PIK3C3: Difference between revisions

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{{Underlinked|date=June 2016}}
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{{Infobox_gene}}
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'''Phosphatidylinositol 3-kinase catalytic subunit type 3''' is an [[enzyme]] that in humans is encoded by the ''PIK3C3'' [[gene]].<ref name="pmid7628435">{{cite journal | vauthors = Volinia S, Dhand R, Vanhaesebroeck B, MacDougall LK, Stein R, Zvelebil MJ, Domin J, Panaretou C, Waterfield MD | title = A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system | journal = EMBO J | volume = 14 | issue = 14 | pages = 3339–48 |date=Sep 1995 | pmid = 7628435 | pmc = 394401 | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PIK3C3 phosphoinositide-3-kinase, class 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5289| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Phosphoinositide-3-kinase, class 3
| HGNCid = 8974
| Symbol = PIK3C3
| AltSymbols =; MGC61518; Vps34
| OMIM = 602609
| ECnumber = 
| Homologene = 1986
| MGIid = 2445019
| GeneAtlas_image1 = PBB_GE_PIK3C3_204297_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004428 |text = inositol or phosphatidylinositol kinase activity}} {{GNF_GO|id=GO:0004672 |text = protein kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016303 |text = 1-phosphatidylinositol-3-kinase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0030145 |text = manganese ion binding}}
| Component = {{GNF_GO|id=GO:0005942 |text = phosphoinositide 3-kinase complex}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5289
    | Hs_Ensembl = ENSG00000078142
    | Hs_RefseqProtein = NP_002638
    | Hs_RefseqmRNA = NM_002647
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 18
    | Hs_GenLoc_start = 37789197
    | Hs_GenLoc_end = 37915442
    | Hs_Uniprot = Q8NEB9
    | Mm_EntrezGene = 225326
    | Mm_Ensembl = ENSMUSG00000033628
    | Mm_RefseqmRNA = NM_181414
    | Mm_RefseqProtein = NP_852079
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 18
    | Mm_GenLoc_start = 30415961
    | Mm_GenLoc_end = 30487098
    | Mm_Uniprot = Q6PF93
  }}
}}
'''Phosphoinositide-3-kinase, class 3''', also known as '''PIK3C3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PIK3C3 phosphoinositide-3-kinase, class 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5289| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Lee C, Liu QH, Tomkowicz B, ''et al.'' |title=Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways. |journal=J. Leukoc. Biol. |volume=74 |issue= 5 |pages= 676-82 |year= 2004 |pmid= 12960231 |doi= 10.1189/jlb.0503206 }}
*{{cite journal   |vauthors=Lee C, Liu QH, Tomkowicz B, etal |title=Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways. |journal=J. Leukoc. Biol. |volume=74 |issue= 5 |pages= 676–82 |year= 2004 |pmid= 12960231 |doi= 10.1189/jlb.0503206 }}
*{{cite journal  | author=Vogel LB, Fujita DJ |title=The SH3 domain of p56lck is involved in binding to phosphatidylinositol 3'-kinase from T lymphocytes. |journal=Mol. Cell. Biol. |volume=13 |issue= 12 |pages= 7408-17 |year= 1994 |pmid= 7504174 |doi=  }}
*{{cite journal  | vauthors=Vogel LB, Fujita DJ |title=The SH3 domain of p56lck is involved in binding to phosphatidylinositol 3'-kinase from T lymphocytes. |journal=Mol. Cell. Biol. |volume=13 |issue= 12 |pages= 7408–17 |year= 1994 |pmid= 7504174 |doi= | pmc=364812 }}
*{{cite journal | author=Volinia S, Dhand R, Vanhaesebroeck B, ''et al.'' |title=A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system. |journal=EMBO J. |volume=14 |issue= 14 |pages= 3339-48 |year= 1995 |pmid= 7628435 |doi=  }}
*{{cite journal   |vauthors=Milani D, Mazzoni M, Borgatti P, etal |title=Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells. |journal=J. Biol. Chem. |volume=271 |issue= 38 |pages= 22961–4 |year= 1996 |pmid= 8798481 |doi=10.1074/jbc.271.38.22961 }}
