PPP2R5C: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform''' is an [[enzyme]] that in humans is encoded by the ''PPP2R5C'' [[gene]].<ref name="pmid7592815">{{cite journal | vauthors = McCright B, Virshup DM | title = Identification of a new family of protein phosphatase 2A regulatory subunits | journal = The Journal of Biological Chemistry | volume = 270 | issue = 44 | pages = 26123–8 | date = Nov 1995 | pmid = 7592815 | pmc = | doi = 10.1074/jbc.270.44.26123 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PPP2R5C protein phosphatase 2, regulatory subunit B', gamma isoform| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5527| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_PPP2R5C_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2iae.
| PDB = {{PDB2|2iae}}, {{PDB2|2jak}}, {{PDB2|2npp}}, {{PDB2|2nyl}}, {{PDB2|2nym}}
| Name = Protein phosphatase 2, regulatory subunit B', gamma isoform
| HGNCid = 9311
| Symbol = PPP2R5C
| AltSymbols =; B56G; MGC23064; PR61G
| OMIM = 601645
| ECnumber = 
| Homologene = 86888
| MGIid = 1349475
| GeneAtlas_image1 = PBB_GE_PPP2R5C_201877_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PPP2R5C_213305_s_at_tn.png
| Function = {{GNF_GO|id=GO:0008233 |text = peptidase activity}} {{GNF_GO|id=GO:0008601 |text = protein phosphatase type 2A regulator activity}}
| Component = {{GNF_GO|id=GO:0000159 |text = protein phosphatase type 2A complex}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0016485 |text = protein processing}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5527
    | Hs_Ensembl = ENSG00000078304
    | Hs_RefseqProtein = NP_002710
    | Hs_RefseqmRNA = NM_002719
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 14
    | Hs_GenLoc_start = 101297975
    | Hs_GenLoc_end = 101463828
    | Hs_Uniprot = Q13362
    | Mm_EntrezGene = 26931
    | Mm_Ensembl = ENSMUSG00000017843
    | Mm_RefseqmRNA = NM_001081457
    | Mm_RefseqProtein = NP_001074926
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 12
    | Mm_GenLoc_start = 110895114
    | Mm_GenLoc_end = 111028667
    | Mm_Uniprot = Q60996
  }}
}}
'''Protein phosphatase 2, regulatory subunit B', gamma isoform''', also known as '''PPP2R5C''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PPP2R5C protein phosphatase 2, regulatory subunit B', gamma isoform| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5527| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The product of this gene belongs to the [[Protein phosphatase 2A]] regulatory subunit B family. [[Protein phosphatase 2A]] is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified.<ref name="entrez">{{cite web | title = Entrez Gene: PPP2R5C protein phosphatase 2, regulatory subunit B', gamma isoform| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5527| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
PPP2R5C has been shown to [[Protein-protein interaction|interact]] with [[PPP2R1B]],<ref name=pmid8703017>{{cite journal | vauthors = McCright B, Rivers AM, Audlin S, Virshup DM | title = The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm | journal = The Journal of Biological Chemistry | volume = 271 | issue = 36 | pages = 22081–9 | date = Sep 1996 | pmid = 8703017 | doi = 10.1074/jbc.271.36.22081 }}</ref> [[PPP2CA]]<ref name=pmid8703017/><ref name=pmid10675325>{{cite journal | vauthors = Ito A, Kataoka TR, Watanabe M, Nishiyama K, Mazaki Y, Sabe H, Kitamura Y, Nojima H | title = A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation | journal = The EMBO Journal | volume = 19 | issue = 4 | pages = 562–71 | date = Feb 2000 | pmid = 10675325 | pmc = 305594 | doi = 10.1093/emboj/19.4.562 }}</ref><ref name=pmid18782753>{{cite journal | vauthors = Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC | title = A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein | journal = Molecular & Cellular Proteomics | volume = 8 | issue = 1 | pages = 157–71 | date = Jan 2009 | pmid = 18782753 | pmc = 2621004 | doi = 10.1074/mcp.M800266-MCP200 }}</ref> and [[PPP2R5A]].<ref name = pmid11929880>{{cite journal | vauthors = Strack S, Ruediger R, Walter G, Dagda RK, Barwacz CA, Cribbs JT | title = Protein phosphatase 2A holoenzyme assembly: identification of contacts between B-family regulatory and scaffolding A subunits | journal = The Journal of Biological Chemistry | volume = 277 | issue = 23 | pages = 20750–5 | date = Jun 2002 | pmid = 11929880 | doi =  10.1074/jbc.M202992200}}</ref>
 
