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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Putative RNA-binding protein 3''' is a [[protein]] that in humans is encoded by the ''RBM3'' [[gene]].<ref name="pmid8634703">{{cite journal | vauthors = Derry JM, Kerns JA, Francke U | title = RBM3, a novel human gene in Xp11.23 with a putative RNA-binding domain | journal = Human Molecular Genetics | volume = 4 | issue = 12 | pages = 2307–11 | date = December 1995 | pmid = 8634703 | pmc = | doi = 10.1093/hmg/4.12.2307 }}</ref><ref name="entrez"/>
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = RNA binding motif (RNP1, RRM) protein 3
| HGNCid = 9900
| Symbol = RBM3
| AltSymbols =; IS1-RNPL; RNPL
| OMIM = 300027
| ECnumber = 
| Homologene = 31404
| MGIid = 1099460
| GeneAtlas_image1 = PBB_GE_RBM3_208319_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}}
| Component =
| Process = {{GNF_GO|id=GO:0006396 |text = RNA processing}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5935
    | Hs_Ensembl = ENSG00000102317
    | Hs_RefseqProtein = NP_001017430
    | Hs_RefseqmRNA = NM_001017430
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 48317780
    | Hs_GenLoc_end = 48322398
    | Hs_Uniprot = P98179
    | Mm_EntrezGene = 19652
    | Mm_Ensembl = ENSMUSG00000031167
    | Mm_RefseqmRNA = NM_016809
    | Mm_RefseqProtein = NP_058089
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 7297026
    | Mm_GenLoc_end = 7302656
    | Mm_Uniprot = Q545K5
  }}
}}
'''RNA binding motif (RNP1, RRM) protein 3''', also known as '''RBM3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RBM3 RNA binding motif (RNP1, RRM) protein 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5935| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene is a member of the [[glycine]]-rich RNA-binding protein family and encodes a protein with one RNA recognition motif (RRM) domain. Expression of this gene is induced by cold shock and low oxygen tension. A [[pseudogene]] exists on chromosome 1. Alternate transcriptional splice variants, encoding different [[isoforms]], have been characterized.<ref name="entrez">{{cite web | title = Entrez Gene: RBM3 RNA binding motif (RNP1, RRM) protein 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5935| accessdate = }}</ref>
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the [[glycine]]-rich RNA-binding protein family and encodes a protein with one RNA recognition motif (RRM) domain. Expression of this gene is induced by cold shock and low oxygen tension. A [[pseudogene]] exists on chromosome 1. Alternate transcriptional splice variants, encoding different [[isoforms]], have been characterized.<ref name="entrez">{{cite web | title = Entrez Gene: RBM3 RNA binding motif (RNP1, RRM) protein 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5935| accessdate = }}</ref>
}}


==References==
RBM3 is cold-induced RNA binding protein and is involved in mRNA biogenesis exerts anti-[[apoptotic]] effects.<ref name="Zhou_2017"/> According to [[antibody]]-based profiling and [[Transcriptomics_technologies|transcriptomics]] analysis, RBM3 protein is present in all analysed human tissues<ref>{{cite web | title = Tissue expression of RBM3 - Summary | work = The Human Protein Atlas | url = http://www.proteinatlas.org/ENSG00000102317-RBM3/tissue }}</ref> and based on [[confocal microscopy]] mainly localised to the [[nucleoplasm]].<ref>{{cite web | title = Cell atlas - RBM3 | work = The Human Protein Atlas | url = http://www.proteinatlas.org/ENSG00000102317-RBM3/cell }}</ref>
{{reflist|2}}
 
