SH3GL3: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Endophilin-A3''' is a [[protein]] that in humans is encoded by the ''SH3GL3'' [[gene]].<ref name="pmid9169142">{{cite journal | vauthors = Giachino C, Lantelme E, Lanzetti L, Saccone S, Bella Valle G, Migone N | title = A novel SH3-containing human gene family preferentially expressed in the central nervous system | journal = Genomics | volume = 41 | issue = 3 | pages = 427–34 | date = July 1997 | pmid = 9169142 | pmc = | doi = 10.1006/geno.1997.4645 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SH3GL3 SH3-domain GRB2-like 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6457| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image = PBB_Protein_SH3GL3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2ew3.
| PDB = {{PDB2|2ew3}}
| Name = SH3-domain GRB2-like 3
| HGNCid = 10832
| Symbol = SH3GL3
| AltSymbols =; CNSA3; EEN-2B-L3; EEN-B2; HsT19371; SH3D2C; SH3P13
| OMIM = 603362
| ECnumber = 
| Homologene = 37723
| MGIid = 700011
| GeneAtlas_image1 = PBB_GE_SH3GL3_205637_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SH3GL3_gnf1h02191_at_tn.png
| GeneAtlas_image3 = PBB_GE_SH3GL3_gnf1h02192_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007417 |text = central nervous system development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6457
    | Hs_Ensembl = ENSG00000140600
    | Hs_RefseqProtein = NP_003018
    | Hs_RefseqmRNA = NM_003027
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 15
    | Hs_GenLoc_start = 81907287
    | Hs_GenLoc_end = 82078495
    | Hs_Uniprot = Q99963
    | Mm_EntrezGene = 20408
    | Mm_Ensembl = ENSMUSG00000030638
    | Mm_RefseqmRNA = NM_017400
    | Mm_RefseqProtein = NP_059096
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 82048309
    | Mm_GenLoc_end = 82183594
    | Mm_Uniprot = Q497N4
  }}
}}
'''SH3-domain GRB2-like 3''', also known as '''SH3GL3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SH3GL3 SH3-domain GRB2-like 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6457| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
SH3GL3 has been shown to [[Protein-protein interaction|interact]] with [[Huntingtin]]<ref name=pmid9809064>{{cite journal | vauthors = Sittler A, Wälter S, Wedemeyer N, Hasenbank R, Scherzinger E, Eickhoff H, Bates GP, Lehrach H, Wanker EE | title = SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates | journal = Mol. Cell | volume = 2 | issue = 4 | pages = 427–36 | date = October 1998 | pmid = 9809064 | doi = 10.1016/S1097-2765(00)80142-2 }}</ref> and [[SH3KBP1]].<ref name=pmid11894096>{{cite journal | vauthors = Petrelli A, Gilestro GF, Lanzardo S, Comoglio PM, Migone N, Giordano S | title = The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met | journal = [[Nature (journal)|Nature]] | volume = 416 | issue = 6877 | pages = 187–90 | date = March 2002 | pmid = 11894096 | doi = 10.1038/416187a }}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = So CW, Caldas C, Liu MM, Chen SJ, Huang QH, Gu LJ, Sham MH, Wiedemann LM, Chan LC | title = EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 6 | pages = 2563–8 | year = 1997 | pmid = 9122235 | pmc = 20128 | doi = 10.1073/pnas.94.6.2563 }}
| citations =
* {{cite journal | vauthors = Ringstad N, Nemoto Y, De Camilli P | title = The SH3p4/Sh3p8/SH3p13 protein family: binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 16 | pages = 8569–74 | year = 1997 | pmid = 9238017 | pmc = 23017 | doi = 10.1073/pnas.94.16.8569 }}
*{{cite journal | author=So CW, Caldas C, Liu MM, ''et al.'' |title=EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 6 |pages= 2563-8 |year= 1997 |pmid= 9122235 |doi= }}
