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{{Infobox_gene}}
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'''Kinetochore protein Nuf2''' is a [[protein]] that in humans is encoded by the ''NUF2'' [[gene]].<ref name="pmid11266451">{{cite journal | vauthors = Wigge PA, Kilmartin JV | title = The Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregation | journal = J Cell Biol | volume = 152 | issue = 2 | pages = 349–60 |date=Mar 2001 | pmid = 11266451 | pmc = 2199619 | doi =10.1083/jcb.152.2.349  }}</ref><ref name="pmid11685532">{{cite journal | vauthors = Nabetani A, Koujin T, Tsutsumi C, Haraguchi T, Hiraoka Y | title = A conserved protein, Nuf2, is implicated in connecting the centromere to the spindle during chromosome segregation: a link between the kinetochore function and the spindle checkpoint | journal = Chromosoma | volume = 110 | issue = 5 | pages = 322–34 |date=Oct 2001 | pmid = 11685532 | pmc =  | doi = 10.1007/s004120100153 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NUF2 NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83540| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)
| HGNCid = 14621
| Symbol = NUF2
| AltSymbols =; CDCA1; NUF2R
| OMIM =
| ECnumber =
| Homologene = 41521
| MGIid = 1914227
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0000775 |text = chromosome, pericentric region}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007059 |text = chromosome segregation}} {{GNF_GO|id=GO:0007067 |text = mitosis}} {{GNF_GO|id=GO:0051301 |text = cell division}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 83540
    | Hs_Ensembl = ENSG00000143228
    | Hs_RefseqProtein = NP_113611
    | Hs_RefseqmRNA = NM_031423
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 161558349
    | Hs_GenLoc_end = 161592178
    | Hs_Uniprot = Q9BZD4
    | Mm_EntrezGene = 66977
    | Mm_Ensembl = ENSMUSG00000026683
    | Mm_RefseqmRNA = XM_001001356
    | Mm_RefseqProtein = XP_001001356
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 171334986
    | Mm_GenLoc_end = 171368103
    | Mm_Uniprot = Q99P69
  }}
}}
'''NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)''', also known as '''NUF2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NUF2 NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83540| accessdate = }}</ref>


