PFDN1: Difference between revisions

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{{Infobox_gene}}
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'''Prefoldin subunit 1''' is a [[protein]] that in humans is encoded by the ''PFDN1'' [[gene]].<ref name="pmid9630229">{{cite journal | vauthors = Vainberg IE, Lewis SA, Rommelaere H, Ampe C, Vandekerckhove J, Klein HL, Cowan NJ | title = Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin | journal = Cell | volume = 93 | issue = 5 | pages = 863–73 |date=Jul 1998 | pmid = 9630229 | pmc = | doi =10.1016/S0092-8674(00)81446-4  }}</ref><ref name="entrez"/>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Prefoldin subunit 1
| HGNCid = 8866
| Symbol = PFDN1
| AltSymbols =; PDF; PFD1
| OMIM = 604897
| ECnumber = 
| Homologene = 37644
| MGIid = 1914449
| GeneAtlas_image1 = PBB_GE_PFDN1_201507_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0051082 |text = unfolded protein binding}}
| Component =
| Process = {{GNF_GO|id=GO:0006457 |text = protein folding}} {{GNF_GO|id=GO:0007049 |text = cell cycle}}  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5201
    | Hs_Ensembl = ENSG00000113068
    | Hs_RefseqProtein = NP_002613
    | Hs_RefseqmRNA = NM_002622
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 139604831
    | Hs_GenLoc_end = 139662867
    | Hs_Uniprot = O60925
    | Mm_EntrezGene = 67199
    | Mm_Ensembl = ENSMUSG00000024346
    | Mm_RefseqmRNA = NM_026027
    | Mm_RefseqProtein = NP_080303
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 18
    | Mm_GenLoc_start = 36529653
    | Mm_GenLoc_end = 36580469
    | Mm_Uniprot = Q8CEH4
  }}
}}
'''Prefoldin subunit 1''', also known as '''PFDN1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PFDN1 prefoldin subunit 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5201| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils.<ref name="entrez">{{cite web | title = Entrez Gene: PFDN1 prefoldin subunit 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5201| accessdate = }}</ref>
| summary_text = This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils.<ref name="entrez">{{cite web | title = Entrez Gene: PFDN1 prefoldin subunit 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5201| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Hartl FU, Hayer-Hartl M |title=Molecular chaperones in the cytosol: from nascent chain to folded protein. |journal=Science |volume=295 |issue= 5561 |pages= 1852-8 |year= 2002 |pmid= 11884745 |doi= 10.1126/science.1068408 }}
*{{cite journal  | vauthors=Hartl FU, Hayer-Hartl M |title=Molecular chaperones in the cytosol: from nascent chain to folded protein. |journal=Science |volume=295 |issue= 5561 |pages= 1852–8 |year= 2002 |pmid= 11884745 |doi= 10.1126/science.1068408 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Iijima M, Kano Y, Nohno T, Namba M |title=Cloning of cDNA with possible transcription factor activity at the G1-S phase transition in human fibroblast cell lines. |journal=Acta Med. Okayama |volume=50 |issue= 2 |pages= 73-7 |year= 1996 |pmid= 8744932 |doi=  }}
*{{cite journal  | vauthors=Iijima M, Kano Y, Nohno T, Namba M |title=Cloning of cDNA with possible transcription factor activity at the G1-S phase transition in human fibroblast cell lines |journal=Acta Med. Okayama |volume=50 |issue= 2 |pages= 73–7 |year= 1996 |pmid= 8744932 |doi=  }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal  | author=Vainberg IE, Lewis SA, Rommelaere H, ''et al.'' |title=Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin. |journal=Cell |volume=93 |issue= 5 |pages= 863-73 |year= 1998 |pmid= 9630229 |doi= }}
*{{cite journal   |vauthors=Horrigan SK, Bartoloni L, Speer MC, etal |title=A radiation hybrid breakpoint map of the acute myeloid leukemia (AML) and limb-girdle muscular dystrophy 1A (LGMD1A) regions of chromosome 5q31 localizing 122 expressed sequences |journal=Genomics |volume=57 |issue= 1 |pages= 24–35 |year= 1999 |pmid= 10191080 |doi= 10.1006/geno.1999.5765 }}
*{{cite journal | author=Horrigan SK, Bartoloni L, Speer MC, ''et al.'' |title=A radiation hybrid breakpoint map of the acute myeloid leukemia (AML) and limb-girdle muscular dystrophy 1A (LGMD1A) regions of chromosome 5q31 localizing 122 expressed sequences. |journal=Genomics |volume=57 |issue= 1 |pages= 24-35 |year= 1999 |pmid= 10191080 |doi= 10.1006/geno.1999.5765 }}
*{{cite journal  | vauthors=Hansen WJ, Cowan NJ, Welch WJ |title=Prefoldin–Nascent Chain Complexes in the Folding of Cytoskeletal Proteins |journal=J. Cell Biol. |volume=145 |issue= 2 |pages= 265–77 |year= 1999 |pmid= 10209023 |doi=10.1083/jcb.145.2.265  | pmc=2133115 }}
*{{cite journal  | author=Hansen WJ, Cowan NJ, Welch WJ |title=Prefoldin-nascent chain complexes in the folding of cytoskeletal proteins. |journal=J. Cell Biol. |volume=145 |issue= 2 |pages= 265-77 |year= 1999 |pmid= 10209023 |doi=  }}