== References ==
{{Reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Le Rouzic E, Benichou S | title = The Vpr protein from HIV-1: distinct roles along the viral life cycle | journal = Retrovirology | volume = 2 | issue =  | pages = 11 | year = 2006 | pmid = 15725353 | pmc = 554975 | doi = 10.1186/1742-4690-2-11 }}
| citations =
* {{cite journal | vauthors = Zhao RY, Elder RT | title = Viral infections and cell cycle G2/M regulation | journal = Cell Research | volume = 15 | issue = 3 | pages = 143–9 | date = Mar 2005 | pmid = 15780175 | doi = 10.1038/sj.cr.7290279 }}
*{{cite journal | author=Le Rouzic E, Benichou S |title=The Vpr protein from HIV-1: distinct roles along the viral life cycle. |journal=Retrovirology |volume=2 |issue=  |pages= 11 |year= 2006 |pmid= 15725353 |doi= 10.1186/1742-4690-2-11 }}
* {{cite journal | vauthors = Zhao RY, Bukrinsky M, Elder RT | title = HIV-1 viral protein R (Vpr) & host cellular responses | journal = The Indian Journal of Medical Research | volume = 121 | issue = 4 | pages = 270–86 | date = Apr 2005 | pmid = 15817944 | doi =  }}
*{{cite journal | author=Zhao RY, Elder RT |title=Viral infections and cell cycle G2/M regulation. |journal=Cell Res. |volume=15 |issue= 3 |pages= 143-9 |year= 2005 |pmid= 15780175 |doi= 10.1038/sj.cr.7290279 }}
* {{cite journal | vauthors = Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S | title = Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 | journal = DNA Research | volume = 1 | issue = 1 | pages = 27–35 | year = 1995 | pmid = 7584026 | doi = 10.1093/dnares/1.1.27 }}
*{{cite journal | author=Zhao RY, Bukrinsky M, Elder RT |title=HIV-1 viral protein R (Vpr) & host cellular responses. |journal=Indian J. Med. Res. |volume=121 |issue= 4 |pages= 270-86 |year= 2005 |pmid= 15817944 |doi=  }}
* {{cite journal | vauthors = Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S | title = Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1 | journal = DNA Research | volume = 1 | issue = 5 | pages = 223–9 | year = 1995 | pmid = 7584044 | doi = 10.1093/dnares/1.5.223 }}
*{{cite journal | author=Nomura N, Miyajima N, Sazuka T, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. |journal=DNA Res. |volume=1 |issue= 1 |pages= 27-35 |year= 1995 |pmid= 7584026 |doi= }}
* {{cite journal | vauthors = Akiyama N, Shima H, Hatano Y, Osawa Y, Sugimura T, Nagao M | title = cDNA cloning of BR gamma, a novel brain-specific isoform of the B regulatory subunit of type-2A protein phosphatase | journal = European Journal of Biochemistry / FEBS | volume = 230 | issue = 2 | pages = 766–72 | date = Jun 1995 | pmid = 7607250 | doi = 10.1111/j.1432-1033.1995.tb20619.x }}
*{{cite journal | author=Nomura N, Nagase T, Miyajima N, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=1 |issue= 5 |pages= 223-9 |year= 1995 |pmid= 7584044 |doi= }}
* {{cite journal | vauthors = Tehrani MA, Mumby MC, Kamibayashi C | title = Identification of a novel protein phosphatase 2A regulatory subunit highly expressed in muscle | journal = The Journal of Biological Chemistry | volume = 271 | issue = 9 | pages = 5164–70 | date = Mar 1996 | pmid = 8617797 | doi = 10.1074/jbc.271.9.5164 }}
*{{cite journal | author=McCright B, Virshup DM |title=Identification of a new family of protein phosphatase 2A regulatory subunits. |journal=J. Biol. Chem. |volume=270 |issue= 44 |pages= 26123-8 |year= 1995 |pmid= 7592815 |doi= }}
* {{cite journal | vauthors = Zolnierowicz S, Van Hoof C, Andjelković N, Cron P, Stevens I, Merlevede W, Goris J, Hemmings BA | title = The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits | journal = The Biochemical Journal | volume = 317 | issue = Pt 1 | pages = 187–94 | date = Jul 1996 | pmid = 8694763 | pmc = 1217462 | doi =  10.1042/bj3170187}}
