SHC3: Difference between revisions

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{{Infobox_gene}}
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'''SHC-transforming protein 3''' is a [[protein]] that in humans is encoded by the ''SHC3'' [[gene]].<ref name="pmid8808684">{{cite journal |author1=Nakamura T |author2=Sanokawa R |author3=Sasaki Y |author4=Ayusawa D |author5=Oishi M |author6=Mori N | title = N-Shc: a neural-specific adapter molecule that mediates signaling from neurotrophin/Trk to Ras/MAPK pathway | journal = Oncogene | volume = 13 | issue = 6 | pages = 1111–21 |date=November 1996 | pmid = 8808684 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SHC3 SHC (Src homology 2 domain containing) transforming protein 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53358| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = SHC (Src homology 2 domain containing) transforming protein 3
| HGNCid = 18181
| Symbol = SHC3
| AltSymbols =; N-Shc; NSHC; SHCC
| OMIM = 605263
| ECnumber = 
| Homologene = 7536
| MGIid = 106179
| GeneAtlas_image1 = PBB_GE_SHC3_206330_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}}
| Process = {{GNF_GO|id=GO:0007173 |text = epidermal growth factor receptor signaling pathway}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0007417 |text = central nervous system development}} {{GNF_GO|id=GO:0007611 |text = learning and/or memory}} {{GNF_GO|id=GO:0035249 |text = synaptic transmission, glutamatergic}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 53358
    | Hs_Ensembl = ENSG00000148082
    | Hs_RefseqProtein = NP_058544
    | Hs_RefseqmRNA = NM_016848
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 9
    | Hs_GenLoc_start = 90817880
    | Hs_GenLoc_end = 90983502
    | Hs_Uniprot = Q92529
    | Mm_EntrezGene = 20418
    | Mm_Ensembl = ENSMUSG00000021448
    | Mm_RefseqmRNA = NM_009167
    | Mm_RefseqProtein = NP_033193
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 51443539
    | Mm_GenLoc_end = 51579580
    | Mm_Uniprot = Q3ZAX2
  }}
}}
'''SHC (Src homology 2 domain containing) transforming protein 3''', also known as '''SHC3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SHC3 SHC (Src homology 2 domain containing) transforming protein 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53358| accessdate = }}</ref>


