RIPK3: Difference between revisions

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{{Infobox gene}}
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'''Receptor-interacting serine/threonine-protein kinase 3''' is an [[enzyme]] that in humans is encoded by the ''RIPK3'' [[gene]].<ref name="pmid10339433">{{cite journal | vauthors = Yu PW, Huang BC, Shen M, Quast J, Chan E, Xu X, Nolan GP, Payan DG, Luo Y | title = Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB | journal = Curr Biol | volume = 9 | issue = 10 | pages = 539–42 |date=Jun 1999 | pmid = 10339433 | pmc =  | doi =10.1016/S0960-9822(99)80239-5 }}</ref><ref name="pmid10358032">{{cite journal | vauthors = Sun X, Lee J, Navas T, Baldwin DT, Stewart TA, Dixit VM | title = RIP3, a novel apoptosis-inducing kinase | journal = J Biol Chem | volume = 274 | issue = 24 | pages = 16871–5 |date=Jul 1999 | pmid = 10358032 | pmc =  | doi =10.1074/jbc.274.24.16871 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RIPK3 receptor-interacting serine-threonine kinase 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11035| accessdate = }}</ref><ref name=":0">Li J, McQuade T, Siemer AB, Napetschnig J, Moriwaki K, Hsiao YS, Damko E, Moquin D, Walz T, McDermott A, Chan FK, Wu H. (July 2012) The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis. ''Cell'' '''150''' (2):339-50. {{DOI|10.1016/j.cell.2012.06.019}}. {{PMID|22817896}}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Receptor-interacting serine-threonine kinase 3
| HGNCid = 10021
| Symbol = RIPK3
| AltSymbols =; RIP3
| OMIM = 605817
| ECnumber =
| Homologene = 31410
| MGIid = 2154952
  | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004704 |text = NF-kappaB-inducing kinase activity}} {{GNF_GO|id=GO:0004713 |text = protein-tyrosine kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
  | Component = {{GNF_GO|id=GO:0005622 |text = intracellular}}  
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007249 |text = I-kappaB kinase/NF-kappaB cascade}} {{GNF_GO|id=GO:0008624 |text = induction of apoptosis by extracellular signals}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 11035
    | Hs_Ensembl = ENSG00000129465
    | Hs_RefseqProtein = NP_006862
    | Hs_RefseqmRNA = NM_006871
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 14
    | Hs_GenLoc_start = 23875072
    | Hs_GenLoc_end = 23879036
    | Hs_Uniprot = Q9Y572
    | Mm_EntrezGene = 56532
    | Mm_Ensembl = ENSMUSG00000022221
    | Mm_RefseqmRNA = NM_019955
    | Mm_RefseqProtein = NP_064339
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 54739067
    | Mm_GenLoc_end = 54742879
    | Mm_Uniprot = Q3U3Z9
  }}
}}
'''Receptor-interacting serine-threonine kinase 3''', also known as '''RIPK3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RIPK3 receptor-interacting serine-threonine kinase 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11035| accessdate = }}</ref>


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| section_title =  
| section_title =  
| summary_text = The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor.<ref name="entrez">{{cite web | title = Entrez Gene: RIPK3 receptor-interacting serine-threonine kinase 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11035| accessdate = }}</ref>
| summary_text = The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor.<ref name="entrez" />
}}
}}


