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{{Infobox_gene}}
{{PBB_Controls
'''Ran-binding protein 3''' is a [[protein]] that in humans is encoded by the ''RANBP3'' [[gene]].<ref name="pmid9637251">{{cite journal |vauthors=Mueller L, Cordes VC, Bischoff FR, Ponstingl H | title = Human RanBP3, a group of nuclear RanGTP binding proteins | journal = FEBS Lett | volume = 427 | issue = 3 | pages = 330–6 |date=July 1998 | pmid = 9637251 | pmc =  | doi =10.1016/S0014-5793(98)00459-1 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RANBP3 RAN binding protein 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8498| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_RANBP3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2crf.
| PDB = {{PDB2|2crf}}
| Name = RAN binding protein 3
| HGNCid = 9850
| Symbol = RANBP3
| AltSymbols =; DKFZp586I1520
| OMIM = 603327
| ECnumber = 
| Homologene = 37828
| MGIid = 1919060
| GeneAtlas_image1 = PBB_GE_RANBP3_202639_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_RANBP3_202640_s_at_tn.png
  | GeneAtlas_image3 = PBB_GE_RANBP3_210120_s_at_tn.png
  | Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008536 |text = Ran GTPase binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005643 |text = nuclear pore}}
| Process = {{GNF_GO|id=GO:0007264 |text = small GTPase mediated signal transduction}} {{GNF_GO|id=GO:0015031 |text = protein transport}} {{GNF_GO|id=GO:0046907 |text = intracellular transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8498
    | Hs_Ensembl = ENSG00000031823
    | Hs_RefseqProtein = NP_003615
    | Hs_RefseqmRNA = NM_003624
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 5868120
    | Hs_GenLoc_end = 5929151
    | Hs_Uniprot = Q9H6Z4
    | Mm_EntrezGene = 71810
    | Mm_Ensembl = ENSMUSG00000002372
    | Mm_RefseqmRNA = NM_027933
    | Mm_RefseqProtein = NP_082209
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 56358482
    | Mm_GenLoc_end = 56396885
    | Mm_Uniprot = Q9CT10
  }}
}}
'''RAN binding protein 3''', also known as '''RANBP3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RANBP3 RAN binding protein 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8498| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =
| summary_text = This gene encodes a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. This protein plays a role in nuclear export as part of a heteromeric complex. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.<ref name="entrez">{{cite web | title = Entrez Gene: RANBP3 RAN binding protein 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8498| accessdate = }}</ref>
| summary_text = This gene encodes a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. This protein plays a role in nuclear export as part of a heteromeric complex. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.<ref name="entrez" />
}}
}}
==Interactions==
RANBP3 has been shown to [[Protein-protein interaction|interact]] with [[RCC1]]<ref name=pmid9637251 /><ref name=pmid11932251>{{cite journal |last=Nemergut |first=Michael E |authorlink= |author2=Lindsay Mark E |author3=Brownawell Amy M |author4=Macara Ian G  |date=May 2002 |title=Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor |journal=J. Biol. Chem. |volume=277 |issue=20 |pages=17385–8 |publisher= |location = United States| issn = 0021-9258| pmid = 11932251 |doi = 10.1074/jbc.C100620200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[XPO1]].<ref name=pmid11425870>{{cite journal |doi=10.1083/jcb.153.7.1391 |last=Lindsay |first=M E |authorlink= |author2=Holaska J M |author3=Welch K |author4=Paschal B M |author5=Macara I G  |date=June 2001 |title=Ran-binding protein 3 is a cofactor for Crm1-mediated nuclear protein export |journal=J. Cell Biol. |volume=153 |issue=7 |pages=1391–402 |publisher= |location = United States| issn = 0021-9525| pmid = 11425870 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=2150735 }}</ref><ref name=pmid12176322>{{cite journal |doi=10.1016/S0092-8674(02)00836-X |last=Lindsay |first=Mark E |authorlink= |author2=Plafker Kendra |author3=Smith Alicia E |author4=Clurman Bruce E |author5=Macara Ian G  |date=August 2002 |title=Npap60/Nup50 is a tri-stable switch that stimulates importin-alpha:beta-mediated nuclear protein import |journal=Cell |volume=110 |issue=3 |pages=349–60 |publisher= |location = United States| issn = 0092-8674| pmid = 12176322 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==References==
==References==
{{reflist|2}}
{{Reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{Refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading
| citations =  
| citations =
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  }}
*{{cite journal  | author=Mueller L, Cordes VC, Bischoff FR, Ponstingl H |title=Human RanBP3, a group of nuclear RanGTP binding proteins. |journal=FEBS Lett. |volume=427 |issue= 3 |pages= 330-6 |year= 1998 |pmid= 9637251 |doi= }}
*{{cite journal   |vauthors=Lindsay ME, Holaska JM, Welch K, etal |title=Ran-binding protein 3 is a cofactor for Crm1-mediated nuclear protein export. |journal=J. Cell Biol. |volume=153 |issue= 7 |pages= 1391–402 |year= 2001 |pmid= 11425870 |doi=10.1083/jcb.153.7.1391  | pmc=2150735 }}
*{{cite journal | author=Lindsay ME, Holaska JM, Welch K, ''et al.'' |title=Ran-binding protein 3 is a cofactor for Crm1-mediated nuclear protein export. |journal=J. Cell Biol. |volume=153 |issue= 7 |pages= 1391-402 |year= 2001 |pmid= 11425870 |doi=  }}
*{{cite journal   |vauthors=Englmeier L, Fornerod M, Bischoff FR, etal |title=RanBP3 influences interactions between CRM1 and its nuclear protein export substrates. |journal=EMBO Rep. |volume=2 |issue= 10 |pages= 926–32 |year= 2002 |pmid= 11571268 |doi= 10.1093/embo-reports/kve200 | pmc=1084078 }}
*{{cite journal | author=Englmeier L, Fornerod M, Bischoff FR, ''et al.'' |title=RanBP3 influences interactions between CRM1 and its nuclear protein export substrates. |journal=EMBO Rep. |volume=2 |issue= 10 |pages= 926-32 |year= 2002 |pmid= 11571268 |doi= 10.1093/embo-reports/kve200 }}
*{{cite journal  |vauthors=Nemergut ME, Lindsay ME, Brownawell AM, Macara IG |title=Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor. |journal=J. Biol. Chem. |volume=277 |issue= 20 |pages= 17385–8 |year= 2002 |pmid= 11932251 |doi= 10.1074/jbc.C100620200 }}
*{{cite journal  | author=Nemergut ME, Lindsay ME, Brownawell AM, Macara IG |title=Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor. |journal=J. Biol. Chem. |volume=277 |issue= 20 |pages= 17385-8 |year= 2002 |pmid= 11932251 |doi= 10.1074/jbc.C100620200 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Hakata Y, Yamada M, Shida H |title=A multifunctional domain in human CRM1 (exportin 1) mediates RanBP3 binding and multimerization of human T-cell leukemia virus type 1 Rex protein. |journal=Mol. Cell. Biol. |volume=23 |issue= 23 |pages= 8751–61 |year= 2003 |pmid= 14612415 |doi=10.1128/MCB.23.23.8751-8761.2003  | pmc=262658 }}
*{{cite journal  | author=Hakata Y, Yamada M, Shida H |title=A multifunctional domain in human CRM1 (exportin 1) mediates RanBP3 binding and multimerization of human T-cell leukemia virus type 1 Rex protein. |journal=Mol. Cell. Biol. |volume=23 |issue= 23 |pages= 8751-61 |year= 2003 |pmid= 14612415 |doi=  }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Grimwood J, Gordon LA, Olsen A, etal |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 }}
*{{cite journal | author=Grimwood J, Gordon LA, Olsen A, ''et al.'' |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529-35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal   |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
}}
{{refend}}
{{Refend}}
{{PDB Gallery|geneid=8498}}
 