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| summary_text =  
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==Interactions==
SHC3 has been shown to [[Protein-protein interaction|interact]] with [[RICS (gene)|RICS]]<ref name=pmid12446789>{{cite journal |doi=10.1128/MCB.22.24.8721-8734.2002 |last=Nakamura |first=Takeshi |authorlink= |author2=Komiya Misako |author3=Sone Kiyoaki |author4=Hirose Eiji |author5=Gotoh Noriko |author6=Morii Hiroshi |author7=Ohta Yasutaka |author8=Mori Nozomu  |date=December 2002  |title=Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules |journal=Mol. Cell. Biol. |volume=22 |issue=24 |pages=8721–34 |publisher= |location = United States| issn = 0270-7306| pmid = 12446789 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=139861 }}</ref> and [[TrkB]].<ref name=pmid9507002>{{cite journal |doi=10.1074/jbc.273.12.6960 |last=Nakamura |first=T |authorlink= |author2=Muraoka S |author3=Sanokawa R |author4=Mori N  |date=March 1998  |title=N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling |journal=J. Biol. Chem. |volume=273 |issue=12 |pages=6960–7 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 9507002 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid12074588>{{cite journal |last=Suzuki |first=Shingo |authorlink= |author2=Mizutani Masaharu |author3=Suzuki Kenji |author4=Yamada Masashi |author5=Kojima Masami |author6=Hatanaka Hiroshi |author7=Koizumi Shinichi  |date=June 2002  |title=Brain-derived neurotrophic factor promotes interaction of the Nck2 adaptor protein with the TrkB tyrosine kinase receptor |journal=Biochem. Biophys. Res. Commun. |volume=294 |issue=5 |pages=1087–92 |publisher= |location = United States| issn = 0006-291X| pmid = 12074588 |doi = 10.1016/S0006-291X(02)00606-X | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=O'Bryan JP, Songyang Z, Cantley L, ''et al.'' |title=A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 7 |pages= 2729-34 |year= 1996 |pmid= 8610109 |doi=  }}
*{{cite journal   |vauthors=O'Bryan JP, Songyang Z, Cantley L, etal |title=A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 7 |pages= 2729–34 |year= 1996 |pmid= 8610109 |doi=10.1073/pnas.93.7.2729  | pmc=39699 }}
*{{cite journal | author=Pelicci G, Dente L, De Giuseppe A, ''et al.'' |title=A family of Shc related proteins with conserved PTB, CH1 and SH2 regions. |journal=Oncogene |volume=13 |issue= 3 |pages= 633-41 |year= 1996 |pmid= 8760305 |doi=  }}
*{{cite journal   |vauthors=Pelicci G, Dente L, De Giuseppe A, etal |title=A family of Shc related proteins with conserved PTB, CH1 and SH2 regions. |journal=Oncogene |volume=13 |issue= 3 |pages= 633–41 |year= 1996 |pmid= 8760305 |doi=  }}
*{{cite journal  | author=Nakamura T, Sanokawa R, Sasaki Y, ''et al.'' |title=N-Shc: a neural-specific adapter molecule that mediates signaling from neurotrophin/Trk to Ras/MAPK pathway. |journal=Oncogene |volume=13 |issue= 6 |pages= 1111-21 |year= 1996 |pmid= 8808684 |doi= }}
*{{cite journal  |author1=Menegon A |author2=Leoni C |author3=Benfenati F |author4=Valtorta F |title=Tat protein from HIV-1 activates MAP kinase in granular neurons and glial cells from rat cerebellum. |journal=Biochem. Biophys. Res. Commun. |volume=238 |issue= 3 |pages= 800–5 |year= 1997 |pmid= 9325171 |doi= 10.1006/bbrc.1997.7393 }}
*{{cite journal | author=Menegon A, Leoni C, Benfenati F, Valtorta F |title=Tat protein from HIV-1 activates MAP kinase in granular neurons and glial cells from rat cerebellum. |journal=Biochem. Biophys. Res. Commun. |volume=238 |issue= 3 |pages= 800-5 |year= 1997 |pmid= 9325171 |doi= 10.1006/bbrc.1997.7393 }}
*{{cite journal   |vauthors=Wang JF, Ganju RK, Liu ZY, etal |title=Signal transduction in human hematopoietic cells by vascular endothelial growth factor related protein, a novel ligand for the FLT4 receptor. |journal=Blood |volume=90 |issue= 9 |pages= 3507–15 |year= 1997 |pmid= 9345034 |doi= }}
*{{cite journal  | author=Wang JF, Ganju RK, Liu ZY, ''et al.'' |title=Signal transduction in human hematopoietic cells by vascular endothelial growth factor related protein, a novel ligand for the FLT4 receptor. |journal=Blood |volume=90 |issue= 9 |pages= 3507-15 |year= 1997 |pmid= 9345034 |doi=  }}
*{{cite journal  |author1=Nakamura T |author2=Muraoka S |author3=Sanokawa R |author4=Mori N |title=N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling. |journal=J. Biol. Chem. |volume=273 |issue= 12 |pages= 6960–7 |year= 1998 |pmid= 9507002 |doi=10.1074/jbc.273.12.6960 }}
*{{cite journal  | author=Nakamura T, Muraoka S, Sanokawa R, Mori N |title=N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling. |journal=J. Biol. Chem. |volume=273 |issue= 12 |pages= 6960-7 |year= 1998 |pmid= 9507002 |doi=  }}
*{{cite journal  |author1=Cook KK |author2=Fadool DA |title=Two adaptor proteins differentially modulate the phosphorylation and biophysics of Kv1.3 ion channel by SRC kinase. |journal=J. Biol. Chem. |volume=277 |issue= 15 |pages= 13268–80 |year= 2002 |pmid= 11812778 |doi= 10.1074/jbc.M108898200 | pmc=2779217 }}
*{{cite journal | author=Cook KK, Fadool DA |title=Two adaptor proteins differentially modulate the phosphorylation and biophysics of Kv1.3 ion channel by SRC kinase. |journal=J. Biol. Chem. |volume=277 |issue= 15 |pages= 13268-80 |year= 2002 |pmid= 11812778 |doi= 10.1074/jbc.M108898200 }}
*{{cite journal   |vauthors=Tarr PE, Roncarati R, Pelicci G, etal |title=Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc. |journal=J. Biol. Chem. |volume=277 |issue= 19 |pages= 16798–804 |year= 2002 |pmid= 11877420 |doi= 10.1074/jbc.M110286200 }}
