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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Replication factor C subunit 2''' is a [[protein]] that in humans is encoded by the ''RFC2'' [[gene]].<ref name="pmid1313560">{{cite journal | vauthors = Chen M, Pan ZQ, Hurwitz J | title = Sequence and expression in Escherichia coli of the 40-kDa subunit of activator 1 (replication factor C) of HeLa cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 89 | issue = 7 | pages = 2516–20 | date = Apr 1992 | pmid = 1313560 | pmc = 48692 | doi = 10.1073/pnas.89.7.2516 }}</ref><ref name="pmid7774928">{{cite journal | vauthors = Okumura K, Nogami M, Taguchi H, Dean FB, Chen M, Pan ZQ, Hurwitz J, Shiratori A, Murakami Y, Ozawa K | title = Assignment of the 36.5-kDa (RFC5), 37-kDa (RFC4), 38-kDa (RFC3), and 40-kDa (RFC2) subunit genes of human replication factor C to chromosome bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23 | journal = Genomics | volume = 25 | issue = 1 | pages = 274–8 | date = Jan 1995 | pmid = 7774928 | pmc =  | doi = 10.1016/0888-7543(95)80135-9 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RFC2 replication factor C (activator 1) 2, 40kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5982| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Replication factor C (activator 1) 2, 40kDa
| HGNCid = 9970
| Symbol = RFC2
| AltSymbols =; A1; MGC3665; RFC40
| OMIM = 600404
| ECnumber = 
| Homologene = 6885
| MGIid = 1341868
| GeneAtlas_image1 = PBB_GE_RFC2_1053_at_tn.png
| GeneAtlas_image2 = PBB_GE_RFC2_203696_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0017111 |text = nucleoside-triphosphatase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005663 |text = DNA replication factor C complex}}
| Process = {{GNF_GO|id=GO:0006260 |text = DNA replication}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5982
    | Hs_Ensembl = ENSG00000049541
    | Hs_RefseqProtein = NP_002905
    | Hs_RefseqmRNA = NM_002914
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 73283770
    | Hs_GenLoc_end = 73306674
    | Hs_Uniprot = P35250
    | Mm_EntrezGene = 19718
    | Mm_Ensembl = ENSMUSG00000023104
    | Mm_RefseqmRNA = NM_020022
    | Mm_RefseqProtein = NP_064406
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 134867317
    | Mm_GenLoc_end = 134882955
    | Mm_Uniprot = Q4KL82
  }}
}}
'''Replication factor C (activator 1) 2, 40kDa''', also known as '''RFC2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RFC2 replication factor C (activator 1) 2, 40kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5982| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also called activator 1, is a protein complex consisting of five distinct subunits of 145, 40, 38, 37, and 36.5 kD. This gene encodes the 40 kD subunit, which has been shown to be responsible for binding ATP. Deletion of this gene has been associated with Williams syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been described.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also called activator 1, is a protein complex consisting of five distinct subunits of 145, 40, 38, 37, and 36.5 kD. This gene encodes the 40 kD subunit, which has been shown to be responsible for binding ATP. Deletion of this gene has been associated with Williams syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been described.<ref name="entrez">{{cite web | title = Entrez Gene: RFC2 replication factor C (activator 1) 2, 40kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5982| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
RFC2 has been shown to [[Protein-protein interaction|interact]] with [[BRD4]],<ref name=pmid12192049>{{cite journal | vauthors = Maruyama T, Farina A, Dey A, Cheong J, Bermudez VP, Tamura T, Sciortino S, Shuman J, Hurwitz J, Ozato K | title = A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase | journal = Molecular and Cellular Biology | volume = 22 | issue = 18 | pages = 6509–20 | date = Sep 2002 | pmid = 12192049 | pmc = 135621 | doi = 10.1128/MCB.22.18.6509-6520.2002 }}</ref> [[CHTF18]],<ref name=pmid12930902>{{cite journal | vauthors = Bermudez VP, Maniwa Y, Tappin I, Ozato K, Yokomori K, Hurwitz J | title = The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 18 | pages = 10237–42 | date = Sep 2003 | pmid = 12930902 | pmc = 193545 | doi = 10.1073/pnas.1434308100 }}</ref><ref name=pmid12766176>{{cite journal | vauthors = Merkle CJ, Karnitz LM, Henry-Sánchez JT, Chen J | title = Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment | journal = The Journal of Biological Chemistry | volume = 278 | issue = 32 | pages = 30051–6 | date = Aug 2003 | pmid = 12766176 | doi = 10.1074/jbc.M211591200 }}</ref> [[PCNA]],<ref name=pmid9228079>{{cite journal | vauthors = Cai J, Gibbs E, Uhlmann F, Phillips B, Yao N, O'Donnell M, Hurwitz J | title = A complex consisting of human replication factor C p40, p37, and p36 subunits is a DNA-dependent ATPase and an intermediate in the assembly of the holoenzyme | journal = The Journal of Biological Chemistry | volume = 272 | issue = 30 | pages = 18974–81 | date = Jul 1997 | pmid = 9228079 | doi = 10.1074/jbc.272.30.18974 }}</ref><ref name=pmid8093561>{{cite journal | vauthors = Pan ZQ, Chen M, Hurwitz J | title = The subunits of activator 1 (replication factor C) carry out multiple functions essential for proliferating-cell nuclear antigen-dependent DNA synthesis | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 90 | issue = 1 | pages = 6–10 | date = Jan 1993 | pmid = 8093561 | pmc = 45588 | doi = 10.1073/pnas.90.1.6 }}</ref><ref name=pmid12171929>{{cite journal | vauthors = Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T | title = A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein | journal = The Journal of Biological Chemistry | volume = 277 | issue = 43 | pages = 40362–7 | date = Oct 2002 | pmid = 12171929 | doi = 10.1074/jbc.M206194200 }}</ref> [[RFC4]]<ref name=pmid9228079/><ref name=pmid9751713>{{cite journal | vauthors = Cai J, Yao N, Gibbs E, Finkelstein J, Phillips B, O'Donnell M, Hurwitz J | title = ATP hydrolysis catalyzed by human replication factor C requires participation of multiple subunits | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 20 | pages = 11607–12 | date = Sep 1998 | pmid = 9751713 | pmc = 21688 | doi = 10.1073/pnas.95.20.11607 }}</ref> and [[RFC5]].<ref name=pmid9228079/><ref name=pmid9751713/>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Pan ZQ, Chen M, Hurwitz J | title = The subunits of activator 1 (replication factor C) carry out multiple functions essential for proliferating-cell nuclear antigen-dependent DNA synthesis | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 90 | issue = 1 | pages = 6–10 | date = Jan 1993 | pmid = 8093561 | pmc = 45588 | doi = 10.1073/pnas.90.1.6 }}
| citations =
* {{cite journal | vauthors = Peoples R, Perez-Jurado L, Wang YK, Kaplan P, Francke U | title = The gene for replication factor C subunit 2 (RFC2) is within the 7q11.23 Williams syndrome deletion | journal = American Journal of Human Genetics | volume = 58 | issue = 6 | pages = 1370–3 | date = Jun 1996 | pmid = 8651315 | pmc = 1915059 | doi =  }}
*{{cite journal | author=Chen M, Pan ZQ, Hurwitz J |title=Sequence and expression in Escherichia coli of the 40-kDa subunit of activator 1 (replication factor C) of HeLa cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 7 |pages= 2516-20 |year= 1992 |pmid= 1313560 |doi= }}
* {{cite journal | vauthors = Uhlmann F, Cai J, Flores-Rozas H, Dean FB, Finkelstein J, O'Donnell M, Hurwitz J | title = In vitro reconstitution of human replication factor C from its five subunits | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 13 | pages = 6521–6 | date = Jun 1996 | pmid = 8692848 | pmc = 39056 | doi = 10.1073/pnas.93.13.6521 }}
*{{cite journal | author=Okumura K, Nogami M, Taguchi H, ''et al.'' |title=Assignment of the 36.5-kDa (RFC5), 37-kDa (RFC4), 38-kDa (RFC3), and 40-kDa (RFC2) subunit genes of human replication factor C to chromosome bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23. |journal=Genomics |volume=25 |issue= 1 |pages= 274-8 |year= 1995 |pmid= 7774928 |doi=  }}
* {{cite journal | vauthors = Osborne LR, Martindale D, Scherer SW, Shi XM, Huizenga J, Heng HH, Costa T, Pober B, Lew L, Brinkman J, Rommens J, Koop B, Tsui LC | title = Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients | journal = Genomics | volume = 36 | issue = 2 | pages = 328–36 | date = Sep 1996 | pmid = 8812460 | doi = 10.1006/geno.1996.0469 }}
