P4HA1: Difference between revisions

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Prolyl 4-hydroxylase subunit alpha-1 is an enzyme that in humans is encoded by the P4HA1 gene.^[1]^[2]

This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described.^[2]

References

↑ Pajunen L, Jones TA, Helaakoski T, Pihlajaniemi T, Solomon E, Sheer D, Kivirikko KI (Jan 1990). "Assignment of the gene coding for the alpha-subunit of prolyl 4-hydroxylase to human chromosome region 10q21.3-23.1". Am J Hum Genet. 45 (6): 829–34. PMC 1683466. PMID 2556027.
↑ ^2.0 ^2.1 "Entrez Gene: P4HA1 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I".

Helaakoski T, Vuori K, Myllylä R, et al. (1989). "Molecular cloning of the alpha-subunit of human prolyl 4-hydroxylase: the complete cDNA-derived amino acid sequence and evidence for alternative splicing of RNA transcripts". Proc. Natl. Acad. Sci. U.S.A. 86 (12): 4392–6. doi:10.1073/pnas.86.12.4392. PMC 287275. PMID 2543975.
Helaakoski T, Veijola J, Vuori K, et al. (1994). "Structure and expression of the human gene for the alpha subunit of prolyl 4-hydroxylase. The two alternatively spliced types of mRNA correspond to two homologous exons the sequences of which are expressed in a variety of tissues". J. Biol. Chem. 269 (45): 27847–54. PMID 7961714.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Annunen P, Helaakoski T, Myllyharju J, et al. (1997). "Cloning of the human prolyl 4-hydroxylase alpha subunit isoform alpha(II) and characterization of the type II enzyme tetramer. The alpha(I) and alpha(II) subunits do not form a mixed alpha(I)alpha(II)beta2 tetramer". J. Biol. Chem. 272 (28): 17342–8. doi:10.1074/jbc.272.28.17342. PMID 9211872.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Horelli-Kuitunen N, Kvist AP, Helaakoski T, et al. (1998). "The order and transcriptional orientation of the human COL13A1 and P4HA genes on chromosome 10 long arm determined by high-resolution FISH". Genomics. 46 (2): 299–302. doi:10.1006/geno.1997.5015. PMID 9417920.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Raveendran M, Senthil D, Utama B, et al. (2004). "Cigarette suppresses the expression of P4Halpha and vascular collagen production". Biochem. Biophys. Res. Commun. 323 (2): 592–8. doi:10.1016/j.bbrc.2004.08.129. PMID 15369792.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Fähling M, Mrowka R, Steege A, et al. (2006). "Heterogeneous nuclear ribonucleoprotein-A2/B1 modulate collagen prolyl 4-hydroxylase, alpha (I) mRNA stability". J. Biol. Chem. 281 (14): 9279–86. doi:10.1074/jbc.M510925200. PMID 16464861.
Chen L, Shen YH, Wang X, et al. (2006). "Human prolyl-4-hydroxylase alpha(I) transcription is mediated by upstream stimulatory factors". J. Biol. Chem. 281 (16): 10849–55. doi:10.1074/jbc.M511237200. PMC 2819823. PMID 16488890.
Fähling M, Mrowka R, Steege A, et al. (2006). "Translational control of collagen prolyl 4-hydroxylase-alpha(I) gene expression under hypoxia". J. Biol. Chem. 281 (36): 26089–101. doi:10.1074/jbc.M604939200. PMID 16837461.
Grimmer C, Balbus N, Lang U, et al. (2006). "Regulation of type II collagen synthesis during osteoarthritis by prolyl-4-hydroxylases: possible influence of low oxygen levels". Am. J. Pathol. 169 (2): 491–502. doi:10.2353/ajpath.2006.050738. PMC 1698781. PMID 16877351.
Koivunen P, Hirsilä M, Kivirikko KI, Myllyharju J (2006). "The length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases". J. Biol. Chem. 281 (39): 28712–20. doi:10.1074/jbc.M604628200. PMID 16885164.

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by expanding it.

[pmid2556027-1] Pajunen L, Jones TA, Helaakoski T, Pihlajaniemi T, Solomon E, Sheer D, Kivirikko KI (Jan 1990). "Assignment of the gene coding for the alpha-subunit of prolyl 4-hydroxylase to human chromosome region 10q21.3-23.1". Am J Hum Genet. 45 (6): 829–34. PMC 1683466. PMID 2556027.

