Hereditary pancreatitis

Hereditary pancreatitis
OMIM	167800
DiseasesDB	30026

WikiDoc Resources for Hereditary pancreatitis
Articles
Most recent articles on Hereditary pancreatitis Most cited articles on Hereditary pancreatitis Review articles on Hereditary pancreatitis Articles on Hereditary pancreatitis in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Hereditary pancreatitis Images of Hereditary pancreatitis Photos of Hereditary pancreatitis Podcasts & MP3s on Hereditary pancreatitis Videos on Hereditary pancreatitis
Evidence Based Medicine
Cochrane Collaboration on Hereditary pancreatitis Bandolier on Hereditary pancreatitis TRIP on Hereditary pancreatitis
Clinical Trials
Ongoing Trials on Hereditary pancreatitis at Clinical Trials.gov Trial results on Hereditary pancreatitis Clinical Trials on Hereditary pancreatitis at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Hereditary pancreatitis NICE Guidance on Hereditary pancreatitis NHS PRODIGY Guidance FDA on Hereditary pancreatitis CDC on Hereditary pancreatitis
Books
Books on Hereditary pancreatitis
News
Hereditary pancreatitis in the news Be alerted to news on Hereditary pancreatitis News trends on Hereditary pancreatitis
Commentary
Blogs on Hereditary pancreatitis
Definitions
Definitions of Hereditary pancreatitis
Patient Resources / Community
Patient resources on Hereditary pancreatitis Discussion groups on Hereditary pancreatitis Patient Handouts on Hereditary pancreatitis Directions to Hospitals Treating Hereditary pancreatitis Risk calculators and risk factors for Hereditary pancreatitis
Healthcare Provider Resources
Symptoms of Hereditary pancreatitis Causes & Risk Factors for Hereditary pancreatitis Diagnostic studies for Hereditary pancreatitis Treatment of Hereditary pancreatitis
Continuing Medical Education (CME)
CME Programs on Hereditary pancreatitis
International
Hereditary pancreatitis en Espanol Hereditary pancreatitis en Francais
Business
Hereditary pancreatitis in the Marketplace Patents on Hereditary pancreatitis
Experimental / Informatics
List of terms related to Hereditary pancreatitis

For patient information click here

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Hereditary Pancreatitis is a genetic disease affecting enzyme production in the pancreas.

Pathophysiology

In the pancreas, a genetic mutation causes the enzyme trypsinogen to be made in a way which renders it resistant to inactivation through autolysis. Normally this autolysis mechanism prevents trypsinogen from being activated within the pancreas. However, when the abnormal trypsinogen is activated, it causes a chain reaction where all the trypsinogen in the pancreas is activated, effectively digesting the pancreas from the inside.

Epidemiology and Demographics

Prevalence

Most estimates place the number of individuals with hereditary pancreatitis in the United States at 1000.

Symptoms

Symptoms are generally the same as acute pancreatitis, including

• Severe abdominal pain
• Vomiting
• Diarrhea

Treatment

There is no treatment for the disease, although complications such as malnutrition can be treated with supplimentary pancreatic enzymes.

References

Template:WikiDoc Sources Bold text