RPN1: Difference between revisions

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{{Infobox_gene}}
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'''Dolichyl-diphosphooligosaccharide—protein glycosyltransferase subunit 1''' is an [[enzyme]] that in humans is encoded by the ''RPN1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RPN1 ribophorin I| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6184| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Ribophorin I
| HGNCid = 10381
| Symbol = RPN1
| AltSymbols =; DKFZp686B16177; OST1; RBPH1
| OMIM = 180470
| ECnumber = 
| Homologene = 2213
| MGIid = 98084
| GeneAtlas_image1 = PBB_GE_RPN1_201011_at_tn.png
| Function = {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0004579 |text = dolichyl-diphosphooligosaccharide-protein glycotransferase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0008250 |text = oligosaccharyl transferase complex}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006486 |text = protein amino acid glycosylation}} {{GNF_GO|id=GO:0018279 |text = protein amino acid N-linked glycosylation via asparagine}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6184
    | Hs_Ensembl = ENSG00000163902
    | Hs_RefseqProtein = NP_002941
    | Hs_RefseqmRNA = NM_002950
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 129821503
    | Hs_GenLoc_end = 129852409
    | Hs_Uniprot = P04843
    | Mm_EntrezGene = 103963
    | Mm_Ensembl = ENSMUSG00000030062
    | Mm_RefseqmRNA = XM_981668
    | Mm_RefseqProtein = XP_986762
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 88050157
    | Mm_GenLoc_end = 88070945
    | Mm_Uniprot = Q3U900
  }}
}}
'''Ribophorin I''', also known as '''RPN1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RPN1 ribophorin I| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6184| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein should not be confused with RPN1 of yeast, Drosophila, and C. elegans, which forms part of the regulatory subunit of the 26S proteasome and may mediate binding of ubiquitin-like domains to this proteasome.  The human version of this proteasome subunit is PSMD2.<ref name="entrez">{{cite web | title = Entrez Gene: RPN1 ribophorin I| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6184| accessdate = }}</ref>
| summary_text = This gene encodes a type I integral [[ribophorin]] membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein should not be confused with RPN1 of yeast, Drosophila, and C. elegans, which forms part of the regulatory subunit of the 26S proteasome and may mediate binding of ubiquitin-like domains to this proteasome.  The human version of this proteasome subunit is PSMD2.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Crimaudo C, Hortsch M, Gausepohl H, Meyer DI |title=Human ribophorins I and II: the primary structure and membrane topology of two highly conserved rough endoplasmic reticulum-specific glycoproteins. |journal=EMBO J. |volume=6 |issue= 1 |pages= 75-82 |year= 1987 |pmid= 3034581 |doi=  }}
*{{cite journal  | vauthors=Crimaudo C, Hortsch M, Gausepohl H, Meyer DI |title=Human ribophorins I and II: the primary structure and membrane topology of two highly conserved rough endoplasmic reticulum-specific glycoproteins. |journal=EMBO J. |volume=6 |issue= 1 |pages= 75–82 |year= 1987 |pmid= 3034581 |doi= | pmc=553359 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Pekarsky Y, Rynditch A, Wieser R, ''et al.'' |title=Activation of a novel gene in 3q21 and identification of intergenic fusion transcripts with ecotropic viral insertion site I in leukemia. |journal=Cancer Res. |volume=57 |issue= 18 |pages= 3914-9 |year= 1997 |pmid= 9307271 |doi=  }}
*{{cite journal   |vauthors=Pekarsky Y, Rynditch A, Wieser R, etal |title=Activation of a novel gene in 3q21 and identification of intergenic fusion transcripts with ecotropic viral insertion site I in leukemia. |journal=Cancer Res. |volume=57 |issue= 18 |pages= 3914–9 |year= 1997 |pmid= 9307271 |doi=  }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal  | author=Fu J, Kreibich G |title=Retention of subunits of the oligosaccharyltransferase complex in the endoplasmic reticulum. |journal=J. Biol. Chem. |volume=275 |issue= 6 |pages= 3984-90 |year= 2000 |pmid= 10660554 |doi=  }}
*{{cite journal  | vauthors=Fu J, Kreibich G |title=Retention of subunits of the oligosaccharyltransferase complex in the endoplasmic reticulum. |journal=J. Biol. Chem. |volume=275 |issue= 6 |pages= 3984–90 |year= 2000 |pmid= 10660554 |doi=10.1074/jbc.275.6.3984 }}