[entrez-2] 2.0 ^2.1 "Entrez Gene: P4HA1 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I".

[1]

[2]

@@ Line 1: / Line 1: @@
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+{{Underlinked|date=June 2016}}
-{{PBB_Controls
+{{Infobox_gene}}
-| update_page = yes
+'''Prolyl 4-hydroxylase subunit alpha-1''' is an [[enzyme]] that in humans is encoded by the ''P4HA1'' [[gene]].<ref name="pmid2556027">{{cite journal | vauthors = Pajunen L, Jones TA, Helaakoski T, Pihlajaniemi T, Solomon E, Sheer D, Kivirikko KI | title = Assignment of the gene coding for the alpha-subunit of prolyl 4-hydroxylase to human chromosome region 10q21.3-23.1 | journal = Am J Hum Genet | volume = 45 | issue = 6 | pages = 829–34 |date=Jan 1990 | pmid = 2556027 | pmc = 1683466 | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: P4HA1 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5033| accessdate = }}</ref>
-| require_manual_inspection = no
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-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image = PBB_Protein_P4HA1_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 1tjc.
- | PDB = {{PDB2|1tjc}}
- | Name = Procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I
- | HGNCid = 8546
- | Symbol = P4HA1
- | AltSymbols =; 4-PH alpha-1; P4HA
- | OMIM = 176710
- | ECnumber =
- | Homologene = 30998
- | MGIid = 97463
- | GeneAtlas_image1 = PBB_GE_P4HA1_207543_s_at_tn.png
- | GeneAtlas_image2 = PBB_GE_P4HA1_212537_x_at_tn.png
- | Function = {{GNF_GO|id=GO:0004656 |text = procollagen-proline 4-dioxygenase activity}} {{GNF_GO|id=GO:0005488 |text = binding}} {{GNF_GO|id=GO:0005506 |text = iron ion binding}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}} {{GNF_GO|id=GO:0016702 |text = oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen}} {{GNF_GO|id=GO:0016706 |text = oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors}} {{GNF_GO|id=GO:0031418 |text = L-ascorbic acid binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
- | Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}}
- | Process = {{GNF_GO|id=GO:0018401 |text = peptidyl-proline hydroxylation to 4-hydroxy-L-proline}} {{GNF_GO|id=GO:0019538 |text = protein metabolic process}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 5033
-    | Hs_Ensembl = ENSG00000122884
-    | Hs_RefseqProtein = NP_000908
-    | Hs_RefseqmRNA = NM_000917
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 10
-    | Hs_GenLoc_start = 74436981
-    | Hs_GenLoc_end = 74526630
-    | Hs_Uniprot = P13674
-    | Mm_EntrezGene = 18451
-    | Mm_Ensembl = ENSMUSG00000019916
-    | Mm_RefseqmRNA = NM_011030
-    | Mm_RefseqProtein = NP_035160
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 10
-    | Mm_GenLoc_start = 58718725
-    | Mm_GenLoc_end = 58767701
-    | Mm_Uniprot = Q3TN84
-  }}
-}}
-'''Procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I''', also known as '''P4HA1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: P4HA1 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5033| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described.<ref name="entrez">{{cite web | title = Entrez Gene: P4HA1 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5033| accessdate = }}</ref>
+| summary_text = This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternatively spliced transcript variants encoding different isoforms have been described.<ref name="entrez" />
 }}
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Helaakoski T, Vuori K, Myllylä R, ''et al.'' |title=Molecular cloning of the alpha-subunit of human prolyl 4-hydroxylase: the complete cDNA-derived amino acid sequence and evidence for alternative splicing of RNA transcripts. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 12 |pages= 4392-6 |year= 1989 |pmid= 2543975 |doi=  }}
