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{{Underlinked|date=March 2014}}
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{{Infobox_gene}}
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'''Ribonuclease inhibitor''' is an [[enzyme]] that in humans is encoded by the ''RNH1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RNH1 ribonuclease/angiogenin inhibitor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6050| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_RNH1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1a4y.
| PDB = {{PDB2|1a4y}}, {{PDB2|1z7x}}, {{PDB2|2bex}}
| Name = Ribonuclease/angiogenin inhibitor 1
| HGNCid = 10074
| Symbol = RNH1
| AltSymbols =; MGC18200; MGC4569; MGC54054; RAI; RNH
| OMIM = 173320
| ECnumber = 
| Homologene = 2204
| MGIid = 1195456
| GeneAtlas_image1 = PBB_GE_RNH1_206050_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008428 |text = ribonuclease inhibitor activity}}  
| Component = {{GNF_GO|id=GO:0032311 |text = angiogenin-PRI complex}}
| Process = {{GNF_GO|id=GO:0006402 |text = mRNA catabolic process}} {{GNF_GO|id=GO:0045765 |text = regulation of angiogenesis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6050
    | Hs_Ensembl = ENSG00000023191
    | Hs_RefseqProtein = NP_002930
    | Hs_RefseqmRNA = NM_002939
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 484513
    | Hs_GenLoc_end = 497300
    | Hs_Uniprot = P13489
    | Mm_EntrezGene = 107702
    | Mm_Ensembl = ENSMUSG00000038650
    | Mm_RefseqmRNA = NM_145135
    | Mm_RefseqProtein = NP_660117
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 141011642
    | Mm_GenLoc_end = 141020009
    | Mm_Uniprot = Q3UM23
  }}
}}
'''Ribonuclease/angiogenin inhibitor 1''', also known as '''RNH1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RNH1 ribonuclease/angiogenin inhibitor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6050| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Zneimer SM, Crawford D, Schneider NR, Beutler B |title=Mapping of the human ribonuclease inhibitor gene (RNH) to chromosome 11p15 by in situ hybridization. |journal=Genomics |volume=8 |issue= 1 |pages= 175-8 |year= 1991 |pmid= 2081593 |doi=  }}
*{{cite journal  | vauthors=Zneimer SM, Crawford D, Schneider NR, Beutler B |title=Mapping of the human ribonuclease inhibitor gene (RNH) to chromosome 11p15 by in situ hybridization. |journal=Genomics |volume=8 |issue= 1 |pages= 175–8 |year= 1991 |pmid= 2081593 |doi=10.1016/0888-7543(90)90242-M }}
*{{cite journal  | author=Weremowicz S, Fox EA, Morton CC, Vallee BL |title=The placental ribonuclease inhibitor (RNH) gene is located on chromosome subband 11p15.5. |journal=Genomics |volume=8 |issue= 4 |pages= 717-21 |year= 1991 |pmid= 2276743 |doi=  }}
*{{cite journal  | vauthors=Weremowicz S, Fox EA, Morton CC, Vallee BL |title=The placental ribonuclease inhibitor (RNH) gene is located on chromosome subband 11p15.5. |journal=Genomics |volume=8 |issue= 4 |pages= 717–21 |year= 1991 |pmid= 2276743 |doi=10.1016/0888-7543(90)90260-2 }}
*{{cite journal  | author=Lee FS, Vallee BL |title=Binding of placental ribonuclease inhibitor to the active site of angiogenin. |journal=Biochemistry |volume=28 |issue= 8 |pages= 3556-61 |year= 1989 |pmid= 2742853 |doi=  }}
*{{cite journal  | vauthors=Lee FS, Vallee BL |title=Binding of placental ribonuclease inhibitor to the active site of angiogenin. |journal=Biochemistry |volume=28 |issue= 8 |pages= 3556–61 |year= 1989 |pmid= 2742853 |doi=10.1021/bi00434a061 }}
*{{cite journal  | author=Bond MD, Vallee BL |title=Isolation of bovine angiogenin using a placental ribonuclease inhibitor binding assay. |journal=Biochemistry |volume=27 |issue= 17 |pages= 6282-7 |year= 1989 |pmid= 3064806 |doi=  }}