*{{cite journal  | author=Tarr PE, Roncarati R, Pelicci G, ''et al.'' |title=Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc. |journal=J. Biol. Chem. |volume=277 |issue= 19 |pages= 16798-804 |year= 2002 |pmid= 11877420 |doi= 10.1074/jbc.M110286200 }}
*{{cite journal  |author1=Liu HY |author2=Meakin SO |title=ShcB and ShcC activation by the Trk family of receptor tyrosine kinases. |journal=J. Biol. Chem. |volume=277 |issue= 29 |pages= 26046–56 |year= 2002 |pmid= 12006576 |doi= 10.1074/jbc.M111659200 }}
*{{cite journal | author=Liu HY, Meakin SO |title=ShcB and ShcC activation by the Trk family of receptor tyrosine kinases. |journal=J. Biol. Chem. |volume=277 |issue= 29 |pages= 26046-56 |year= 2002 |pmid= 12006576 |doi= 10.1074/jbc.M111659200 }}
*{{cite journal   |vauthors=Miyake I, Hakomori Y, Shinohara A, etal |title=Activation of anaplastic lymphoma kinase is responsible for hyperphosphorylation of ShcC in neuroblastoma cell lines. |journal=Oncogene |volume=21 |issue= 38 |pages= 5823–34 |year= 2002 |pmid= 12185581 |doi= 10.1038/sj.onc.1205735 }}
*{{cite journal | author=Miyake I, Hakomori Y, Shinohara A, ''et al.'' |title=Activation of anaplastic lymphoma kinase is responsible for hyperphosphorylation of ShcC in neuroblastoma cell lines. |journal=Oncogene |volume=21 |issue= 38 |pages= 5823-34 |year= 2002 |pmid= 12185581 |doi= 10.1038/sj.onc.1205735 }}
*{{cite journal   |vauthors=Pelicci G, Troglio F, Bodini A, etal |title=The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway. |journal=Mol. Cell. Biol. |volume=22 |issue= 20 |pages= 7351–63 |year= 2002 |pmid= 12242309 |doi=10.1128/MCB.22.20.7351-7363.2002  | pmc=139827  }}
*{{cite journal | author=Pelicci G, Troglio F, Bodini A, ''et al.'' |title=The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway. |journal=Mol. Cell. Biol. |volume=22 |issue= 20 |pages= 7351-63 |year= 2002 |pmid= 12242309 |doi=  }}
*{{cite journal   |vauthors=Nakamura T, Komiya M, Sone K, etal |title=Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules. |journal=Mol. Cell. Biol. |volume=22 |issue= 24 |pages= 8721–34 |year= 2003 |pmid= 12446789 |doi=10.1128/MCB.22.24.8721-8734.2002  | pmc=139861 }}
*{{cite journal | author=Nakamura T, Komiya M, Sone K, ''et al.'' |title=Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules. |journal=Mol. Cell. Biol. |volume=22 |issue= 24 |pages= 8721-34 |year= 2003 |pmid= 12446789 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Miyake I, Hakomori Y, Misu Y, etal |title=Domain-specific function of ShcC docking protein in neuroblastoma cells. |journal=Oncogene |volume=24 |issue= 19 |pages= 3206–15 |year= 2005 |pmid= 15735675 |doi= 10.1038/sj.onc.1208523 }}
*{{cite journal | author=Miyake I, Hakomori Y, Misu Y, ''et al.'' |title=Domain-specific function of ShcC docking protein in neuroblastoma cells. |journal=Oncogene |volume=24 |issue= 19 |pages= 3206-15 |year= 2005 |pmid= 15735675 |doi= 10.1038/sj.onc.1208523 }}
*{{cite journal   |vauthors=Magrassi L, Conti L, Lanterna A, etal |title=Shc3 affects human high-grade astrocytomas survival. |journal=Oncogene |volume=24 |issue= 33 |pages= 5198–206 |year= 2005 |pmid= 15870690 |doi= 10.1038/sj.onc.1208708 }}
*{{cite journal | author=Magrassi L, Conti L, Lanterna A, ''et al.'' |title=Shc3 affects human high-grade astrocytomas survival. |journal=Oncogene |volume=24 |issue= 33 |pages= 5198-206 |year= 2005 |pmid= 15870690 |doi= 10.1038/sj.onc.1208708 }}
*{{cite journal   |vauthors=De Falco V, Guarino V, Malorni L, etal |title=RAI(ShcC/N-Shc)-dependent recruitment of GAB 1 to RET oncoproteins potentiates PI 3-K signalling in thyroid tumors. |journal=Oncogene |volume=24 |issue= 41 |pages= 6303–13 |year= 2005 |pmid= 15940252 |doi= 10.1038/sj.onc.1208776 }}
*{{cite journal | author=De Falco V, Guarino V, Malorni L, ''et al.'' |title=RAI(ShcC/N-Shc)-dependent recruitment of GAB 1 to RET oncoproteins potentiates PI 3-K signalling in thyroid tumors. |journal=Oncogene |volume=24 |issue= 41 |pages= 6303-13 |year= 2005 |pmid= 15940252 |doi= 10.1038/sj.onc.1208776 }}
*{{cite journal   |vauthors=Toschi E, Bacigalupo I, Strippoli R, etal |title=HIV-1 Tat regulates endothelial cell cycle progression via activation of the Ras/ERK MAPK signaling pathway. |journal=Mol. Biol. Cell |volume=17 |issue= 4 |pages= 1985–94 |year= 2006 |pmid= 16436505 |doi= 10.1091/mbc.E05-08-0717 | pmc=1415297 }}
*{{cite journal | author=Toschi E, Bacigalupo I, Strippoli R, ''et al.'' |title=HIV-1 Tat regulates endothelial cell cycle progression via activation of the Ras/ERK MAPK signaling pathway. |journal=Mol. Biol. Cell |volume=17 |issue= 4 |pages= 1985-94 |year= 2006 |pmid= 16436505 |doi= 10.1091/mbc.E05-08-0717 }}
*{{cite journal   |vauthors=Li MD, Sun D, Lou XY, etal |title=Linkage and association studies in African- and Caucasian-American populations demonstrate that SHC3 is a novel susceptibility locus for nicotine dependence. |journal=Mol. Psychiatry |volume=12 |issue= 5 |pages= 462–73 |year= 2007 |pmid= 17179996 |doi= 10.1038/sj.mp.4001933 }}
*{{cite journal | author=Li MD, Sun D, Lou XY, ''et al.'' |title=Linkage and association studies in African- and Caucasian-American populations demonstrate that SHC3 is a novel susceptibility locus for nicotine dependence. |journal=Mol. Psychiatry |volume=12 |issue= 5 |pages= 462-73 |year= 2007 |pmid= 17179996 |doi= 10.1038/sj.mp.4001933 }}
}}
}}
{{refend}}
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Revision as of 06:19, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

