PPP1R10: Difference between revisions
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{{ | '''Serine/threonine-protein phosphatase 1 regulatory subunit 10''' is an [[enzyme]] that in humans is encoded by the ''PPP1R10'' [[gene]]. This gene lies within the [[major histocompatibility complex]] class I region on chromosome 6.<ref name="pmid9461602">{{cite journal | vauthors = Allen PB, Kwon YG, Nairn AC, Greengard P | title = Isolation and characterization of PNUTS, a putative protein phosphatase 1 nuclear targeting subunit | journal = J Biol Chem | volume = 273 | issue = 7 | pages = 4089–95 |date=Mar 1998 | pmid = 9461602 | pmc = | doi =10.1074/jbc.273.7.4089 }}</ref><ref name="pmid9784381">{{cite journal | vauthors = Totaro A, Grifa A, Carella M, Rommens JM, Valentino MA, Roetto A, Zelante L, Gasparini P | title = Cloning of a new gene (FB19) within HLA class I region | journal = Biochem Biophys Res Commun | volume = 250 | issue = 3 | pages = 555–7 |date=Nov 1998 | pmid = 9784381 | pmc = | doi = 10.1006/bbrc.1998.9354 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PPP1R10 protein phosphatase 1, regulatory (inhibitor) subunit 10| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5514| accessdate = }}</ref> | ||
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== Function == | |||
This gene encodes a protein with similarity to a rat protein that has an inhibitory effect on protein phosphatase-1 ([[PP1]]). The rat protein localizes to the [[cell nucleus|nucleus]] and colocalizes with [[chromatin]] at distinct phases during [[mitosis]].<ref name="entrez"/> | |||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
*{{cite journal |vauthors=Totaro A, Rommens JM, Grifa A, etal |title=Hereditary hemochromatosis: generation of a transcription map within a refined and extended map of the HLA class I region. |journal=Genomics |volume=31 |issue= 3 |pages= 319–26 |year= 1997 |pmid= 8838313 |doi= 10.1006/geno.1996.0054 }} | |||
*{{cite journal |vauthors=Kreivi JP, Trinkle-Mulcahy L, Lyon CE, etal |title=Purification and characterisation of p99, a nuclear modulator of protein phosphatase 1 activity. |journal=FEBS Lett. |volume=420 |issue= 1 |pages= 57–62 |year= 1998 |pmid= 9450550 |doi=10.1016/S0014-5793(97)01485-3 }} | |||
*{{cite journal | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | ||
*{{cite journal | *{{cite journal |vauthors=Kim YM, Watanabe T, Allen PB, etal |title=PNUTS, a protein phosphatase 1 (PP1) nuclear targeting subunit. Characterization of its PP1- and RNA-binding domains and regulation by phosphorylation. |journal=J. Biol. Chem. |volume=278 |issue= 16 |pages= 13819–28 |year= 2003 |pmid= 12574161 |doi= 10.1074/jbc.M209621200 }} | ||
*{{cite journal |vauthors=Reeder JE, Sowden MP, Messing EM, etal |title=Inducible expression of catalytically active type 1 serine/threonine protein phosphatase in a human carcinoma cell line. |journal= Cancer Cell International|volume=3 |issue= 1 |pages= 12 |year= 2003|pmid= 12914669 |doi= 10.1186/1475-2867-3-12 | pmc=183861 }} | |||
*{{cite journal |vauthors=Mungall AJ, Palmer SA, Sims SK, etal |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }} | |||
*{{cite journal | *{{cite journal |vauthors=Colland F, Jacq X, Trouplin V, etal |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 | pmc=442148 }} | ||
*{{cite journal | *{{cite journal | vauthors=Raha-Chowdhury R, Andrews SR, Gruen JR |title=CAT 53: a protein phosphatase 1 nuclear targeting subunit encoded in the MHC Class I region strongly expressed in regions of the brain involved in memory, learning, and Alzheimer's disease. |journal=Brain Res. Mol. Brain Res. |volume=138 |issue= 1 |pages= 70–83 |year= 2005 |pmid= 15894402 |doi= 10.1016/j.molbrainres.2005.04.001 }} | ||
*{{cite journal | *{{cite journal |vauthors=Landsverk HB, Kirkhus M, Bollen M, etal |title=PNUTS enhances in vitro chromosome decondensation in a PP1-dependent manner. |journal=Biochem. J. |volume=390 |issue= Pt 3 |pages= 709–17 |year= 2006 |pmid= 15907195 |doi= 10.1042/BJ20050678 | pmc=1199665 }} | ||
*{{cite journal | *{{cite journal |vauthors=Beausoleil SA, Villén J, Gerber SA, etal |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }} | ||
