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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Squamous cell carcinoma antigen recognized by T-cells 3''' is a [[protein]] that in humans is encoded by the ''SART3'' [[gene]].<ref name="pmid8590280">{{cite journal | vauthors = Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N | title = Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1 | journal = DNA Research | volume = 2 | issue = 4 | pages = 167–74, 199-210 | date = August 1995 | pmid = 8590280 | pmc =  | doi = 10.1093/dnares/2.4.167 }}</ref><ref name="pmid8590280" /><ref name="pmid10761712">{{cite journal | vauthors = Harada K, Yamada A, Mine T, Kawagoe N, Takasu H, Itoh K | title = Mouse homologue of the human SART3 gene encoding tumor-rejection antigen | journal = Japanese Journal of Cancer Research | volume = 91 | issue = 2 | pages = 239–47 | date = February 2000 | pmid = 10761712 | pmc =  | doi = 10.1111/j.1349-7006.2000.tb00937.x }}</ref><ref name="pmid10761712" /><ref name="entrez">{{cite web | title = Entrez Gene: SART3 squamous cell carcinoma antigen recognized by T cells 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9733| accessdate = }}</ref>
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| require_manual_inspection = no
| update_protein_box = yes
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| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The [[protein]] encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection [[antigen]]. This antigen possesses tumor [[epitope]]s capable of inducing [[HLA-A24]]-restricted and tumor-specific cytotoxic [[T lymphocyte]]s in cancer patients and may be useful for specific [[immunotherapy]]. This gene product is found to be an important cellular factor for [[HIV-1]] gene expression and viral replication. It also associates transiently with U6 and U4/U6 [[snRNP]]s during the recycling phase of the [[spliceosome]] cycle. This encoded protein is thought to be involved in the regulation of [[mRNA]] splicing.<ref name="entrez"/>
{{GNF_Protein_box
| image = PBB_Protein_SART3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2do4.
| PDB = {{PDB2|2do4}}
| Name = Squamous cell carcinoma antigen recognized by T cells 3
| HGNCid = 16860
| Symbol = SART3
| AltSymbols =; KIAA0156; MGC138188; RP11-13G14; TIP110; p110(nrb)
| OMIM = 
| ECnumber = 
| Homologene = 40977
| MGIid = 1858230
| GeneAtlas_image1 = PBB_GE_SART3_209127_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SART3_209128_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006396 |text = RNA processing}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9733
    | Hs_Ensembl = ENSG00000075856
    | Hs_RefseqProtein = NP_055521
    | Hs_RefseqmRNA = NM_014706
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 107440487
    | Hs_GenLoc_end = 107479067
    | Hs_Uniprot = Q15020
    | Mm_EntrezGene = 53890
    | Mm_Ensembl = ENSMUSG00000018974
    | Mm_RefseqmRNA = NM_016926
    | Mm_RefseqProtein = NP_058622
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 114003445
    | Mm_GenLoc_end = 114032648
    | Mm_Uniprot = Q9JLI8
  }}
}}
'''Squamous cell carcinoma antigen recognized by T cells 3''', also known as '''SART3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SART3 squamous cell carcinoma antigen recognized by T cells 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9733| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{PBB_Summary
| section_title =  
| summary_text = The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing.<ref name="entrez">{{cite web | title = Entrez Gene: SART3 squamous cell carcinoma antigen recognized by T cells 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9733| accessdate = }}</ref>
}}


