SH2B2: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''SH2B adapter protein 2''' is a [[protein]] that in humans is encoded by the ''SH2B2'' [[gene]].<ref name="pmid9233773">{{cite journal | vauthors = Yokouchi M, Suzuki R, Masuhara M, Komiya S, Inoue A, Yoshimura A | title = Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation | journal = Oncogene | volume = 15 | issue = 1 | pages = 7–15 | date = Aug 1997 | pmid = 9233773 | pmc =  | doi = 10.1038/sj.onc.1201163 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SH2B2 SH2B adaptor protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10603| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_SH2B2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1q2h.
| PDB = {{PDB2|1q2h}}, {{PDB2|1rpy}}, {{PDB2|1rqq}}, {{PDB2|1v5m}}
| Name = SH2B adaptor protein 2
| HGNCid = 17381
| Symbol = SH2B2
| AltSymbols =; APS
| OMIM = 605300
| ECnumber = 
| Homologene = 10309
| MGIid = 1345171
| Function = {{GNF_GO|id=GO:0005070 |text = SH3/SH2 adaptor activity}} {{GNF_GO|id=GO:0008269 |text = JAK pathway signal transduction adaptor activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}}
| Process = {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0019735 |text = antimicrobial humoral response}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10603
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_066189
    | Hs_RefseqmRNA = NM_020979
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 23921
    | Mm_Ensembl = ENSMUSG00000005057
    | Mm_RefseqmRNA = NM_018825
    | Mm_RefseqProtein = NP_061295
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 136502776
    | Mm_GenLoc_end = 136529530
    | Mm_Uniprot = Q6PG00
  }}
}}
'''SH2B adaptor protein 2''', also known as '''SH2B2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SH2B2 SH2B adaptor protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10603| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt lymphoma cell lines, it is tyrosine phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to Shc/Grb2.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt lymphoma cell lines, it is tyrosine phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to Shc/Grb2.<ref name="entrez">{{cite web | title = Entrez Gene: SH2B2 SH2B adaptor protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10603| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
SH2B2 has been shown to [[Protein-protein interaction|interact]] with [[TrkA]]<ref name=pmid9856458>{{cite journal | vauthors = Qian X, Riccio A, Zhang Y, Ginty DD | title = Identification and characterization of novel substrates of Trk receptors in developing neurons | journal = Neuron | volume = 21 | issue = 5 | pages = 1017–29 | date = Nov 1998 | pmid = 9856458 | doi = 10.1016/S0896-6273(00)80620-0 }}</ref> and [[Cbl gene]].<ref name=pmid10374881>{{cite journal | vauthors = Wakioka T, Sasaki A, Mitsui K, Yokouchi M, Inoue A, Komiya S, Yoshimura A | title = APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl | journal = Leukemia | volume = 13 | issue = 5 | pages = 760–7 | date = May 1999 | pmid = 10374881 | doi = 10.1038/sj/leu/2401397 }}</ref><ref name=pmid18273061>{{cite journal | vauthors = Ng C, Jackson RA, Buschdorf JP, Sun Q, Guy GR, Sivaraman J | title = Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates | journal = EMBO J. | volume = 27 | issue = 5 | pages = 804–16 | date = Mar 2008 | pmid = 18273061 | pmc = 2265755 | doi = 10.1038/emboj.2008.18 }}</ref>
 
