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{{ | '''Regulator of G-protein signaling 3''' is a [[protein]] that in humans is encoded by the ''RGS3'' [[gene]].<ref name="pmid8602223">{{cite journal |vauthors=Druey KM, Blumer KJ, Kang VH, Kehrl JH | title = Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family | journal = Nature | volume = 379 | issue = 6567 | pages = 742–6 |date=May 1996 | pmid = 8602223 | pmc = | doi = 10.1038/379742a0 }}</ref><ref name="pmid11034339">{{cite journal |vauthors=Linares JL, Wendling C, Tomasetto C, Rio MC | title = C2PA, a new protein expressed during mouse spermatogenesis | journal = FEBS Lett | volume = 480 | issue = 2–3 | pages = 249–54 |date=Nov 2000 | pmid = 11034339 | pmc = | doi =10.1016/S0014-5793(00)01942-6 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RGS3 regulator of G-protein signalling 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5998| accessdate = }}</ref> | ||
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{{PBB_Summary | {{PBB_Summary | ||
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| summary_text = This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTP-ase activating protein which inhibits G-protein mediated signal transduction. The protein is largely cytosolic, but G-protein activation leads to translocation of this protein to the plasma membrane. A nuclear form of this protein has also been described, but its sequence has not been identified. Multiple alternatively spliced transcript variants have been described for this gene but the full-length nature of some transcripts is not yet known.<ref name="entrez" | | summary_text = This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTP-ase activating protein which inhibits G-protein mediated signal transduction. The protein is largely cytosolic, but G-protein activation leads to translocation of this protein to the plasma membrane. A nuclear form of this protein has also been described, but its sequence has not been identified. Multiple alternatively spliced transcript variants have been described for this gene but the full-length nature of some transcripts is not yet known.<ref name="entrez" /> | ||
}} | }} | ||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | | *{{cite journal |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Chatterjee TK, Eapen A, Kanis AB, Fisher RA |title=Genomic organization, 5'-flanking region, and chromosomal localization of the human RGS3 gene |journal=Genomics |volume=45 |issue= 2 |pages= 429–33 |year= 1998 |pmid= 9344672 |doi= 10.1006/geno.1997.4929 }} | ||
*{{cite journal | author= | *{{cite journal | author=Suzuki Y |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |name-list-format=vanc| author2=Yoshitomo-Nakagawa K | author3=Maruyama K | display-authors=3 | last4=Suyama | first4=A | last5=Sugano | first5=S }} | ||
*{{cite journal | author=Dulin NO |title=RGS3 Inhibits G Protein-Mediated Signaling via Translocation to the Membrane and Binding to Gα11 |journal=Mol. Cell. Biol. |volume=19 |issue= 1 |pages= 714–23 |year= 1999 |pmid= 9858594 |doi= | pmc=83928 |name-list-format=vanc| author2=Sorokin A | author3=Reed E | display-authors=3 | last4=Elliott | first4=S | last5=Kehrl | first5=JH | last6=Dunn | first6=MJ }} | |||
*{{cite journal | author=Dulin NO | *{{cite journal | author=Dulin NO |title=Regulator of G protein signaling RGS3T is localized to the nucleus and induces apoptosis |journal=J. Biol. Chem. |volume=275 |issue= 28 |pages= 21317–23 |year= 2000 |pmid= 10749886 |doi= 10.1074/jbc.M910079199 |name-list-format=vanc| author2=Pratt P | author3=Tiruppathi C | display-authors=3 | last4=Niu | first4=J | last5=Voyno-Yasenetskaya | first5=T | last6=Dunn | first6=MJ }} | ||
*{{cite journal | author=Shi CS |title=Regulator of G-protein signaling 3 (RGS3) inhibits Gbeta1gamma 2-induced inositol phosphate production, mitogen-activated protein kinase activation, and Akt activation |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 24293–300 |year= 2001 |pmid= 11294858 |doi= 10.1074/jbc.M100089200 |name-list-format=vanc| author2=Lee SB | author3=Sinnarajah S | display-authors=3 | last4=Dessauer | first4=CW | last5=Rhee | first5=SG | last6=Kehrl | first6=JH }} | |||
*{{cite journal | author= | *{{cite journal |vauthors=Lu Q, Sun EE, Klein RS, Flanagan JG |title=Ephrin-B reverse signaling is mediated by a novel PDZ-RGS protein and selectively inhibits G protein-coupled chemoattraction |journal=Cell |volume=105 |issue= 1 |pages= 69–79 |year= 2001 |pmid= 11301003 |doi=10.1016/S0092-8674(01)00297-5 }} | ||
*{{cite journal | author=Mittmann C |title=Evidence for a short form of RGS3 preferentially expressed in the human heart |journal=Naunyn Schmiedebergs Arch. Pharmacol. |volume=363 |issue= 4 |pages= 456–63 |year= 2001 |pmid= 11330340 |doi=10.1007/s002100000376 |name-list-format=vanc| author2=Schüler C | author3=Chung CH | display-authors=3 | last4=Not Available | first4=Not Available | last5=Not Available | first5=Not Available | last6=Not Available | first6=Not Available | last7=Not Available | first7=Not Available }} | |||
