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{{ | '''Protein arginine N-methyltransferase 2''' is an [[enzyme]] that in humans is encoded by the ''PRMT2'' [[gene]].<ref name="pmid9545638">{{cite journal |vauthors=Scott HS, Antonarakis SE, Lalioti MD, Rossier C, Silver PA, Henry MF | title = Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2) | journal = Genomics | volume = 48 | issue = 3 | pages = 330–40 |date=Jun 1998 | pmid = 9545638 | pmc = | doi = 10.1006/geno.1997.5190 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PRMT2 protein arginine methyltransferase 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3275| accessdate = }}</ref> | ||
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==Interactions== | |||
PRMT2 has been shown to [[Protein-protein interaction|interact]] with [[Estrogen receptor alpha]]<ref name=pmid12039952>{{cite journal |last=Qi |first=Chao |authorlink= |author2=Chang Jeffrey |author3=Zhu Yiwei |author4=Yeldandi Anjana V |author5=Rao Sambasiva M |author6=Zhu Yi-Jun |date=Aug 2002 |title=Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha |journal=J. Biol. Chem. |volume=277 |issue=32 |pages=28624–30 |publisher= |location = United States| issn = 0021-9258| pmid = 12039952 |doi = 10.1074/jbc.M201053200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[HNRPUL1]].<ref name=pmid11513728>{{cite journal |last=Kzhyshkowska |first=J |authorlink= |author2=Schütt H |author3=Liss M |author4=Kremmer E |author5=Stauber R |author6=Wolf H |author7=Dobner T |date=Sep 2001 |title=Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in its Arg-Gly-Gly (RGG) box and interacts with human arginine methyltransferase HRMT1L1 |journal=Biochem. J. |volume=358 |issue=Pt 2 |pages=305–14 |publisher= |location = England| issn = 0264-6021| pmid = 11513728 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1042/0264-6021:3580305 |pmc=1222062 }}</ref> | |||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | | *{{cite journal |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }} | ||
*{{cite journal | author=Andersson B | *{{cite journal | author=Andersson B |title=A "double adaptor" method for improved shotgun library construction |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 |name-list-format=vanc| author2=Wentland MA | author3=Ricafrente JY | display-authors=3 | last4=Liu | first4=W | last5=Gibbs | first5=RA }} | ||
*{{cite journal | author=Yu W | *{{cite journal | author=Yu W |title=Large-Scale Concatenation cDNA Sequencing |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi= 10.1101/gr.7.4.353| pmc=139146 |name-list-format=vanc| author2=Andersson B | author3=Worley KC | display-authors=3 | last4=Muzny | first4=DM | last5=Ding | first5=Y | last6=Liu | first6=W | last7=Ricafrente | first7=JY | last8=Wentland | first8=MA | last9=Lennon | first9=G }} | ||
*{{cite journal | | *{{cite journal |vauthors=Katsanis N, Yaspo ML, Fisher EM |title=Identification and mapping of a novel human gene, HRMT1L1, homologous to the rat protein arginine N-methyltransferase 1 (PRMT1) gene |journal=Mamm. Genome |volume=8 |issue= 7 |pages= 526–9 |year= 1997 |pmid= 9196002 |doi=10.1007/s003359900491 }} | ||
*{{cite journal | author=Suzuki Y | *{{cite journal | author=Suzuki Y |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |name-list-format=vanc| author2=Yoshitomo-Nakagawa K | author3=Maruyama K | display-authors=3 | last4=Suyama | first4=A | last5=Sugano | first5=S }} | ||
*{{cite journal | author=Hattori M |title=The DNA sequence of human chromosome 21 |journal=Nature |volume=405 |issue= 6784 |pages= 311–9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518 |name-list-format=vanc| author2=Fujiyama A | author3=Taylor TD | display-authors=3 | last4=Taylor | first4=T. D. | last5=Watanabe | first5=H. | last6=Yada | first6=T. | last7=Park | first7=H.-S. | last8=Toyoda | first8=A. | last9=Ishii | first9=K. }} | |||
*{{cite journal | author=Hattori M | *{{cite journal | author=Kzhyshkowska J |title=Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in its Arg-Gly-Gly (RGG) box and interacts with human arginine methyltransferase HRMT1L1 |journal=Biochem. J. |volume=358 |issue= Pt 2 |pages= 305–14 |year= 2001 |pmid= 11513728 |doi=10.1042/0264-6021:3580305 | pmc=1222062 |name-list-format=vanc| author2=Schütt H | author3=Liss M | display-authors=3 | last4=Kremmer | first4=Elisabeth | last5=Stauber | first5=Roland | last6=Wolf | first6=Hans | last7=Dobner | first7=Thomas }} | ||
*{{cite journal | author=Kzhyshkowska J | *{{cite journal | author=Qi C |title=Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha |journal=J. Biol. Chem. |volume=277 |issue= 32 |pages= 28624–30 |year= 2002 |pmid= 12039952 |doi= 10.1074/jbc.M201053200 |name-list-format=vanc| author2=Chang J | author3=Zhu Y | display-authors=3 | last4=Yeldandi | first4=AV | last5=Rao | first5=SM | last6=Zhu | first6=YJ }} | ||