SHC-transforming protein 3 is a protein that in humans is encoded by the SHC3 gene.[1][2]


Interactions

SHC3 has been shown to interact with RICS[3] and TrkB.[4][5]

References

  1. ↑ Nakamura T; Sanokawa R; Sasaki Y; Ayusawa D; Oishi M; Mori N (November 1996). "N-Shc: a neural-specific adapter molecule that mediates signaling from neurotrophin/Trk to Ras/MAPK pathway". Oncogene. 13 (6): 1111–21. PMID 8808684.
  2. ↑ "Entrez Gene: SHC3 SHC (Src homology 2 domain containing) transforming protein 3".
  3. ↑ Nakamura, Takeshi; Komiya Misako; Sone Kiyoaki; Hirose Eiji; Gotoh Noriko; Morii Hiroshi; Ohta Yasutaka; Mori Nozomu (December 2002). "Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules". Mol. Cell. Biol. United States. 22 (24): 8721–34. doi:10.1128/MCB.22.24.8721-8734.2002. ISSN 0270-7306. PMC 139861. PMID 12446789.
  4. ↑ Nakamura, T; Muraoka S; Sanokawa R; Mori N (March 1998). "N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling". J. Biol. Chem. UNITED STATES. 273 (12): 6960–7. doi:10.1074/jbc.273.12.6960. ISSN 0021-9258. PMID 9507002.
  5. ↑ Suzuki, Shingo; Mizutani Masaharu; Suzuki Kenji; Yamada Masashi; Kojima Masami; Hatanaka Hiroshi; Koizumi Shinichi (June 2002). "Brain-derived neurotrophic factor promotes interaction of the Nck2 adaptor protein with the TrkB tyrosine kinase receptor". Biochem. Biophys. Res. Commun. United States. 294 (5): 1087–92. doi:10.1016/S0006-291X(02)00606-X. ISSN 0006-291X. PMID 12074588.

Further reading



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