SLIT1: Difference between revisions

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{{Infobox_gene}}
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'''Slit homolog 1 protein''' is a [[protein]] that in humans is encoded by the ''SLIT1'' [[gene]].<ref name="pmid9693030">{{cite journal | vauthors = Nakayama M, Nakajima D, Nagase T, Nomura N, Seki N, Ohara O | title = Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening | journal = Genomics | volume = 51 | issue = 1 | pages = 27–34 | date = July 1998 | pmid = 9693030 | pmc =  | doi = 10.1006/geno.1998.5341 }}</ref><ref name="pmid9813312">{{cite journal | vauthors = Itoh A, Miyabayashi T, Ohno M, Sakano S | title = Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system | journal = Brain Research. Molecular Brain Research | volume = 62 | issue = 2 | pages = 175–86 | date = November 1998 | pmid = 9813312 | pmc =  | doi = 10.1016/S0169-328X(98)00224-1 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLIT1 slit homolog 1 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6585| accessdate = }}</ref>
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== References ==
{{GNF_Protein_box
{{reflist}}
| image = 
| image_source = 
| PDB =
| Name = Slit homolog 1 (Drosophila)
| HGNCid = 11085
| Symbol = SLIT1
| AltSymbols =; MEGF4; SLIL1; SLIT3; Slit-1
| OMIM = 603742
| ECnumber = 
| Homologene = 2302
| MGIid = 1315203
| Function = {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0007411 |text = axon guidance}} {{GNF_GO|id=GO:0007420 |text = brain development}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0040023 |text = establishment of nucleus localization}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6585
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_003052
    | Hs_RefseqmRNA = NM_003061
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 20562
    | Mm_Ensembl = ENSMUSG00000025020
    | Mm_RefseqmRNA = NM_015748
    | Mm_RefseqProtein = NP_056563
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 19
    | Mm_GenLoc_start = 41653570
    | Mm_GenLoc_end = 41797167
    | Mm_Uniprot = Q80TR4
  }}
}}
'''Slit homolog 1 (Drosophila)''', also known as '''SLIT1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLIT1 slit homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6585| accessdate = }}</ref>


