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{{Infobox_gene}}
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'''Calcineurin subunit B type 1''' also known as '''protein phosphatase 2B regulatory subunit 1''' is a [[protein]] that in humans is encoded by the ''PPP3R1'' [[gene]].<ref name="pmid8978785">{{cite journal | vauthors = Wang MG, Yi H, Guerini D, Klee CB, McBride OW | title = Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21→q22 and 2p16→p15 respectively | journal = Cytogenet Cell Genet | volume = 72 | issue = 2-3 | pages = 236–41 |date=Jan 1997 | pmid = 8978785 | pmc =  | doi =10.1159/000134198  }}</ref><ref name="pmid2558868">{{cite journal | vauthors = Guerini D, Krinks MH, Sikela JM, Hahn WE, Klee CB | title = Isolation and sequence of a cDNA clone for human calcineurin B, the Ca2+-binding subunit of the Ca2+/calmodulin-stimulated protein phosphatase | journal = DNA | volume = 8 | issue = 9 | pages = 675–82 |date=Mar 1990 | pmid = 2558868 | pmc =  | doi =  10.1089/dna.1.1989.8.675}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PPP3R1 protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5534| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Clinical significance ==
{{GNF_Protein_box
| image = PBB_Protein_PPP3R1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1aui.
| PDB = {{PDB2|1aui}}, {{PDB2|1m63}}, {{PDB2|1mf8}}, {{PDB2|1tco}}, {{PDB2|2p6b}}
| Name = Protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform
| HGNCid = 9317
| Symbol = PPP3R1
| AltSymbols =; CALNB1; CNB; CNB1
| OMIM = 601302
| ECnumber = 
| Homologene = 68099
| MGIid = 107172
| Function = {{GNF_GO|id=GO:0004723 |text = calcium-dependent protein serine/threonine phosphatase activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005517 |text = calmodulin inhibitor activity}}
| Component = {{GNF_GO|id=GO:0005955 |text = calcineurin complex}}
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5534
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_000936
    | Hs_RefseqmRNA = NM_000945
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 19058
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_024459
    | Mm_RefseqProtein = NP_077779
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform''', also known as '''PPP3R1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PPP3R1 protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5534| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The presence of a [[single nucleotide polymorphism]] rs1868402 in the ''PPP3R1'' gene is strongly correlated with rapid progress of [[Alzheimer's disease]].<ref name = "Cruchaga_2010">{{cite journal |vauthors=Cruchaga C, Kauwe JS, Mayo K, Spiegel N, Bertelsen S, etal | editor1-last = Myers | editor1-first = Amanda J. | title = SNPs Associated with Cerebrospinal Fluid Phospho-Tau Levels Influence Rate of Decline in Alzheimer's Disease | journal = PLoS Genet | year = 2010 | volume = 6 | pmid = 20862329 | issue = 9 | pmc = 2940763 | pages = e1001101|doi=10.1371/journal.pgen.1001101 }}</ref>
{{PBB_Summary
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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Guerini D, Krinks MH, Sikela JM, ''et al.'' |title=Isolation and sequence of a cDNA clone for human calcineurin B, the Ca2+-binding subunit of the Ca2+/calmodulin-stimulated protein phosphatase. |journal=DNA |volume=8 |issue= 9 |pages= 675-82 |year= 1990 |pmid= 2558868 |doi=  }}
*{{cite journal  | vauthors=Kawamura A, Su MS |title=Interaction of FKBP12-FK506 with calcineurin A at the B subunit-binding domain. |journal=J. Biol. Chem. |volume=270 |issue= 26 |pages= 15463–6 |year= 1995 |pmid= 7541044 |doi=10.1074/jbc.270.26.15463 }}
*{{cite journal | author=Kawamura A, Su MS |title=Interaction of FKBP12-FK506 with calcineurin A at the B subunit-binding domain. |journal=J. Biol. Chem. |volume=270 |issue= 26 |pages= 15463-6 |year= 1995 |pmid= 7541044 |doi= }}
*{{cite journal   |vauthors=Kissinger CR, Parge HE, Knighton DR, etal |title=Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex. |journal=Nature |volume=378 |issue= 6557 |pages= 641–4 |year= 1996 |pmid= 8524402 |doi= 10.1038/378641a0 }}
*{{cite journal  | author=Kissinger CR, Parge HE, Knighton DR, ''et al.'' |title=Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex. |journal=Nature |volume=378 |issue= 6557 |pages= 641-4 |year= 1996 |pmid= 8524402 |doi= 10.1038/378641a0 }}
*{{cite journal  | vauthors=Feng B, Stemmer PM |title=Interactions of calcineurin A, calcineurin B, and Ca2+. |journal=Biochemistry |volume=38 |issue= 38 |pages= 12481–9 |year= 1999 |pmid= 10493818 |doi=10.1021/bi990492w  }}
*{{cite journal  | author=Wang MG, Yi H, Guerini D, ''et al.'' |title=Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21-->q22 and 2p16-->p15 respectively. |journal=Cytogenet. Cell Genet. |volume=72 |issue= 2-3 |pages= 236-41 |year= 1997 |pmid= 8978785 |doi=  }}
*{{cite journal  | vauthors=Stratakis CA, Taymans SE |title=Structure of the gene coding for calcineurin B (PPP3R1) and mapping to D2S358-D2S1778 (chromosomal region 2p15). |journal=DNA Seq. |volume=9 |issue= 4 |pages= 227–30 |year= 1999 |pmid= 10520753 |doi=10.3109/10425179809105209 }}
*{{cite journal | author=Feng B, Stemmer PM |title=Interactions of calcineurin A, calcineurin B, and Ca2+. |journal=Biochemistry |volume=38 |issue= 38 |pages= 12481-9 |year= 1999 |pmid= 10493818 |doi= }}
*{{cite journal   |vauthors=Nishio H, Matsui K, Tsuji H, etal |title=Immunolocalization of calcineurin and FKBP12, the FK506-binding protein, in Hassall's corpuscles of human thymus and epidermis. |journal=Histochem. Cell Biol. |volume=114 |issue= 1 |pages= 9–14 |year= 2000 |pmid= 10959817 |doi= 10.1007/s004180000168 }}
