1998). "Human and rat testis express two mRNA species encoding variants of NRD convertase, a metalloendopeptidase of the insulinase family". Biochem J. 327 (3): 773–9. PMC 1218856. PMID 9581555.
  2. ↑ Fumagalli P, Accarino M, Egeo A, Scartezzini P, Rappazzo G, Pizzuti A, Avvantaggiato V, Simeone A, Arrigo G, Zuffardi O, Ottolenghi S, Taramelli R (Apr 1998). "Human NRD convertase: a highly conserved metalloendopeptidase expressed at specific sites during development and in adult tissues". Genomics. 47 (2): 238–45. doi:10.1006/geno.1997.5078. PMID 9479496.
  3. ↑ "Entrez Gene: NRD1 nardilysin (N-arginine dibasic convertase)".
  4. ↑ Nishi, E; Prat A; Hospital V; Elenius K; Klagsbrun M (Jul 2001). "N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration". EMBO J. England. 20 (13): 3342–50. doi:10.1093/emboj/20.13.3342. ISSN 0261-4189. PMC 125525. PMID 11432822.

Further reading



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