S100A3: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{reflist}} +{{reflist|2}}, -<references /> +{{reflist|2}}, -{{WikiDoc Cardiology Network Infobox}} +))
 
m (Bot: HTTP→HTTPS)
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Underlinked|date=March 2015}}
{{PBB_Controls
{{Infobox_gene}}
| update_page = yes
'''[[S100 protein|S100]] calcium-binding protein A3''' ('''S100A3''') is a [[protein]] that in humans is encoded by the ''S100A3'' [[gene]].<ref name="pmid8341667">{{cite journal | vauthors = Engelkamp D, Schafer BW, Mattei MG, Erne P, Heizmann CW | title = Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E | journal = Proc Natl Acad Sci U S A | volume = 90 | issue = 14 | pages = 6547–51 |date=Aug 1993 | pmid = 8341667 | pmc = 46969 | doi =10.1073/pnas.90.14.6547 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: S100A3 S100 calcium binding protein A3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6274| accessdate = }}</ref>
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
 
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_S100A3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1kso.
| PDB = {{PDB2|1kso}}
| Name = S100 calcium binding protein A3
| HGNCid = 10493
| Symbol = S100A3
| AltSymbols =; S100E
| OMIM = 176992
| ECnumber = 
| Homologene = 2223
| MGIid = 1338849
| GeneAtlas_image1 = PBB_GE_S100A3_206027_at_tn.png
| Function = {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}}
| Component =  
| Process =  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6274
    | Hs_Ensembl = ENSG00000188015
    | Hs_RefseqProtein = NP_002951
    | Hs_RefseqmRNA = NM_002960
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 151786429
    | Hs_GenLoc_end = 151788472
    | Hs_Uniprot = P33764
    | Mm_EntrezGene = 20197
    | Mm_Ensembl = ENSMUSG00000001021
    | Mm_RefseqmRNA = NM_011310
    | Mm_RefseqProtein = NP_035440
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 90672879
    | Mm_GenLoc_end = 90688629
    | Mm_Uniprot = Q496W1
  }}
}}
'''S100 calcium binding protein A3''', also known as '''S100A3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: S100A3 S100 calcium binding protein A3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6274| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has the highest content of cysteines of all S100 proteins, has a high affinity for Zinc, and is highly expressed in human hair cuticle. The precise function of this protein is unknown.<ref name="entrez">{{cite web | title = Entrez Gene: S100A3 S100 calcium binding protein A3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6274| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has the highest content of cysteines of all S100 proteins, has a high affinity for Zinc, and is highly expressed in human hair cuticle. The precise function of this protein is unknown.<ref name="entrez"/>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Schäfer BW, Heizmann CW |title=The S100 family of EF-hand calcium-binding proteins: functions and pathology. |journal=Trends Biochem. Sci. |volume=21 |issue= 4 |pages= 134-40 |year= 1996 |pmid= 8701470 |doi=  }}
*{{cite journal  | vauthors=Schäfer BW, Heizmann CW |title=The S100 family of EF-hand calcium-binding proteins: functions and pathology. |journal=Trends Biochem. Sci. |volume=21 |issue= 4 |pages= 134–40 |year= 1996 |pmid= 8701470 |doi=  10.1016/S0968-0004(96)80167-8}}
*{{cite journal | author=Föhr UG, Heizmann CW, Engelkamp D, ''et al.'' |title=Purification and cation binding properties of the recombinant human S100 calcium-binding protein A3, an EF-hand motif protein with high affinity for zinc. |journal=J. Biol. Chem. |volume=270 |issue= 36 |pages= 21056-61 |year= 1995 |pmid= 7673133 |doi=  }}