== References ==
{{reflist}}
{{Clear}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Glöckner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A | title = Large-Scale Sequencing of Two Regions in Human Chromosome 7q22: Analysis of 650 kb of Genomic Sequence around the EPO and CUTL1 Loci Reveals 17 Genes | journal = Genome Res. | volume = 8 | issue = 10 | pages = 1060–73 | year = 1998 | pmid = 9799793 | pmc = 310788 | doi = 10.1101/gr.8.10.1060 }}
| citations =
* {{cite journal | vauthors = Qian X, Riccio A, Zhang Y, Ginty DD | title = Identification and characterization of novel substrates of Trk receptors in developing neurons | journal = Neuron | volume = 21 | issue = 5 | pages = 1017–29 | year = 1999 | pmid = 9856458 | doi = 10.1016/S0896-6273(00)80620-0 }}
*{{cite journal  | author=Yokouchi M, Suzuki R, Masuhara M, ''et al.'' |title=Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation. |journal=Oncogene |volume=15 |issue= 1 |pages= 7-15 |year= 1997 |pmid= 9233773 |doi= 10.1038/sj.onc.1201163 }}
* {{cite journal | vauthors = Yokouchi M, Wakioka T, Sakamoto H, Yasukawa H, Ohtsuka S, Sasaki A, Ohtsubo M, Valius M, Inoue A, Komiya S, Yoshimura A | title = APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis | journal = Oncogene | volume = 18 | issue = 3 | pages = 759–67 | year = 1999 | pmid = 9989826 | doi = 10.1038/sj.onc.1202326 }}
*{{cite journal | author=Glöckner G, Scherer S, Schattevoy R, ''et al.'' |title=Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes. |journal=Genome Res. |volume=8 |issue= 10 |pages= 1060-73 |year= 1998 |pmid= 9799793 |doi= }}
* {{cite journal | vauthors = Moodie SA, Alleman-Sposeto J, Gustafson TA | title = Identification of the APS protein as a novel insulin receptor substrate | journal = J. Biol. Chem. | volume = 274 | issue = 16 | pages = 11186–93 | year = 1999 | pmid = 10196204 | doi = 10.1074/jbc.274.16.11186 }}
*{{cite journal | author=Qian X, Riccio A, Zhang Y, Ginty DD |title=Identification and characterization of novel substrates of Trk receptors in developing neurons. |journal=Neuron |volume=21 |issue= 5 |pages= 1017-29 |year= 1999 |pmid= 9856458 |doi= }}
* {{cite journal | vauthors = Wakioka T, Sasaki A, Mitsui K, Yokouchi M, Inoue A, Komiya S, Yoshimura A | title = APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl | journal = Leukemia | volume = 13 | issue = 5 | pages = 760–7 | year = 1999 | pmid = 10374881 | doi = 10.1038/sj/leu/2401397 }}
*{{cite journal | author=Yokouchi M, Wakioka T, Sakamoto H, ''et al.'' |title=APS, an adaptor protein containing PH and SH2 domains, is associated with the PDGF receptor and c-Cbl and inhibits PDGF-induced mitogenesis. |journal=Oncogene |volume=18 |issue= 3 |pages= 759-67 |year= 1999 |pmid= 9989826 |doi= 10.1038/sj.onc.1202326 }}
* {{cite journal | vauthors = Iseki M, Takaki S, Takatsu K | title = Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins | journal = Biochem. Biophys. Res. Commun. | volume = 272 | issue = 1 | pages = 45–54 | year = 2000 | pmid = 10872802 | doi = 10.1006/bbrc.2000.2736 }}
*{{cite journal | author=Moodie SA, Alleman-Sposeto J, Gustafson TA |title=Identification of the APS protein as a novel insulin receptor substrate. |journal=J. Biol. Chem. |volume=274 |issue= 16 |pages= 11186-93 |year= 1999 |pmid= 10196204 |doi= }}
* {{cite journal | vauthors = O'Brien KB, O'Shea JJ, Carter-Su C | title = SH2-B family members differentially regulate JAK family tyrosine kinases | journal = J. Biol. Chem. | volume = 277 | issue = 10 | pages = 8673–81 | year = 2002 | pmid = 11751854 | doi = 10.1074/jbc.M109165200 }}
*{{cite journal | author=Wakioka T, Sasaki A, Mitsui K, ''et al.'' |title=APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl. |journal=Leukemia |volume=13 |issue= 5 |pages= 760-7 |year= 1999 |pmid= 10374881 |doi= }}
* {{cite journal | vauthors = Liu J, Kimura A, Baumann CA, Saltiel AR | title = APS Facilitates c-Cbl Tyrosine Phosphorylation and GLUT4 Translocation in Response to Insulin in 3T3-L1 Adipocytes | journal = Mol. Cell. Biol. | volume = 22 | issue = 11 | pages = 3599–609 | year = 2002 | pmid = 11997497 | pmc = 133825 | doi = 10.1128/MCB.22.11.3599-3609.2002 }}
*{{cite journal | author=Iseki M, Takaki S, Takatsu K |title=Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins. |journal=Biochem. Biophys. Res. Commun. |volume=272 |issue= 1 |pages= 45-54 |year= 2000 |pmid= 10872802 |doi= 10.1006/bbrc.2000.2736 }}
* {{cite journal | vauthors = Yabana N, Shibuya M | title = Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity | journal = Oncogene | volume = 21 | issue = 50 | pages = 7720–9 | year = 2002 | pmid = 12400014 | doi = 10.1038/sj.onc.1205927 }}
*{{cite journal | author=O'Brien KB, O'Shea JJ, Carter-Su C |title=SH2-B family members differentially regulate JAK family tyrosine kinases. |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 8673-81 |year= 2002 |pmid= 11751854 |doi= 10.1074/jbc.M109165200 }}
