RIT2: Difference between revisions

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{{Infobox_gene}}
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'''GTP-binding protein Rit2''' is a [[protein]] that in humans is encoded by the ''RIT2'' [[gene]].<ref name="pmid8824319">{{cite journal |vauthors=Lee CH, Della NG, Chew CE, Zack DJ | title = Rin, a neuron-specific and calmodulin-binding small G-protein, and Rit define a novel subfamily of ras proteins | journal = J Neurosci | volume = 16 | issue = 21 | pages = 6784–94 |date=Nov 1996 | pmid = 8824319 | pmc =  | doi =  }}</ref><ref name="pmid8918462">{{cite journal |vauthors=Wes PD, Yu M, Montell C | title = RIC, a calmodulin-binding Ras-like GTPase | journal = EMBO J | volume = 15 | issue = 21 | pages = 5839–48 |date=Jan 1997 | pmid = 8918462 | pmc = 452332 | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RIT2 Ras-like without CAAX 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6014| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Ras-like without CAAX 2
| HGNCid = 10017
| Symbol = RIT2
| AltSymbols =; RIBA; RIN; ROC2
| OMIM = 609592
| ECnumber =
| Homologene = 2198
| MGIid = 108054
  | GeneAtlas_image1 = PBB_GE_RIT2_206984_s_at_tn.png
  | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0005516 |text = calmodulin binding}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007264 |text = small GTPase mediated signal transduction}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6014
    | Hs_Ensembl = ENSG00000152214
    | Hs_RefseqProtein = NP_002921
    | Hs_RefseqmRNA = NM_002930
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 18
    | Hs_GenLoc_start = 38577191
    | Hs_GenLoc_end = 38949655
    | Hs_Uniprot = Q99578
    | Mm_EntrezGene = 19762
    | Mm_Ensembl = ENSMUSG00000057455
    | Mm_RefseqmRNA = NM_009065
    | Mm_RefseqProtein = NP_033091
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 18
    | Mm_GenLoc_start = 31117324
    | Mm_GenLoc_end = 31460138
    | Mm_Uniprot = P70425
  }}
}}
'''Ras-like without CAAX 2''', also known as '''RIT2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RIT2 Ras-like without CAAX 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6014| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = RIN belongs to the RAS (HRAS; MIM 190020) superfamily of small GTPases (Shao et al., 1999).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: RIT2 Ras-like without CAAX 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6014| accessdate = }}</ref>
| summary_text = RIN belongs to the RAS (HRAS; MIM 190020) superfamily of small GTPases (Shao et al., 1999).[supplied by OMIM]<ref name="entrez"/>
}}
}}
RIT2 has been associated with Parkinson's disease in two large genetic studies.<ref>{{Cite journal
| pmid = 22451204
| pmc = 3354734
| year = 2012
| author1 = Pankratz
| first1 = N
| title = Meta-analysis of Parkinson's disease: Identification of a novel locus, RIT2
| journal = Annals of Neurology
| volume = 71
| issue = 3
| pages = 370–84
| last2 = Beecham
| first2 = G. W.
| last3 = Destefano
| first3 = A. L.
| last4 = Dawson
| first4 = T. M.
| last5 = Doheny
| first5 = K. F.
| last6 = Factor
| first6 = S. A.
| last7 = Hamza
| first7 = T. H.
| last8 = Hung
| first8 = A. Y.
| last9 = Hyman
| first9 = B. T.
| last10 = Ivinson
| first10 = A. J.
| last11 = Krainc
| first11 = D
| last12 = Latourelle
| first12 = J. C.
| last13 = Clark
| first13 = L. N.
| last14 = Marder
| first14 = K
| last15 = Martin
| first15 = E. R.
| last16 = Mayeux
| first16 = R
| last17 = Ross
| first17 = O. A.
| last18 = Scherzer
| first18 = C. R.
| last19 = Simon
| first19 = D. K.
| last20 = Tanner
| first20 = C
| last21 = Vance
| first21 = J. M.
| last22 = Wszolek
| first22 = Z. K.
| last23 = Zabetian
| first23 = C. P.
| last24 = Myers
| first24 = R. H.
| last25 = Payami
| first25 = H
| last26 = Scott
| first26 = W. K.
| last27 = Foroud
| first27 = T
| last28 = Pd Gwas
| first28 = Consortium
| doi = 10.1002/ana.22687
}}</ref><ref>{{Cite journal
| pmid = 25064009
| pmc = 4146673
| year = 2014
| author1 = Nalls
| first1 = M. A.
| title = Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease
| journal = Nature Genetics
| volume = 46
| issue = 9
| pages = 989–93
| last2 = Pankratz
| first2 = N
| last3 = Lill
| first3 = C. M.
| last4 = Do
| first4 = C. B.
| last5 = Hernandez
| first5 = D. G.
| last6 = Saad
| first6 = M
| last7 = Destefano
| first7 = A. L.
| last8 = Kara
| first8 = E
| last9 = Bras
| first9 = J
| last10 = Sharma
| first10 = M
| last11 = Schulte
| first11 = C
| last12 = Keller
| first12 = M. F.
| last13 = Arepalli
| first13 = S
| last14 = Letson
| first14 = C
| last15 = Edsall
| first15 = C
| last16 = Stefansson
| first16 = H
| last17 = Liu
| first17 = X
| last18 = Pliner
| first18 = H
| last19 = Lee
| first19 = J. H.
| last20 = Cheng
| first20 = R
| author21 = International Parkinson's Disease Genomics Consortium (IPDGC)
| author22 = Parkinson's Study Group (PSG) Parkinson's Research: The Organized GENetics Initiative (PROGENI)
| author25 = NeuroGenetics Research Consortium (NGRC)