*{{cite journal | author=Dias Neto E, Correa RG, Verjovski-Almeida S, ''et al.'' |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491-6 |year= 2000 |pmid= 10737800 |doi=  }}
*{{cite journal   |vauthors=Dias Neto E, Correa RG, Verjovski-Almeida S, etal |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=10.1073/pnas.97.7.3491  | pmc=16267 }}
*{{cite journal | author=Elsasser S, Gali RR, Schwickart M, ''et al.'' |title=Proteasome subunit Rpn1 binds ubiquitin-like protein domains. |journal=Nat. Cell Biol. |volume=4 |issue= 9 |pages= 725-30 |year= 2002 |pmid= 12198498 |doi= 10.1038/ncb845 }}
*{{cite journal   |vauthors=Elsasser S, Gali RR, Schwickart M, etal |title=Proteasome subunit Rpn1 binds ubiquitin-like protein domains. |journal=Nat. Cell Biol. |volume=4 |issue= 9 |pages= 725–30 |year= 2002 |pmid= 12198498 |doi= 10.1038/ncb845 }}
*{{cite journal  | author=Saeki Y, Sone T, Toh-e A, Yokosawa H |title=Identification of ubiquitin-like protein-binding subunits of the 26S proteasome. |journal=Biochem. Biophys. Res. Commun. |volume=296 |issue= 4 |pages= 813-9 |year= 2002 |pmid= 12200120 |doi=  }}
*{{cite journal  | vauthors=Saeki Y, Sone T, Toh-e A, Yokosawa H |title=Identification of ubiquitin-like protein-binding subunits of the 26S proteasome. |journal=Biochem. Biophys. Res. Commun. |volume=296 |issue= 4 |pages= 813–9 |year= 2002 |pmid= 12200120 |doi=10.1016/S0006-291X(02)02002-8 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Basrur V, Yang F, Kushimoto T, ''et al.'' |title=Proteomic analysis of early melanosomes: identification of novel melanosomal proteins. |journal=J. Proteome Res. |volume=2 |issue= 1 |pages= 69-79 |year= 2003 |pmid= 12643545 |doi=  }}
*{{cite journal   |vauthors=Basrur V, Yang F, Kushimoto T, etal |title=Proteomic analysis of early melanosomes: identification of novel melanosomal proteins. |journal=J. Proteome Res. |volume=2 |issue= 1 |pages= 69–79 |year= 2003 |pmid= 12643545 |doi=10.1021/pr025562r }}
*{{cite journal  | author=Kelleher DJ, Karaoglu D, Mandon EC, Gilmore R |title=Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties. |journal=Mol. Cell |volume=12 |issue= 1 |pages= 101-11 |year= 2003 |pmid= 12887896 |doi=  }}
*{{cite journal  | vauthors=Kelleher DJ, Karaoglu D, Mandon EC, Gilmore R |title=Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties. |journal=Mol. Cell |volume=12 |issue= 1 |pages= 101–11 |year= 2003 |pmid= 12887896 |doi=10.1016/S1097-2765(03)00243-0 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Shibatani T, David LL, McCormack AL, ''et al.'' |title=Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits. |journal=Biochemistry |volume=44 |issue= 16 |pages= 5982-92 |year= 2005 |pmid= 15835887 |doi= 10.1021/bi047328f }}
*{{cite journal   |vauthors=Shibatani T, David LL, McCormack AL, etal |title=Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits. |journal=Biochemistry |volume=44 |issue= 16 |pages= 5982–92 |year= 2005 |pmid= 15835887 |doi= 10.1021/bi047328f }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal   |vauthors=Lim J, Hao T, Shaw C, etal |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal | author=Chi A, Valencia JC, Hu ZZ, ''et al.'' |title=Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. |journal=J. Proteome Res. |volume=5 |issue= 11 |pages= 3135-44 |year= 2007 |pmid= 17081065 |doi= 10.1021/pr060363j }}
*{{cite journal   |vauthors=Chi A, Valencia JC, Hu ZZ, etal |title=Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. |journal=J. Proteome Res. |volume=5 |issue= 11 |pages= 3135–44 |year= 2007 |pmid= 17081065 |doi= 10.1021/pr060363j }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
*{{cite journal   |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 09:27, 10 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Dolichyl-diphosphooligosaccharide—protein glycosyltransferase subunit 1 is an enzyme that in humans is encoded by the RPN1 gene.[1]

This gene encodes a type I integral ribophorin membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein should not be confused with RPN1 of yeast, Drosophila, and C. elegans, which forms part of the regulatory subunit of the 26S proteasome and may mediate binding of ubiquitin-like domains to this proteasome. The human version of this proteasome subunit is PSMD2.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: RPN1 ribophorin I".

Further reading



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