*{{cite journal | author=Akiyama N, Shima H, Hatano Y, ''et al.'' |title=cDNA cloning of BR gamma, a novel brain-specific isoform of the B regulatory subunit of type-2A protein phosphatase. |journal=Eur. J. Biochem. |volume=230 |issue= 2 |pages= 766-72 |year= 1995 |pmid= 7607250 |doi= }}
* {{cite journal | vauthors = McCright B, Rivers AM, Audlin S, Virshup DM | title = The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm | journal = The Journal of Biological Chemistry | volume = 271 | issue = 36 | pages = 22081–9 | date = Sep 1996 | pmid = 8703017 | doi = 10.1074/jbc.271.36.22081 }}
*{{cite journal | author=Tehrani MA, Mumby MC, Kamibayashi C |title=Identification of a novel protein phosphatase 2A regulatory subunit highly expressed in muscle. |journal=J. Biol. Chem. |volume=271 |issue= 9 |pages= 5164-70 |year= 1996 |pmid= 8617797 |doi=  }}
* {{cite journal | vauthors = McCright B, Brothman AR, Virshup DM | title = Assignment of human protein phosphatase 2A regulatory subunit genes b56alpha, b56beta, b56gamma, b56delta, and b56epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12 | journal = Genomics | volume = 36 | issue = 1 | pages = 168–70 | date = Aug 1996 | pmid = 8812429 | doi = 10.1006/geno.1996.0438 }}
*{{cite journal | author=Zolnierowicz S, Van Hoof C, Andjelković N, ''et al.'' |title=The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits. |journal=Biochem. J. |volume=317 ( Pt 1) |issue= |pages= 187-94 |year= 1996 |pmid= 8694763 |doi= }}
* {{cite journal | vauthors = Tung HY, De Rocquigny H, Zhao LJ, Cayla X, Roques BP, Ozon R | title = Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr | journal = FEBS Letters | volume = 401 | issue = 2-3 | pages = 197–201 | date = Jan 1997 | pmid = 9013886 | doi = 10.1016/S0014-5793(96)01470-6 }}
*{{cite journal | author=McCright B, Rivers AM, Audlin S, Virshup DM |title=The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm. |journal=J. Biol. Chem. |volume=271 |issue= 36 |pages= 22081-9 |year= 1996 |pmid= 8703017 |doi= }}
* {{cite journal | vauthors = Ruediger R, Brewis N, Ohst K, Walter G | title = Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production | journal = Virology | volume = 238 | issue = 2 | pages = 432–43 | date = Nov 1997 | pmid = 9400615 | doi = 10.1006/viro.1997.8873 }}
*{{cite journal | author=McCright B, Brothman AR, Virshup DM |title=Assignment of human protein phosphatase 2A regulatory subunit genes b56alpha, b56beta, b56gamma, b56delta, and b56epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12. |journal=Genomics |volume=36 |issue= 1 |pages= 168-70 |year= 1997 |pmid= 8812429 |doi=  }}
* {{cite journal | vauthors = Scanlan MJ, Gordan JD, Williamson B, Stockert E, Bander NH, Jongeneel V, Gure AO, Jäger D, Jäger E, Knuth A, Chen YT, Old LJ | title = Antigens recognized by autologous antibody in patients with renal-cell carcinoma | journal = International Journal of Cancer | volume = 83 | issue = 4 | pages = 456–64 | date = Nov 1999 | pmid = 10508479 | doi = 10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5 }}
*{{cite journal | author=Tung HY, De Rocquigny H, Zhao LJ, ''et al.'' |title=Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr. |journal=FEBS Lett. |volume=401 |issue= 2-3 |pages= 197-201 |year= 1997 |pmid= 9013886 |doi= }}
* {{cite journal | vauthors = Ito A, Kataoka TR, Watanabe M, Nishiyama K, Mazaki Y, Sabe H, Kitamura Y, Nojima H | title = A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation | journal = The EMBO Journal | volume = 19 | issue = 4 | pages = 562–71 | date = Feb 2000 | pmid = 10675325 | pmc = 305594 | doi = 10.1093/emboj/19.4.562 }}