*{{cite journal | author= | *{{cite journal | author=Niu J |title=RGS3 interacts with 14-3-3 via the N-terminal region distinct from the RGS (regulator of G-protein signalling) domain |journal=Biochem. J. |volume=365 |issue= Pt 3 |pages= 677–84 |year= 2002 |pmid= 11985497 |doi= 10.1042/BJ20020390 | pmc=1222729 |name-list-format=vanc| author2=Scheschonka A | author3=Druey KM | display-authors=3 | last4=Davis | first4=Amanda | last5=Reed | first5=Eleanor | last6=Kolenko | first6=Vladimir | last7=Bodnar | first7=Richard | last8=Voyno-Yasenetskaya | first8=Tatyana | last9=Du | first9=Xiaoping }} | ||
*{{cite journal | author=Kehrl JH |title=Additional 5' exons in the RGS3 locus generate multiple mRNA transcripts, one of which accounts for the origin of human PDZ-RGS3 |journal=Genomics |volume=79 |issue= 6 |pages= 860–8 |year= 2002 |pmid= 12036301 |doi= 10.1006/geno.2002.6773 |name-list-format=vanc| author2=Srikumar D | author3=Harrison K | display-authors=3 | last4=Wilson | first4=Gaye L. | last5=Shi | first5=Chong-Shan }} | |||
*{{cite journal | | *{{cite journal | author=Ikeda M |title=Transcriptional suppression of the estrogen receptor by truncated estrogen receptor-alpha |journal=Horm. Metab. Res. |volume=34 |issue= 8 |pages= 425–30 |year= 2003 |pmid= 12198596 |doi= 10.1055/s-2002-33599 |name-list-format=vanc| author2=Okai M | author3=Miyoshi T | display-authors=3 | last4=Tone | first4=S. | last5=Minatogawa | first5=Y. }} | ||
*{{cite journal | author= | *{{cite journal |vauthors=Hirabayashi S, Ohno H, Iida J, Hata Y |title=C2PA is a nuclear protein implicated in the heat shock response |journal=J. Cell. Biochem. |volume=87 |issue= 1 |pages= 65–74 |year= 2003 |pmid= 12210723 |doi= 10.1002/jcb.10279 }} | ||
*{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }} | |||
*{{cite journal | author= | *{{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki }} | ||
*{{cite journal | author=Humphray SJ |title=DNA sequence and analysis of human chromosome 9 |journal=Nature |volume=429 |issue= 6990 |pages= 369–74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 | pmc=2734081 |name-list-format=vanc| author2=Oliver K | author3=Hunt AR | display-authors=3 | last4=Plumb | first4=R. W. | last5=Loveland | first5=J. E. | last6=Howe | first6=K. L. | last7=Andrews | first7=T. D. | last8=Searle | first8=S. | last9=Hunt | first9=S. E. }} | |||
*{{cite journal | author= | *{{cite journal |vauthors=Tovey SC, Willars GB |title=Single-cell imaging of intracellular Ca2+ and phospholipase C activity reveals that RGS 2, 3, and 4 differentially regulate signaling via the Galphaq/11-linked muscarinic M3 receptor |journal=Mol. Pharmacol. |volume=66 |issue= 6 |pages= 1453–64 |year= 2005 |pmid= 15383626 |doi= 10.1124/mol.104.005827 }} | ||
*{{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-format=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }} | |||
*{{cite journal | author= | *{{cite journal | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |name-list-format=vanc| author2=Venkatesan K | author3=Hao T | display-authors=3 | last4=Hirozane-Kishikawa | first4=Tomoko | last5=Dricot | first5=Amélie | last6=Li | first6=Ning | last7=Berriz | first7=Gabriel F. | last8=Gibbons | first8=Francis D. | last9=Dreze | first9=Matija }} | ||
*{{cite journal | author= | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
{{PDB Gallery|geneid=5998}} | |||
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Latest revision as of 09:10, 10 September 2017
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| External IDs | GeneCards: [1] | ||||||
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| Species | Human | Mouse | |||||
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| Location (UCSC) | n/a | n/a | |||||
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| Wikidata | |||||||
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Regulator of G-protein signaling 3 is a protein that in humans is encoded by the RGS3 gene.[1][2][3]
This gene encodes a member of the regulator of G-protein signaling (RGS) family. This protein is a GTP-ase activating protein which inhibits G-protein mediated signal transduction. The protein is largely cytosolic, but G-protein activation leads to translocation of this protein to the plasma membrane. A nuclear form of this protein has also been described, but its sequence has not been identified. Multiple alternatively spliced transcript variants have been described for this gene but the full-length nature of some transcripts is not yet known.[3]
References
- ↑ Druey KM, Blumer KJ, Kang VH, Kehrl JH (May 1996). "Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family". Nature. 379 (6567): 742–6. doi:10.1038/379742a0. PMID 8602223.