==References==
SART3 has been shown to [[Protein-protein interaction|interact]] with [[RNPS1]]<ref name=pmid11477570>{{cite journal | vauthors = Harada K, Yamada A, Yang D, Itoh K, Shichijo S | title = Binding of a SART3 tumor-rejection antigen to a pre-mRNA splicing factor RNPS1: a possible regulation of splicing by a complex formation | journal = International Journal of Cancer | volume = 93 | issue = 5 | pages = 623–8 | date = September 2001 | pmid = 11477570 | doi = 10.1002/ijc.1391 }}</ref> and [[Androgen receptor]].<ref name=pmid15031286>{{cite journal | vauthors = Liu Y, Kim BO, Kao C, Jung C, Dalton JT, He JJ | title = Tip110, the human immunodeficiency virus type 1 (HIV-1) Tat-interacting protein of 110 kDa as a negative regulator of androgen receptor (AR) transcriptional activation | journal = The Journal of Biological Chemistry | volume = 279 | issue = 21 | pages = 21766–73 | date = May 2004 | pmid = 15031286 | doi = 10.1074/jbc.M314321200 }}</ref>
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | author=Nagase T, Seki N, Tanaka A, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=2 |issue= 4 |pages= 167-74, 199-210 |year= 1996 |pmid= 8590280 |doi=  }}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  | author=Yang D, Nakao M, Shichijo S, ''et al.'' |title=Identification of a gene coding for a protein possessing shared tumor epitopes capable of inducing HLA-A24-restricted cytotoxic T lymphocytes in cancer patients. |journal=Cancer Res. |volume=59 |issue= 16 |pages= 4056-63 |year= 1999 |pmid= 10463607 |doi=  }}
*{{cite journal | author=Harada K, Yamada A, Mine T, ''et al.'' |title=Mouse homologue of the human SART3 gene encoding tumor-rejection antigen. |journal=Jpn. J. Cancer Res. |volume=91 |issue= 2 |pages= 239-47 |year= 2000 |pmid= 10761712 |doi=  }}
*{{cite journal  | author=Tanaka S, Tsuda N, Kawano K, ''et al.'' |title=Expression of tumor-rejection antigens in gynecologic cancers. |journal=Jpn. J. Cancer Res. |volume=91 |issue= 11 |pages= 1177-84 |year= 2001 |pmid= 11092984 |doi=  }}
*{{cite journal  | author=Harada K, Yamada A, Yang D, ''et al.'' |title=Binding of a SART3 tumor-rejection antigen to a pre-mRNA splicing factor RNPS1: a possible regulation of splicing by a complex formation. |journal=Int. J. Cancer |volume=93 |issue= 5 |pages= 623-8 |year= 2001 |pmid= 11477570 |doi=  }}
*{{cite journal  | author=Sasatomi T, Suefuji Y, Matsunaga K, ''et al.'' |title=Expression of tumor rejection antigens in colorectal carcinomas. |journal=Cancer |volume=94 |issue= 6 |pages= 1636-41 |year= 2002 |pmid= 11920522 |doi=  }}
*{{cite journal  | author=Liu Y, Li J, Kim BO, ''et al.'' |title=HIV-1 Tat protein-mediated transactivation of the HIV-1 long terminal repeat promoter is potentiated by a novel nuclear Tat-interacting protein of 110 kDa, Tip110. |journal=J. Biol. Chem. |volume=277 |issue= 26 |pages= 23854-63 |year= 2002 |pmid= 11959860 |doi= 10.1074/jbc.M200773200 }}
*{{cite journal  | author=Bell M, Schreiner S, Damianov A, ''et al.'' |title=p110, a novel human U6 snRNP protein and U4/U6 snRNP recycling factor. |journal=EMBO J. |volume=21 |issue= 11 |pages= 2724-35 |year= 2002 |pmid= 12032085 |doi= 10.1093/emboj/21.11.2724 }}
*{{cite journal  | author=Nottrott S, Urlaub H, Lührmann R |title=Hierarchical, clustered protein interactions with U4/U6 snRNA: a biochemical role for U4/U6 proteins. |journal=EMBO J. |volume=21 |issue= 20 |pages= 5527-38 |year= 2002 |pmid= 12374753 |doi=  }}
*{{cite journal  | author=Nakayama M, Kikuno R, Ohara O |title=Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. |journal=Genome Res. |volume=12 |issue= 11 |pages= 1773-84 |year= 2003 |pmid= 12421765 |doi= 10.1101/gr.406902 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Stanĕk D, Rader SD, Klingauf M, Neugebauer KM |title=Targeting of U4/U6 small nuclear RNP assembly factor SART3/p110 to Cajal bodies. |journal=J. Cell Biol. |volume=160 |issue= 4 |pages= 505-16 |year= 2003 |pmid= 12578909 |doi= 10.1083/jcb.200210087 }}
*{{cite journal  | author=Damianov A, Schreiner S, Bindereif A |title=Recycling of the U12-type spliceosome requires p110, a component of the U6atac snRNP. |journal=Mol. Cell. Biol. |volume=24 |issue= 4 |pages= 1700-8 |year= 2004 |pmid= 14749385 |doi=  }}
*{{cite journal | author=Liu Y, Kim BO, Kao C, ''et al.'' |title=Tip110, the human immunodeficiency virus type 1 (HIV-1) Tat-interacting protein of 110 kDa as a negative regulator of androgen receptor (AR) transcriptional activation. |journal=J. Biol. Chem. |volume=279 |issue= 21 |pages= 21766-73 |year= 2004 |pmid= 15031286 |doi= 10.1074/jbc.M314321200 }}
*{{cite journal  | author=Brandenberger R, Wei H, Zhang S, ''et al.'' |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707-16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
*{{cite journal  | author=Medenbach J, Schreiner S, Liu S, ''et al.'' |title=Human U4/U6 snRNP recycling factor p110: mutational analysis reveals the function of the tetratricopeptide repeat domain in recycling. |journal=Mol. Cell. Biol. |volume=24 |issue= 17 |pages= 7392-401 |year= 2004 |pmid= 15314151 |doi= 10.1128/MCB.24.17.7392-7401.2004 }}
*{{cite journal  | author=Stanĕk D, Neugebauer KM |title=Detection of snRNP assembly intermediates in Cajal bodies by fluorescence resonance energy transfer. |journal=J. Cell Biol. |volume=166 |issue= 7 |pages= 1015-25 |year= 2004 |pmid= 15452143 |doi= 10.1083/jcb.200405160 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}


