NXT1: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
m (Bot: HTTP→HTTPS)
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''NTF2-related export protein 1''' is a [[protein]] that in humans is encoded by the ''NXT1'' [[gene]].<ref name="pmid10567585">{{cite journal |vauthors=Black BE, Levesque L, Holaska JM, Wood TC, Paschal BM | title = Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export | journal = Mol Cell Biol | volume = 19 | issue = 12 | pages = 8616–24 |date=Jan 2000 | pmid = 10567585 | pmc = 84993 | doi =  }}</ref><ref name="pmid11259602">{{cite journal |vauthors=Guzik BW, Levesque L, Prasad S, Bor YC, Black BE, Paschal BM, Rekosh D, Hammarskjold ML | title = NXT1 (p15) is a crucial cellular cofactor in TAP-dependent export of intron-containing RNA in mammalian cells | journal = Mol Cell Biol | volume = 21 | issue = 7 | pages = 2545–54 |date=Mar 2001 | pmid = 11259602 | pmc = 86886 | doi = 10.1128/MCB.21.7.2545-2554.2001 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NXT1 NTF2-like export factor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29107| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
 
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_NXT1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1jkg.
| PDB = {{PDB2|1jkg}}, {{PDB2|1jn5}}
| Name = NTF2-like export factor 1
| HGNCid = 15913
| Symbol = NXT1
| AltSymbols =; P15; MTR2
| OMIM = 605811
| ECnumber =
| Homologene = 8301
| MGIid = 1929619
| GeneAtlas_image1 = PBB_GE_NXT1_218708_at_tn.png
  | Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008536 |text = Ran GTPase binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005643 |text = nuclear pore}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006405 |text = RNA export from nucleus}} {{GNF_GO|id=GO:0006611 |text = protein export from nucleus}} {{GNF_GO|id=GO:0015031 |text = protein transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 29107
    | Hs_Ensembl = ENSG00000132661
    | Hs_RefseqProtein = NP_037380
    | Hs_RefseqmRNA = NM_013248
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 20
    | Hs_GenLoc_start = 23279373
    | Hs_GenLoc_end = 23283408
    | Hs_Uniprot = Q9UKK6
    | Mm_EntrezGene = 56488
    | Mm_Ensembl = ENSMUSG00000036992
    | Mm_RefseqmRNA = NM_019761
    | Mm_RefseqProtein = NP_062735
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 148364083
    | Mm_GenLoc_end = 148367464
    | Mm_Uniprot = Q9QZV9
  }}
}}
'''NTF2-like export factor 1''', also known as '''NXT1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NXT1 NTF2-like export factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29107| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is located in the nuclear envelope. It has protein similarity to nuclear transport factor 2. This protein functions as a nuclear export factor in both RAN (Ras-related nuclear protein)- and CRM1 (required for chromosome region maintenance)-dependent pathways. It is found to stimulate the export of U1 snRNA in RAN- and CRM1-dependent pathways and the export of tRNA and mRNA in a CRM1-independent pathway. The encoded protein heterodimerizes with Tap protein and may regulate the ability of Tap protein to mediate nuclear mRNA export. The use of alternate polyadenylation sites has been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: NXT1 NTF2-like export factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29107| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is located in the nuclear envelope. It has protein similarity to nuclear transport factor 2. This protein functions as a nuclear export factor in both RAN (Ras-related nuclear protein)- and CRM1 (required for chromosome region maintenance)-dependent pathways. It is found to stimulate the export of U1 snRNA in RAN- and CRM1-dependent pathways and the export of tRNA and mRNA in a CRM1-independent pathway. The encoded protein heterodimerizes with Tap protein and may regulate the ability of Tap protein to mediate nuclear mRNA export. The use of alternate polyadenylation sites has been found for this gene.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Katahira J, Strässer K, Podtelejnikov A, ''et al.'' |title=The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human. |journal=EMBO J. |volume=18 |issue= 9 |pages= 2593-609 |year= 1999 |pmid= 10228171 |doi= 10.1093/emboj/18.9.2593 }}
*{{cite journal  | author=Katahira J |title=The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human |journal=EMBO J. |volume=18 |issue= 9 |pages= 2593–609 |year= 1999 |pmid= 10228171 |doi= 10.1093/emboj/18.9.2593  | pmc=1171339  |name-list-format=vanc| author2=Strässer K  | author3=Podtelejnikov A  | display-authors=3  | last4=Mann  | first4=Matthias  | last5=Jung  | first5=Jae U.  | last6=Hurt | first6=Ed }}
*{{cite journal | author=Black BE, Lévesque L, Holaska JM, ''et al.'' |title=Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export. |journal=Mol. Cell. Biol. |volume=19 |issue= 12 |pages= 8616-24 |year= 2000 |pmid= 10567585 |doi=  }}
*{{cite journal  | author=Ossareh-Nazari B |title=RanGTP-binding protein NXT1 facilitates nuclear export of different classes of RNA in vitro |journal=Mol. Cell. Biol. |volume=20 |issue= 13 |pages= 4562–71 |year= 2000 |pmid= 10848583 |doi=10.1128/MCB.20.13.4562-4571.2000  | pmc=85847  |name-list-format=vanc| author2=Maison C  | author3=Black BE  | display-authors=3  | last4=Levesque  | first4=L.  | last5=Paschal  | first5=B. M.  | last6=Dargemont  | first6=C. }}
*{{cite journal  | author=Ossareh-Nazari B, Maison C, Black BE, ''et al.'' |title=RanGTP-binding protein NXT1 facilitates nuclear export of different classes of RNA in vitro. |journal=Mol. Cell. Biol. |volume=20 |issue= 13 |pages= 4562-71 |year= 2000 |pmid= 10848583 |doi=  }}