*{{cite journal  | author=Milani D, Mazzoni M, Borgatti P, ''et al.'' |title=Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells. |journal=J. Biol. Chem. |volume=271 |issue= 38 |pages= 22961-4 |year= 1996 |pmid= 8798481 |doi=  }}
*{{cite journal  | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
*{{cite journal  | vauthors=Panaretou C, Domin J, Cockcroft S, Waterfield MD |title=Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150.Ptdins 3-kinase complex. |journal=J. Biol. Chem. |volume=272 |issue= 4 |pages= 2477–85 |year= 1997 |pmid= 8999962 |doi=10.1074/jbc.272.4.2477  }}
*{{cite journal  | author=Panaretou C, Domin J, Cockcroft S, Waterfield MD |title=Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150.Ptdins 3-kinase complex. |journal=J. Biol. Chem. |volume=272 |issue= 4 |pages= 2477-85 |year= 1997 |pmid= 8999962 |doi=  }}
*{{cite journal  | vauthors=Mazerolles F, Barbat C, Fischer A |title=Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity. |journal=Eur. J. Immunol. |volume=27 |issue= 9 |pages= 2457–65 |year= 1997 |pmid= 9341793 |doi=10.1002/eji.1830270946 }}
*{{cite journal | author=Mazerolles F, Barbat C, Fischer A |title=Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity. |journal=Eur. J. Immunol. |volume=27 |issue= 9 |pages= 2457-65 |year= 1997 |pmid= 9341793 |doi=  }}
*{{cite journal   |vauthors=Borgatti P, Zauli G, Colamussi ML, etal |title=Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells. |journal=Eur. J. Immunol. |volume=27 |issue= 11 |pages= 2805–11 |year= 1998 |pmid= 9394803 |doi=10.1002/eji.1830271110 }}
*{{cite journal  | author=Borgatti P, Zauli G, Colamussi ML, ''et al.'' |title=Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells. |journal=Eur. J. Immunol. |volume=27 |issue= 11 |pages= 2805-11 |year= 1998 |pmid= 9394803 |doi=  }}
*{{cite journal  | vauthors=Borgatti P, Zauli G, Cantley LC, Capitani S |title=Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells. |journal=Biochem. Biophys. Res. Commun. |volume=242 |issue= 2 |pages= 332–7 |year= 1998 |pmid= 9446795 |doi=10.1006/bbrc.1997.7877 }}
*{{cite journal | author=Borgatti P, Zauli G, Cantley LC, Capitani S |title=Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells. |journal=Biochem. Biophys. Res. Commun. |volume=242 |issue= 2 |pages= 332-7 |year= 1998 |pmid= 9446795 |doi=  }}
*{{cite journal   |vauthors=Milani D, Mazzoni M, Zauli G, etal |title=HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells. |journal=AIDS |volume=12 |issue= 11 |pages= 1275–84 |year= 1998 |pmid= 9708406 |doi=10.1097/00002030-199811000-00008 }}
*{{cite journal | author=Milani D, Mazzoni M, Zauli G, ''et al.'' |title=HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells. |journal=AIDS |volume=12 |issue= 11 |pages= 1275-84 |year= 1998 |pmid= 9708406 |doi= }}
*{{cite journal   |vauthors=Jauliac S, Mazerolles F, Jabado N, etal |title=Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity. |journal=Eur. J. Immunol. |volume=28 |issue= 10 |pages= 3183–91 |year= 1998 |pmid= 9808187 |doi=10.1002/(SICI)1521-4141(199810)28:10<3183::AID-IMMU3183>3.0.CO;2-A  }}
*{{cite journal  | author=Jauliac S, Mazerolles F, Jabado N, ''et al.'' |title=Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity. |journal=Eur. J. Immunol. |volume=28 |issue= 10 |pages= 3183-91 |year= 1998 |pmid= 9808187 |doi=  }}
*{{cite journal  | vauthors=Park IW, Wang JF, Groopman JE |title=HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes. |journal=Blood |volume=97 |issue= 2 |pages= 352–8 |year= 2001 |pmid= 11154208 |doi=10.1182/blood.V97.2.352 }}
*{{cite journal | author=Park IW, Wang JF, Groopman JE |title=HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes. |journal=Blood |volume=97 |issue= 2 |pages= 352-8 |year= 2001 |pmid= 11154208 |doi= }}
