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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Ras-related protein Rab-8A''' is a [[protein]] that in humans is encoded by the ''RAB8A'' [[gene]].<ref name="pmid1886711">{{cite journal | vauthors = Nimmo ER, Sanders PG, Padua RA, Hughes D, Williamson R, Johnson KJ | title = The MEL gene: a new member of the RAB/YPT class of RAS-related genes | journal = Oncogene | volume = 6 | issue = 8 | pages = 1347–51 | date = Aug 1991 | pmid = 1886711 | pmc =  | doi =  }}</ref><ref name="pmid8408203">{{cite journal | vauthors = Huber LA, Pimplikar S, Parton RG, Virta H, Zerial M, Simons K | title = Rab8, a small GTPase involved in vesicular traffic between the TGN and the basolateral plasma membrane | journal = The Journal of Cell Biology | volume = 123 | issue = 1 | pages = 35–45 | date = Oct 1993 | pmid = 8408203 | pmc = 2119815 | doi = 10.1083/jcb.123.1.35 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RAB8A RAB8A, member RAS oncogene family| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4218| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_RAB8A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2fu5.
| PDB = {{PDB2|2fu5}}
| Name = RAB8A, member RAS oncogene family
| HGNCid = 7007
| Symbol = RAB8A
| AltSymbols =; MEL; RAB8
| OMIM = 165040
| ECnumber = 
| Homologene = 21111
| MGIid = 96960
| GeneAtlas_image1 = PBB_GE_RAB8A_208819_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007264 |text = small GTPase mediated signal transduction}} {{GNF_GO|id=GO:0015031 |text = protein transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4218
    | Hs_Ensembl = ENSG00000167461
    | Hs_RefseqProtein = NP_005361
    | Hs_RefseqmRNA = NM_005370
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 16083467
    | Hs_GenLoc_end = 16106037
    | Hs_Uniprot = P61006
    | Mm_EntrezGene = 17274
    | Mm_Ensembl = ENSMUSG00000003037
    | Mm_RefseqmRNA = XM_981797
    | Mm_RefseqProtein = XP_986891
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 75090189
    | Mm_GenLoc_end = 75110349
    | Mm_Uniprot = Q0PD50
  }}
}}
'''RAB8A, member RAS oncogene family''', also known as '''RAB8A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RAB8A RAB8A, member RAS oncogene family| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4218| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrated. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1.<ref name="entrez">{{cite web | title = Entrez Gene: RAB8A RAB8A, member RAS oncogene family| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4218| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
RAB8A has been shown to [[Protein-protein interaction|interact]] with [[Optineurin]]<ref name=pmid11137014>{{cite journal | vauthors = Hattula K, Peränen J | title = FIP-2, a coiled-coil protein, links Huntingtin to Rab8 and modulates cellular morphogenesis | journal = Current Biology | volume = 10 | issue = 24 | pages = 1603–6 | year = 2000 | pmid = 11137014 | doi = 10.1016/S0960-9822(00)00864-2 }}</ref> and [[MAP4K2]].<ref name=pmid8643544>{{cite journal | vauthors = Ren M, Zeng J, De Lemos-Chiarandini C, Rosenfeld M, Adesnik M, Sabatini DD | title = In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 10 | pages = 5151–5 | date = May 1996 | pmid = 8643544 | pmc = 39423 | doi = 10.1073/pnas.93.10.5151 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Newport J, Roemer MI | title = Comparative perinatal mortality under medical care foundations and other delivery models | journal = Inquiry | volume = 12 | issue = 1 | pages = 10–7 | date = Mar 1975 | pmid = 123217 | doi =  }}
| citations =
* {{cite journal | vauthors = Nimmo E, Padua RA, Hughes D, Brook JD, Williamson R, Johnson KJ | title = Confirmation and refinement of the localisation of the c-MEL locus on chromosome 19 by physical and genetic mapping | journal = Human Genetics | volume = 81 | issue = 4 | pages = 382–4 | date = Mar 1989 | pmid = 2564840 | doi = 10.1007/BF00283697 }}
*{{cite journal | author=Newport J, Roemer MI |title=Comparative perinatal mortality under medical care foundations and other delivery models. |journal=Inquiry : a journal of medical care organization, provision and financing |volume=12 |issue= 1 |pages= 10-7 |year= 1975 |pmid= 123217 |doi=  }}