| author26 = Hussman Institute of Human Genomics (HIHG)
| author27 = Ashkenazi Jewish Dataset Investigator
| author28 = Cohorts for Health Aging Research in Genetic Epidemiology (CHARGE)
| author29 = North American Brain Expression Consortium (NABEC)
| author30 = United Kingdom Brain Expression Consortium (UKBEC)
| display-authors = 29
| doi = 10.1038/ng.3043
| last23 = Hadjigeorgiou
| first23 = Georgios M
| last24 = Bis
| first24 = Joshua C
}}</ref> An gene expression study of postmortem brain has suggested RIT2 interacts with [[interferon-γ]] signalling.<ref>{{Cite journal
| pmid = 25493648
| pmc = 4262449
| year = 2014
| author1 = Liscovitch
| first1 = N
| title = Differential Co-Expression between α-Synuclein and IFN-γ Signaling Genes across Development and in Parkinson's Disease
| journal = PLoS ONE
| volume = 9
| issue = 12
| pages = e115029
| last2 = French
| first2 = L
| doi = 10.1371/journal.pone.0115029
}}</ref>
==Interactions==
RIT2 has been shown to [[Protein-protein interaction|interact]] with [[POU4F1]].<ref name=pmid12934100>{{cite journal |last=Calissano |first=M |authorlink= |author2=Latchman D S  |date=Aug 2003 |title=Functional interaction between the small GTP-binding protein Rin and the N-terminal of Brn-3a transcription factor |journal=Oncogene |volume=22 |issue=35 |pages=5408–14 |publisher= |location = England| issn = 0950-9232| pmid = 12934100 |doi = 10.1038/sj.onc.1206635 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Lee CH, Della NG, Chew CE, Zack DJ |title=Rin, a neuron-specific and calmodulin-binding small G-protein, and Rit define a novel subfamily of ras proteins. |journal=J. Neurosci. |volume=16 |issue= 21 |pages= 6784-94 |year= 1996 |pmid= 8824319 |doi=  }}
*{{cite journal  |vauthors=Shao H, Kadono-Okuda K, Finlin BS, Andres DA |title=Biochemical characterization of the Ras-related GTPases Rit and Rin. |journal=Arch. Biochem. Biophys. |volume=371 |issue= 2 |pages= 207–19 |year= 1999 |pmid= 10545207 |doi= 10.1006/abbi.1999.1448 }}
*{{cite journal  | author=Wes PD, Yu M, Montell C |title=RIC, a calmodulin-binding Ras-like GTPase. |journal=EMBO J. |volume=15 |issue= 21 |pages= 5839-48 |year= 1997 |pmid= 8918462 |doi=  }}
*{{cite journal  |vauthors=Hoshino M, Nakamura S |title=The Ras-like small GTP-binding protein Rin is activated by growth factor stimulation. |journal=Biochem. Biophys. Res. Commun. |volume=295 |issue= 3 |pages= 651–6 |year= 2002 |pmid= 12099688 |doi=10.1016/S0006-291X(02)00731-3 }}
*{{cite journal  | author=Shao H, Kadono-Okuda K, Finlin BS, Andres DA |title=Biochemical characterization of the Ras-related GTPases Rit and Rin. |journal=Arch. Biochem. Biophys. |volume=371 |issue= 2 |pages= 207-19 |year= 1999 |pmid= 10545207 |doi= 10.1006/abbi.1999.1448 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Hoshino M, Nakamura S |title=The Ras-like small GTP-binding protein Rin is activated by growth factor stimulation. |journal=Biochem. Biophys. Res. Commun. |volume=295 |issue= 3 |pages= 651-6 |year= 2002 |pmid= 12099688 |doi=  }}
*{{cite journal  |vauthors=Calissano M, Latchman DS |title=Functional interaction between the small GTP-binding protein Rin and the N-terminal of Brn-3a transcription factor. |journal=Oncogene |volume=22 |issue= 35 |pages= 5408–14 |year= 2003 |pmid= 12934100 |doi= 10.1038/sj.onc.1206635 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal  | author=Calissano M, Latchman DS |title=Functional interaction between the small GTP-binding protein Rin and the N-terminal of Brn-3a transcription factor. |journal=Oncogene |volume=22 |issue= 35 |pages= 5408-14 |year= 2003 |pmid= 12934100 |doi= 10.1038/sj.onc.1206635 }}
*{{cite journal   |vauthors=Hartwig C, Veske A, Krejcova S, etal |title=Plexin B3 promotes neurite outgrowth, interacts homophilically, and interacts with Rin. |journal=BMC Neuroscience |volume=6|pages= 53 |year= 2006 |pmid= 16122393 |doi= 10.1186/1471-2202-6-53 | pmc=1215486 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  |vauthors=Shi GX, Han J, Andres DA |title=Rin GTPase couples nerve growth factor signaling to p38 and b-Raf/ERK pathways to promote neuronal differentiation. |journal=J. Biol. Chem. |volume=280 |issue= 45 |pages= 37599–609 |year= 2006 |pmid= 16157584 |doi= 10.1074/jbc.M507364200 }}
*{{cite journal | author=Hartwig C, Veske A, Krejcova S, ''et al.'' |title=Plexin B3 promotes neurite outgrowth, interacts homophilically, and interacts with Rin. |journal=BMC neuroscience |volume=6 |issue=  |pages= 53 |year= 2006 |pmid= 16122393 |doi= 10.1186/1471-2202-6-53 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Shi GX, Han J, Andres DA |title=Rin GTPase couples nerve growth factor signaling to p38 and b-Raf/ERK pathways to promote neuronal differentiation. |journal=J. Biol. Chem. |volume=280 |issue= 45 |pages= 37599-609 |year= 2006 |pmid= 16157584 |doi= 10.1074/jbc.M507364200 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
}}
{{refend}}
{{refend}}
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Revision as of 00:42, 9 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Wikidata
View/Edit Human