*{{cite journal | author=Qi C | *{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }} | ||
*{{cite journal | author=Strausberg RL | *{{cite journal | author=Lehner B |title=Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region |journal=Genomics |volume=83 |issue= 1 |pages= 153–67 |year= 2004 |pmid= 14667819 |doi=10.1016/S0888-7543(03)00235-0 |name-list-format=vanc| author2=Semple JI | author3=Brown SE | display-authors=3 | last4=Counsell | first4=Damian | last5=Campbell | first5=R.Duncan | last6=Sanderson | first6=Christopher M }} | ||
*{{cite journal | author=Lehner B | *{{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki }} | ||
*{{cite journal | author=Ota T | *{{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-format=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }} | ||
*{{cite journal | author=Gerhard DS | *{{cite journal | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |name-list-format=vanc| author2=Venkatesan K | author3=Hao T | display-authors=3 | last4=Hirozane-Kishikawa | first4=Tomoko | last5=Dricot | first5=Amélie | last6=Li | first6=Ning | last7=Berriz | first7=Gabriel F. | last8=Gibbons | first8=Francis D. | last9=Dreze | first9=Matija }} | ||
*{{cite journal | author=Rual JF | *{{cite journal | author=Ganesh L |title=Protein Methyltransferase 2 Inhibits NF-κB Function and Promotes Apoptosis |journal=Mol. Cell. Biol. |volume=26 |issue= 10 |pages= 3864–74 |year= 2006 |pmid= 16648481 |doi= 10.1128/MCB.26.10.3864-3874.2006 | pmc=1488990 |name-list-format=vanc| author2=Yoshimoto T | author3=Moorthy NC | display-authors=3 | last4=Akahata | first4=W. | last5=Boehm | first5=M. | last6=Nabel | first6=E. G. | last7=Nabel | first7=G. J. }} | ||
*{{cite journal | author=Ganesh L | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
{{PDB Gallery|geneid=3275}} | |||
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{{gene-21-stub}} | {{gene-21-stub}} | ||
Revision as of 18:43, 7 September 2017
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Species | Human | Mouse | |||||
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Ensembl |
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UniProt |
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RefSeq (mRNA) |
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Location (UCSC) | n/a | n/a | |||||
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Protein arginine N-methyltransferase 2 is an enzyme that in humans is encoded by the PRMT2 gene.[1][2]
Interactions
PRMT2 has been shown to interact with Estrogen receptor alpha[3] and HNRPUL1.[4]
References
- ↑ Scott HS, Antonarakis SE, Lalioti MD, Rossier C, Silver PA, Henry MF (Jun 1998). "Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2)". Genomics. 48 (3): 330–40. doi:10.1006/geno.1997.5190. PMID 9545638.
- ↑ "Entrez Gene: PRMT2 protein arginine methyltransferase 2".
- ↑ Qi, Chao; Chang Jeffrey; Zhu Yiwei; Yeldandi Anjana V; Rao Sambasiva M; Zhu Yi-Jun (Aug 2002). "Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha". J. Biol. Chem. United States. 277 (32): 28624–30. doi:10.1074/jbc.M201053200. ISSN 0021-9258. PMID 12039952.
- ↑ Kzhyshkowska, J; Schütt H; Liss M; Kremmer E; Stauber R; Wolf H; Dobner T (Sep 2001). "Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in its Arg-Gly-Gly (RGG) box and interacts with human arginine methyltransferase HRMT1L1". Biochem. J. England. 358 (Pt 2): 305–14. doi:10.1042/0264-6021:3580305. ISSN 0264-6021. PMC 1222062. PMID 11513728.
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
- Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
- Katsanis N, Yaspo ML, Fisher EM (1997). "Identification and mapping of a novel human gene, HRMT1L1, homologous to the rat protein arginine N-methyltransferase 1 (PRMT1) gene". Mamm. Genome. 8 (7): 526–9. doi:10.1007/s003359900491. PMID 9196002.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.
- Kzhyshkowska J, Schütt H, Liss M, et al. (2001). "Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in its Arg-Gly-Gly (RGG) box and interacts with human arginine methyltransferase HRMT1L1". Biochem. J. 358 (Pt 2): 305–14. doi:10.1042/0264-6021:3580305. PMC 1222062. PMID 11513728.
- Qi C, Chang J, Zhu Y, et al. (2002). "Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha". J. Biol. Chem. 277 (32): 28624–30. doi:10.1074/jbc.M201053200. PMID 12039952.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Ganesh L, Yoshimoto T, Moorthy NC, et al. (2006). "Protein Methyltransferase 2 Inhibits NF-κB Function and Promotes Apoptosis". Mol. Cell. Biol. 26 (10): 3864–74. doi:10.1128/MCB.26.10.3864-3874.2006. PMC 1488990. PMID 16648481.
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