* {{cite journal | vauthors = Zahraoui A, Joberty G, Arpin M, Fontaine JJ, Hellio R, Tavitian A, Louvard D | title = A small rab GTPase is distributed in cytoplasmic vesicles in non polarized cells but colocalizes with the tight junction marker ZO-1 in polarized epithelial cells | journal = The Journal of Cell Biology | volume = 124 | issue = 1-2 | pages = 101–15 | date = Jan 1994 | pmid = 8294494 | pmc = 2119893 | doi = 10.1083/jcb.124.1.101 }}
*{{cite journal | author=Nimmo ER, Sanders PG, Padua RA, ''et al.'' |title=The MEL gene: a new member of the RAB/YPT class of RAS-related genes. |journal=Oncogene |volume=6 |issue= 8 |pages= 1347-51 |year= 1991 |pmid= 1886711 |doi=  }}
* {{cite journal | vauthors = Joberty G, Tavitian A, Zahraoui A | title = Isoprenylation of Rab proteins possessing a C-terminal CaaX motif | journal = FEBS Letters | volume = 330 | issue = 3 | pages = 323–8 | date = Sep 1993 | pmid = 8375503 | doi = 10.1016/0014-5793(93)80897-4 }}
*{{cite journal  | author=Nimmo E, Padua RA, Hughes D, ''et al.'' |title=Confirmation and refinement of the localisation of the c-MEL locus on chromosome 19 by physical and genetic mapping. |journal=Hum. Genet. |volume=81 |issue= 4 |pages= 382-4 |year= 1989 |pmid= 2564840 |doi= }}
* {{cite journal | vauthors = Ren M, Zeng J, De Lemos-Chiarandini C, Rosenfeld M, Adesnik M, Sabatini DD | title = In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 10 | pages = 5151–5 | date = May 1996 | pmid = 8643544 | pmc = 39423 | doi = 10.1073/pnas.93.10.5151 }}
*{{cite journal | author=Zahraoui A, Joberty G, Arpin M, ''et al.'' |title=A small rab GTPase is distributed in cytoplasmic vesicles in non polarized cells but colocalizes with the tight junction marker ZO-1 in polarized epithelial cells. |journal=J. Cell Biol. |volume=124 |issue= 1-2 |pages= 101-15 |year= 1994 |pmid= 8294494 |doi= }}
* {{cite journal | vauthors = Bähler M, Kehrer I, Gordon L, Stoffler HE, Olsen AS | title = Physical mapping of human myosin-IXB (MYO9B), the human orthologue of the rat myosin myr 5, to chromosome 19p13.1 | journal = Genomics | volume = 43 | issue = 1 | pages = 107–9 | date = Jul 1997 | pmid = 9226381 | doi = 10.1006/geno.1997.4776 }}
*{{cite journal | author=Joberty G, Tavitian A, Zahraoui A |title=Isoprenylation of Rab proteins possessing a C-terminal CaaX motif. |journal=FEBS Lett. |volume=330 |issue= 3 |pages= 323-8 |year= 1993 |pmid= 8375503 |doi= }}
* {{cite journal | vauthors = Wilson AL, Erdman RA, Castellano F, Maltese WA | title = Prenylation of Rab8 GTPase by type I and type II geranylgeranyl transferases | journal = The Biochemical Journal | volume = 333 ( Pt 3) | issue = Pt 3 | pages = 497–504 | date = Aug 1998 | pmid = 9677305 | pmc = 1219609 | doi =  }}
*{{cite journal  | author=Huber LA, Pimplikar S, Parton RG, ''et al.'' |title=Rab8, a small GTPase involved in vesicular traffic between the TGN and the basolateral plasma membrane. |journal=J. Cell Biol. |volume=123 |issue= 1 |pages= 35-45 |year= 1993 |pmid= 8408203 |doi=  }}
* {{cite journal | vauthors = Bao S, Zhu J, Garvey WT | title = Cloning of Rab GTPases expressed in human skeletal muscle: studies in insulin-resistant subjects | journal = Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme | volume = 30 | issue = 11 | pages = 656–62 | date = Nov 1998 | pmid = 9918381 | doi = 10.1055/s-2007-978953 }}
*{{cite journal | author=Ren M, Zeng J, De Lemos-Chiarandini C, ''et al.'' |title=In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 10 |pages= 5151-5 |year= 1996 |pmid= 8643544 |doi= }}
* {{cite journal | vauthors = Shisheva A, Chinni SR, DeMarco C | title = General role of GDP dissociation inhibitor 2 in membrane release of Rab proteins: modulations of its functional interactions by in vitro and in vivo structural modifications | journal = Biochemistry | volume = 38 | issue = 36 | pages = 11711–21 | date = Sep 1999 | pmid = 10512627 | doi = 10.1021/bi990200r }}
*{{cite journal | author=Bähler M, Kehrer I, Gordon L, ''et al.'' |title=Physical mapping of human myosin-IXB (MYO9B), the human orthologue of the rat myosin myr 5, to chromosome 19p13.1. |journal=Genomics |volume=43 |issue= 1 |pages= 107-9 |year= 1997 |pmid= 9226381 |doi= 10.1006/geno.1997.4776 }}