*{{cite journal   |vauthors=Föhr UG, Heizmann CW, Engelkamp D, etal |title=Purification and cation binding properties of the recombinant human S100 calcium-binding protein A3, an EF-hand motif protein with high affinity for zinc. |journal=J. Biol. Chem. |volume=270 |issue= 36 |pages= 21056–61 |year= 1995 |pmid= 7673133 |doi=10.1074/jbc.270.36.21056 }}
*{{cite journal | author=Schäfer BW, Wicki R, Engelkamp D, ''et al.'' |title=Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family. |journal=Genomics |volume=25 |issue= 3 |pages= 638-43 |year= 1995 |pmid= 7759097 |doi= }}
*{{cite journal   |vauthors=Schäfer BW, Wicki R, Engelkamp D, etal |title=Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family. |journal=Genomics |volume=25 |issue= 3 |pages= 638–43 |year= 1995 |pmid= 7759097 |doi=10.1016/0888-7543(95)80005-7 }}
*{{cite journal  | author=Engelkamp D, Schäfer BW, Mattei MG, ''et al.'' |title=Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 14 |pages= 6547-51 |year= 1993 |pmid= 8341667 |doi= }}
*{{cite journal  | vauthors=Kizawa K, Uchiwa H, Murakami U |title=Highly-expressed S100A3, a calcium-binding protein, in human hair cuticle. |journal=Biochim. Biophys. Acta |volume=1312 |issue= 2 |pages= 94–8 |year= 1996 |pmid= 8672544 |doi=10.1016/0167-4889(96)00023-7 }}
*{{cite journal  | author=Kizawa K, Uchiwa H, Murakami U |title=Highly-expressed S100A3, a calcium-binding protein, in human hair cuticle. |journal=Biochim. Biophys. Acta |volume=1312 |issue= 2 |pages= 94-8 |year= 1996 |pmid= 8672544 |doi=  }}
*{{cite journal   |vauthors=Böni R, Burg G, Doguoglu A, etal |title=Immunohistochemical localization of the Ca2+ binding S100 proteins in normal human skin and melanocytic lesions. |journal=Br. J. Dermatol. |volume=137 |issue= 1 |pages= 39–43 |year= 1997 |pmid= 9274623 |doi=10.1111/j.1365-2133.1997.tb03698.x }}
*{{cite journal | author=Böni R, Burg G, Doguoglu A, ''et al.'' |title=Immunohistochemical localization of the Ca2+ binding S100 proteins in normal human skin and melanocytic lesions. |journal=Br. J. Dermatol. |volume=137 |issue= 1 |pages= 39-43 |year= 1997 |pmid= 9274623 |doi=  }}
*{{cite journal  | vauthors=Groves P, Finn BE, Kuźnicki J, Forsén S |title=A model for target protein binding to calcium-activated S100 dimers. |journal=FEBS Lett. |volume=421 |issue= 3 |pages= 175–9 |year= 1998 |pmid= 9468301 |doi=10.1016/S0014-5793(97)01535-4 }}
*{{cite journal  | author=Groves P, Finn BE, Kuźnicki J, Forsén S |title=A model for target protein binding to calcium-activated S100 dimers. |journal=FEBS Lett. |volume=421 |issue= 3 |pages= 175-9 |year= 1998 |pmid= 9468301 |doi=  }}
*{{cite journal   |vauthors=Ridinger K, Ilg EC, Niggli FK, etal |title=Clustered organization of S100 genes in human and mouse. |journal=Biochim. Biophys. Acta |volume=1448 |issue= 2 |pages= 254–63 |year= 1999 |pmid= 9920416 |doi=  10.1016/S0167-4889(98)00137-2}}
*{{cite journal | author=Ridinger K, Ilg EC, Niggli FK, ''et al.'' |title=Clustered organization of S100 genes in human and mouse. |journal=Biochim. Biophys. Acta |volume=1448 |issue= 2 |pages= 254-63 |year= 1999 |pmid= 9920416 |doi=  }}
*{{cite journal  | vauthors=Fritz G, Heizmann CW, Kroneck PM |title=Probing the structure of the human Ca2+- and Zn2+-binding protein S100A3: spectroscopic investigations of its transition metal ion complexes, and three-dimensional structural model. |journal=Biochim. Biophys. Acta |volume=1448 |issue= 2 |pages= 264–76 |year= 1999 |pmid= 9920417 |doi=  10.1016/S0167-4889(98)00138-4}}
