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{{Infobox_gene}}
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'''DNA polymerase subunit gamma-2, mitochondrial''' is an [[protein]] that in humans is encoded by the ''POLG2'' [[gene]].  The ''POLG2'' gene encodes a 55 kDa accessory subunit protein that imparts high processivity and salt tolerance to the catalytic subunit of DNA polymerase gamma, encoded by the ''[[POLG]]'' gene.<ref name="pmid9153213">{{cite journal |vauthors=Wang Y, Farr CL, Kaguni LS | title = Accessory subunit of mitochondrial DNA polymerase from Drosophila embryos. Cloning, molecular analysis, and association in the native enzyme | journal = J Biol Chem | volume = 272 | issue = 21 | pages = 13640–6 |date=Jul 1997 | pmid = 9153213 | pmc =  | doi =10.1074/jbc.272.21.13640 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: POLG2 polymerase (DNA directed), gamma 2, accessory subunit| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11232| accessdate = }}</ref><ref>{{cite journal | last1 = Lim | first1 = SE | last2 = Longley | first2 = MJ | last3 = Copeland | first3 = WC |name-list-format=vanc | year = 1999 | title = The mitochondrial p55 accessory subunit of human DNA polymerase gamma enhances DNA binding, promotes processive DNA synthesis, and confers N-ethylmaleimide resistance | url = | journal = J. Biol. Chem. | volume = 274 | issue = 53| pages = 38197–203 | doi = 10.1074/jbc.274.53.38197 | pmid = 10608893 }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_POLG2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2g4c.
| PDB = {{PDB2|2g4c}}
| Name = Polymerase (DNA directed), gamma 2, accessory subunit
| HGNCid = 9180
| Symbol = POLG2
| AltSymbols =; POLB; HP55; MTPOLB; PEOA4; POLGB
| OMIM = 604983
| ECnumber = 
| Homologene = 5221
| MGIid = 1354947
| GeneAtlas_image1 = PBB_GE_POLG2_205811_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}}{{GNF_GO|id=GO:0003697 |text = single-stranded DNA binding}}{{GNF_GO|id=GO:0003895 |text = gamma DNA-directed DNA polymerase activity}}{{GNF_GO|id=GO:0004820 |text = glycine-tRNA ligase activity}}{{GNF_GO|id=GO:0005524 |text = ATP binding}}{{GNF_GO|id=GO:0016740 |text = transferase activity}}{{GNF_GO|id=GO:0042802 |text = identical protein binding}}
  | Component = {{GNF_GO|id=GO:0000262 |text = mitochondrial chromosome}} {{GNF_GO|id=GO:0005739 |text = mitochondrion}}
  | Process = {{GNF_GO|id=GO:0006261 |text = DNA-dependent DNA replication}} {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0006412 |text = translation}} {{GNF_GO|id=GO:0006426 |text = glycyl-tRNA aminoacylation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 11232
    | Hs_Ensembl = ENSG00000136480
    | Hs_RefseqProtein = NP_009146
    | Hs_RefseqmRNA = NM_007215
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 59904366
    | Hs_GenLoc_end = 59923631
    | Hs_Uniprot = Q9UHN1
    | Mm_EntrezGene = 50776
    | Mm_Ensembl = ENSMUSG00000020718
    | Mm_RefseqmRNA = NM_015810
    | Mm_RefseqProtein = NP_056625
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 106584396
    | Mm_GenLoc_end = 106595532
    | Mm_Uniprot = Q0VES3
  }}
}}
'''Polymerase (DNA directed), gamma 2, accessory subunit''', also known as '''POLG2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: POLG2 polymerase (DNA directed), gamma 2, accessory subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11232| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Michiels S, Danoy P, Dessen P, ''et al.'' |title=Polymorphism discovery in 62 DNA repair genes and haplotype associations with risks for lung and head and neck cancers. |journal=Carcinogenesis |volume=28 |issue= 8 |pages= 1731-9 |year= 2007 |pmid= 17494052 |doi= 10.1093/carcin/bgm111 }}
*{{cite journal   |vauthors=Michiels S, Danoy P, Dessen P, etal |title=Polymorphism discovery in 62 DNA repair genes and haplotype associations with risks for lung and head and neck cancers. |journal=Carcinogenesis |volume=28 |issue= 8 |pages= 1731–9 |year= 2007 |pmid= 17494052 |doi= 10.1093/carcin/bgm111 }}
*{{cite journal | author=Huang H, Shiffman ML, Cheung RC, ''et al.'' |title=Identification of two gene variants associated with risk of advanced fibrosis in patients with chronic hepatitis C. |journal=Gastroenterology |volume=130 |issue= 6 |pages= 1679-87 |year= 2006 |pmid= 16697732 |doi= 10.1053/j.gastro.2006.02.032 }}
*{{cite journal   |vauthors=Huang H, Shiffman ML, Cheung RC, etal |title=Identification of two gene variants associated with risk of advanced fibrosis in patients with chronic hepatitis C. |journal=Gastroenterology |volume=130 |issue= 6 |pages= 1679–87 |year= 2006 |pmid= 16697732 |doi= 10.1053/j.gastro.2006.02.032 }}
*{{cite journal | author=Longley MJ, Clark S, Yu Wai Man C, ''et al.'' |title=Mutant POLG2 disrupts DNA polymerase gamma subunits and causes progressive external ophthalmoplegia. |journal=Am. J. Hum. Genet. |volume=78 |issue= 6 |pages= 1026-34 |year= 2006 |pmid= 16685652 |doi= 10.1086/504303 }}