==Further reading==
== Clinical significance ==
 
RBM3 is a [[proto-oncogene]] that is associated with tumor progression and metastasis and is a potential cancer [[biomarker]].<ref name="Zhou_2017">{{cite journal | vauthors = Zhou RB, Lu XL, Zhang CY, Yin DC | title = RNA binding motif protein 3: a potential biomarker in cancer and therapeutic target in neuroprotection | journal = Oncotarget | volume = 8 | issue = 13 | pages = 22235–22250 | date = March 2017 | pmid = 28118608 | pmc = 5400660 | doi = 10.18632/oncotarget.14755 }}</ref> Based on patient survival data, high levels of RBM3 protein in tumor cells is a favourable [[Biomarker_(medicine)|prognostic biomarker]] in [[colorectal cancer]].<ref>{{cite web | title = Expression of RBM3 in cancer - Summary | work = The Human Protein Atlas|url=http://www.proteinatlas.org/ENSG00000102317-RBM3/pathology }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Danno S, Nishiyama H, Higashitsuji H, Yokoi H, Xue JH, Itoh K, Matsuda T, Fujita J | title = Increased transcript level of RBM3, a member of the glycine-rich RNA-binding protein family, in human cells in response to cold stress | journal = Biochemical and Biophysical Research Communications | volume = 236 | issue = 3 | pages = 804–7 | date = July 1997 | pmid = 9245737 | doi = 10.1006/bbrc.1997.7059 }}
| citations =
* {{cite journal | vauthors = Chappell SA, Mauro VP | title = The internal ribosome entry site (IRES) contained within the RNA-binding motif protein 3 (Rbm3) mRNA is composed of functionally distinct elements | journal = The Journal of Biological Chemistry | volume = 278 | issue = 36 | pages = 33793–800 | date = September 2003 | pmid = 12824175 | doi = 10.1074/jbc.M303495200 }}
*{{cite journal  | author=Derry JM, Kerns JA, Francke U |title=RBM3, a novel human gene in Xp11.23 with a putative RNA-binding domain. |journal=Hum. Mol. Genet. |volume=4 |issue= 12 |pages= 2307-11 |year= 1996 |pmid= 8634703 |doi=  }}
* {{cite journal | vauthors = Wellmann S, Bührer C, Moderegger E, Zelmer A, Kirschner R, Koehne P, Fujita J, Seeger K | title = Oxygen-regulated expression of the RNA-binding proteins RBM3 and CIRP by a HIF-1-independent mechanism | journal = Journal of Cell Science | volume = 117 | issue = Pt 9 | pages = 1785–94 | date = April 2004 | pmid = 15075239 | doi = 10.1242/jcs.01026 }}
*{{cite journal | author=Danno S, Nishiyama H, Higashitsuji H, ''et al.'' |title=Increased transcript level of RBM3, a member of the glycine-rich RNA-binding protein family, in human cells in response to cold stress. |journal=Biochem. Biophys. Res. Commun. |volume=236 |issue= 3 |pages= 804-7 |year= 1997 |pmid= 9245737 |doi= 10.1006/bbrc.1997.7059 }}
* {{cite journal | vauthors = Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC | title = Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry | journal = Analytical Chemistry | volume = 76 | issue = 10 | pages = 2763–72 | date = May 2004 | pmid = 15144186 | doi = 10.1021/ac035352d }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Dellis S, Strickland KC, McCrary WJ, Patel A, Stocum E, Wright CF | title = Protein interactions among the vaccinia virus late transcription factors | journal = Virology | volume = 329 | issue = 2 | pages = 328–36 | date = November 2004 | pmid = 15518812 | doi = 10.1016/j.virol.2004.08.017 }}
*{{cite journal  | author=Chappell SA, Mauro VP |title=The internal ribosome entry site (IRES) contained within the RNA-binding motif protein 3 (Rbm3) mRNA is composed of functionally distinct elements. |journal=J. Biol. Chem. |volume=278 |issue= 36 |pages= 33793-800 |year= 2003 |pmid= 12824175 |doi= 10.1074/jbc.M303495200 }}
* {{cite journal | vauthors = Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M | title = Nucleolar proteome dynamics | journal = Nature | volume = 433 | issue = 7021 | pages = 77–83 | date = January 2005 | pmid = 15635413 | doi = 10.1038/nature03207 }}
*{{cite journal | author=Wellmann S, Bührer C, Moderegger E, ''et al.'' |title=Oxygen-regulated expression of the RNA-binding proteins RBM3 and CIRP by a HIF-1-independent mechanism. |journal=J. Cell. Sci. |volume=117 |issue= Pt 9 |pages= 1785-94 |year= 2004 |pmid= 15075239 |doi= 10.1242/jcs.01026 }}
* {{cite journal | vauthors = Ong SE, Mittler G, Mann M | title = Identifying and quantifying in vivo methylation sites by heavy methyl SILAC | journal = Nature Methods | volume = 1 | issue = 2 | pages = 119–26 | date = November 2004 | pmid = 15782174 | doi = 10.1038/nmeth715 }}
*{{cite journal | author=Brill LM, Salomon AR, Ficarro SB, ''et al.'' |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763-72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d }}
* {{cite journal | vauthors = Martínez-Arribas F, Agudo D, Pollán M, Gómez-Esquer F, Díaz-Gil G, Lucas R, Schneider J | title = Positive correlation between the expression of X-chromosome RBM genes (RBMX, RBM3, RBM10) and the proapoptotic Bax gene in human breast cancer | journal = Journal of Cellular Biochemistry | volume = 97 | issue = 6 | pages = 1275–82 | date = April 2006 | pmid = 16552754 | doi = 10.1002/jcb.20725 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Dellis S, Strickland KC, McCrary WJ, ''et al.'' |title=Protein interactions among the vaccinia virus late transcription factors. |journal=Virology |volume=329 |issue= 2 |pages= 328-36 |year= 2005 |pmid= 15518812 |doi= 10.1016/j.virol.2004.08.017 }}
*{{cite journal | author=Andersen JS, Lam YW, Leung AK, ''et al.'' |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77-83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
*{{cite journal | author=Ross MT, Grafham DV, Coffey AJ, ''et al.'' |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325-37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 }}
*{{cite journal  | author=Ong SE, Mittler G, Mann M |title=Identifying and quantifying in vivo methylation sites by heavy methyl SILAC. |journal=Nat. Methods |volume=1 |issue= 2 |pages= 119-26 |year= 2005 |pmid= 15782174 |doi= 10.1038/nmeth715 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Martínez-Arribas F, Agudo D, Pollán M, ''et al.'' |title=Positive correlation between the expression of X-chromosome RBM genes (RBMX, RBM3, RBM10) and the proapoptotic Bax gene in human breast cancer. |journal=J. Cell. Biochem. |volume=97 |issue= 6 |pages= 1275-82 |year= 2006 |pmid= 16552754 |doi= 10.1002/jcb.20725 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{gene-X-stub}}
{{WikiDoc Sources}}