GTP-binding protein Rit2 is a protein that in humans is encoded by the RIT2 gene.[1][2][3]

RIN belongs to the RAS (HRAS; MIM 190020) superfamily of small GTPases (Shao et al., 1999).[supplied by OMIM][3]

RIT2 has been associated with Parkinson's disease in two large genetic studies.[4][5] An gene expression study of postmortem brain has suggested RIT2 interacts with interferon-γ signalling.[6]

Interactions

RIT2 has been shown to interact with POU4F1.[7]

References

  1. ↑ Lee CH, Della NG, Chew CE, Zack DJ (Nov 1996). "Rin, a neuron-specific and calmodulin-binding small G-protein, and Rit define a novel subfamily of ras proteins". J Neurosci. 16 (21): 6784–94. PMID 8824319.
  2. ↑ Wes PD, Yu M, Montell C (Jan 1997). "RIC, a calmodulin-binding Ras-like GTPase". EMBO J. 15 (21): 5839–48. PMC 452332. PMID 8918462.
  3. ↑ 3.0 3.1 "Entrez Gene: RIT2 Ras-like without CAAX 2".
  4. ↑ Pankratz, N; Beecham, G. W.; Destefano, A. L.; Dawson, T. M.; Doheny, K. F.; Factor, S. A.; Hamza, T. H.; Hung, A. Y.; Hyman, B. T.; Ivinson, A. J.; Krainc, D; Latourelle, J. C.; Clark, L. N.; Marder, K; Martin, E. R.; Mayeux, R; Ross, O. A.; Scherzer, C. R.; Simon, D. K.; Tanner, C; Vance, J. M.; Wszolek, Z. K.; Zabetian, C. P.; Myers, R. H.; Payami, H; Scott, W. K.; Foroud, T; Pd Gwas, Consortium (2012). "Meta-analysis of Parkinson's disease: Identification of a novel locus, RIT2". Annals of Neurology. 71 (3): 370–84. doi:10.1002/ana.22687. PMC 3354734. PMID 22451204.
  5. ↑ Nalls, M. A.; Pankratz, N; Lill, C. M.; Do, C. B.; Hernandez, D. G.; Saad, M; Destefano, A. L.; Kara, E; Bras, J; Sharma, M; Schulte, C; Keller, M. F.; Arepalli, S; Letson, C; Edsall, C; Stefansson, H; Liu, X; Pliner, H; Lee, J. H.; Cheng, R; International Parkinson's Disease Genomics Consortium (IPDGC); Parkinson's Study Group (PSG) Parkinson's Research: The Organized GENetics Initiative (PROGENI); Hadjigeorgiou, Georgios M; Bis, Joshua C; NeuroGenetics Research Consortium (NGRC); Hussman Institute of Human Genomics (HIHG); Ashkenazi Jewish Dataset Investigator; Cohorts for Health Aging Research in Genetic Epidemiology (CHARGE); North American Brain Expression Consortium (NABEC); et al. (2014). "Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease". Nature Genetics. 46 (9): 989–93. doi:10.1038/ng.3043. PMC 4146673. PMID 25064009.
  6. ↑ Liscovitch, N; French, L (2014). "Differential Co-Expression between α-Synuclein and IFN-γ Signaling Genes across Development and in Parkinson's Disease". PLoS ONE. 9 (12): e115029. doi:10.1371/journal.pone.0115029. PMC 4262449. PMID 25493648.
  7. ↑ Calissano, M; Latchman D S (Aug 2003). "Functional interaction between the small GTP-binding protein Rin and the N-terminal of Brn-3a transcription factor". Oncogene. England. 22 (35): 5408–14. doi:10.1038/sj.onc.1206635. ISSN 0950-9232. PMID 12934100.

Further reading



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