* {{cite journal | vauthors = Sittler A, Wälter S, Wedemeyer N, Hasenbank R, Scherzinger E, Eickhoff H, Bates GP, Lehrach H, Wanker EE | title = SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates. | journal = Mol. Cell | volume = 2 | issue = 4 | pages = 427–36 | year = 1998 | pmid = 9809064 | doi = 10.1016/S1097-2765(00)80142-2 }}
*{{cite journal | author=Giachino C, Lantelme E, Lanzetti L, ''et al.'' |title=A novel SH3-containing human gene family preferentially expressed in the central nervous system. |journal=Genomics |volume=41 |issue= 3 |pages= 427-34 |year= 1997 |pmid= 9169142 |doi= }}
* {{cite journal | vauthors = Tang Y, Hu LA, Miller WE, Ringstad N, Hall RA, Pitcher JA, DeCamilli P, Lefkowitz RJ | title = Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 22 | pages = 12559–64 | year = 1999 | pmid = 10535961 | pmc = 22990 | doi = 10.1073/pnas.96.22.12559 }}
*{{cite journal | author=Ringstad N, Nemoto Y, De Camilli P |title=The SH3p4/Sh3p8/SH3p13 protein family: binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 16 |pages= 8569-74 |year= 1997 |pmid= 9238017 |doi= }}
* {{cite journal | vauthors = Cestra G, Castagnoli L, Dente L, Minenkova O, Petrelli A, Migone N, Hoffmüller U, Schneider-Mergener J, Cesareni G | title = The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity. | journal = J. Biol. Chem. | volume = 274 | issue = 45 | pages = 32001–7 | year = 1999 | pmid = 10542231 | doi = 10.1074/jbc.274.45.32001 }}
*{{cite journal | author=Sittler A, Wälter S, Wedemeyer N, ''et al.'' |title=SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates. |journal=Mol. Cell |volume=2 |issue= 4 |pages= 427-36 |year= 1998 |pmid= 9809064 |doi= }}
* {{cite journal | vauthors = So CW, So CK, Cheung N, Chew SL, Sham MH, Chan LC | title = The interaction between EEN and Abi-1, two MLL fusion partners, and synaptojanin and dynamin: implications for leukaemogenesis. | journal = Leukemia | volume = 14 | issue = 4 | pages = 594–601 | year = 2000 | pmid = 10764144 | doi = 10.1038/sj.leu.2401692 }}
*{{cite journal | author=Tang Y, Hu LA, Miller WE, ''et al.'' |title=Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 22 |pages= 12559-64 |year= 1999 |pmid= 10535961 |doi= }}
* {{cite journal | vauthors = So CW, Sham MH, Chew SL, Cheung N, So CK, Chung SK, Caldas C, Wiedemann LM, Chan LC | title = Expression and protein-binding studies of the EEN gene family, new interacting partners for dynamin, synaptojanin and huntingtin proteins. | journal = Biochem. J. | volume = 348 | issue = 2 | pages = 447–58 | year = 2000 | pmid = 10816441 | pmc = 1221085 | doi = 10.1042/0264-6021:3480447 }}
*{{cite journal | author=Cestra G, Castagnoli L, Dente L, ''et al.'' |title=The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity. |journal=J. Biol. Chem. |volume=274 |issue= 45 |pages= 32001-7 |year= 1999 |pmid= 10542231 |doi= }}
* {{cite journal | vauthors = Petrelli A, Gilestro GF, Lanzardo S, Comoglio PM, Migone N, Giordano S | title = The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met. | journal = Nature | volume = 416 | issue = 6877 | pages = 187–90 | year = 2002 | pmid = 11894096 | doi = 10.1038/416187a }}
*{{cite journal | author=So CW, So CK, Cheung N, ''et al.'' |title=The interaction between EEN and Abi-1, two MLL fusion partners, and synaptojanin and dynamin: implications for leukaemogenesis. |journal=Leukemia |volume=14 |issue= 4 |pages= 594-601 |year= 2000 |pmid= 10764144 |doi= }}
* {{cite journal | vauthors = Chatellard-Causse C, Blot B, Cristina N, Torch S, Missotten M, Sadoul R | title = Alix (ALG-2-interacting protein X), a protein involved in apoptosis, binds to endophilins and induces cytoplasmic vacuolization. | journal = J. Biol. Chem. | volume = 277 | issue = 32 | pages = 29108–15 | year = 2002 | pmid = 12034747 | doi = 10.1074/jbc.M204019200 }}