*{{cite journal | author=Ruediger R, Brewis N, Ohst K, Walter G |title=Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production. |journal=Virology |volume=238 |issue= 2 |pages= 432-43 |year= 1998 |pmid= 9400615 |doi= 10.1006/viro.1997.8873 }}
* {{cite journal | vauthors = Ikeda S, Kishida M, Matsuura Y, Usui H, Kikuchi A | title = GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin | journal = Oncogene | volume = 19 | issue = 4 | pages = 537–45 | date = Jan 2000 | pmid = 10698523 | doi = 10.1038/sj.onc.1203359 }}
*{{cite journal | author=Scanlan MJ, Gordan JD, Williamson B, ''et al.'' |title=Antigens recognized by autologous antibody in patients with renal-cell carcinoma. |journal=Int. J. Cancer |volume=83 |issue= 4 |pages= 456-64 |year= 1999 |pmid= 10508479 |doi= }}
* {{cite journal | vauthors = Elder RT, Yu M, Chen M, Zhu X, Yanagida M, Zhao Y | title = HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25 | journal = Virology | volume = 287 | issue = 2 | pages = 359–70 | date = Sep 2001 | pmid = 11531413 | doi = 10.1006/viro.2001.1007 }}
*{{cite journal | author=Ito A, Kataoka TR, Watanabe M, ''et al.'' |title=A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation. |journal=EMBO J. |volume=19 |issue= 4 |pages= 562-71 |year= 2000 |pmid= 10675325 |doi= 10.1093/emboj/19.4.562 }}
* {{cite journal | vauthors = Muneer S, Ramalingam V, Wyatt R, Schultz RA, Minna JD, Kamibayashi C | title = Genomic organization and mapping of the gene encoding the PP2A B56gamma regulatory subunit | journal = Genomics | volume = 79 | issue = 3 | pages = 344–8 | date = Mar 2002 | pmid = 11863364 | doi = 10.1006/geno.2002.6721 }}
*{{cite journal | author=Ikeda S, Kishida M, Matsuura Y, ''et al.'' |title=GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin. |journal=Oncogene |volume=19 |issue= 4 |pages= 537-45 |year= 2000 |pmid= 10698523 |doi= 10.1038/sj.onc.1203359 }}
* {{cite journal | vauthors = Strack S, Ruediger R, Walter G, Dagda RK, Barwacz CA, Cribbs JT | title = Protein phosphatase 2A holoenzyme assembly: identification of contacts between B-family regulatory and scaffolding A subunits | journal = The Journal of Biological Chemistry | volume = 277 | issue = 23 | pages = 20750–5 | date = Jun 2002 | pmid = 11929880 | doi = 10.1074/jbc.M202992200 }}
*{{cite journal | author=Hrimech M, Yao XJ, Branton PE, Cohen EA |title=Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A. |journal=EMBO J. |volume=19 |issue= 15 |pages= 3956-67 |year= 2000 |pmid= 10921877 |doi= 10.1093/emboj/19.15.3956 }}
*{{cite journal | author=Elder RT, Yu M, Chen M, ''et al.'' |title=HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25. |journal=Virology |volume=287 |issue= 2 |pages= 359-70 |year= 2001 |pmid= 11531413 |doi= 10.1006/viro.2001.1007 }}
*{{cite journal  | author=Muneer S, Ramalingam V, Wyatt R, ''et al.'' |title=Genomic organization and mapping of the gene encoding the PP2A B56gamma regulatory subunit. |journal=Genomics |volume=79 |issue= 3 |pages= 344-8 |year= 2002 |pmid= 11863364 |doi= 10.1006/geno.2002.6721 }}
*{{cite journal  | author=Strack S, Ruediger R, Walter G, ''et al.'' |title=Protein phosphatase 2A holoenzyme assembly: identification of contacts between B-family regulatory and scaffolding A subunits. |journal=J. Biol. Chem. |volume=277 |issue= 23 |pages= 20750-5 |year= 2002 |pmid= 11929880 |doi= 10.1074/jbc.M202992200 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=5527}}
{{WikiDoc Sources}}
 