*{{cite journal  | author=Fritz G, Heizmann CW, Kroneck PM |title=Probing the structure of the human Ca2+- and Zn2+-binding protein S100A3: spectroscopic investigations of its transition metal ion complexes, and three-dimensional structural model. |journal=Biochim. Biophys. Acta |volume=1448 |issue= 2 |pages= 264-76 |year= 1999 |pmid= 9920417 |doi=  }}
*{{cite journal   |vauthors=Hoyaux D, Decaestecker C, Heizmann CW, etal |title=S100 proteins in Corpora amylacea from normal human brain. |journal=Brain Res. |volume=867 |issue= 1–2 |pages= 280–8 |year= 2000 |pmid= 10837826 |doi=10.1016/S0006-8993(00)02393-3 }}
*{{cite journal | author=Hoyaux D, Decaestecker C, Heizmann CW, ''et al.'' |title=S100 proteins in Corpora amylacea from normal human brain. |journal=Brain Res. |volume=867 |issue= 1-2 |pages= 280-8 |year= 2000 |pmid= 10837826 |doi=  }}
*{{cite journal   |vauthors=Fritz G, Mittl PR, Vasak M, etal |title=The crystal structure of metal-free human EF-hand protein S100A3 at 1.7-A resolution |journal=J. Biol. Chem. |volume=277 |issue= 36 |pages= 33092–8 |year= 2002 |pmid= 12045193 |doi= 10.1074/jbc.M200574200 }}
*{{cite journal | author=Fritz G, Mittl PR, Vasak M, ''et al.'' |title=The crystal structure of metal-free human EF-hand protein S100A3 at 1.7-A resolution. |journal=J. Biol. Chem. |volume=277 |issue= 36 |pages= 33092-8 |year= 2002 |pmid= 12045193 |doi= 10.1074/jbc.M200574200 }}
*{{cite journal   |vauthors=Mittl PR, Fritz G, Sargent DF, etal |title=Metal-free MIRAS phasing: structure of apo-S100A3 |journal=Acta Crystallogr. D |volume=58 |issue= Pt 8 |pages= 1255–61 |year= 2003 |pmid= 12136135 |doi=10.1107/S0907444902008430 }}
*{{cite journal | author=Mittl PR, Fritz G, Sargent DF, ''et al.'' |title=Metal-free MIRAS phasing: structure of apo-S100A3. |journal=Acta Crystallogr. D Biol. Crystallogr. |volume=58 |issue= Pt 8 |pages= 1255-61 |year= 2003 |pmid= 12136135 |doi=  }}
*{{cite journal   |vauthors=Kizawa K, Troxler H, Kleinert P, etal |title=Characterization of the cysteine-rich calcium-binding S100A3 protein from human hair cuticles |journal=Biochem. Biophys. Res. Commun. |volume=299 |issue= 5 |pages= 857–62 |year= 2003 |pmid= 12470658 |doi=10.1016/S0006-291X(02)02744-4 }}
*{{cite journal | author=Kizawa K, Troxler H, Kleinert P, ''et al.'' |title=Characterization of the cysteine-rich calcium-binding S100A3 protein from human hair cuticles. |journal=Biochem. Biophys. Res. Commun. |volume=299 |issue= 5 |pages= 857-62 |year= 2003 |pmid= 12470658 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Gregory SG, Barlow KF, McLay KE, etal |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal   |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein-protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=6274}}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
{{gene-1-stub}}


{{protein-stub}}
[[Category:S100 proteins]]
{{WikiDoc Sources}}

Revision as of 05:49, 11 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

S100 calcium-binding protein A3 (S100A3) is a protein that in humans is encoded by the S100A3 gene.[1][2]

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has the highest content of cysteines of all S100 proteins, has a high affinity for Zinc, and is highly expressed in human hair cuticle. The precise function of this protein is unknown.[2]

References

  1. ↑ Engelkamp D, Schafer BW, Mattei MG, Erne P, Heizmann CW (Aug 1993). "Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E". Proc Natl Acad Sci U S A. 90 (14): 6547–51. doi:10.1073/pnas.90.14.6547. PMC 46969. PMID 8341667.
  2. ↑ 2.0 2.1 "Entrez Gene: S100A3 S100 calcium binding protein A3".

Further reading



Retrieved from "https://www.wikidoc.org/index.php?title=S100A3&oldid=1411853"