*{{cite journal | author=Pan ZQ, Chen M, Hurwitz J |title=The subunits of activator 1 (replication factor C) carry out multiple functions essential for proliferating-cell nuclear antigen-dependent DNA synthesis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 1 |pages= 6-10 |year= 1993 |pmid= 8093561 |doi= }}
* {{cite journal | vauthors = Cujec TP, Cho H, Maldonado E, Meyer J, Reinberg D, Peterlin BM | title = The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme | journal = Molecular and Cellular Biology | volume = 17 | issue = 4 | pages = 1817–23 | date = Apr 1997 | pmid = 9121429 | pmc = 232028 | doi =  }}
*{{cite journal | author=Peoples R, Perez-Jurado L, Wang YK, ''et al.'' |title=The gene for replication factor C subunit 2 (RFC2) is within the 7q11.23 Williams syndrome deletion. |journal=Am. J. Hum. Genet. |volume=58 |issue= 6 |pages= 1370-3 |year= 1996 |pmid= 8651315 |doi= }}
* {{cite journal | vauthors = Cai J, Gibbs E, Uhlmann F, Phillips B, Yao N, O'Donnell M, Hurwitz J | title = A complex consisting of human replication factor C p40, p37, and p36 subunits is a DNA-dependent ATPase and an intermediate in the assembly of the holoenzyme | journal = The Journal of Biological Chemistry | volume = 272 | issue = 30 | pages = 18974–81 | date = Jul 1997 | pmid = 9228079 | doi = 10.1074/jbc.272.30.18974 }}
*{{cite journal | author=Uhlmann F, Cai J, Flores-Rozas H, ''et al.'' |title=In vitro reconstitution of human replication factor C from its five subunits. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 13 |pages= 6521-6 |year= 1996 |pmid= 8692848 |doi=  }}
* {{cite journal | vauthors = Ellison V, Stillman B | title = Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity | journal = The Journal of Biological Chemistry | volume = 273 | issue = 10 | pages = 5979–87 | date = Mar 1998 | pmid = 9488738 | doi = 10.1074/jbc.273.10.5979 }}
*{{cite journal | author=Osborne LR, Martindale D, Scherer SW, ''et al.'' |title=Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients. |journal=Genomics |volume=36 |issue= 2 |pages= 328-36 |year= 1997 |pmid= 8812460 |doi= 10.1006/geno.1996.0469 }}
* {{cite journal | vauthors = Zhang G, Gibbs E, Kelman Z, O'Donnell M, Hurwitz J | title = Studies on the interactions between human replication factor C and human proliferating cell nuclear antigen | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 5 | pages = 1869–74 | date = Mar 1999 | pmid = 10051561 | pmc = 26703 | doi = 10.1073/pnas.96.5.1869 }}
*{{cite journal | author=Cujec TP, Cho H, Maldonado E, ''et al.'' |title=The human immunodeficiency virus transactivator Tat interacts with the RNA polymerase II holoenzyme. |journal=Mol. Cell. Biol. |volume=17 |issue= 4 |pages= 1817-23 |year= 1997 |pmid= 9121429 |doi= }}
* {{cite journal | vauthors = Wang Y, Cortez D, Yazdi P, Neff N, Elledge SJ, Qin J | title = BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures | journal = Genes & Development | volume = 14 | issue = 8 | pages = 927–39 | date = Apr 2000 | pmid = 10783165 | pmc = 316544 | doi = 10.1101/gad.14.8.927 }}
*{{cite journal | author=Cai J, Gibbs E, Uhlmann F, ''et al.'' |title=A complex consisting of human replication factor C p40, p37, and p36 subunits is a DNA-dependent ATPase and an intermediate in the assembly of the holoenzyme. |journal=J. Biol. Chem. |volume=272 |issue= 30 |pages= 18974-81 |year= 1997 |pmid= 9228079 |doi= }}
* {{cite journal | vauthors = Martindale DW, Wilson MD, Wang D, Burke RD, Chen X, Duronio V, Koop BF | title = Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23 | journal = Mammalian Genome | volume = 11 | issue = 10 | pages = 890–8 | date = Oct 2000 | pmid = 11003705 | doi = 10.1007/s003350010166 }}
*{{cite journal | author=Ellison V, Stillman B |title=Reconstitution of recombinant human replication factor C (RFC) and identification of an RFC subcomplex possessing DNA-dependent ATPase activity. |journal=J. Biol. Chem. |volume=273 |issue= 10 |pages= 5979-87 |year= 1998 |pmid= 9488738 |doi= }}
* {{cite journal | vauthors = Griffith JD, Lindsey-Boltz LA, Sancar A | title = Structures of the human Rad17-replication factor C and checkpoint Rad 9-1-1 complexes visualized by glycerol spray/low voltage microscopy | journal = The Journal of Biological Chemistry | volume = 277 | issue = 18 | pages = 15233–6 | date = May 2002 | pmid = 11907025 | doi = 10.1074/jbc.C200129200 }}