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== Further reading ==
{{PBB_Summary
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| summary_text =
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==References==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T | title = Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones | journal = DNA Research | volume = 9 | issue = 3 | pages = 99–106 | date = June 2002 | pmid = 12168954 | doi = 10.1093/dnares/9.3.99 }}
| citations =
* {{cite journal | vauthors = Wong K, Park HT, Wu JY, Rao Y | title = Slit proteins: molecular guidance cues for cells ranging from neurons to leukocytes | journal = Current Opinion in Genetics & Development | volume = 12 | issue = 5 | pages = 583–91 | date = October 2002 | pmid = 12200164 | doi = 10.1016/S0959-437X(02)00343-X }}
*{{cite journal | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi= }}
* {{cite journal | vauthors = Liang Y, Annan RS, Carr SA, Popp S, Mevissen M, Margolis RK, Margolis RU | title = Mammalian homologues of the Drosophila slit protein are ligands of the heparan sulfate proteoglycan glypican-1 in brain | journal = The Journal of Biological Chemistry | volume = 274 | issue = 25 | pages = 17885–92 | date = June 1999 | pmid = 10364234 | doi = 10.1074/jbc.274.25.17885 }}
*{{cite journal | author=Wong K, Park HT, Wu JY, Rao Y |title=Slit proteins: molecular guidance cues for cells ranging from neurons to leukocytes. |journal=Curr. Opin. Genet. Dev. |volume=12 |issue= 5 |pages= 583-91 |year= 2003 |pmid= 12200164 |doi=  }}
* {{cite journal | vauthors = Wu W, Wong K, Chen J, Jiang Z, Dupuis S, Wu JY, Rao Y | title = Directional guidance of neuronal migration in the olfactory system by the protein Slit | journal = Nature | volume = 400 | issue = 6742 | pages = 331–6 | date = July 1999 | pmid = 10432110 | pmc = 2041931 | doi = 10.1038/22477 }}
*{{cite journal  | author=Nakayama M, Nakajima D, Nagase T, ''et al.'' |title=Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening. |journal=Genomics |volume=51 |issue= 1 |pages= 27-34 |year= 1998 |pmid= 9693030 |doi= 10.1006/geno.1998.5341 }}
* {{cite journal | vauthors = Yuan W, Zhou L, Chen JH, Wu JY, Rao Y, Ornitz DM | title = The mouse SLIT family: secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance | journal = Developmental Biology | volume = 212 | issue = 2 | pages = 290–306 | date = August 1999 | pmid = 10433822 | doi = 10.1006/dbio.1999.9371 }}
*{{cite journal  | author=Itoh A, Miyabayashi T, Ohno M, Sakano S |title=Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system. |journal=Brain Res. Mol. Brain Res. |volume=62 |issue= 2 |pages= 175-86 |year= 1999 |pmid= 9813312 |doi=  }}
* {{cite journal | vauthors = Little M, Rumballe B, Georgas K, Yamada T, Teasdale RD | title = Conserved modularity and potential for alternate splicing in mouse and human Slit genes | journal = The International Journal of Developmental Biology | volume = 46 | issue = 4 | pages = 385–91 | year = 2003 | pmid = 12141424 | doi =  }}
*{{cite journal | author=Liang Y, Annan RS, Carr SA, ''et al.'' |title=Mammalian homologues of the Drosophila slit protein are ligands of the heparan sulfate proteoglycan glypican-1 in brain. |journal=J. Biol. Chem. |volume=274 |issue= 25 |pages= 17885-92 |year= 1999 |pmid= 10364234 |doi= }}
* {{cite journal | vauthors = Hammond R, Vivancos V, Naeem A, Chilton J, Mambetisaeva E, Mambitisaeva E, Andrews W, Sundaresan V, Guthrie S | title = Slit-mediated repulsion is a key regulator of motor axon pathfinding in the hindbrain | journal = Development | volume = 132 | issue = 20 | pages = 4483–95 | date = October 2005 | pmid = 16162649 | doi = 10.1242/dev.02038 }}
*{{cite journal | author=Wu W, Wong K, Chen J, ''et al.'' |title=Directional guidance of neuronal migration in the olfactory system by the protein Slit. |journal=Nature |volume=400 |issue= 6742 |pages= 331-6 |year= 1999 |pmid= 10432110 |doi= 10.1038/22477 }}
* {{cite journal | vauthors = Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY | title = A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration | journal = Cell | volume = 125 | issue = 4 | pages = 801–14 | date = May 2006 | pmid = 16713569 | doi = 10.1016/j.cell.2006.03.032 }}
*{{cite journal | author=Yuan W, Zhou L, Chen JH, ''et al.'' |title=The mouse SLIT family: secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance. |journal=Dev. Biol. |volume=212 |issue= 2 |pages= 290-306 |year= 1999 |pmid= 10433822 |doi= 10.1006/dbio.1999.9371 }}
* {{cite journal | vauthors = Lin L, Isacson O | title = Axonal growth regulation of fetal and embryonic stem cell-derived dopaminergic neurons by Netrin-1 and Slits | journal = Stem Cells | volume = 24 | issue = 11 | pages = 2504–13 | date = November 2006 | pmid = 16840550 | pmc = 2613222 | doi = 10.1634/stemcells.2006-0119 }}
*{{cite journal | author=Little M, Rumballe B, Georgas K, ''et al.'' |title=Conserved modularity and potential for alternate splicing in mouse and human Slit genes. |journal=Int. J. Dev. Biol. |volume=46 |issue= 4 |pages= 385-91 |year= 2003 |pmid= 12141424 |doi=  }}
* {{cite journal | vauthors = Hussain SA, Piper M, Fukuhara N, Strochlic L, Cho G, Howitt JA, Ahmed Y, Powell AK, Turnbull JE, Holt CE, Hohenester E | title = A molecular mechanism for the heparan sulfate dependence of slit-robo signaling | journal = The Journal of Biological Chemistry | volume = 281 | issue = 51 | pages = 39693–8 | date = December 2006 | pmid = 17062560 | doi = 10.1074/jbc.M609384200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Hammond R, Vivancos V, Naeem A, ''et al.'' |title=Slit-mediated repulsion is a key regulator of motor axon pathfinding in the hindbrain. |journal=Development |volume=132 |issue= 20 |pages= 4483-95 |year= 2005 |pmid= 16162649 |doi= 10.1242/dev.02038 }}
*{{cite journal | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal | author=Lin L, Isacson O |title=Axonal growth regulation of fetal and embryonic stem cell-derived dopaminergic neurons by Netrin-1 and Slits. |journal=Stem Cells |volume=24 |issue= 11 |pages= 2504-13 |year= 2006 |pmid= 16840550 |doi= 10.1634/stemcells.2006-0119 }}
*{{cite journal | author=Hussain SA, Piper M, Fukuhara N, ''et al.'' |title=A molecular mechanism for the heparan sulfate dependence of slit-robo signaling. |journal=J. Biol. Chem. |volume=281 |issue= 51 |pages= 39693-8 |year= 2007 |pmid= 17062560 |doi= 10.1074/jbc.M609384200 }}
}}
{{refend}}
{{refend}}


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[[Category:Slit proteins]]

Latest revision as of 02:41, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Slit homolog 1 protein is a protein that in humans is encoded by the SLIT1 gene.[1][2][3]

References

  1. Nakayama M, Nakajima D, Nagase T, Nomura N, Seki N, Ohara O (July 1998). "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening". Genomics. 51 (1): 27–34. doi:10.1006/geno.1998.5341. PMID 9693030.
  2. Itoh A, Miyabayashi T, Ohno M, Sakano S (November 1998). "Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system". Brain Research. Molecular Brain Research. 62 (2): 175–86. doi:10.1016/S0169-328X(98)00224-1. PMID 9813312.
  3. "Entrez Gene: SLIT1 slit homolog 1 (Drosophila)".

Further reading