* {{cite journal | vauthors = Ahn MY, Katsanakis KD, Bheda F, Pillay TS | title = Primary and essential role of the adaptor protein APS for recruitment of both c-Cbl and its associated protein CAP in insulin signaling | journal = J. Biol. Chem. | volume = 279 | issue = 20 | pages = 21526–32 | year = 2004 | pmid = 15031295 | doi = 10.1074/jbc.M307740200 }}
*{{cite journal | author=Liu J, Kimura A, Baumann CA, Saltiel AR |title=APS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytes. |journal=Mol. Cell. Biol. |volume=22 |issue= 11 |pages= 3599-609 |year= 2002 |pmid= 11997497 |doi= }}
* {{cite journal | vauthors = Wilcox A, Katsanakis KD, Bheda F, Pillay TS | title = Asb6, an adipocyte-specific ankyrin and SOCS box protein, interacts with APS to enable recruitment of elongins B and C to the insulin receptor signaling complex | journal = J. Biol. Chem. | volume = 279 | issue = 37 | pages = 38881–8 | year = 2004 | pmid = 15231829 | doi = 10.1074/jbc.M406101200 }}
*{{cite journal | author=Yabana N, Shibuya M |title=Adaptor protein APS binds the NH2-terminal autoinhibitory domain of guanine nucleotide exchange factor Vav3 and augments its activity. |journal=Oncogene |volume=21 |issue= 50 |pages= 7720-9 |year= 2002 |pmid= 12400014 |doi= 10.1038/sj.onc.1205927 }}
* {{cite journal | vauthors = Hu J, Hubbard SR | title = Structural characterization of a novel Cbl phosphotyrosine recognition motif in the APS family of adapter proteins | journal = J. Biol. Chem. | volume = 280 | issue = 19 | pages = 18943–9 | year = 2005 | pmid = 15737992 | doi = 10.1074/jbc.M414157200 }}
*{{cite journal | author=Ahn MY, Katsanakis KD, Bheda F, Pillay TS |title=Primary and essential role of the adaptor protein APS for recruitment of both c-Cbl and its associated protein CAP in insulin signaling. |journal=J. Biol. Chem. |volume=279 |issue= 20 |pages= 21526-32 |year= 2004 |pmid= 15031295 |doi= 10.1074/jbc.M307740200 }}
* {{cite journal | vauthors = Iseki M, Kubo-Akashi C, Kwon SM, Yamaguchi A, Takatsu K, Takaki S | title = APS, an adaptor molecule containing PH and SH2 domains, has a negative regulatory role in B cell proliferation | journal = Biochem. Biophys. Res. Commun. | volume = 330 | issue = 3 | pages = 1005–13 | year = 2005 | pmid = 15809095 | doi = 10.1016/j.bbrc.2005.03.073 }}
*{{cite journal | author=Wilcox A, Katsanakis KD, Bheda F, Pillay TS |title=Asb6, an adipocyte-specific ankyrin and SOCS box protein, interacts with APS to enable recruitment of elongins B and C to the insulin receptor signaling complex. |journal=J. Biol. Chem. |volume=279 |issue= 37 |pages= 38881-8 |year= 2004 |pmid= 15231829 |doi= 10.1074/jbc.M406101200 }}
* {{cite journal | vauthors = Katsanakis KD, Pillay TS | title = Cross-talk between the two divergent insulin signaling pathways is revealed by the protein kinase B (Akt)-mediated phosphorylation of adapter protein APS on serine 588 | journal = J. Biol. Chem. | volume = 280 | issue = 45 | pages = 37827–32 | year = 2006 | pmid = 16141217 | doi = 10.1074/jbc.M505959200 }}
*{{cite journal | author=Hu J, Hubbard SR |title=Structural characterization of a novel Cbl phosphotyrosine recognition motif in the APS family of adapter proteins. |journal=J. Biol. Chem. |volume=280 |issue= 19 |pages= 18943-9 |year= 2005 |pmid= 15737992 |doi= 10.1074/jbc.M414157200 }}
* {{cite journal | vauthors = Li M, Li Z, Morris DL, Rui L | title = Identification of SH2B2beta as an inhibitor for SH2B1- and SH2B2alpha-promoted Janus kinase-2 activation and insulin signaling | journal = Endocrinology | volume = 148 | issue = 4 | pages = 1615–21 | year = 2007 | pmid = 17204555 | doi = 10.1210/en.2006-1010 }}
*{{cite journal | author=Iseki M, Kubo-Akashi C, Kwon SM, ''et al.'' |title=APS, an adaptor molecule containing PH and SH2 domains, has a negative regulatory role in B cell proliferation. |journal=Biochem. Biophys. Res. Commun. |volume=330 |issue= 3 |pages= 1005-13 |year= 2005 |pmid= 15809095 |doi= 10.1016/j.bbrc.2005.03.073 }}
*{{cite journal | author=Katsanakis KD, Pillay TS |title=Cross-talk between the two divergent insulin signaling pathways is revealed by the protein kinase B (Akt)-mediated phosphorylation of adapter protein APS on serine 588. |journal=J. Biol. Chem. |volume=280 |issue= 45 |pages= 37827-32 |year= 2006 |pmid= 16141217 |doi= 10.1074/jbc.M505959200 }}
*{{cite journal | author=Li M, Li Z, Morris DL, Rui L |title=Identification of SH2B2beta as an inhibitor for SH2B1- and SH2B2alpha-promoted Janus kinase-2 activation and insulin signaling. |journal=Endocrinology |volume=148 |issue= 4 |pages= 1615-21 |year= 2007 |pmid= 17204555 |doi= 10.1210/en.2006-1010 }}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=10603}}