*{{cite journal   |vauthors=Zauli G, Milani D, Mirandola P, etal |title=HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway. |journal=FASEB J. |volume=15 |issue= 2 |pages= 483–91 |year= 2001 |pmid= 11156964 |doi= 10.1096/fj.00-0354com }}
*{{cite journal | author=Zauli G, Milani D, Mirandola P, ''et al.'' |title=HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway. |journal=FASEB J. |volume=15 |issue= 2 |pages= 483-91 |year= 2001 |pmid= 11156964 |doi= 10.1096/fj.00-0354com }}
*{{cite journal   |vauthors=Deregibus MC, Cantaluppi V, Doublier S, etal |title=HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells. |journal=J. Biol. Chem. |volume=277 |issue= 28 |pages= 25195–202 |year= 2002 |pmid= 11994280 |doi= 10.1074/jbc.M200921200 }}
*{{cite journal  | author=Deregibus MC, Cantaluppi V, Doublier S, ''et al.'' |title=HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells. |journal=J. Biol. Chem. |volume=277 |issue= 28 |pages= 25195-202 |year= 2002 |pmid= 11994280 |doi= 10.1074/jbc.M200921200 }}
*{{cite journal  | vauthors=Cook JA, August A, Henderson AJ |title=Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism. |journal=J. Immunol. |volume=169 |issue= 1 |pages= 254–60 |year= 2002 |pmid= 12077252 |doi= 10.4049/jimmunol.169.1.254}}
*{{cite journal | author=Cook JA, August A, Henderson AJ |title=Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism. |journal=J. Immunol. |volume=169 |issue= 1 |pages= 254-60 |year= 2002 |pmid= 12077252 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=François F, Klotman ME |title=Phosphatidylinositol 3-kinase regulates human immunodeficiency virus type 1 replication following viral entry in primary CD4+ T lymphocytes and macrophages. |journal=J. Virol. |volume=77 |issue= 4 |pages= 2539–49 |year= 2003 |pmid= 12551992 |doi=10.1128/JVI.77.4.2539-2549.2003  | pmc=141101  }}
*{{cite journal  | author=François F, Klotman ME |title=Phosphatidylinositol 3-kinase regulates human immunodeficiency virus type 1 replication following viral entry in primary CD4+ T lymphocytes and macrophages. |journal=J. Virol. |volume=77 |issue= 4 |pages= 2539-49 |year= 2003 |pmid= 12551992 |doi= }}
*{{cite journal  | vauthors=Vergne I, Chua J, Deretic V |title=Tuberculosis toxin blocking phagosome maturation inhibits a novel Ca2+/calmodulin-PI3K hVPS34 cascade. |journal=J. Exp. Med. |volume=198 |issue= 4 |pages= 653–9 |year= 2003 |pmid= 12925680 |doi= 10.1084/jem.20030527  | pmc=2194170 }}
*{{cite journal  | author=Vergne I, Chua J, Deretic V |title=Tuberculosis toxin blocking phagosome maturation inhibits a novel Ca2+/calmodulin-PI3K hVPS34 cascade. |journal=J. Exp. Med. |volume=198 |issue= 4 |pages= 653-9 |year= 2003 |pmid= 12925680 |doi= 10.1084/jem.20030527 }}
*{{cite journal  | vauthors=Khan NA, Di Cello F, Nath A, Kim KS |title=Human immunodeficiency virus type 1 tat-mediated cytotoxicity of human brain microvascular endothelial cells. |journal=J. Neurovirol. |volume=9 |issue= 6 |pages= 584–93 |year= 2004 |pmid= 14602571 |doi=10.1080/jnv.9.6.584.593 }}
*{{cite journal  | author=Khan NA, Di Cello F, Nath A, Kim KS |title=Human immunodeficiency virus type 1 tat-mediated cytotoxicity of human brain microvascular endothelial cells. |journal=J. Neurovirol. |volume=9 |issue= 6 |pages= 584-93 |year= 2004 |pmid= 14602571 |doi= }}
}}
}}
{{refend}}
{{refend}}


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{{gene-18-stub}}

Latest revision as of 18:08, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Phosphatidylinositol 3-kinase catalytic subunit type 3 is an enzyme that in humans is encoded by the PIK3C3 gene.[1][2]


References

  1. ↑ Volinia S, Dhand R, Vanhaesebroeck B, MacDougall LK, Stein R, Zvelebil MJ, Domin J, Panaretou C, Waterfield MD (Sep 1995). "A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system". EMBO J. 14 (14): 3339–48. PMC 394401. PMID 7628435.
  2. ↑ "Entrez Gene: PIK3C3 phosphoinositide-3-kinase, class 3".

Further reading



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