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{{Infobox_gene}}
{{PBB_Controls
'''Vinexin''' is a [[protein]] that in humans is encoded by the ''SORBS3'' [[gene]].<ref name="pmid9885244">{{cite journal |author1=Kioka N |author2=Sakata S |author3=Kawauchi T |author4=Amachi T |author5=Akiyama SK |author6=Okazaki K |author7=Yaen C |author8=Yamada KM |author9=Aota S | title = Vinexin: a novel vinculin-binding protein with multiple SH3 domains enhances actin cytoskeletal organization | journal = J Cell Biol | volume = 144 | issue = 1 | pages = 59–69 |date=Mar 1999 | pmid = 9885244 | pmc = 2148117 | doi =10.1083/jcb.144.1.59 }}</ref><ref name="pmid12510380">{{cite journal | author = Kioka N | title = [A novel adaptor protein family regulating cytoskeletal organization and signal transduction--Vinexin, CAP/ponsin, ArgBP2] | journal = Seikagaku | volume = 74 | issue = 11 | pages = 1356–60 |date=Jan 2003 | pmid = 12510380 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SORBS3 sorbin and SH3 domain containing 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10174| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_SORBS3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2ct3.
| PDB = {{PDB2|2ct3}}, {{PDB2|2dlm}}, {{PDB2|2nwm}}
| Name = Sorbin and SH3 domain containing 3
| HGNCid = 30907
| Symbol = SORBS3
| AltSymbols =; SCAM-1; SH3D4; vinexin
| OMIM = 610795
| ECnumber =
| Homologene = 4218
| MGIid = 700013
| GeneAtlas_image1 = PBB_GE_SORBS3_209253_at_tn.png
| GeneAtlas_image2 = PBB_GE_SORBS3_207788_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005200 |text = structural constituent of cytoskeleton}} {{GNF_GO|id=GO:0008134 |text = transcription factor binding}} {{GNF_GO|id=GO:0017166 |text = vinculin binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0005925 |text = focal adhesion}}
  | Process = {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0031589 |text = cell-substrate adhesion}} {{GNF_GO|id=GO:0043410 |text = positive regulation of MAPKKK cascade}} {{GNF_GO|id=GO:0051495 |text = positive regulation of cytoskeleton organization and biogenesis}} {{GNF_GO|id=GO:0051496 |text = positive regulation of stress fiber formation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10174
    | Hs_Ensembl = ENSG00000120896
    | Hs_RefseqProtein = NP_001018003
    | Hs_RefseqmRNA = NM_001018003
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 22465196
    | Hs_GenLoc_end = 22488951
    | Hs_Uniprot = O60504
    | Mm_EntrezGene = 20410
    | Mm_Ensembl = ENSMUSG00000022091
    | Mm_RefseqmRNA = NM_011366
    | Mm_RefseqProtein = NP_035496
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 68915548
    | Mm_GenLoc_end = 68942717
    | Mm_Uniprot = Q8K0M3
  }}
}}
'''Sorbin and SH3 domain containing 3''', also known as '''SORBS3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SORBS3 sorbin and SH3 domain containing 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10174| accessdate = }}</ref>


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| summary_text =  
| summary_text =  
}}
}}
==Interactions==
SORBS3 has been shown to [[Protein-protein interaction|interact]] with [[DLG5]]<ref name=pmid12657639>{{cite journal |last=Wakabayashi |first=Makoto |authorlink= |author2=Ito Takuya |author3=Mitsushima Masaru |author4=Aizawa Sanae |author5=Ueda Kazumitsu |author6=Amachi Teruo |author7=Kioka Noriyuki  |date=Jun 2003 |title=Interaction of lp-dlg/KIAA0583, a membrane-associated guanylate kinase family protein, with vinexin and beta-catenin at sites of cell-cell contact |journal=J. Biol. Chem. |volume=278 |issue=24 |pages=21709–14 |publisher= |location = United States| issn = 0021-9258| pmid = 12657639 |doi = 10.1074/jbc.M211004200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[MAPK1]].<ref name=pmid15184391>{{cite journal |last=Mitsushima |first=Masaru |authorlink= |author2=Suwa Akira |author3=Amachi Teruo |author4=Ueda Kazumitsu |author5=Kioka Noriyuki  |date=Aug 2004 |title=Extracellular signal-regulated kinase activated by epidermal growth factor and cell adhesion interacts with and phosphorylates vinexin |journal=J. Biol. Chem. |volume=279 |issue=33 |pages=34570–7 |publisher= |location = United States| issn = 0021-9258| pmid = 15184391 |doi = 10.1074/jbc.M402304200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Kioka N |title=[A novel adaptor protein family regulating cytoskeletal organization and signal transduction--Vinexin, CAP/ponsin, ArgBP2] |journal=Seikagaku |volume=74 |issue= 11 |pages= 1356-60 |year= 2003 |pmid= 12510380 |doi=  }}