==References==
== Interactions ==
{{reflist|2}}
RIPK3 has been shown to [[Protein-protein interaction|interact]] with [[RIPK1]].<ref name="pmid10339433" /><ref name=":0" />
==Further reading==
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
{{PBB Further reading
| citations =  
| citations =  
*{{cite journal | author=Yu PW, Huang BC, Shen M, ''et al.'' |title=Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB. |journal=Curr. Biol. |volume=9 |issue= 10 |pages= 539-42 |year= 1999 |pmid= 10339433 |doi=  }}
*{{cite journal   |vauthors=Kasof GM, Prosser JC, Liu D, etal |title=The RIP-like kinase, RIP3, induces apoptosis and NF-kappaB nuclear translocation and localizes to mitochondria |journal=FEBS Lett. |volume=473 |issue= 3 |pages= 285–91 |year= 2000 |pmid= 10818227 |doi=10.1016/S0014-5793(00)01473-3 }}
*{{cite journal  | author=Sun X, Lee J, Navas T, ''et al.'' |title=RIP3, a novel apoptosis-inducing kinase. |journal=J. Biol. Chem. |volume=274 |issue= 24 |pages= 16871-5 |year= 1999 |pmid= 10358032 |doi=  }}
*{{cite journal   |vauthors=Sun X, Yin J, Starovasnik MA, etal |title=Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3 |journal=J. Biol. Chem. |volume=277 |issue= 11 |pages= 9505–11 |year= 2002 |pmid= 11734559 |doi= 10.1074/jbc.M109488200 }}
*{{cite journal  | author=Kasof GM, Prosser JC, Liu D, ''et al.'' |title=The RIP-like kinase, RIP3, induces apoptosis and NF-kappaB nuclear translocation and localizes to mitochondria. |journal=FEBS Lett. |volume=473 |issue= 3 |pages= 285-91 |year= 2000 |pmid= 10818227 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Sun X, Yin J, Starovasnik MA, ''et al.'' |title=Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3. |journal=J. Biol. Chem. |volume=277 |issue= 11 |pages= 9505-11 |year= 2002 |pmid= 11734559 |doi= 10.1074/jbc.M109488200 }}
*{{cite journal   |vauthors=Bouwmeester T, Bauch A, Ruffner H, etal |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Meylan E, Burns K, Hofmann K, etal |title=RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation |journal=Nat. Immunol. |volume=5 |issue= 5 |pages= 503–7 |year= 2004 |pmid= 15064760 |doi= 10.1038/ni1061 }}
*{{cite journal | author=Bouwmeester T, Bauch A, Ruffner H, ''et al.'' |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97-105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 }}
*{{cite journal  | vauthors=Yang Y, Ma J, Chen Y, Wu M |title=Nucleocytoplasmic shuttling of receptor-interacting protein 3 (RIP3): identification of novel nuclear export and import signals in RIP3 |journal=J. Biol. Chem. |volume=279 |issue= 37 |pages= 38820–9 |year= 2004 |pmid= 15208320 |doi= 10.1074/jbc.M401663200 }}
*{{cite journal | author=Meylan E, Burns K, Hofmann K, ''et al.'' |title=RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation. |journal=Nat. Immunol. |volume=5 |issue= 5 |pages= 503-7 |year= 2004 |pmid= 15064760 |doi= 10.1038/ni1061 }}
*{{cite journal   |vauthors=Yang Y, Hu W, Feng S, etal |title=RIP3 beta and RIP3 gamma, two novel splice variants of receptor-interacting protein 3 (RIP3), downregulate RIP3-induced apoptosis |journal=Biochem. Biophys. Res. Commun. |volume=332 |issue= 1 |pages= 181–7 |year= 2005 |pmid= 15896315 |doi= 10.1016/j.bbrc.2005.04.114 }}
*{{cite journal  | author=Yang Y, Ma J, Chen Y, Wu M |title=Nucleocytoplasmic shuttling of receptor-interacting protein 3 (RIP3): identification of novel nuclear export and import signals in RIP3. |journal=J. Biol. Chem. |volume=279 |issue= 37 |pages= 38820-9 |year= 2004 |pmid= 15208320 |doi= 10.1074/jbc.M401663200 }}
*{{cite journal   |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }}
*{{cite journal | author=Yang Y, Hu W, Feng S, ''et al.'' |title=RIP3 beta and RIP3 gamma, two novel splice variants of receptor-interacting protein 3 (RIP3), downregulate RIP3-induced apoptosis. |journal=Biochem. Biophys. Res. Commun. |volume=332 |issue= 1 |pages= 181-7 |year= 2005 |pmid= 15896315 |doi= 10.1016/j.bbrc.2005.04.114 }}
*{{cite journal   |vauthors=Zhao L, Wang G, Lu D, etal |title=Homocysteine, hRIP3 and congenital cardiovascular malformations |journal=Anat. Embryol. |volume=211 |issue= 3 |pages= 203–12 |year= 2006 |pmid= 16429275 |doi= 10.1007/s00429-005-0074-9 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal  | vauthors=Feng S, Ma L, Yang Y, Wu M |title=Truncated RIP3 (tRIP3) acts upstream of FADD to induce apoptosis in the human hepatocellular carcinoma cell line QGY-7703 |journal=Biochem. Biophys. Res. Commun. |volume=347 |issue= 3 |pages= 558–65 |year= 2006 |pmid= 16844082 |doi= 10.1016/j.bbrc.2006.06.118 }}
*{{cite journal | author=Zhao L, Wang G, Lu D, ''et al.'' |title=Homocysteine, hRIP3 and congenital cardiovascular malformations. |journal=Anat. Embryol. |volume=211 |issue= 3 |pages= 203-12 |year= 2006 |pmid= 16429275 |doi= 10.1007/s00429-005-0074-9 }}
*{{cite journal  | vauthors=Ahn KS, Sethi G, Krishnan K, Aggarwal BB |title=Gamma-tocotrienol inhibits nuclear factor-kappaB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis |journal=J. Biol. Chem. |volume=282 |issue= 1 |pages= 809–20 |year= 2007 |pmid= 17114179 |doi= 10.1074/jbc.M610028200 }}
*{{cite journal  | author=Feng S, Ma L, Yang Y, Wu M |title=Truncated RIP3 (tRIP3) acts upstream of FADD to induce apoptosis in the human hepatocellular carcinoma cell line QGY-7703. |journal=Biochem. Biophys. Res. Commun. |volume=347 |issue= 3 |pages= 558-65 |year= 2006 |pmid= 16844082 |doi= 10.1016/j.bbrc.2006.06.118 }}
*{{cite journal  | author=Ahn KS, Sethi G, Krishnan K, Aggarwal BB |title=Gamma-tocotrienol inhibits nuclear factor-kappaB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis. |journal=J. Biol. Chem. |volume=282 |issue= 1 |pages= 809-20 |year= 2007 |pmid= 17114179 |doi= 10.1074/jbc.M610028200 }}
}}
}}
{{refend}}
{{refend}}


