NUTF2: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
m (Bot: HTTP→HTTPS)
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Nuclear transport factor 2''' is a [[protein]] that in humans is encoded by the ''NUTF2'' [[gene]].<ref name="pmid7744965">{{cite journal | vauthors = Paschal BM, Gerace L | title = Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62 | journal = J Cell Biol | volume = 129 | issue = 4 | pages = 925–937 | date = Jun 1995 | pmid = 7744965 | pmc = 2120498 | doi = 10.1083/jcb.129.4.925 }}</ref><ref name="pmid3380696">{{cite journal | vauthors = Grundmann U, Nerlich C, Rein T, Lottspeich F, Küpper HA | title = Isolation of cDNA coding for the placental protein 15 (PP15) | journal = Nucleic Acids Res | volume = 16 | issue = 10 | pages = 4721–4721 | date = Jul 1988 | pmid = 3380696 | pmc = 336660 | doi = 10.1093/nar/16.10.4721 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NUTF2 nuclear transport factor 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10204| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_NUTF2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1a2k.
| PDB = {{PDB2|1a2k}}, {{PDB2|1ar0}}, {{PDB2|1ask}}, {{PDB2|1gy5}}, {{PDB2|1gy6}}, {{PDB2|1jb2}}, {{PDB2|1jb4}}, {{PDB2|1jb5}}, {{PDB2|1oun}}, {{PDB2|1qma}}, {{PDB2|1u5o}}
| Name = Nuclear transport factor 2
| HGNCid = 13722
| Symbol = NUTF2
| AltSymbols =; NTF2; PP15
| OMIM = 605813
| ECnumber = 
| Homologene = 38101
| MGIid = 1915301
| Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005643 |text = nuclear pore}} {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process = {{GNF_GO|id=GO:0015031 |text = protein transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10204
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_005787
    | Hs_RefseqmRNA = NM_005796
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 68051
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_026532
    | Mm_RefseqProtein = NP_080808
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Nuclear transport factor 2''', also known as '''NUTF2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NUTF2 nuclear transport factor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10204| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is a cytosolic factor that facilitates protein transport into the nucleus. It interacts with the nuclear pore complex glycoprotein p62. This encoded protein acts at a relative late stage of nuclear protein import, subsequent to the initial docking of nuclear import ligand at the nuclear envelope. It is thought to be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a cytosolic factor that facilitates protein transport into the nucleus. It interacts with the nuclear pore complex glycoprotein p62. This encoded protein acts at a relative late stage of nuclear protein import, subsequent to the initial docking of nuclear import ligand at the nuclear envelope. It is thought to be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import.<ref name="entrez">{{cite web | title = Entrez Gene: NUTF2 nuclear transport factor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10204| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
NUTF2 has been shown to [[Protein-protein interaction|interact]] with [[Nucleoporin 62]]<ref name=pmid7744965 />{<ref name=pmid8707840>{{cite journal | vauthors = Hu T, Guan T, Gerace L | title = Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins | journal = J. Cell Biol. | volume = 134 | issue = 3 | pages = 589–601 | date = Aug 1996 | pmid = 8707840 | pmc = 2120945 | doi = 10.1083/jcb.134.3.589 }}</ref> and [[Ran (gene)|RAN]].<ref name=pmid15522285>{{cite journal | vauthors = Cushman I, Bowman BR, Sowa ME, Lichtarge O, Quiocho FA, Moore MS | title = Computational and biochemical identification of a nuclear pore complex binding site on the nuclear transport carrier NTF2 | journal = J. Mol. Biol. | volume = 344 | issue = 2 | pages = 303–310 | date = Nov 2004 | pmid = 15522285 | doi = 10.1016/j.jmb.2004.09.043 }}</ref><ref name=pmid9533885>{{cite journal | vauthors = Stewart M, Kent HM, McCoy AJ | title = Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the Ras-family GTPase Ran | journal = J. Mol. Biol. | volume = 277 | issue = 3 | pages = 635–646 | date = Apr 1998 | pmid = 9533885 | doi = 10.1006/jmbi.1997.1602 }}</ref>
 