*{{cite journal  | vauthors=Bond MD, Vallee BL |title=Isolation of bovine angiogenin using a placental ribonuclease inhibitor binding assay. |journal=Biochemistry |volume=27 |issue= 17 |pages= 6282–7 |year= 1989 |pmid= 3064806 |doi=10.1021/bi00417a013 }}
*{{cite journal | author=Hofsteenge J, Kieffer B, Matthies R, ''et al.'' |title=Amino acid sequence of the ribonuclease inhibitor from porcine liver reveals the presence of leucine-rich repeats. |journal=Biochemistry |volume=27 |issue= 23 |pages= 8537-44 |year= 1989 |pmid= 3219361 |doi=  }}
*{{cite journal   |vauthors=Hofsteenge J, Kieffer B, Matthies R, etal |title=Amino acid sequence of the ribonuclease inhibitor from porcine liver reveals the presence of leucine-rich repeats. |journal=Biochemistry |volume=27 |issue= 23 |pages= 8537–44 |year= 1989 |pmid= 3219361 |doi=10.1021/bi00423a006 }}
*{{cite journal | author=Lee FS, Fox EA, Zhou HM, ''et al.'' |title=Primary structure of human placental ribonuclease inhibitor. |journal=Biochemistry |volume=27 |issue= 23 |pages= 8545-53 |year= 1989 |pmid= 3219362 |doi=  }}
*{{cite journal   |vauthors=Lee FS, Fox EA, Zhou HM, etal |title=Primary structure of human placental ribonuclease inhibitor. |journal=Biochemistry |volume=27 |issue= 23 |pages= 8545–53 |year= 1989 |pmid= 3219362 |doi=10.1021/bi00423a007 }}
*{{cite journal | author=Schneider R, Schneider-Scherzer E, Thurnher M, ''et al.'' |title=The primary structure of human ribonuclease/angiogenin inhibitor (RAI) discloses a novel highly diversified protein superfamily with a common repetitive module. |journal=EMBO J. |volume=7 |issue= 13 |pages= 4151-6 |year= 1989 |pmid= 3243277 |doi=  }}
*{{cite journal   |vauthors=Schneider R, Schneider-Scherzer E, Thurnher M, etal |title=The primary structure of human ribonuclease/angiogenin inhibitor (RAI) discloses a novel highly diversified protein superfamily with a common repetitive module |journal=EMBO J. |volume=7 |issue= 13 |pages= 4151–6 |year= 1989 |pmid= 3243277 |doi= | pmc=455125 }}
*{{cite journal  | author=Shapiro R, Vallee BL |title=Human placental ribonuclease inhibitor abolishes both angiogenic and ribonucleolytic activities of angiogenin. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 8 |pages= 2238-41 |year= 1987 |pmid= 3470787 |doi=  }}
*{{cite journal  | vauthors=Shapiro R, Vallee BL |title=Human placental ribonuclease inhibitor abolishes both angiogenic and ribonucleolytic activities of angiogenin |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 8 |pages= 2238–41 |year= 1987 |pmid= 3470787 |doi=10.1073/pnas.84.8.2238  | pmc=304624 }}
*{{cite journal  | author=Kiyohara H, Menjo M |title=Ribonuclease and ribonuclease inhibitor in the human pancreas. |journal=Gastroenterol. Jpn. |volume=18 |issue= 5 |pages= 468-73 |year= 1984 |pmid= 6653993 |doi=  }}
*{{cite journal  | vauthors=Kiyohara H, Menjo M |title=Ribonuclease and ribonuclease inhibitor in the human pancreas |journal=Gastroenterol. Jpn. |volume=18 |issue= 5 |pages= 468–73 |year= 1984 |pmid= 6653993 |doi=  }}
*{{cite journal | author=Nadano D, Yasuda T, Takeshita H, ''et al.'' |title=Purification and characterization of human brain ribonuclease inhibitor. |journal=Arch. Biochem. Biophys. |volume=312 |issue= 2 |pages= 421-8 |year= 1994 |pmid= 8037455 |doi= 10.1006/abbi.1994.1328 }}
*{{cite journal   |vauthors=Nadano D, Yasuda T, Takeshita H, etal |title=Purification and characterization of human brain ribonuclease inhibitor |journal=Arch. Biochem. Biophys. |volume=312 |issue= 2 |pages= 421–8 |year= 1994 |pmid= 8037455 |doi= 10.1006/abbi.1994.1328 }}
*{{cite journal  | author=Kobe B, Deisenhofer J |title=Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeats. |journal=Nature |volume=366 |issue= 6457 |pages= 751-6 |year= 1994 |pmid= 8264799 |doi= 10.1038/366751a08107760 }}