*{{cite journal | *{{cite journal |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Lee SJ, Lim CJ, Min JK, etal |title=Protein phosphatase 1 nuclear targeting subunit is a hypoxia inducible gene: its role in post-translational modification of p53 and MDM2. |journal=Cell Death Differ. |volume=14 |issue= 6 |pages= 1106–16 |year= 2007 |pmid= 17318220 |doi= 10.1038/sj.cdd.4402111 }} | ||
*{{cite journal | |||
*{{cite journal | |||
*{{cite journal | |||
*{{cite journal | |||
}} | |||
{{refend}} | {{refend}} | ||
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Latest revision as of 18:33, 7 September 2017
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External IDs | GeneCards: [1] | ||||||
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Species | Human | Mouse | |||||
Entrez |
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Ensembl |
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UniProt |
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RefSeq (mRNA) |
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RefSeq (protein) |
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Location (UCSC) | n/a | n/a | |||||
PubMed search | n/a | n/a | |||||
Wikidata | |||||||
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Serine/threonine-protein phosphatase 1 regulatory subunit 10 is an enzyme that in humans is encoded by the PPP1R10 gene. This gene lies within the major histocompatibility complex class I region on chromosome 6.[1][2][3]
Function
This gene encodes a protein with similarity to a rat protein that has an inhibitory effect on protein phosphatase-1 (PP1). The rat protein localizes to the nucleus and colocalizes with chromatin at distinct phases during mitosis.[3]
References
- ↑ Allen PB, Kwon YG, Nairn AC, Greengard P (Mar 1998). "Isolation and characterization of PNUTS, a putative protein phosphatase 1 nuclear targeting subunit". J Biol Chem. 273 (7): 4089–95. doi:10.1074/jbc.273.7.4089. PMID 9461602.
- ↑ Totaro A, Grifa A, Carella M, Rommens JM, Valentino MA, Roetto A, Zelante L, Gasparini P (Nov 1998). "Cloning of a new gene (FB19) within HLA class I region". Biochem Biophys Res Commun. 250 (3): 555–7. doi:10.1006/bbrc.1998.9354. PMID 9784381.
- ↑ 3.0 3.1 "Entrez Gene: PPP1R10 protein phosphatase 1, regulatory (inhibitor) subunit 10".
Further reading
- Totaro A, Rommens JM, Grifa A, et al. (1997). "Hereditary hemochromatosis: generation of a transcription map within a refined and extended map of the HLA class I region". Genomics. 31 (3): 319–26. doi:10.1006/geno.1996.0054. PMID 8838313.
- Kreivi JP, Trinkle-Mulcahy L, Lyon CE, et al. (1998). "Purification and characterisation of p99, a nuclear modulator of protein phosphatase 1 activity". FEBS Lett. 420 (1): 57–62. doi:10.1016/S0014-5793(97)01485-3. PMID 9450550.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Kim YM, Watanabe T, Allen PB, et al. (2003). "PNUTS, a protein phosphatase 1 (PP1) nuclear targeting subunit. Characterization of its PP1- and RNA-binding domains and regulation by phosphorylation". J. Biol. Chem. 278 (16): 13819–28. doi:10.1074/jbc.M209621200. PMID 12574161.
- Reeder JE, Sowden MP, Messing EM, et al. (2003). "Inducible expression of catalytically active type 1 serine/threonine protein phosphatase in a human carcinoma cell line". Cancer Cell International. 3 (1): 12. doi:10.1186/1475-2867-3-12. PMC 183861. PMID 12914669.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
- Raha-Chowdhury R, Andrews SR, Gruen JR (2005). "CAT 53: a protein phosphatase 1 nuclear targeting subunit encoded in the MHC Class I region strongly expressed in regions of the brain involved in memory, learning, and Alzheimer's disease". Brain Res. Mol. Brain Res. 138 (1): 70–83. doi:10.1016/j.molbrainres.2005.04.001. PMID 15894402.
- Landsverk HB, Kirkhus M, Bollen M, et al. (2006). "PNUTS enhances in vitro chromosome decondensation in a PP1-dependent manner". Biochem. J. 390 (Pt 3): 709–17. doi:10.1042/BJ20050678. PMC 1199665. PMID 15907195.
- Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Lee SJ, Lim CJ, Min JK, et al. (2007). "Protein phosphatase 1 nuclear targeting subunit is a hypoxia inducible gene: its role in post-translational modification of p53 and MDM2". Cell Death Differ. 14 (6): 1106–16. doi:10.1038/sj.cdd.4402111. PMID 17318220.
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