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{{PBB_Summary
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| section_title =  
| section_title =  
| summary_text = This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the spindle pole body, and plays a regulatory role in chromosome segregation. The encoded protein is found to be associated with centromeres of mitotic HeLa cells, which suggests that this protein is a functional homolog of yeast Nuf2. Alternatively spliced transcript variants that encode the same protein have been described.<ref name="entrez">{{cite web | title = Entrez Gene: NUF2 NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83540| accessdate = }}</ref>
| summary_text = This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the spindle pole body, and plays a regulatory role in chromosome segregation. The encoded protein is found to be associated with centromeres of mitotic HeLa cells, which suggests that this protein is a functional homolog of yeast Nuf2. Alternatively spliced transcript variants that encode the same protein have been described.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Wigge PA, Kilmartin JV |title=The Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregation. |journal=J. Cell Biol. |volume=152 |issue= 2 |pages= 349-60 |year= 2001 |pmid= 11266451 |doi=  }}
*{{cite journal   |vauthors=DeLuca JG, Moree B, Hickey JM, etal |title=hNuf2 inhibition blocks stable kinetochore-microtubule attachment and induces mitotic cell death in HeLa cells. |journal=J. Cell Biol. |volume=159 |issue= 4 |pages= 549–55 |year= 2003 |pmid= 12438418 |doi= 10.1083/jcb.200208159 | pmc=2173110 }}
*{{cite journal | author=Nabetani A, Koujin T, Tsutsumi C, ''et al.'' |title=A conserved protein, Nuf2, is implicated in connecting the centromere to the spindle during chromosome segregation: a link between the kinetochore function and the spindle checkpoint. |journal=Chromosoma |volume=110 |issue= 5 |pages= 322-34 |year= 2002 |pmid= 11685532 |doi= 10.1007/s004120100153 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal | author=DeLuca JG, Moree B, Hickey JM, ''et al.'' |title=hNuf2 inhibition blocks stable kinetochore-microtubule attachment and induces mitotic cell death in HeLa cells. |journal=J. Cell Biol. |volume=159 |issue= 4 |pages= 549-55 |year= 2003 |pmid= 12438418 |doi= 10.1083/jcb.200208159 }}
*{{cite journal   |vauthors=Tien AC, Lin MH, Su LJ, etal |title=Identification of the substrates and interaction proteins of aurora kinases from a protein-protein interaction model. |journal=Mol. Cell. Proteomics |volume=3 |issue= 1 |pages= 93–104 |year= 2004 |pmid= 14602875 |doi= 10.1074/mcp.M300072-MCP200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=DeLuca JG, Howell BJ, Canman JC, etal |title=Nuf2 and Hec1 are required for retention of the checkpoint proteins Mad1 and Mad2 to kinetochores. |journal=Curr. Biol. |volume=13 |issue= 23 |pages= 2103–9 |year= 2004 |pmid= 14654001 |doi=10.1016/j.cub.2003.10.056  }}
*{{cite journal  | author=Tien AC, Lin MH, Su LJ, ''et al.'' |title=Identification of the substrates and interaction proteins of aurora kinases from a protein-protein interaction model. |journal=Mol. Cell Proteomics |volume=3 |issue= 1 |pages= 93-104 |year= 2004 |pmid= 14602875 |doi= 10.1074/mcp.M300072-MCP200 }}
*{{cite journal  | vauthors=Bharadwaj R, Qi W, Yu H |title=Identification of two novel components of the human NDC80 kinetochore complex. |journal=J. Biol. Chem. |volume=279 |issue= 13 |pages= 13076–85 |year= 2004 |pmid= 14699129 |doi= 10.1074/jbc.M310224200 }}
*{{cite journal | author=DeLuca JG, Howell BJ, Canman JC, ''et al.'' |title=Nuf2 and Hec1 are required for retention of the checkpoint proteins Mad1 and Mad2 to kinetochores. |journal=Curr. Biol. |volume=13 |issue= 23 |pages= 2103-9 |year= 2004 |pmid= 14654001 |doi= }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Bharadwaj R, Qi W, Yu H |title=Identification of two novel components of the human NDC80 kinetochore complex. |journal=J. Biol. Chem. |volume=279 |issue= 13 |pages= 13076-85 |year= 2004 |pmid= 14699129 |doi= 10.1074/jbc.M310224200 }}
*{{cite journal   |vauthors=Joseph J, Liu ST, Jablonski SA, etal |title=The RanGAP1-RanBP2 complex is essential for microtubule-kinetochore interactions in vivo. |journal=Curr. Biol. |volume=14 |issue= 7 |pages= 611–7 |year= 2004 |pmid= 15062103 |doi= 10.1016/j.cub.2004.03.031 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Stucke VM, Baumann C, Nigg EA |title=Kinetochore localization and microtubule interaction of the human spindle checkpoint kinase Mps1. |journal=Chromosoma |volume=113 |issue= 1 |pages= 1–15 |year= 2005 |pmid= 15235793 |doi= 10.1007/s00412-004-0288-2 }}
*{{cite journal  | author=Joseph J, Liu ST, Jablonski SA, ''et al.'' |title=The RanGAP1-RanBP2 complex is essential for microtubule-kinetochore interactions in vivo. |journal=Curr. Biol. |volume=14 |issue= 7 |pages= 611-7 |year= 2004 |pmid= 15062103 |doi= 10.1016/j.cub.2004.03.031 }}
*{{cite journal  | vauthors=Meraldi P, Draviam VM, Sorger PK |title=Timing and checkpoints in the regulation of mitotic progression. |journal=Dev. Cell |volume=7 |issue= 1 |pages= 45–60 |year= 2004 |pmid= 15239953 |doi= 10.1016/j.devcel.2004.06.006 }}