*{{cite journal  | vauthors=Kobe B, Deisenhofer J |title=Crystal structure of porcine ribonuclease inhibitor, a protein with leucine-rich repeats |journal=Nature |volume=366 |issue= 6457 |pages= 751–6 |year= 1994 |pmid= 8264799 |doi= 10.1038/366751a0 }}
*{{cite journal  | author=Papageorgiou AC, Shapiro R, Acharya KR |title=Molecular recognition of human angiogenin by placental ribonuclease inhibitor--an X-ray crystallographic study at 2.0 A resolution. |journal=EMBO J. |volume=16 |issue= 17 |pages= 5162-77 |year= 1997 |pmid= 9311977 |doi= 10.1093/emboj/16.17.5162 }}
*{{cite journal  | vauthors=Papageorgiou AC, Shapiro R, Acharya KR |title=Molecular recognition of human angiogenin by placental ribonuclease inhibitor--an X-ray crystallographic study at 2.0 A resolution |journal=EMBO J. |volume=16 |issue= 17 |pages= 5162–77 |year= 1997 |pmid= 9311977 |doi= 10.1093/emboj/16.17.5162 | pmc=1170149 }}
*{{cite journal  | author=Gaur D, Swaminathan S, Batra JK |title=Interaction of human pancreatic ribonuclease with human ribonuclease inhibitor. Generation of inhibitor-resistant cytotoxic variants. |journal=J. Biol. Chem. |volume=276 |issue= 27 |pages= 24978-84 |year= 2001 |pmid= 11342552 |doi= 10.1074/jbc.M102440200 }}
*{{cite journal  | vauthors=Gaur D, Swaminathan S, Batra JK |title=Interaction of human pancreatic ribonuclease with human ribonuclease inhibitor. Generation of inhibitor-resistant cytotoxic variants |journal=J. Biol. Chem. |volume=276 |issue= 27 |pages= 24978–84 |year= 2001 |pmid= 11342552 |doi= 10.1074/jbc.M102440200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Fu P, Chen J, Tian Y, ''et al.'' |title=Anti-tumor effect of hematopoietic cells carrying the gene of ribonuclease inhibitor. |journal=Cancer Gene Ther. |volume=12 |issue= 3 |pages= 268-75 |year= 2005 |pmid= 15592448 |doi= 10.1038/sj.cgt.7700742 }}
*{{cite journal   |vauthors=Fu P, Chen J, Tian Y, etal |title=Anti-tumor effect of hematopoietic cells carrying the gene of ribonuclease inhibitor |journal=Cancer Gene Ther. |volume=12 |issue= 3 |pages= 268–75 |year= 2005 |pmid= 15592448 |doi= 10.1038/sj.cgt.7700742 }}
*{{cite journal | author=Iyer S, Holloway DE, Kumar K, ''et al.'' |title=Molecular recognition of human eosinophil-derived neurotoxin (RNase 2) by placental ribonuclease inhibitor. |journal=J. Mol. Biol. |volume=347 |issue= 3 |pages= 637-55 |year= 2005 |pmid= 15755456 |doi= 10.1016/j.jmb.2005.01.035 }}
*{{cite journal   |vauthors=Iyer S, Holloway DE, Kumar K, etal |title=Molecular recognition of human eosinophil-derived neurotoxin (RNase 2) by placental ribonuclease inhibitor |journal=J. Mol. Biol. |volume=347 |issue= 3 |pages= 637–55 |year= 2005 |pmid= 15755456 |doi= 10.1016/j.jmb.2005.01.035 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Johnson RJ, McCoy JG, Bingman CA, ''et al.'' |title=Inhibition of human pancreatic ribonuclease by the human ribonuclease inhibitor protein. |journal=J. Mol. Biol. |volume=368 |issue= 2 |pages= 434-49 |year= 2007 |pmid= 17350650 |doi= 10.1016/j.jmb.2007.02.005 }}
*{{cite journal   |vauthors=Johnson RJ, McCoy JG, Bingman CA, etal |title=Inhibition of Human Pancreatic Ribonuclease by the Human Ribonuclease Inhibitor Protein |journal=J. Mol. Biol. |volume=368 |issue= 2 |pages= 434–49 |year= 2007 |pmid= 17350650 |doi= 10.1016/j.jmb.2007.02.005 | pmc=1993901 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=6050}}
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Revision as of 09:22, 10 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ribonuclease inhibitor is an enzyme that in humans is encoded by the RNH1 gene.[1]


References

  1. ↑ "Entrez Gene: RNH1 ribonuclease/angiogenin inhibitor 1".

Further reading



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