+* {{cite journal   |vauthors=Helaakoski T, Vuori K, Myllylä R, etal |title=Molecular cloning of the alpha-subunit of human prolyl 4-hydroxylase: the complete cDNA-derived amino acid sequence and evidence for alternative splicing of RNA transcripts. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 12 |pages= 4392–6 |year= 1989 |pmid= 2543975 |doi=  10.1073/pnas.86.12.4392| pmc=287275  }}
-*{{cite journal  | author=Pajunen L, Jones TA, Helaakoski T, ''et al.'' |title=Assignment of the gene coding for the alpha-subunit of prolyl 4-hydroxylase to human chromosome region 10q21.3-23.1. |journal=Am. J. Hum. Genet. |volume=45 |issue= 6 |pages= 829-34 |year= 1990 |pmid= 2556027 |doi=  }}
+* {{cite journal   |vauthors=Helaakoski T, Veijola J, Vuori K, etal |title=Structure and expression of the human gene for the alpha subunit of prolyl 4-hydroxylase. The two alternatively spliced types of mRNA correspond to two homologous exons the sequences of which are expressed in a variety of tissues. |journal=J. Biol. Chem. |volume=269 |issue= 45 |pages= 27847–54 |year= 1994 |pmid= 7961714 |doi=  }}
-*{{cite journal  | author=Helaakoski T, Veijola J, Vuori K, ''et al.'' |title=Structure and expression of the human gene for the alpha subunit of prolyl 4-hydroxylase. The two alternatively spliced types of mRNA correspond to two homologous exons the sequences of which are expressed in a variety of tissues. |journal=J. Biol. Chem. |volume=269 |issue= 45 |pages= 27847-54 |year= 1994 |pmid= 7961714 |doi=  }}
+* {{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
-*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
+* {{cite journal   |vauthors=Annunen P, Helaakoski T, Myllyharju J, etal |title=Cloning of the human prolyl 4-hydroxylase alpha subunit isoform alpha(II) and characterization of the type II enzyme tetramer. The alpha(I) and alpha(II) subunits do not form a mixed alpha(I)alpha(II)beta2 tetramer. |journal=J. Biol. Chem. |volume=272 |issue= 28 |pages= 17342–8 |year= 1997 |pmid= 9211872 |doi=10.1074/jbc.272.28.17342  }}
-*{{cite journal  | author=Annunen P, Helaakoski T, Myllyharju J, ''et al.'' |title=Cloning of the human prolyl 4-hydroxylase alpha subunit isoform alpha(II) and characterization of the type II enzyme tetramer. The alpha(I) and alpha(II) subunits do not form a mixed alpha(I)alpha(II)beta2 tetramer. |journal=J. Biol. Chem. |volume=272 |issue= 28 |pages= 17342-8 |year= 1997 |pmid= 9211872 |doi=  }}
+* {{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  }}
-*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
+* {{cite journal   |vauthors=Horelli-Kuitunen N, Kvist AP, Helaakoski T, etal |title=The order and transcriptional orientation of the human COL13A1 and P4HA genes on chromosome 10 long arm determined by high-resolution FISH. |journal=Genomics |volume=46 |issue= 2 |pages= 299–302 |year= 1998 |pmid= 9417920 |doi= 10.1006/geno.1997.5015 }}
-*{{cite journal  | author=Horelli-Kuitunen N, Kvist AP, Helaakoski T, ''et al.'' |title=The order and transcriptional orientation of the human COL13A1 and P4HA genes on chromosome 10 long arm determined by high-resolution FISH. |journal=Genomics |volume=46 |issue= 2 |pages= 299-302 |year= 1998 |pmid= 9417920 |doi= 10.1006/geno.1997.5015 }}
+* {{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+* {{cite journal   |vauthors=Deloukas P, Earthrowl ME, Grafham DV, etal |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375–81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462 }}
-*{{cite journal  | author=Deloukas P, Earthrowl ME, Grafham DV, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375-81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462 }}