*{{cite journal | author=Stucke VM, Baumann C, Nigg EA |title=Kinetochore localization and microtubule interaction of the human spindle checkpoint kinase Mps1. |journal=Chromosoma |volume=113 |issue= 1 |pages= 1-15 |year= 2005 |pmid= 15235793 |doi= 10.1007/s00412-004-0288-2 }}
*{{cite journal   |vauthors=Cheeseman IM, Niessen S, Anderson S, etal |title=A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension. |journal=Genes Dev. |volume=18 |issue= 18 |pages= 2255–68 |year= 2004 |pmid= 15371340 |doi= 10.1101/gad.1234104  | pmc=517519 }}
*{{cite journal | author=Meraldi P, Draviam VM, Sorger PK |title=Timing and checkpoints in the regulation of mitotic progression. |journal=Dev. Cell |volume=7 |issue= 1 |pages= 45-60 |year= 2004 |pmid= 15239953 |doi= 10.1016/j.devcel.2004.06.006 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal | author=Cheeseman IM, Niessen S, Anderson S, ''et al.'' |title=A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension. |journal=Genes Dev. |volume=18 |issue= 18 |pages= 2255-68 |year= 2004 |pmid= 15371340 |doi= 10.1101/gad.1234104 }}
*{{cite journal   |vauthors=DeLuca JG, Dong Y, Hergert P, etal |title=Hec1 and nuf2 are core components of the kinetochore outer plate essential for organizing microtubule attachment sites. |journal=Mol. Biol. Cell |volume=16 |issue= 2 |pages= 519–31 |year= 2005 |pmid= 15548592 |doi= 10.1091/mbc.E04-09-0852  | pmc=545888 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Ciferri C, De Luca J, Monzani S, etal |title=Architecture of the human ndc80-hec1 complex, a critical constituent of the outer kinetochore. |journal=J. Biol. Chem. |volume=280 |issue= 32 |pages= 29088–95 |year= 2005 |pmid= 15961401 |doi= 10.1074/jbc.M504070200 }}
*{{cite journal | author=DeLuca JG, Dong Y, Hergert P, ''et al.'' |title=Hec1 and nuf2 are core components of the kinetochore outer plate essential for organizing microtubule attachment sites. |journal=Mol. Biol. Cell |volume=16 |issue= 2 |pages= 519-31 |year= 2005 |pmid= 15548592 |doi= 10.1091/mbc.E04-09-0852 }}
*{{cite journal   |vauthors=Nousiainen M, Silljé HH, Sauer G, etal |title=Phosphoproteome analysis of the human mitotic spindle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391–6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103  | pmc=1459365 }}
*{{cite journal | author=Ciferri C, De Luca J, Monzani S, ''et al.'' |title=Architecture of the human ndc80-hec1 complex, a critical constituent of the outer kinetochore. |journal=J. Biol. Chem. |volume=280 |issue= 32 |pages= 29088-95 |year= 2005 |pmid= 15961401 |doi= 10.1074/jbc.M504070200 }}
*{{cite journal   |vauthors=Gregory SG, Barlow KF, McLay KE, etal |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal | author=Nousiainen M, Silljé HH, Sauer G, ''et al.'' |title=Phosphoproteome analysis of the human mitotic spindle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391-6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103 }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal   |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }}
*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal   |vauthors=Liu D, Ding X, Du J, etal |title=Human NUF2 interacts with centromere-associated protein E and is essential for a stable spindle microtubule-kinetochore attachment. |journal=J. Biol. Chem. |volume=282 |issue= 29 |pages= 21415–24 |year= 2007 |pmid= 17535814 |doi= 10.1074/jbc.M609026200 }}
*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
*{{cite journal | author=Liu D, Ding X, Du J, ''et al.'' |title=Human NUF2 interacts with centromere-associated protein E and is essential for a stable spindle microtubule-kinetochore attachment. |journal=J. Biol. Chem. |volume=282 |issue= 29 |pages= 21415-24 |year= 2007 |pmid= 17535814 |doi= 10.1074/jbc.M609026200 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 13:21, 5 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Kinetochore protein Nuf2 is a protein that in humans is encoded by the NUF2 gene.[1][2][3]

This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the spindle pole body, and plays a regulatory role in chromosome segregation. The encoded protein is found to be associated with centromeres of mitotic HeLa cells, which suggests that this protein is a functional homolog of yeast Nuf2. Alternatively spliced transcript variants that encode the same protein have been described.[3]

References

  1. ↑ Wigge PA, Kilmartin JV (Mar 2001). "The Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregation". J Cell Biol. 152 (2): 349–60. doi:10.1083/jcb.152.2.349. PMC 2199619. PMID 11266451.
  2. ↑ Nabetani A, Koujin T, Tsutsumi C, Haraguchi T, Hiraoka Y (Oct 2001). "A conserved protein, Nuf2, is implicated in connecting the centromere to the spindle during chromosome segregation: a link between the kinetochore function and the spindle checkpoint". Chromosoma. 110 (5): 322–34. doi:10.1007/s004120100153. PMID 11685532.
  3. ↑ 3.0 3.1 "Entrez Gene: NUF2 NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)".

Further reading



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