Revision as of 06:59, 9 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Putative RNA-binding protein 3 is a protein that in humans is encoded by the RBM3 gene.[1][2]

Function

This gene is a member of the glycine-rich RNA-binding protein family and encodes a protein with one RNA recognition motif (RRM) domain. Expression of this gene is induced by cold shock and low oxygen tension. A pseudogene exists on chromosome 1. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[2]

RBM3 is cold-induced RNA binding protein and is involved in mRNA biogenesis exerts anti-apoptotic effects.[3] According to antibody-based profiling and transcriptomics analysis, RBM3 protein is present in all analysed human tissues[4] and based on confocal microscopy mainly localised to the nucleoplasm.[5]

Clinical significance

RBM3 is a proto-oncogene that is associated with tumor progression and metastasis and is a potential cancer biomarker.[3] Based on patient survival data, high levels of RBM3 protein in tumor cells is a favourable prognostic biomarker in colorectal cancer.[6]

References

  1. ↑ Derry JM, Kerns JA, Francke U (December 1995). "RBM3, a novel human gene in Xp11.23 with a putative RNA-binding domain". Human Molecular Genetics. 4 (12): 2307–11. doi:10.1093/hmg/4.12.2307. PMID 8634703.
  2. ↑ 2.0 2.1 "Entrez Gene: RBM3 RNA binding motif (RNP1, RRM) protein 3".
  3. ↑ 3.0 3.1 Zhou RB, Lu XL, Zhang CY, Yin DC (March 2017). "RNA binding motif protein 3: a potential biomarker in cancer and therapeutic target in neuroprotection". Oncotarget. 8 (13): 22235–22250. doi:10.18632/oncotarget.14755. PMC 5400660. PMID 28118608.
  4. ↑ "Tissue expression of RBM3 - Summary". The Human Protein Atlas.
  5. ↑ "Cell atlas - RBM3". The Human Protein Atlas.
  6. ↑ "Expression of RBM3 in cancer - Summary". The Human Protein Atlas.

Further reading

  • Danno S, Nishiyama H, Higashitsuji H, Yokoi H, Xue JH, Itoh K, Matsuda T, Fujita J (July 1997). "Increased transcript level of RBM3, a member of the glycine-rich RNA-binding protein family, in human cells in response to cold stress". Biochemical and Biophysical Research Communications. 236 (3): 804–7. doi:10.1006/bbrc.1997.7059. PMID 9245737.
  • Chappell SA, Mauro VP (September 2003). "The internal ribosome entry site (IRES) contained within the RNA-binding motif protein 3 (Rbm3) mRNA is composed of functionally distinct elements". The Journal of Biological Chemistry. 278 (36): 33793–800. doi:10.1074/jbc.M303495200. PMID 12824175.
  • Wellmann S, Bührer C, Moderegger E, Zelmer A, Kirschner R, Koehne P, Fujita J, Seeger K (April 2004). "Oxygen-regulated expression of the RNA-binding proteins RBM3 and CIRP by a HIF-1-independent mechanism". Journal of Cell Science. 117 (Pt 9): 1785–94. doi:10.1242/jcs.01026. PMID 15075239.
  • Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (May 2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Analytical Chemistry. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
  • Dellis S, Strickland KC, McCrary WJ, Patel A, Stocum E, Wright CF (November 2004). "Protein interactions among the vaccinia virus late transcription factors". Virology. 329 (2): 328–36. doi:10.1016/j.virol.2004.08.017. PMID 15518812.
  • Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (January 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
  • Ong SE, Mittler G, Mann M (November 2004). "Identifying and quantifying in vivo methylation sites by heavy methyl SILAC". Nature Methods. 1 (2): 119–26. doi:10.1038/nmeth715. PMID 15782174.
  • Martínez-Arribas F, Agudo D, Pollán M, Gómez-Esquer F, Díaz-Gil G, Lucas R, Schneider J (April 2006). "Positive correlation between the expression of X-chromosome RBM genes (RBMX, RBM3, RBM10) and the proapoptotic Bax gene in human breast cancer". Journal of Cellular Biochemistry. 97 (6): 1275–82. doi:10.1002/jcb.20725. PMID 16552754.
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