{{protein-stub}}
== References ==
{{WikiDoc Sources}}
{{Reflist}}
 
== Further reading ==
{{Refbegin | 2}}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
* {{cite journal | vauthors = Yang D, Nakao M, Shichijo S, Sasatomi T, Takasu H, Matsumoto H, Mori K, Hayashi A, Yamana H, Shirouzu K, Itoh K | title = Identification of a gene coding for a protein possessing shared tumor epitopes capable of inducing HLA-A24-restricted cytotoxic T lymphocytes in cancer patients | journal = Cancer Research | volume = 59 | issue = 16 | pages = 4056–63 | date = August 1999 | pmid = 10463607 | doi =  }}
* {{cite journal | vauthors = Tanaka S, Tsuda N, Kawano K, Sakamoto M, Nishida T, Hashimoto T, Shichijo S, Kamura T, Itoh K | title = Expression of tumor-rejection antigens in gynecologic cancers | journal = Japanese Journal of Cancer Research | volume = 91 | issue = 11 | pages = 1177–84 | date = November 2000 | pmid = 11092984 | doi = 10.1111/j.1349-7006.2000.tb00902.x }}
* {{cite journal | vauthors = Harada K, Yamada A, Yang D, Itoh K, Shichijo S | title = Binding of a SART3 tumor-rejection antigen to a pre-mRNA splicing factor RNPS1: a possible regulation of splicing by a complex formation | journal = International Journal of Cancer | volume = 93 | issue = 5 | pages = 623–8 | date = September 2001 | pmid = 11477570 | doi = 10.1002/ijc.1391 }}
* {{cite journal | vauthors = Sasatomi T, Suefuji Y, Matsunaga K, Yamana H, Miyagi Y, Araki Y, Ogata Y, Itoh K, Shirouzu K | title = Expression of tumor rejection antigens in colorectal carcinomas | journal = Cancer | volume = 94 | issue = 6 | pages = 1636–41 | date = March 2002 | pmid = 11920522 | doi = 10.1002/cncr.10421 }}
* {{cite journal | vauthors = Liu Y, Li J, Kim BO, Pace BS, He JJ | title = HIV-1 Tat protein-mediated transactivation of the HIV-1 long terminal repeat promoter is potentiated by a novel nuclear Tat-interacting protein of 110 kDa, Tip110 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 26 | pages = 23854–63 | date = June 2002 | pmid = 11959860 | doi = 10.1074/jbc.M200773200 }}
* {{cite journal | vauthors = Bell M, Schreiner S, Damianov A, Reddy R, Bindereif A | title = p110, a novel human U6 snRNP protein and U4/U6 snRNP recycling factor | journal = The EMBO Journal | volume = 21 | issue = 11 | pages = 2724–35 | date = June 2002 | pmid = 12032085 | pmc = 126028 | doi = 10.1093/emboj/21.11.2724 }}
* {{cite journal | vauthors = Nottrott S, Urlaub H, Lührmann R | title = Hierarchical, clustered protein interactions with U4/U6 snRNA: a biochemical role for U4/U6 proteins | journal = The EMBO Journal | volume = 21 | issue = 20 | pages = 5527–38 | date = October 2002 | pmid = 12374753 | pmc = 129076 | doi = 10.1093/emboj/cdf544 }}
* {{cite journal | vauthors = Nakayama M, Kikuno R, Ohara O | title = Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs | journal = Genome Research | volume = 12 | issue = 11 | pages = 1773–84 | date = November 2002 | pmid = 12421765 | pmc = 187542 | doi = 10.1101/gr.406902 }}
* {{cite journal | vauthors = Stanĕk D, Rader SD, Klingauf M, Neugebauer KM | title = Targeting of U4/U6 small nuclear RNP assembly factor SART3/p110 to Cajal bodies | journal = The Journal of Cell Biology | volume = 160 | issue = 4 | pages = 505–16 | date = February 2003 | pmid = 12578909 | pmc = 2173746 | doi = 10.1083/jcb.200210087 }}
* {{cite journal | vauthors = Damianov A, Schreiner S, Bindereif A | title = Recycling of the U12-type spliceosome requires p110, a component of the U6atac snRNP | journal = Molecular and Cellular Biology | volume = 24 | issue = 4 | pages = 1700–8 | date = February 2004 | pmid = 14749385 | pmc = 344176 | doi = 10.1128/MCB.24.4.1700-1708.2004 }}
* {{cite journal | vauthors = Liu Y, Kim BO, Kao C, Jung C, Dalton JT, He JJ | title = Tip110, the human immunodeficiency virus type 1 (HIV-1) Tat-interacting protein of 110 kDa as a negative regulator of androgen receptor (AR) transcriptional activation | journal = The Journal of Biological Chemistry | volume = 279 | issue = 21 | pages = 21766–73 | date = May 2004 | pmid = 15031286 | doi = 10.1074/jbc.M314321200 }}
* {{cite journal | vauthors = Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW | title = Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation | journal = Nature Biotechnology | volume = 22 | issue = 6 | pages = 707–16 | date = June 2004 | pmid = 15146197 | doi = 10.1038/nbt971 }}
* {{cite journal | vauthors = Medenbach J, Schreiner S, Liu S, Lührmann R, Bindereif A | title = Human U4/U6 snRNP recycling factor p110: mutational analysis reveals the function of the tetratricopeptide repeat domain in recycling | journal = Molecular and Cellular Biology | volume = 24 | issue = 17 | pages = 7392–401 | date = September 2004 | pmid = 15314151 | pmc = 506986 | doi = 10.1128/MCB.24.17.7392-7401.2004 }}
* {{cite journal | vauthors = Stanĕk D, Neugebauer KM | title = Detection of snRNP assembly intermediates in Cajal bodies by fluorescence resonance energy transfer | journal = The Journal of Cell Biology | volume = 166 | issue = 7 | pages = 1015–25 | date = September 2004 | pmid = 15452143 | pmc = 2172029 | doi = 10.1083/jcb.200405160 }}
{{Refend}}
{{PDB Gallery|geneid=9733}}
 