*{{cite journal   |vauthors=Longley MJ, Clark S, Yu Wai Man C, etal |title=Mutant POLG2 Disrupts DNA Polymerase γ Subunits and Causes Progressive External Ophthalmoplegia |journal=Am. J. Hum. Genet. |volume=78 |issue= 6 |pages= 1026–34 |year= 2006 |pmid= 16685652 |doi= 10.1086/504303 | pmc=1474082 }}
*{{cite journal | author=Yakubovskaya E, Chen Z, Carrodeguas JA, ''et al.'' |title=Functional human mitochondrial DNA polymerase gamma forms a heterotrimer. |journal=J. Biol. Chem. |volume=281 |issue= 1 |pages= 374-82 |year= 2006 |pmid= 16263719 |doi= 10.1074/jbc.M509730200 }}
*{{cite journal   |vauthors=Yakubovskaya E, Chen Z, Carrodeguas JA, etal |title=Functional human mitochondrial DNA polymerase gamma forms a heterotrimer |journal=J. Biol. Chem. |volume=281 |issue= 1 |pages= 374–82 |year= 2006 |pmid= 16263719 |doi= 10.1074/jbc.M509730200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Carrodeguas JA, Pinz KG, Bogenhagen DF |title=DNA binding properties of human pol gammaB. |journal=J. Biol. Chem. |volume=277 |issue= 51 |pages= 50008-14 |year= 2003 |pmid= 12379656 |doi= 10.1074/jbc.M207030200 }}
*{{cite journal  |vauthors=Carrodeguas JA, Pinz KG, Bogenhagen DF |title=DNA binding properties of human pol gammaB |journal=J. Biol. Chem. |volume=277 |issue= 51 |pages= 50008–14 |year= 2003 |pmid= 12379656 |doi= 10.1074/jbc.M207030200 }}
*{{cite journal  | author=Johnson AA, Tsai Y, Graves SW, Johnson KA |title=Human mitochondrial DNA polymerase holoenzyme: reconstitution and characterization. |journal=Biochemistry |volume=39 |issue= 7 |pages= 1702-8 |year= 2000 |pmid= 10677218 |doi=  }}
*{{cite journal  |vauthors=Johnson AA, Tsai Y, Graves SW, Johnson KA |title=Human mitochondrial DNA polymerase holoenzyme: reconstitution and characterization |journal=Biochemistry |volume=39 |issue= 7 |pages= 1702–8 |year= 2000 |pmid= 10677218 |doi=10.1021/bi992104w }}
*{{cite journal  | author=Carrodeguas JA, Bogenhagen DF |title=Protein sequences conserved in prokaryotic aminoacyl-tRNA synthetases are important for the activity of the processivity factor of human mitochondrial DNA polymerase. |journal=Nucleic Acids Res. |volume=28 |issue= 5 |pages= 1237-44 |year= 2000 |pmid= 10666468 |doi=  }}
*{{cite journal  |vauthors=Carrodeguas JA, Bogenhagen DF |title=Protein sequences conserved in prokaryotic aminoacyl-tRNA synthetases are important for the activity of the processivity factor of human mitochondrial DNA polymerase |journal=Nucleic Acids Res. |volume=28 |issue= 5 |pages= 1237–44 |year= 2000 |pmid= 10666468 |doi=10.1093/nar/28.5.1237  | pmc=102604 }}
*{{cite journal  | author=Lim SE, Longley MJ, Copeland WC |title=The mitochondrial p55 accessory subunit of human DNA polymerase gamma enhances DNA binding, promotes processive DNA synthesis, and confers N-ethylmaleimide resistance. |journal=J. Biol. Chem. |volume=274 |issue= 53 |pages= 38197-203 |year= 2000 |pmid= 10608893 |doi= }}
*{{cite journal  |vauthors=Lim SE, Longley MJ, Copeland WC |title=The mitochondrial p55 accessory subunit of human DNA polymerase gamma enhances DNA binding, promotes processive DNA synthesis, and confers N-ethylmaleimide resistance |journal=J. Biol. Chem. |volume=274 |issue= 53 |pages= 38197–203 |year= 1999 |pmid= 10608893 |doi=10.1074/jbc.274.53.38197 }}
*{{cite journal  | author=Wang Y, Farr CL, Kaguni LS |title=Accessory subunit of mitochondrial DNA polymerase from Drosophila embryos. Cloning, molecular analysis, and association in the native enzyme. |journal=J. Biol. Chem. |volume=272 |issue= 21 |pages= 13640-6 |year= 1997 |pmid= 9153213 |doi= }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=11232}}
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Revision as of 18:24, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

DNA polymerase subunit gamma-2, mitochondrial is an protein that in humans is encoded by the POLG2 gene. The POLG2 gene encodes a 55 kDa accessory subunit protein that imparts high processivity and salt tolerance to the catalytic subunit of DNA polymerase gamma, encoded by the POLG gene.[1][2][3]


References

  1. ↑ Wang Y, Farr CL, Kaguni LS (Jul 1997). "Accessory subunit of mitochondrial DNA polymerase from Drosophila embryos. Cloning, molecular analysis, and association in the native enzyme". J Biol Chem. 272 (21): 13640–6. doi:10.1074/jbc.272.21.13640. PMID 9153213.
  2. ↑ "Entrez Gene: POLG2 polymerase (DNA directed), gamma 2, accessory subunit".
  3. ↑ Lim SE, Longley MJ, Copeland WC (1999). "The mitochondrial p55 accessory subunit of human DNA polymerase gamma enhances DNA binding, promotes processive DNA synthesis, and confers N-ethylmaleimide resistance". J. Biol. Chem. 274 (53): 38197–203. doi:10.1074/jbc.274.53.38197. PMID 10608893.

Further reading



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