*{{cite journal | author=Stratakis CA, Taymans SE |title=Structure of the gene coding for calcineurin B (PPP3R1) and mapping to D2S358-D2S1778 (chromosomal region 2p15). |journal=DNA Seq. |volume=9 |issue= 4 |pages= 227-30 |year= 1999 |pmid= 10520753 |doi=  }}
*{{cite journal   |vauthors=Sokal I, Li N, Verlinde CL, etal |title=Ca(2+)-binding proteins in the retina: from discovery to etiology of human disease(1). |journal=Biochim. Biophys. Acta |volume=1498 |issue= 2-3 |pages= 233–51 |year= 2001 |pmid= 11108966 |doi=  10.1016/S0167-4889(00)00099-9}}
*{{cite journal | author=Nishio H, Matsui K, Tsuji H, ''et al.'' |title=Immunolocalization of calcineurin and FKBP12, the FK506-binding protein, in Hassall's corpuscles of human thymus and epidermis. |journal=Histochem. Cell Biol. |volume=114 |issue= 1 |pages= 9-14 |year= 2000 |pmid= 10959817 |doi=  }}
*{{cite journal   |vauthors=Graef IA, Chen F, Chen L, etal |title=Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature. |journal=Cell |volume=105 |issue= 7 |pages= 863–75 |year= 2001 |pmid= 11439183 |doi=10.1016/S0092-8674(01)00396-8 }}
*{{cite journal | author=Sokal I, Li N, Verlinde CL, ''et al.'' |title=Ca(2+)-binding proteins in the retina: from discovery to etiology of human disease(1). |journal=Biochim. Biophys. Acta |volume=1498 |issue= 2-3 |pages= 233-51 |year= 2001 |pmid= 11108966 |doi= }}
*{{cite journal   |vauthors=Al-Daraji WI, Grant KR, Ryan K, etal |title=Localization of calcineurin/NFAT in human skin and psoriasis and inhibition of calcineurin/NFAT activation in human keratinocytes by cyclosporin A. |journal=J. Invest. Dermatol. |volume=118 |issue= 5 |pages= 779–88 |year= 2002 |pmid= 11982754 |doi= 10.1046/j.1523-1747.2002.01709.x }}
*{{cite journal | author=Graef IA, Chen F, Chen L, ''et al.'' |title=Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature. |journal=Cell |volume=105 |issue= 7 |pages= 863-75 |year= 2001 |pmid= 11439183 |doi=  }}
*{{cite journal   |vauthors=Huai Q, Kim HY, Liu Y, etal |title=Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 19 |pages= 12037–42 |year= 2002 |pmid= 12218175 |doi= 10.1073/pnas.192206699 | pmc=129394 }}
*{{cite journal  | author=Al-Daraji WI, Grant KR, Ryan K, ''et al.'' |title=Localization of calcineurin/NFAT in human skin and psoriasis and inhibition of calcineurin/NFAT activation in human keratinocytes by cyclosporin A. |journal=J. Invest. Dermatol. |volume=118 |issue= 5 |pages= 779-88 |year= 2002 |pmid= 11982754 |doi= 10.1046/j.1523-1747.2002.01709.x }}
*{{cite journal  | vauthors=Jin L, Harrison SC |title=Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 21 |pages= 13522–6 |year= 2002 |pmid= 12357034 |doi= 10.1073/pnas.212504399  | pmc=129706 }}
*{{cite journal | author=Huai Q, Kim HY, Liu Y, ''et al.'' |title=Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 19 |pages= 12037-42 |year= 2002 |pmid= 12218175 |doi= 10.1073/pnas.192206699 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  | author=Jin L, Harrison SC |title=Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 21 |pages= 13522-6 |year= 2002 |pmid= 12357034 |doi= 10.1073/pnas.212504399 }}
*{{cite journal  | vauthors=Bennasser Y, Badou A, Tkaczuk J, Bahraoui E |title=Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha. |journal=Virology |volume=303 |issue= 1 |pages= 174–80 |year= 2003 |pmid= 12482669 |doi=10.1006/viro.2002.1676  }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal | author=Bennasser Y, Badou A, Tkaczuk J, Bahraoui E |title=Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha. |journal=Virology |volume=303 |issue= 1 |pages= 174-80 |year= 2003 |pmid= 12482669 |doi= }}
*{{cite journal   |vauthors=Bittinger MA, McWhinnie E, Meltzer J, etal |title=Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins. |journal=Curr. Biol. |volume=14 |issue= 23 |pages= 2156–61 |year= 2005 |pmid= 15589160 |doi= 10.1016/j.cub.2004.11.002 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Hillier LW, Graves TA, Fulton RS, etal |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}
*{{cite journal | author=Bittinger MA, McWhinnie E, Meltzer J, ''et al.'' |title=Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins. |journal=Curr. Biol. |volume=14 |issue= 23 |pages= 2156-61 |year= 2005 |pmid= 15589160 |doi= 10.1016/j.cub.2004.11.002 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Hillier LW, Graves TA, Fulton RS, ''et al.'' |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724-31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}
*{{cite journal  | vauthors=Winslow MM, Gallo EM, Neilson JR, Crabtree GR |title=The calcineurin phosphatase complex modulates immunogenic B cell responses. |journal=Immunity |volume=24 |issue= 2 |pages= 141–52 |year= 2006 |pmid= 16473827 |doi= 10.1016/j.immuni.2005.12.013 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Liu Q, Wilkins BJ, Lee YJ, etal |title=Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth. |journal=Mol. Cell. Biol. |volume=26 |issue= 10 |pages= 3785–97 |year= 2006 |pmid= 16648474 |doi= 10.1128/MCB.26.10.3785-3797.2006 | pmc=1489013 }}
*{{cite journal  | author=Winslow MM, Gallo EM, Neilson JR, Crabtree GR |title=The calcineurin phosphatase complex modulates immunogenic B cell responses. |journal=Immunity |volume=24 |issue= 2 |pages= 141-52 |year= 2006 |pmid= 16473827 |doi= 10.1016/j.immuni.2005.12.013 }}
*{{cite journal  | author=Liu Q, Wilkins BJ, Lee YJ, ''et al.'' |title=Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth. |journal=Mol. Cell. Biol. |volume=26 |issue= 10 |pages= 3785-97 |year= 2006 |pmid= 16648474 |doi= 10.1128/MCB.26.10.3785-3797.2006 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=5534}}
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{{protein-stub}}
{{protein-stub}}
{{WikiDoc Sources}}
 