== References ==
{{reflist}}
{{Clear}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Bukrinsky MI, Haffar OK | title = HIV-1 nuclear import: matrix protein is back on center stage, this time together with Vpr | journal = Mol. Med. | volume = 4 | issue = 3 | pages = 138–43 | year = 1998 | pmid = 9562972 | pmc = 2230352 | doi =  }}
| citations =
* {{cite journal | vauthors = Stewart M | title = Insights into the molecular mechanism of nuclear trafficking using nuclear transport factor 2 (NTF2) | journal = Cell Struct. Funct. | volume = 25 | issue = 4 | pages = 217–225 | year = 2001 | pmid = 11129791 | doi = 10.1247/csf.25.217 }}
*{{cite journal | author=Bukrinsky MI, Haffar OK |title=HIV-1 nuclear import: matrix protein is back on center stage, this time together with Vpr. |journal=Mol. Med. |volume=4 |issue= 3 |pages= 138-43 |year= 1998 |pmid= 9562972 |doi=  }}
* {{cite journal | vauthors = Bohn H, Johannsen R, Kraus W | title = [New placental protein (PP15) with immunosuppressive properties (author's transl)] | journal = Arch. Gynecol. | volume = 230 | issue = 2 | pages = 167–72 | year = 1981 | pmid = 7458421 | doi =  }}
*{{cite journal | author=Stewart M |title=Insights into the molecular mechanism of nuclear trafficking using nuclear transport factor 2 (NTF2). |journal=Cell Struct. Funct. |volume=25 |issue= 4 |pages= 217-25 |year= 2001 |pmid= 11129791 |doi= }}
* {{cite journal | vauthors = Hu T, Guan T, Gerace L | title = Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins | journal = J. Cell Biol. | volume = 134 | issue = 3 | pages = 589–601 | year = 1996 | pmid = 8707840 | pmc = 2120945 | doi = 10.1083/jcb.134.3.589 }}
*{{cite journal  | author=Grundmann U, Nerlich C, Rein T, ''et al.'' |title=Isolation of cDNA coding for the placental protein 15 (PP15). |journal=Nucleic Acids Res. |volume=16 |issue= 10 |pages= 4721 |year= 1988 |pmid= 3380696 |doi=  }}
* {{cite journal | vauthors = Bullock TL, Clarkson WD, Kent HM, Stewart M | title = The 1.6 angstroms resolution crystal structure of nuclear transport factor 2 (NTF2) | journal = J. Mol. Biol. | volume = 260 | issue = 3 | pages = 422–431 | year = 1996 | pmid = 8757804 | doi = 10.1006/jmbi.1996.0411 }}
*{{cite journal | author=Bohn H, Johannsen R, Kraus W |title=[New placental protein (PP15) with immunosuppressive properties (author's transl)] |journal=Arch. Gynecol. |volume=230 |issue= 2 |pages= 167-72 |year= 1981 |pmid= 7458421 |doi=  }}
* {{cite journal | vauthors = Clarkson WD, Corbett AH, Paschal BM, Kent HM, McCoy AJ, Gerace L, Silver PA, Stewart M | title = Nuclear protein import is decreased by engineered mutants of nuclear transport factor 2 (NTF2) that do not bind GDP-Ran | journal = J. Mol. Biol. | volume = 272 | issue = 5 | pages = 716–730 | year = 1997 | pmid = 9368653 | doi = 10.1006/jmbi.1997.1255 }}
*{{cite journal | author=Paschal BM, Gerace L |title=Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62. |journal=J. Cell Biol. |volume=129 |issue= 4 |pages= 925-37 |year= 1995 |pmid= 7744965 |doi=  }}
* {{cite journal | vauthors = Stewart M, Kent HM, McCoy AJ | title = Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the Ras-family GTPase Ran | journal = J. Mol. Biol. | volume = 277 | issue = 3 | pages = 635–646 | year = 1998 | pmid = 9533885 | doi = 10.1006/jmbi.1997.1602 }}
*{{cite journal  | author=Hu T, Guan T, Gerace L |title=Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins. |journal=J. Cell Biol. |volume=134 |issue= 3 |pages= 589-601 |year= 1996 |pmid= 8707840 |doi= }}
* {{cite journal | vauthors = Ribbeck K, Lipowsky G, Kent HM, Stewart M, Görlich D | title = NTF2 mediates nuclear import of Ran | journal = EMBO J. | volume = 17 | issue = 22 | pages = 6587–6598 | year = 1999 | pmid = 9822603 | pmc = 1171005 | doi = 10.1093/emboj/17.22.6587 }}
*{{cite journal | author=Bullock TL, Clarkson WD, Kent HM, Stewart M |title=The 1.6 angstroms resolution crystal structure of nuclear transport factor 2 (NTF2). |journal=J. Mol. Biol. |volume=260 |issue= 3 |pages= 422-31 |year= 1996 |pmid= 8757804 |doi= }}
* {{cite journal | vauthors = Steggerda SM, Black BE, Paschal BM | title = Monoclonal antibodies to NTF2 inhibit nuclear protein import by preventing nuclear translocation of the GTPase Ran | journal = Mol. Biol. Cell | volume = 11 | issue = 2 | pages = 703–19 | year = 2000 | pmid = 10679025 | pmc = 14804 | doi = 10.1091/mbc.11.2.703 }}
*{{cite journal | author=Clarkson WD, Corbett AH, Paschal BM, ''et al.'' |title=Nuclear protein import is decreased by engineered mutants of nuclear transport factor 2 (NTF2) that do not bind GDP-Ran. |journal=J. Mol. Biol. |volume=272 |issue= 5 |pages= 716-30 |year= 1997 |pmid= 9368653 |doi= 10.1006/jmbi.1997.1255 }}
* {{cite journal | vauthors = Freire J, Covelo G, Sarandeses C, Díaz-Jullien C, Freire M | title = Identification of nuclear-import and cell-cycle regulatory proteins that bind to prothymosin alpha | journal = Biochem. Cell Biol. | volume = 79 | issue = 2 | pages = 123–131 | year = 2001 | pmid = 11310559 | doi = 10.1139/bcb-79-2-123 }}
*{{cite journal | author=Stewart M, Kent HM, McCoy AJ |title=Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the Ras-family GTPase Ran. |journal=J. Mol. Biol. |volume=277 |issue= 3 |pages= 635-46 |year= 1998 |pmid= 9533885 |doi= 10.1006/jmbi.1997.1602 }}
* {{cite journal | vauthors = Cushman I, Bowman BR, Sowa ME, Lichtarge O, Quiocho FA, Moore MS | title = Computational and biochemical identification of a nuclear pore complex binding site on the nuclear transport carrier NTF2 | journal = J. Mol. Biol. | volume = 344 | issue = 2 | pages = 303–310 | year = 2004 | pmid = 15522285 | doi = 10.1016/j.jmb.2004.09.043 }}
*{{cite journal | author=Ribbeck K, Lipowsky G, Kent HM, ''et al.'' |title=NTF2 mediates nuclear import of Ran. |journal=EMBO J. |volume=17 |issue= 22 |pages= 6587-98 |year= 1999 |pmid= 9822603 |doi= 10.1093/emboj/17.22.6587 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–1178 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Steggerda SM, Black BE, Paschal BM |title=Monoclonal antibodies to NTF2 inhibit nuclear protein import by preventing nuclear translocation of the GTPase Ran. |journal=Mol. Biol. Cell |volume=11 |issue= 2 |pages= 703-19 |year= 2000 |pmid= 10679025 |doi= }}
*{{cite journal | author=Freire J, Covelo G, Sarandeses C, ''et al.'' |title=Identification of nuclear-import and cell-cycle regulatory proteins that bind to prothymosin alpha. |journal=Biochem. Cell Biol. |volume=79 |issue= 2 |pages= 123-31 |year= 2001 |pmid= 11310559 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Cushman I, Bowman BR, Sowa ME, ''et al.'' |title=Computational and biochemical identification of a nuclear pore complex binding site on the nuclear transport carrier NTF2. |journal=J. Mol. Biol. |volume=344 |issue= 2 |pages= 303-10 |year= 2004 |pmid= 15522285 |doi= 10.1016/j.jmb.2004.09.043 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
{{refend}}
{{refend}}
== External links ==
* {{UCSC genome browser|NUTF2}}
* {{UCSC gene details|NUTF2}}
{{PDB Gallery|geneid=10204}}