* {{cite journal | vauthors = Hattula K, Peränen J | title = FIP-2, a coiled-coil protein, links Huntingtin to Rab8 and modulates cellular morphogenesis | journal = Current Biology | volume = 10 | issue = 24 | pages = 1603–6 | year = 2001 | pmid = 11137014 | doi = 10.1016/S0960-9822(00)00864-2 }}
*{{cite journal | author=Wilson AL, Erdman RA, Castellano F, Maltese WA |title=Prenylation of Rab8 GTPase by type I and type II geranylgeranyl transferases. |journal=Biochem. J. |volume=333 ( Pt 3) |issue= |pages= 497-504 |year= 1998 |pmid= 9677305 |doi=  }}
* {{cite journal | vauthors = Kuroda TS, Fukuda M, Ariga H, Mikoshiba K | title = The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain | journal = The Journal of Biological Chemistry | volume = 277 | issue = 11 | pages = 9212–8 | date = Mar 2002 | pmid = 11773082 | doi = 10.1074/jbc.M112414200 }}
*{{cite journal | author=Bao S, Zhu J, Garvey WT |title=Cloning of Rab GTPases expressed in human skeletal muscle: studies in insulin-resistant subjects. |journal=Horm. Metab. Res. |volume=30 |issue= 11 |pages= 656-62 |year= 1999 |pmid= 9918381 |doi= }}
* {{cite journal | vauthors = Hattula K, Furuhjelm J, Arffman A, Peränen J | title = A Rab8-specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport | journal = Molecular Biology of the Cell | volume = 13 | issue = 9 | pages = 3268–80 | date = Sep 2002 | pmid = 12221131 | pmc = 124888 | doi = 10.1091/mbc.E02-03-0143 }}
*{{cite journal | author=Shisheva A, Chinni SR, DeMarco C |title=General role of GDP dissociation inhibitor 2 in membrane release of Rab proteins: modulations of its functional interactions by in vitro and in vivo structural modifications. |journal=Biochemistry |volume=38 |issue= 36 |pages= 11711-21 |year= 1999 |pmid= 10512627 |doi= }}
* {{cite journal | vauthors = Fukuda M | title = Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2 | journal = The Journal of Biological Chemistry | volume = 278 | issue = 17 | pages = 15373–80 | date = Apr 2003 | pmid = 12578829 | doi = 10.1074/jbc.M212341200 }}
*{{cite journal | author=Hattula K, Peränen J |title=FIP-2, a coiled-coil protein, links Huntingtin to Rab8 and modulates cellular morphogenesis. |journal=Curr. Biol. |volume=10 |issue= 24 |pages= 1603-6 |year= 2001 |pmid= 11137014 |doi= }}
* {{cite journal | vauthors = Lau AS, Mruk DD | title = Rab8B GTPase and junction dynamics in the testis | journal = Endocrinology | volume = 144 | issue = 4 | pages = 1549–63 | date = Apr 2003 | pmid = 12639940 | doi = 10.1210/en.2002-220893 }}
*{{cite journal | author=Kuroda TS, Fukuda M, Ariga H, Mikoshiba K |title=The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain. |journal=J. Biol. Chem. |volume=277 |issue= 11 |pages= 9212-8 |year= 2002 |pmid= 11773082 |doi= 10.1074/jbc.M112414200 }}
* {{cite journal | vauthors = Linder MD, Uronen RL, Hölttä-Vuori M, van der Sluijs P, Peränen J, Ikonen E | title = Rab8-dependent recycling promotes endosomal cholesterol removal in normal and sphingolipidosis cells | journal = Molecular Biology of the Cell | volume = 18 | issue = 1 | pages = 47–56 | date = Jan 2007 | pmid = 17050734 | pmc = 1751315 | doi = 10.1091/mbc.E06-07-0575 }}
*{{cite journal | author=Hattula K, Furuhjelm J, Arffman A, Peränen J |title=A Rab8-specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport. |journal=Mol. Biol. Cell |volume=13 |issue= 9 |pages= 3268-80 |year= 2003 |pmid= 12221131 |doi= 10.1091/mbc.E02-03-0143 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Fukuda M |title=Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2. |journal=J. Biol. Chem. |volume=278 |issue= 17 |pages= 15373-80 |year= 2003 |pmid= 12578829 |doi= 10.1074/jbc.M212341200 }}
*{{cite journal | author=Lau AS, Mruk DD |title=Rab8B GTPase and junction dynamics in the testis. |journal=Endocrinology |volume=144 |issue= 4 |pages= 1549-63 |year= 2003 |pmid= 12639940 |doi=  }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Linder MD, Uronen RL, Hölttä-Vuori M, ''et al.'' |title=Rab8-dependent recycling promotes endosomal cholesterol removal in normal and sphingolipidosis cells. |journal=Mol. Biol. Cell |volume=18 |issue= 1 |pages= 47-56 |year= 2007 |pmid= 17050734 |doi= 10.1091/mbc.E06-07-0575 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=4218}}
{{WikiDoc Sources}}
 