[[Category:EF-hand-containing proteins]]

Latest revision as of 18:36, 7 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

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Ensembl

n/a

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UniProt

n/a

n/a

RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Calcineurin subunit B type 1 also known as protein phosphatase 2B regulatory subunit 1 is a protein that in humans is encoded by the PPP3R1 gene.[1][2][3]

Clinical significance

The presence of a single nucleotide polymorphism rs1868402 in the PPP3R1 gene is strongly correlated with rapid progress of Alzheimer's disease.[4]

References

  1. ↑ Wang MG, Yi H, Guerini D, Klee CB, McBride OW (Jan 1997). "Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21→q22 and 2p16→p15 respectively". Cytogenet Cell Genet. 72 (2–3): 236–41. doi:10.1159/000134198. PMID 8978785.
  2. ↑ Guerini D, Krinks MH, Sikela JM, Hahn WE, Klee CB (Mar 1990). "Isolation and sequence of a cDNA clone for human calcineurin B, the Ca2+-binding subunit of the Ca2+/calmodulin-stimulated protein phosphatase". DNA. 8 (9): 675–82. doi:10.1089/dna.1.1989.8.675. PMID 2558868.
  3. ↑ "Entrez Gene: PPP3R1 protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform".
  4. ↑ Cruchaga C, Kauwe JS, Mayo K, Spiegel N, Bertelsen S, et al. (2010). Myers AJ, ed. "SNPs Associated with Cerebrospinal Fluid Phospho-Tau Levels Influence Rate of Decline in Alzheimer's Disease". PLoS Genet. 6 (9): e1001101. doi:10.1371/journal.pgen.1001101. PMC 2940763. PMID 20862329.

Further reading



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