*{{cite journal  | author=Herold A |title=TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture |journal=Mol. Cell. Biol. |volume=20 |issue= 23 |pages= 8996–9008 |year= 2000 |pmid= 11073998 |doi=10.1128/MCB.20.23.8996-9008.2000  | pmc=86553  |name-list-format=vanc| author2=Suyama M  | author3=Rodrigues JP  | display-authors=3  | last4=Braun  | first4=I. C.  | last5=Kutay  | first5=U.  | last6=Carmo-Fonseca  | first6=M.  | last7=Bork  | first7=P.  | last8=Izaurralde  | first8=E. }}
*{{cite journal  | author=Herold A, Suyama M, Rodrigues JP, ''et al.'' |title=TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture. |journal=Mol. Cell. Biol. |volume=20 |issue= 23 |pages= 8996-9008 |year= 2000 |pmid= 11073998 |doi=  }}
*{{cite journal  | author=Black BE |title=NXT1 is necessary for the terminal step of Crm1-mediated nuclear export |journal=J. Cell Biol. |volume=152 |issue= 1 |pages= 141–55 |year= 2001 |pmid= 11149927 |doi=10.1083/jcb.152.1.141  | pmc=2193657 |name-list-format=vanc| author2=Holaska JM | author3=Lévesque L | display-authors=3  | last4=Ossareh-Nazari  | first4=B. | last5=Gwizdek  | first5=C.  | last6=Dargemont  | first6=C.  | last7=Paschal  | first7=B. M. }}
*{{cite journal  | author=Black BE, Holaska JM, Lévesque L, ''et al.'' |title=NXT1 is necessary for the terminal step of Crm1-mediated nuclear export. |journal=J. Cell Biol. |volume=152 |issue= 1 |pages= 141-55 |year= 2001 |pmid= 11149927 |doi=  }}
*{{cite journal  | author=Jun L |title=NXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardation |journal=Curr. Biol. |volume=11 |issue= 18 |pages= 1381–91 |year= 2002 |pmid= 11566096 |doi=10.1016/S0960-9822(01)00419-5  |name-list-format=vanc| author2=Frints S  | author3=Duhamel H  | display-authors=3  | last4=Herold  | first4=Andrea  | last5=Abad-Rodrigues  | first5=Jose  | last6=Dotti  | first6=Carlos  | last7=Izaurralde  | first7=Elisa  | last8=Marynen  | first8=Peter  | last9=Froyen  | first9=Guy }}
*{{cite journal | author=Guzik BW, Levesque L, Prasad S, ''et al.'' |title=NXT1 (p15) is a crucial cellular cofactor in TAP-dependent export of intron-containing RNA in mammalian cells. |journal=Mol. Cell. Biol. |volume=21 |issue= 7 |pages= 2545-54 |year= 2001 |pmid= 11259602 |doi= 10.1128/MCB.21.7.2545-2554.2001 }}
*{{cite journal  |vauthors=Fribourg S, Braun IC, Izaurralde E, Conti E |title=Structural basis for the recognition of a nucleoporin FG repeat by the NTF2-like domain of the TAP/p15 mRNA nuclear export factor |journal=Mol. Cell |volume=8 |issue= 3 |pages= 645–56 |year= 2001 |pmid= 11583626 |doi=10.1016/S1097-2765(01)00348-3 }}
*{{cite journal  | author=Jun L, Frints S, Duhamel H, ''et al.'' |title=NXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardation. |journal=Curr. Biol. |volume=11 |issue= 18 |pages= 1381-91 |year= 2002 |pmid= 11566096 |doi=  }}
*{{cite journal  | author=Wiegand HL |title=Formation of Tap/NXT1 heterodimers activates Tap-dependent nuclear mRNA export by enhancing recruitment to nuclear pore complexes |journal=Mol. Cell. Biol. |volume=22 |issue= 1 |pages= 245–56 |year= 2002 |pmid= 11739738 |doi=10.1128/MCB.22.1.245-256.2002  | pmc=134221  |name-list-format=vanc| author2=Coburn GA  | author3=Zeng Y  | display-authors=3  | last4=Kang  | first4=Y.  | last5=Bogerd  | first5=H. P.  | last6=Cullen  | first6=B. R. }}
*{{cite journal  | author=Fribourg S, Braun IC, Izaurralde E, Conti E |title=Structural basis for the recognition of a nucleoporin FG repeat by the NTF2-like domain of the TAP/p15 mRNA nuclear export factor. |journal=Mol. Cell |volume=8 |issue= 3 |pages= 645-56 |year= 2001 |pmid= 11583626 |doi=  }}
*{{cite journal  | author=Katahira J |title=Complex formation between Tap and p15 affects binding to FG-repeat nucleoporins and nucleocytoplasmic shuttling |journal=J. Biol. Chem. |volume=277 |issue= 11 |pages= 9242–6 |year= 2002 |pmid= 11756420 |doi= 10.1074/jbc.M110007200 |name-list-format=vanc| author2=Straesser K  | author3=Saiwaki T  | display-authors=3  | last4=Yoneda  | first4=Y  | last5=Hurt  | first5=E }}
*{{cite journal  | author=Wiegand HL, Coburn GA, Zeng Y, ''et al.'' |title=Formation of Tap/NXT1 heterodimers activates Tap-dependent nuclear mRNA export by enhancing recruitment to nuclear pore complexes. |journal=Mol. Cell. Biol. |volume=22 |issue= 1 |pages= 245-56 |year= 2002 |pmid= 11739738 |doi=  }}
*{{cite journal  | author=Deloukas P |title=The DNA sequence and comparative analysis of human chromosome 20 |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a |name-list-format=vanc| author2=Matthews LH  | author3=Ashurst J  | display-authors=3  | last4=Burton  | first4=J.  | last5=Gilbert  | first5=J. G. R.  | last6=Jones  | first6=M.  | last7=Stavrides  | first7=G.  | last8=Almeida  | first8=J. P.  | last9=Babbage  | first9=A. K. }}
*{{cite journal  | author=Katahira J, Straesser K, Saiwaki T, ''et al.'' |title=Complex formation between Tap and p15 affects binding to FG-repeat nucleoporins and nucleocytoplasmic shuttling. |journal=J. Biol. Chem. |volume=277 |issue= 11 |pages= 9242-6 |year= 2002 |pmid= 11756420 |doi= 10.1074/jbc.M110007200 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Deloukas P, Matthews LH, Ashurst J, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865-71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
*{{cite journal  | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |name-list-format=vanc| author2=Venkatesan K  | author3=Hao T  | display-authors=3  | last4=Hirozane-Kishikawa  | first4=Tomoko  | last5=Dricot  | first5=Amélie  | last6=Li  | first6=Ning  | last7=Berriz  | first7=Gabriel F.  | last8=Gibbons  | first8=Francis D.  | last9=Dreze  | first9=Matija }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=29107}}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