{{gene-19-stub}}

Latest revision as of 08:48, 10 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ras-related protein Rab-8A is a protein that in humans is encoded by the RAB8A gene.[1][2][3]

Function

The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrated. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1.[3]

Interactions

RAB8A has been shown to interact with Optineurin[4] and MAP4K2.[5]

References

  1. ↑ Nimmo ER, Sanders PG, Padua RA, Hughes D, Williamson R, Johnson KJ (Aug 1991). "The MEL gene: a new member of the RAB/YPT class of RAS-related genes". Oncogene. 6 (8): 1347–51. PMID 1886711.
  2. ↑ Huber LA, Pimplikar S, Parton RG, Virta H, Zerial M, Simons K (Oct 1993). "Rab8, a small GTPase involved in vesicular traffic between the TGN and the basolateral plasma membrane". The Journal of Cell Biology. 123 (1): 35–45. doi:10.1083/jcb.123.1.35. PMC 2119815. PMID 8408203.
  3. ↑ 3.0 3.1 "Entrez Gene: RAB8A RAB8A, member RAS oncogene family".
  4. ↑ Hattula K, Peränen J (2000). "FIP-2, a coiled-coil protein, links Huntingtin to Rab8 and modulates cellular morphogenesis". Current Biology. 10 (24): 1603–6. doi:10.1016/S0960-9822(00)00864-2. PMID 11137014.
  5. ↑ Ren M, Zeng J, De Lemos-Chiarandini C, Rosenfeld M, Adesnik M, Sabatini DD (May 1996). "In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase". Proceedings of the National Academy of Sciences of the United States of America. 93 (10): 5151–5. doi:10.1073/pnas.93.10.5151. PMC 39423. PMID 8643544.

Further reading

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