{{protein-stub}}
{{protein-stub}}
{{WikiDoc Sources}}

Latest revision as of 13:22, 5 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Nuclear transport factor 2 is a protein that in humans is encoded by the NUTF2 gene.[1][2][3]

Function

The protein encoded by this gene is a cytosolic factor that facilitates protein transport into the nucleus. It interacts with the nuclear pore complex glycoprotein p62. This encoded protein acts at a relative late stage of nuclear protein import, subsequent to the initial docking of nuclear import ligand at the nuclear envelope. It is thought to be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import.[3]

Interactions

NUTF2 has been shown to interact with Nucleoporin 62[1]{[4] and RAN.[5][6]

References

  1. ↑ 1.0 1.1 Paschal BM, Gerace L (Jun 1995). "Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62". J Cell Biol. 129 (4): 925–937. doi:10.1083/jcb.129.4.925. PMC 2120498. PMID 7744965.
  2. ↑ Grundmann U, Nerlich C, Rein T, Lottspeich F, Küpper HA (Jul 1988). "Isolation of cDNA coding for the placental protein 15 (PP15)". Nucleic Acids Res. 16 (10): 4721–4721. doi:10.1093/nar/16.10.4721. PMC 336660. PMID 3380696.
  3. ↑ 3.0 3.1 "Entrez Gene: NUTF2 nuclear transport factor 2".
  4. ↑ Hu T, Guan T, Gerace L (Aug 1996). "Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins". J. Cell Biol. 134 (3): 589–601. doi:10.1083/jcb.134.3.589. PMC 2120945. PMID 8707840.
  5. ↑ Cushman I, Bowman BR, Sowa ME, Lichtarge O, Quiocho FA, Moore MS (Nov 2004). "Computational and biochemical identification of a nuclear pore complex binding site on the nuclear transport carrier NTF2". J. Mol. Biol. 344 (2): 303–310. doi:10.1016/j.jmb.2004.09.043. PMID 15522285.
  6. ↑ Stewart M, Kent HM, McCoy AJ (Apr 1998). "Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the Ras-family GTPase Ran". J. Mol. Biol. 277 (3): 635–646. doi:10.1006/jmbi.1997.1602. PMID 9533885.

Further reading

External links


Retrieved from "https://www.wikidoc.org/index.php?title=NUTF2&oldid=1417379"