*{{cite journal | author=So CW, Sham MH, Chew SL, ''et al.'' |title=Expression and protein-binding studies of the EEN gene family, new interacting partners for dynamin, synaptojanin and huntingtin proteins. |journal=Biochem. J. |volume=348 Pt 2 |issue= |pages= 447-58 |year= 2000 |pmid= 10816441 |doi= }}
* {{cite journal | vauthors = Verdier F, Valovka T, Zhyvoloup A, Drobot LB, Buchman V, Waterfield M, Gout I | title = Ruk is ubiquitinated but not degraded by the proteasome. | journal = Eur. J. Biochem. | volume = 269 | issue = 14 | pages = 3402–8 | year = 2002 | pmid = 12135478 | doi = 10.1046/j.1432-1033.2002.03031.x }}
*{{cite journal | author=Petrelli A, Gilestro GF, Lanzardo S, ''et al.'' |title=The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met. |journal=Nature |volume=416 |issue= 6877 |pages= 187-90 |year= 2002 |pmid= 11894096 |doi= 10.1038/416187a }}
* {{cite journal | vauthors = Szymkiewicz I, Kowanetz K, Soubeyran P, Dinarina A, Lipkowitz S, Dikic I | title = CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases. | journal = J. Biol. Chem. | volume = 277 | issue = 42 | pages = 39666–72 | year = 2002 | pmid = 12177062 | doi = 10.1074/jbc.M205535200 }}
*{{cite journal | author=Chatellard-Causse C, Blot B, Cristina N, ''et al.'' |title=Alix (ALG-2-interacting protein X), a protein involved in apoptosis, binds to endophilins and induces cytoplasmic vacuolization. |journal=J. Biol. Chem. |volume=277 |issue= 32 |pages= 29108-15 |year= 2002 |pmid= 12034747 |doi= 10.1074/jbc.M204019200 }}
* {{cite journal | vauthors = Otsuki M, Itoh T, Takenawa T | title = Neural Wiskott-Aldrich syndrome protein is recruited to rafts and associates with endophilin A in response to epidermal growth factor. | journal = J. Biol. Chem. | volume = 278 | issue = 8 | pages = 6461–9 | year = 2003 | pmid = 12477732 | doi = 10.1074/jbc.M207433200 }}
*{{cite journal | author=Verdier F, Valovka T, Zhyvoloup A, ''et al.'' |title=Ruk is ubiquitinated but not degraded by the proteasome. |journal=Eur. J. Biochem. |volume=269 |issue= 14 |pages= 3402-8 |year= 2002 |pmid= 12135478 |doi= }}
* {{cite journal | vauthors = Yam JW, Jin DY, So CW, Chan LC | title = Identification and characterization of EBP, a novel EEN binding protein that inhibits Ras signaling and is recruited into the nucleus by the MLL-EEN fusion protein. | journal = Blood | volume = 103 | issue = 4 | pages = 1445–53 | year = 2004 | pmid = 14551139 | doi = 10.1182/blood-2003-07-2452 }}
*{{cite journal | author=Szymkiewicz I, Kowanetz K, Soubeyran P, ''et al.'' |title=CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases. |journal=J. Biol. Chem. |volume=277 |issue= 42 |pages= 39666-72 |year= 2002 |pmid= 12177062 |doi= 10.1074/jbc.M205535200 }}
* {{cite journal | vauthors = Goehler H, Lalowski M, Stelzl U, Waelter S, Stroedicke M, Worm U, Droege A, Lindenberg KS, Knoblich M, Haenig C, Herbst M, Suopanki J, Scherzinger E, Abraham C, Bauer B, Hasenbank R, Fritzsche A, Ludewig AH, Büssow K, Buessow K, Coleman SH, Gutekunst CA, Landwehrmeyer BG, Lehrach H, Wanker EE | title = A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. | journal = Mol. Cell | volume = 15 | issue = 6 | pages = 853–65 | year = 2004 | pmid = 15383276 | doi = 10.1016/j.molcel.2004.09.016 }}
*{{cite journal | author=Otsuki M, Itoh T, Takenawa T |title=Neural Wiskott-Aldrich syndrome protein is recruited to rafts and associates with endophilin A in response to epidermal growth factor. |journal=J. Biol. Chem. |volume=278 |issue= 8 |pages= 6461-9 |year= 2003 |pmid= 12477732 |doi= 10.1074/jbc.M207433200 }}