 
[[Category:Spliceosome]]
 
{{Gene-12-stub}}

Latest revision as of 05:55, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Squamous cell carcinoma antigen recognized by T-cells 3 is a protein that in humans is encoded by the SART3 gene.[1][1][2][2][3]

The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing.[3]

Interactions

SART3 has been shown to interact with RNPS1[4] and Androgen receptor.[5]

References

  1. ↑ 1.0 1.1 Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (August 1995). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280.
  2. ↑ 2.0 2.1 Harada K, Yamada A, Mine T, Kawagoe N, Takasu H, Itoh K (February 2000). "Mouse homologue of the human SART3 gene encoding tumor-rejection antigen". Japanese Journal of Cancer Research. 91 (2): 239–47. doi:10.1111/j.1349-7006.2000.tb00937.x. PMID 10761712.
  3. ↑ 3.0 3.1 "Entrez Gene: SART3 squamous cell carcinoma antigen recognized by T cells 3".
  4. ↑ Harada K, Yamada A, Yang D, Itoh K, Shichijo S (September 2001). "Binding of a SART3 tumor-rejection antigen to a pre-mRNA splicing factor RNPS1: a possible regulation of splicing by a complex formation". International Journal of Cancer. 93 (5): 623–8. doi:10.1002/ijc.1391. PMID 11477570.
  5. ↑ Liu Y, Kim BO, Kao C, Jung C, Dalton JT, He JJ (May 2004). "Tip110, the human immunodeficiency virus type 1 (HIV-1) Tat-interacting protein of 110 kDa as a negative regulator of androgen receptor (AR) transcriptional activation". The Journal of Biological Chemistry. 279 (21): 21766–73. doi:10.1074/jbc.M314321200. PMID 15031286.

Further reading

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