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Revision as of 09:14, 10 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Receptor-interacting serine/threonine-protein kinase 3 is an enzyme that in humans is encoded by the RIPK3 gene.[1][2][3][4]

The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor.[3]

Interactions

RIPK3 has been shown to interact with RIPK1.[1][4]

References

  1. ↑ 1.0 1.1 Yu PW, Huang BC, Shen M, Quast J, Chan E, Xu X, Nolan GP, Payan DG, Luo Y (Jun 1999). "Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB". Curr Biol. 9 (10): 539–42. doi:10.1016/S0960-9822(99)80239-5. PMID 10339433.
  2. ↑ Sun X, Lee J, Navas T, Baldwin DT, Stewart TA, Dixit VM (Jul 1999). "RIP3, a novel apoptosis-inducing kinase". J Biol Chem. 274 (24): 16871–5. doi:10.1074/jbc.274.24.16871. PMID 10358032.
  3. ↑ 3.0 3.1 "Entrez Gene: RIPK3 receptor-interacting serine-threonine kinase 3".
  4. ↑ 4.0 4.1 Li J, McQuade T, Siemer AB, Napetschnig J, Moriwaki K, Hsiao YS, Damko E, Moquin D, Walz T, McDermott A, Chan FK, Wu H. (July 2012) The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis. Cell 150 (2):339-50. doi:10.1016/j.cell.2012.06.019. PMID 22817896

Further reading


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