{{protein-stub}}
{{gene-20-stub}}
{{WikiDoc Sources}}

Latest revision as of 13:23, 5 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

NTF2-related export protein 1 is a protein that in humans is encoded by the NXT1 gene.[1][2][3]

The protein encoded by this gene is located in the nuclear envelope. It has protein similarity to nuclear transport factor 2. This protein functions as a nuclear export factor in both RAN (Ras-related nuclear protein)- and CRM1 (required for chromosome region maintenance)-dependent pathways. It is found to stimulate the export of U1 snRNA in RAN- and CRM1-dependent pathways and the export of tRNA and mRNA in a CRM1-independent pathway. The encoded protein heterodimerizes with Tap protein and may regulate the ability of Tap protein to mediate nuclear mRNA export. The use of alternate polyadenylation sites has been found for this gene.[3]

References

  1. ↑ Black BE, Levesque L, Holaska JM, Wood TC, Paschal BM (Jan 2000). "Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export". Mol Cell Biol. 19 (12): 8616–24. PMC 84993. PMID 10567585.
  2. ↑ Guzik BW, Levesque L, Prasad S, Bor YC, Black BE, Paschal BM, Rekosh D, Hammarskjold ML (Mar 2001). "NXT1 (p15) is a crucial cellular cofactor in TAP-dependent export of intron-containing RNA in mammalian cells". Mol Cell Biol. 21 (7): 2545–54. doi:10.1128/MCB.21.7.2545-2554.2001. PMC 86886. PMID 11259602.
  3. ↑ 3.0 3.1 "Entrez Gene: NXT1 NTF2-like export factor 1".

Further reading



Retrieved from "https://www.wikidoc.org/index.php?title=NXT1&oldid=1419603"