- ↑ Linares JL, Wendling C, Tomasetto C, Rio MC (Nov 2000). "C2PA, a new protein expressed during mouse spermatogenesis". FEBS Lett. 480 (2–3): 249–54. doi:10.1016/S0014-5793(00)01942-6. PMID 11034339.
- ↑ 3.0 3.1 "Entrez Gene: RGS3 regulator of G-protein signalling 3".
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Chatterjee TK, Eapen A, Kanis AB, Fisher RA (1998). "Genomic organization, 5'-flanking region, and chromosomal localization of the human RGS3 gene". Genomics. 45 (2): 429–33. doi:10.1006/geno.1997.4929. PMID 9344672.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Dulin NO, Sorokin A, Reed E, et al. (1999). "RGS3 Inhibits G Protein-Mediated Signaling via Translocation to the Membrane and Binding to Gα11". Mol. Cell. Biol. 19 (1): 714–23. PMC 83928. PMID 9858594.
- Dulin NO, Pratt P, Tiruppathi C, et al. (2000). "Regulator of G protein signaling RGS3T is localized to the nucleus and induces apoptosis". J. Biol. Chem. 275 (28): 21317–23. doi:10.1074/jbc.M910079199. PMID 10749886.
- Shi CS, Lee SB, Sinnarajah S, et al. (2001). "Regulator of G-protein signaling 3 (RGS3) inhibits Gbeta1gamma 2-induced inositol phosphate production, mitogen-activated protein kinase activation, and Akt activation". J. Biol. Chem. 276 (26): 24293–300. doi:10.1074/jbc.M100089200. PMID 11294858.
- Lu Q, Sun EE, Klein RS, Flanagan JG (2001). "Ephrin-B reverse signaling is mediated by a novel PDZ-RGS protein and selectively inhibits G protein-coupled chemoattraction". Cell. 105 (1): 69–79. doi:10.1016/S0092-8674(01)00297-5. PMID 11301003.
- Mittmann C, Schüler C, Chung CH, et al. (2001). "Evidence for a short form of RGS3 preferentially expressed in the human heart". Naunyn Schmiedebergs Arch. Pharmacol. 363 (4): 456–63. doi:10.1007/s002100000376. PMID 11330340.
- Niu J, Scheschonka A, Druey KM, et al. (2002). "RGS3 interacts with 14-3-3 via the N-terminal region distinct from the RGS (regulator of G-protein signalling) domain". Biochem. J. 365 (Pt 3): 677–84. doi:10.1042/BJ20020390. PMC 1222729. PMID 11985497.
- Kehrl JH, Srikumar D, Harrison K, et al. (2002). "Additional 5' exons in the RGS3 locus generate multiple mRNA transcripts, one of which accounts for the origin of human PDZ-RGS3". Genomics. 79 (6): 860–8. doi:10.1006/geno.2002.6773. PMID 12036301.
- Ikeda M, Okai M, Miyoshi T, et al. (2003). "Transcriptional suppression of the estrogen receptor by truncated estrogen receptor-alpha". Horm. Metab. Res. 34 (8): 425–30. doi:10.1055/s-2002-33599. PMID 12198596.
- Hirabayashi S, Ohno H, Iida J, Hata Y (2003). "C2PA is a nuclear protein implicated in the heat shock response". J. Cell. Biochem. 87 (1): 65–74. doi:10.1002/jcb.10279. PMID 12210723.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
- Tovey SC, Willars GB (2005). "Single-cell imaging of intracellular Ca2+ and phospholipase C activity reveals that RGS 2, 3, and 4 differentially regulate signaling via the Galphaq/11-linked muscarinic M3 receptor". Mol. Pharmacol. 66 (6): 1453–64. doi:10.1124/mol.104.005827. PMID 15383626.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
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