*{{cite journal | author=Zhang G, Gibbs E, Kelman Z, ''et al.'' |title=Studies on the interactions between human replication factor C and human proliferating cell nuclear antigen. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 5 |pages= 1869-74 |year= 1999 |pmid= 10051561 |doi= }}
* {{cite journal | vauthors = Nieborowska-Skorska M, Hoser G, Kossev P, Wasik MA, Skorski T | title = Complementary functions of the antiapoptotic protein A1 and serine/threonine kinase pim-1 in the BCR/ABL-mediated leukemogenesis | journal = Blood | volume = 99 | issue = 12 | pages = 4531–9 | date = Jun 2002 | pmid = 12036885 | doi = 10.1182/blood.V99.12.4531 }}
*{{cite journal | author=Wang Y, Cortez D, Yazdi P, ''et al.'' |title=BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. |journal=Genes Dev. |volume=14 |issue= 8 |pages= 927-39 |year= 2000 |pmid= 10783165 |doi= }}
* {{cite journal | vauthors = Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T | title = A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein | journal = The Journal of Biological Chemistry | volume = 277 | issue = 43 | pages = 40362–7 | date = Oct 2002 | pmid = 12171929 | doi = 10.1074/jbc.M206194200 }}
*{{cite journal | author=Martindale DW, Wilson MD, Wang D, ''et al.'' |title=Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23. |journal=Mamm. Genome |volume=11 |issue= 10 |pages= 890-8 |year= 2000 |pmid= 11003705 |doi= }}
* {{cite journal | vauthors = Maruyama T, Farina A, Dey A, Cheong J, Bermudez VP, Tamura T, Sciortino S, Shuman J, Hurwitz J, Ozato K | title = A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase | journal = Molecular and Cellular Biology | volume = 22 | issue = 18 | pages = 6509–20 | date = Sep 2002 | pmid = 12192049 | pmc = 135621 | doi = 10.1128/MCB.22.18.6509-6520.2002 }}
*{{cite journal | author=Griffith JD, Lindsey-Boltz LA, Sancar A |title=Structures of the human Rad17-replication factor C and checkpoint Rad 9-1-1 complexes visualized by glycerol spray/low voltage microscopy. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15233-6 |year= 2002 |pmid= 11907025 |doi= 10.1074/jbc.C200129200 }}
* {{cite journal | vauthors = Merkle CJ, Karnitz LM, Henry-Sánchez JT, Chen J | title = Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment | journal = The Journal of Biological Chemistry | volume = 278 | issue = 32 | pages = 30051–6 | date = Aug 2003 | pmid = 12766176 | doi = 10.1074/jbc.M211591200 }}
*{{cite journal | author=Nieborowska-Skorska M, Hoser G, Kossev P, ''et al.'' |title=Complementary functions of the antiapoptotic protein A1 and serine/threonine kinase pim-1 in the BCR/ABL-mediated leukemogenesis. |journal=Blood |volume=99 |issue= 12 |pages= 4531-9 |year= 2002 |pmid= 12036885 |doi= }}
* {{cite journal | vauthors = Bermudez VP, Maniwa Y, Tappin I, Ozato K, Yokomori K, Hurwitz J | title = The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 18 | pages = 10237–42 | date = Sep 2003 | pmid = 12930902 | pmc = 193545 | doi = 10.1073/pnas.1434308100 }}
*{{cite journal | author=Ohta S, Shiomi Y, Sugimoto K, ''et al.'' |title=A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein. |journal=J. Biol. Chem. |volume=277 |issue= 43 |pages= 40362-7 |year= 2002 |pmid= 12171929 |doi= 10.1074/jbc.M206194200 }}
*{{cite journal | author=Maruyama T, Farina A, Dey A, ''et al.'' |title=A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase. |journal=Mol. Cell. Biol. |volume=22 |issue= 18 |pages= 6509-20 |year= 2002 |pmid= 12192049 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Merkle CJ, Karnitz LM, Henry-Sánchez JT, Chen J |title=Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment. |journal=J. Biol. Chem. |volume=278 |issue= 32 |pages= 30051-6 |year= 2003 |pmid= 12766176 |doi= 10.1074/jbc.M211591200 }}
*{{cite journal  | author=Hillier LW, Fulton RS, Fulton LA, ''et al.'' |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157-64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal  | author=Bermudez VP, Maniwa Y, Tappin I, ''et al.'' |title=The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 18 |pages= 10237-42 |year= 2003 |pmid= 12930902 |doi= 10.1073/pnas.1434308100 }}
}}
{{refend}}
{{refend}}
{{protein-stub}}
{{WikiDoc Sources}}