 
{{Gene-14-stub}}

Latest revision as of 22:03, 25 November 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform is an enzyme that in humans is encoded by the PPP2R5C gene.[1][2]

Function

The product of this gene belongs to the Protein phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified.[2]

Interactions

PPP2R5C has been shown to interact with PPP2R1B,[3] PPP2CA[3][4][5] and PPP2R5A.[6]

References

  1. ↑ McCright B, Virshup DM (Nov 1995). "Identification of a new family of protein phosphatase 2A regulatory subunits". The Journal of Biological Chemistry. 270 (44): 26123–8. doi:10.1074/jbc.270.44.26123. PMID 7592815.
  2. ↑ 2.0 2.1 "Entrez Gene: PPP2R5C protein phosphatase 2, regulatory subunit B', gamma isoform".
  3. ↑ 3.0 3.1 McCright B, Rivers AM, Audlin S, Virshup DM (Sep 1996). "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm". The Journal of Biological Chemistry. 271 (36): 22081–9. doi:10.1074/jbc.271.36.22081. PMID 8703017.
  4. ↑ Ito A, Kataoka TR, Watanabe M, Nishiyama K, Mazaki Y, Sabe H, Kitamura Y, Nojima H (Feb 2000). "A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation". The EMBO Journal. 19 (4): 562–71. doi:10.1093/emboj/19.4.562. PMC 305594. PMID 10675325.
  5. ↑ Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Molecular & Cellular Proteomics. 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.
  6. ↑ Strack S, Ruediger R, Walter G, Dagda RK, Barwacz CA, Cribbs JT (Jun 2002). "Protein phosphatase 2A holoenzyme assembly: identification of contacts between B-family regulatory and scaffolding A subunits". The Journal of Biological Chemistry. 277 (23): 20750–5. doi:10.1074/jbc.M202992200. PMID 11929880.

Further reading

  • Le Rouzic E, Benichou S (2006). "The Vpr protein from HIV-1: distinct roles along the viral life cycle". Retrovirology. 2: 11. doi:10.1186/1742-4690-2-11. PMC 554975. PMID 15725353.
  • Zhao RY, Elder RT (Mar 2005). "Viral infections and cell cycle G2/M regulation". Cell Research. 15 (3): 143–9. doi:10.1038/sj.cr.7290279. PMID 15780175.
  • Zhao RY, Bukrinsky M, Elder RT (Apr 2005). "HIV-1 viral protein R (Vpr) & host cellular responses". The Indian Journal of Medical Research. 121 (4): 270–86. PMID 15817944.
  • Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Research. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
  • Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.
  • Akiyama N, Shima H, Hatano Y, Osawa Y, Sugimura T, Nagao M (Jun 1995). "cDNA cloning of BR gamma, a novel brain-specific isoform of the B regulatory subunit of type-2A protein phosphatase". European Journal of Biochemistry / FEBS. 230 (2): 766–72. doi:10.1111/j.1432-1033.1995.tb20619.x. PMID 7607250.
  • Tehrani MA, Mumby MC, Kamibayashi C (Mar 1996). "Identification of a novel protein phosphatase 2A regulatory subunit highly expressed in muscle". The Journal of Biological Chemistry. 271 (9): 5164–70. doi:10.1074/jbc.271.9.5164. PMID 8617797.
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