* {{cite journal | vauthors = Trevaskis J, Walder K, Foletta V, Kerr-Bayles L, McMillan J, Cooper A, Lee S, Bolton K, Prior M, Fahey R, Whitecross K, Morton GJ, Schwartz MW, Collier GR | title = Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1, a novel neuronal protein that regulates energy balance. | journal = Endocrinology | volume = 146 | issue = 9 | pages = 3757–64 | year = 2005 | pmid = 15919751 | doi = 10.1210/en.2005-0282 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Ralser M, Nonhoff U, Albrecht M, Lengauer T, Wanker EE, Lehrach H, Krobitsch S | title = Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated pathways. | journal = Hum. Mol. Genet. | volume = 14 | issue = 19 | pages = 2893–909 | year = 2005 | pmid = 16115810 | doi = 10.1093/hmg/ddi321 }}
*{{cite journal | author=Yam JW, Jin DY, So CW, Chan LC |title=Identification and characterization of EBP, a novel EEN binding protein that inhibits Ras signaling and is recruited into the nucleus by the MLL-EEN fusion protein. |journal=Blood |volume=103 |issue= 4 |pages= 1445-53 |year= 2004 |pmid= 14551139 |doi= 10.1182/blood-2003-07-2452 }}
* {{cite journal | vauthors = Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE | title = A human protein-protein interaction network: a resource for annotating the proteome. | journal = Cell | volume = 122 | issue = 6 | pages = 957–68 | year = 2005 | pmid = 16169070 | doi = 10.1016/j.cell.2005.08.029 }}
*{{cite journal | author=Goehler H, Lalowski M, Stelzl U, ''et al.'' |title=A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease. |journal=Mol. Cell |volume=15 |issue= 6 |pages= 853-65 |year= 2004 |pmid= 15383276 |doi= 10.1016/j.molcel.2004.09.016 }}
* {{cite journal | vauthors = Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY | title = A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. | journal = Cell | volume = 125 | issue = 4 | pages = 801–14 | year = 2006 | pmid = 16713569 | doi = 10.1016/j.cell.2006.03.032 }}
*{{cite journal | author=Trevaskis J, Walder K, Foletta V, ''et al.'' |title=Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1, a novel neuronal protein that regulates energy balance. |journal=Endocrinology |volume=146 |issue= 9 |pages= 3757-64 |year= 2005 |pmid= 15919751 |doi= 10.1210/en.2005-0282 }}
*{{cite journal | author=Ralser M, Nonhoff U, Albrecht M, ''et al.'' |title=Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated pathways. |journal=Hum. Mol. Genet. |volume=14 |issue= 19 |pages= 2893-909 |year= 2005 |pmid= 16115810 |doi= 10.1093/hmg/ddi321 }}
*{{cite journal  | author=Stelzl U, Worm U, Lalowski M, ''et al.'' |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957-68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
*{{cite journal  | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 06:17, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Endophilin-A3 is a protein that in humans is encoded by the SH3GL3 gene.[1][2]

Interactions

SH3GL3 has been shown to interact with Huntingtin[3] and SH3KBP1.[4]

References

  1. Giachino C, Lantelme E, Lanzetti L, Saccone S, Bella Valle G, Migone N (July 1997). "A novel SH3-containing human gene family preferentially expressed in the central nervous system". Genomics. 41 (3): 427–34. doi:10.1006/geno.1997.4645. PMID 9169142.
  2. "Entrez Gene: SH3GL3 SH3-domain GRB2-like 3".
  3. Sittler A, Wälter S, Wedemeyer N, Hasenbank R, Scherzinger E, Eickhoff H, Bates GP, Lehrach H, Wanker EE (October 1998). "SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates". Mol. Cell. 2 (4): 427–36. doi:10.1016/S1097-2765(00)80142-2. PMID 9809064.
  4. Petrelli A, Gilestro GF, Lanzardo S, Comoglio PM, Migone N, Giordano S (March 2002). "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met". Nature. 416 (6877): 187–90. doi:10.1038/416187a. PMID 11894096.

Further reading