Latest revision as of 09:08, 10 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
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View/Edit Human

Replication factor C subunit 2 is a protein that in humans is encoded by the RFC2 gene.[1][2][3]

Function

The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also called activator 1, is a protein complex consisting of five distinct subunits of 145, 40, 38, 37, and 36.5 kD. This gene encodes the 40 kD subunit, which has been shown to be responsible for binding ATP. Deletion of this gene has been associated with Williams syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been described.[3]

Interactions

RFC2 has been shown to interact with BRD4,[4] CHTF18,[5][6] PCNA,[7][8][9] RFC4[7][10] and RFC5.[7][10]

References

  1. ↑ Chen M, Pan ZQ, Hurwitz J (Apr 1992). "Sequence and expression in Escherichia coli of the 40-kDa subunit of activator 1 (replication factor C) of HeLa cells". Proceedings of the National Academy of Sciences of the United States of America. 89 (7): 2516–20. doi:10.1073/pnas.89.7.2516. PMC 48692. PMID 1313560.
  2. ↑ Okumura K, Nogami M, Taguchi H, Dean FB, Chen M, Pan ZQ, Hurwitz J, Shiratori A, Murakami Y, Ozawa K (Jan 1995). "Assignment of the 36.5-kDa (RFC5), 37-kDa (RFC4), 38-kDa (RFC3), and 40-kDa (RFC2) subunit genes of human replication factor C to chromosome bands 12q24.2-q24.3, 3q27, 13q12.3-q13, and 7q11.23". Genomics. 25 (1): 274–8. doi:10.1016/0888-7543(95)80135-9. PMID 7774928.
  3. ↑ 3.0 3.1 "Entrez Gene: RFC2 replication factor C (activator 1) 2, 40kDa".
  4. ↑ Maruyama T, Farina A, Dey A, Cheong J, Bermudez VP, Tamura T, Sciortino S, Shuman J, Hurwitz J, Ozato K (Sep 2002). "A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase". Molecular and Cellular Biology. 22 (18): 6509–20. doi:10.1128/MCB.22.18.6509-6520.2002. PMC 135621. PMID 12192049.
  5. ↑ Bermudez VP, Maniwa Y, Tappin I, Ozato K, Yokomori K, Hurwitz J (Sep 2003). "The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA". Proceedings of the National Academy of Sciences of the United States of America. 100 (18): 10237–42. doi:10.1073/pnas.1434308100. PMC 193545. PMID 12930902.
  6. ↑ Merkle CJ, Karnitz LM, Henry-Sánchez JT, Chen J (Aug 2003). "Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment". The Journal of Biological Chemistry. 278 (32): 30051–6. doi:10.1074/jbc.M211591200. PMID 12766176.
  7. ↑ 7.0 7.1 7.2 Cai J, Gibbs E, Uhlmann F, Phillips B, Yao N, O'Donnell M, Hurwitz J (Jul 1997). "A complex consisting of human replication factor C p40, p37, and p36 subunits is a DNA-dependent ATPase and an intermediate in the assembly of the holoenzyme". The Journal of Biological Chemistry. 272 (30): 18974–81. doi:10.1074/jbc.272.30.18974. PMID 9228079.
  8. ↑ Pan ZQ, Chen M, Hurwitz J (Jan 1993). "The subunits of activator 1 (replication factor C) carry out multiple functions essential for proliferating-cell nuclear antigen-dependent DNA synthesis". Proceedings of the National Academy of Sciences of the United States of America. 90 (1): 6–10. doi:10.1073/pnas.90.1.6. PMC 45588. PMID 8093561.
  9. ↑ Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (Oct 2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". The Journal of Biological Chemistry. 277 (43): 40362–7. doi:10.1074/jbc.M206194200. PMID 12171929.
  10. ↑ 10.0 10.1 Cai J, Yao N, Gibbs E, Finkelstein J, Phillips B, O'Donnell M, Hurwitz J (Sep 1998). "ATP hydrolysis catalyzed by human replication factor C requires participation of multiple subunits". Proceedings of the National Academy of Sciences of the United States of America. 95 (20): 11607–12. doi:10.1073/pnas.95.20.11607. PMC 21688. PMID 9751713.

Further reading

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