+* {{cite journal   |vauthors=Raveendran M, Senthil D, Utama B, etal |title=Cigarette suppresses the expression of P4Halpha and vascular collagen production. |journal=Biochem. Biophys. Res. Commun. |volume=323 |issue= 2 |pages= 592–8 |year= 2004 |pmid= 15369792 |doi= 10.1016/j.bbrc.2004.08.129 }}
-*{{cite journal  | author=Raveendran M, Senthil D, Utama B, ''et al.'' |title=Cigarette suppresses the expression of P4Halpha and vascular collagen production. |journal=Biochem. Biophys. Res. Commun. |volume=323 |issue= 2 |pages= 592-8 |year= 2004 |pmid= 15369792 |doi= 10.1016/j.bbrc.2004.08.129 }}
+* {{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+* {{cite journal   |vauthors=Fähling M, Mrowka R, Steege A, etal |title=Heterogeneous nuclear ribonucleoprotein-A2/B1 modulate collagen prolyl 4-hydroxylase, alpha (I) mRNA stability. |journal=J. Biol. Chem. |volume=281 |issue= 14 |pages= 9279–86 |year= 2006 |pmid= 16464861 |doi= 10.1074/jbc.M510925200 }}
-*{{cite journal  | author=Fähling M, Mrowka R, Steege A, ''et al.'' |title=Heterogeneous nuclear ribonucleoprotein-A2/B1 modulate collagen prolyl 4-hydroxylase, alpha (I) mRNA stability. |journal=J. Biol. Chem. |volume=281 |issue= 14 |pages= 9279-86 |year= 2006 |pmid= 16464861 |doi= 10.1074/jbc.M510925200 }}
+* {{cite journal   |vauthors=Chen L, Shen YH, Wang X, etal |title=Human prolyl-4-hydroxylase alpha(I) transcription is mediated by upstream stimulatory factors. |journal=J. Biol. Chem. |volume=281 |issue= 16 |pages= 10849–55 |year= 2006 |pmid= 16488890 |doi= 10.1074/jbc.M511237200  | pmc=2819823 }}
-*{{cite journal  | author=Chen L, Shen YH, Wang X, ''et al.'' |title=Human prolyl-4-hydroxylase alpha(I) transcription is mediated by upstream stimulatory factors. |journal=J. Biol. Chem. |volume=281 |issue= 16 |pages= 10849-55 |year= 2006 |pmid= 16488890 |doi= 10.1074/jbc.M511237200 }}
+* {{cite journal   |vauthors=Fähling M, Mrowka R, Steege A, etal |title=Translational control of collagen prolyl 4-hydroxylase-alpha(I) gene expression under hypoxia. |journal=J. Biol. Chem. |volume=281 |issue= 36 |pages= 26089–101 |year= 2006 |pmid= 16837461 |doi= 10.1074/jbc.M604939200 }}
-*{{cite journal  | author=Fähling M, Mrowka R, Steege A, ''et al.'' |title=Translational control of collagen prolyl 4-hydroxylase-alpha(I) gene expression under hypoxia. |journal=J. Biol. Chem. |volume=281 |issue= 36 |pages= 26089-101 |year= 2006 |pmid= 16837461 |doi= 10.1074/jbc.M604939200 }}
+* {{cite journal   |vauthors=Grimmer C, Balbus N, Lang U, etal |title=Regulation of type II collagen synthesis during osteoarthritis by prolyl-4-hydroxylases: possible influence of low oxygen levels. |journal=Am. J. Pathol. |volume=169 |issue= 2 |pages= 491–502 |year= 2006 |pmid= 16877351 |doi=  10.2353/ajpath.2006.050738| pmc=1698781  }}
-*{{cite journal  | author=Grimmer C, Balbus N, Lang U, ''et al.'' |title=Regulation of type II collagen synthesis during osteoarthritis by prolyl-4-hydroxylases: possible influence of low oxygen levels. |journal=Am. J. Pathol. |volume=169 |issue= 2 |pages= 491-502 |year= 2006 |pmid= 16877351 |doi=  }}
+* {{cite journal  | vauthors=Koivunen P, Hirsilä M, Kivirikko KI, Myllyharju J |title=The length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases. |journal=J. Biol. Chem. |volume=281 |issue= 39 |pages= 28712–20 |year= 2006 |pmid= 16885164 |doi= 10.1074/jbc.M604628200 }}
-*{{cite journal  | author=Koivunen P, Hirsilä M, Kivirikko KI, Myllyharju J |title=The length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases. |journal=J. Biol. Chem. |volume=281 |issue= 39 |pages= 28712-20 |year= 2006 |pmid= 16885164 |doi= 10.1074/jbc.M604628200 }}
 }}
 {{refend}}
+{{PDB Gallery|geneid=5033}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
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+{{gene-10-stub}}
-{{WikiDoc Sources}}

P4HA1: Difference between revisions

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