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{{protein-stub}}
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Revision as of 06:16, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

SH2B adapter protein 2 is a protein that in humans is encoded by the SH2B2 gene.[1][2]

Function

The protein encoded by this gene is expressed in B lymphocytes and contains pleckstrin homology and src homology 2 (SH2) domains. In Burkitt lymphoma cell lines, it is tyrosine phosphorylated in response to B cell receptor stimulation. Because it binds Shc independent of stimulation and Grb2 after stimulation, it appears to play a role in signal transduction from the receptor to Shc/Grb2.[2]

Interactions

SH2B2 has been shown to interact with TrkA[3] and Cbl gene.[4][5]

References

  1. ↑ Yokouchi M, Suzuki R, Masuhara M, Komiya S, Inoue A, Yoshimura A (Aug 1997). "Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation". Oncogene. 15 (1): 7–15. doi:10.1038/sj.onc.1201163. PMID 9233773.
  2. ↑ 2.0 2.1 "Entrez Gene: SH2B2 SH2B adaptor protein 2".
  3. ↑ Qian X, Riccio A, Zhang Y, Ginty DD (Nov 1998). "Identification and characterization of novel substrates of Trk receptors in developing neurons". Neuron. 21 (5): 1017–29. doi:10.1016/S0896-6273(00)80620-0. PMID 9856458.
  4. ↑ Wakioka T, Sasaki A, Mitsui K, Yokouchi M, Inoue A, Komiya S, Yoshimura A (May 1999). "APS, an adaptor protein containing Pleckstrin homology (PH) and Src homology-2 (SH2) domains inhibits the JAK-STAT pathway in collaboration with c-Cbl". Leukemia. 13 (5): 760–7. doi:10.1038/sj/leu/2401397. PMID 10374881.
  5. ↑ Ng C, Jackson RA, Buschdorf JP, Sun Q, Guy GR, Sivaraman J (Mar 2008). "Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates". EMBO J. 27 (5): 804–16. doi:10.1038/emboj.2008.18. PMC 2265755. PMID 18273061.

Further reading


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