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Revision as of 08:53, 10 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ran-binding protein 3 is a protein that in humans is encoded by the RANBP3 gene.[1][2]

This gene encodes a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. This protein plays a role in nuclear export as part of a heteromeric complex. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[2]

Interactions

RANBP3 has been shown to interact with RCC1[1][3] and XPO1.[4][5]

References

  1. ↑ 1.0 1.1 Mueller L, Cordes VC, Bischoff FR, Ponstingl H (July 1998). "Human RanBP3, a group of nuclear RanGTP binding proteins". FEBS Lett. 427 (3): 330–6. doi:10.1016/S0014-5793(98)00459-1. PMID 9637251.
  2. ↑ 2.0 2.1 "Entrez Gene: RANBP3 RAN binding protein 3".
  3. ↑ Nemergut, Michael E; Lindsay Mark E; Brownawell Amy M; Macara Ian G (May 2002). "Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor". J. Biol. Chem. United States. 277 (20): 17385–8. doi:10.1074/jbc.C100620200. ISSN 0021-9258. PMID 11932251.
  4. ↑ Lindsay, M E; Holaska J M; Welch K; Paschal B M; Macara I G (June 2001). "Ran-binding protein 3 is a cofactor for Crm1-mediated nuclear protein export". J. Cell Biol. United States. 153 (7): 1391–402. doi:10.1083/jcb.153.7.1391. ISSN 0021-9525. PMC 2150735. PMID 11425870.
  5. ↑ Lindsay, Mark E; Plafker Kendra; Smith Alicia E; Clurman Bruce E; Macara Ian G (August 2002). "Npap60/Nup50 is a tri-stable switch that stimulates importin-alpha:beta-mediated nuclear protein import". Cell. United States. 110 (3): 349–60. doi:10.1016/S0092-8674(02)00836-X. ISSN 0092-8674. PMID 12176322.

Further reading



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