*{{cite journal  | vauthors=Cowan NJ, Lewis SA |title=A chaperone with a hydrophilic surface |journal=Nat. Struct. Biol. |volume=6 |issue= 11 |pages= 990–1 |year= 2002 |pmid= 10542082 |doi= 10.1038/14870 }}
*{{cite journal  | author=Cowan NJ, Lewis SA |title=A chaperone with a hydrophilic surface. |journal=Nat. Struct. Biol. |volume=6 |issue= 11 |pages= 990-1 |year= 2002 |pmid= 10542082 |doi= 10.1038/14870 }}
*{{cite journal   |vauthors=Munnia A, Schütz N, Romeike BF, etal |title=Expression, cellular distribution and protein binding of the glioma amplified sequence (GAS41), a highly conserved putative transcription factor |journal=Oncogene |volume=20 |issue= 35 |pages= 4853–63 |year= 2001 |pmid= 11521196 |doi= 10.1038/sj.onc.1204650 }}
*{{cite journal | author=Munnia A, Schütz N, Romeike BF, ''et al.'' |title=Expression, cellular distribution and protein binding of the glioma amplified sequence (GAS41), a highly conserved putative transcription factor. |journal=Oncogene |volume=20 |issue= 35 |pages= 4853-63 |year= 2001 |pmid= 11521196 |doi= 10.1038/sj.onc.1204650 }}
*{{cite journal   |vauthors=Rommelaere H, De Neve M, Neirynck K, etal |title=Prefoldin recognition motifs in the nonhomologous proteins of the actin and tubulin families |journal=J. Biol. Chem. |volume=276 |issue= 44 |pages= 41023–8 |year= 2001 |pmid= 11535601 |doi= 10.1074/jbc.M106591200 }}
*{{cite journal | author=Rommelaere H, De Neve M, Neirynck K, ''et al.'' |title=Prefoldin recognition motifs in the nonhomologous proteins of the actin and tubulin families. |journal=J. Biol. Chem. |volume=276 |issue= 44 |pages= 41023-8 |year= 2001 |pmid= 11535601 |doi= 10.1074/jbc.M106591200 }}
*{{cite journal   |vauthors=Martín-Benito J, Boskovic J, Gómez-Puertas P, etal |title=Structure of eukaryotic prefoldin and of its complexes with unfolded actin and the cytosolic chaperonin CCT |journal=EMBO J. |volume=21 |issue= 23 |pages= 6377–86 |year= 2003 |pmid= 12456645 |doi=10.1093/emboj/cdf640  | pmc=136944 }}
*{{cite journal | author=Martín-Benito J, Boskovic J, Gómez-Puertas P, ''et al.'' |title=Structure of eukaryotic prefoldin and of its complexes with unfolded actin and the cytosolic chaperonin CCT. |journal=EMBO J. |volume=21 |issue= 23 |pages= 6377-86 |year= 2003 |pmid= 12456645 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Bruneel A, Labas V, Mailloux A, etal |title=Proteomic study of human umbilical vein endothelial cells in culture |journal=Proteomics |volume=3 |issue= 5 |pages= 714–23 |year= 2004 |pmid= 12748950 |doi= 10.1002/pmic.200300409 }}
*{{cite journal | author=Bruneel A, Labas V, Mailloux A, ''et al.'' |title=Proteomic study of human umbilical vein endothelial cells in culture. |journal=Proteomics |volume=3 |issue= 5 |pages= 714-23 |year= 2004 |pmid= 12748950 |doi= 10.1002/pmic.200300409 }}
*{{cite journal   |vauthors=Gstaiger M, Luke B, Hess D, etal |title=Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI |journal=Science |volume=302 |issue= 5648 |pages= 1208–12 |year= 2003 |pmid= 14615539 |doi= 10.1126/science.1088401 }}
*{{cite journal | author=Gstaiger M, Luke B, Hess D, ''et al.'' |title=Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI. |journal=Science |volume=302 |issue= 5648 |pages= 1208-12 |year= 2003 |pmid= 14615539 |doi= 10.1126/science.1088401 }}
*{{cite journal   |vauthors=Simons CT, Staes A, Rommelaere H, etal |title=Selective contribution of eukaryotic prefoldin subunits to actin and tubulin binding |journal=J. Biol. Chem. |volume=279 |issue= 6 |pages= 4196–203 |year= 2004 |pmid= 14634002 |doi= 10.1074/jbc.M306053200 }}
*{{cite journal | author=Simons CT, Staes A, Rommelaere H, ''et al.'' |title=Selective contribution of eukaryotic prefoldin subunits to actin and tubulin binding. |journal=J. Biol. Chem. |volume=279 |issue= 6 |pages= 4196-203 |year= 2004 |pmid= 14634002 |doi= 10.1074/jbc.M306053200 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Stelzl U, Worm U, Lalowski M, etal |title=A human protein-protein interaction network: a resource for annotating the proteome |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
*{{cite journal | author=Stelzl U, Worm U, Lalowski M, ''et al.'' |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957-68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
}}
{{refend}}
{{refend}}


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Revision as of 17:59, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Prefoldin subunit 1 is a protein that in humans is encoded by the PFDN1 gene.[1][2]

This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils.[2]

References

  1. ↑ Vainberg IE, Lewis SA, Rommelaere H, Ampe C, Vandekerckhove J, Klein HL, Cowan NJ (Jul 1998). "Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin". Cell. 93 (5): 863–73. doi:10.1016/S0092-8674(00)81446-4. PMID 9630229.
  2. ↑ 2.0 2.1 "Entrez Gene: PFDN1 prefoldin subunit 1".

Further reading



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