*{{cite journal   |vauthors=Akamatsu M, Aota S, Suwa A, etal |title=Vinexin forms a signaling complex with Sos and modulates epidermal growth factor-induced c-Jun N-terminal kinase/stress-activated protein kinase activities. |journal=J. Biol. Chem. |volume=274 |issue= 50 |pages= 35933–7 |year= 2000 |pmid= 10585480 |doi=10.1074/jbc.274.50.35933 }}
*{{cite journal  | author=Kioka N, Sakata S, Kawauchi T, ''et al.'' |title=Vinexin: a novel vinculin-binding protein with multiple SH3 domains enhances actin cytoskeletal organization. |journal=J. Cell Biol. |volume=144 |issue= 1 |pages= 59-69 |year= 1999 |pmid= 9885244 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Akamatsu M, Aota S, Suwa A, ''et al.'' |title=Vinexin forms a signaling complex with Sos and modulates epidermal growth factor-induced c-Jun N-terminal kinase/stress-activated protein kinase activities. |journal=J. Biol. Chem. |volume=274 |issue= 50 |pages= 35933-7 |year= 2000 |pmid= 10585480 |doi=  }}
*{{cite journal   |vauthors=Wakabayashi M, Ito T, Mitsushima M, etal |title=Interaction of lp-dlg/KIAA0583, a membrane-associated guanylate kinase family protein, with vinexin and beta-catenin at sites of cell-cell contact. |journal=J. Biol. Chem. |volume=278 |issue= 24 |pages= 21709–14 |year= 2003 |pmid= 12657639 |doi= 10.1074/jbc.M211004200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Townson SM, Dobrzycka KM, Lee AV, etal |title=SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressor. |journal=J. Biol. Chem. |volume=278 |issue= 22 |pages= 20059–68 |year= 2003 |pmid= 12660241 |doi= 10.1074/jbc.M212988200 }}
*{{cite journal | author=Wakabayashi M, Ito T, Mitsushima M, ''et al.'' |title=Interaction of lp-dlg/KIAA0583, a membrane-associated guanylate kinase family protein, with vinexin and beta-catenin at sites of cell-cell contact. |journal=J. Biol. Chem. |volume=278 |issue= 24 |pages= 21709-14 |year= 2003 |pmid= 12657639 |doi= 10.1074/jbc.M211004200 }}
*{{cite journal   |vauthors=Mitsushima M, Suwa A, Amachi T, etal |title=Extracellular signal-regulated kinase activated by epidermal growth factor and cell adhesion interacts with and phosphorylates vinexin. |journal=J. Biol. Chem. |volume=279 |issue= 33 |pages= 34570–7 |year= 2004 |pmid= 15184391 |doi= 10.1074/jbc.M402304200 }}
*{{cite journal | author=Townson SM, Dobrzycka KM, Lee AV, ''et al.'' |title=SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressor. |journal=J. Biol. Chem. |volume=278 |issue= 22 |pages= 20059-68 |year= 2003 |pmid= 12660241 |doi= 10.1074/jbc.M212988200 }}
*{{cite journal   |vauthors=Martens N, Wery M, Wang P, etal |title=The suppressor of cytokine signaling (SOCS)-7 interacts with the actin cytoskeleton through vinexin. |journal=Exp. Cell Res. |volume=298 |issue= 1 |pages= 239–48 |year= 2004 |pmid= 15242778 |doi= 10.1016/j.yexcr.2004.04.002 }}
*{{cite journal | author=Mitsushima M, Suwa A, Amachi T, ''et al.'' |title=Extracellular signal-regulated kinase activated by epidermal growth factor and cell adhesion interacts with and phosphorylates vinexin. |journal=J. Biol. Chem. |volume=279 |issue= 33 |pages= 34570-7 |year= 2004 |pmid= 15184391 |doi= 10.1074/jbc.M402304200 }}
*{{cite journal   |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 }}
*{{cite journal | author=Martens N, Wery M, Wang P, ''et al.'' |title=The suppressor of cytokine signaling (SOCS)-7 interacts with the actin cytoskeleton through vinexin. |journal=Exp. Cell Res. |volume=298 |issue= 1 |pages= 239-48 |year= 2004 |pmid= 15242778 |doi= 10.1016/j.yexcr.2004.04.002 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal   |vauthors=Bour G, Plassat JL, Bauer A, etal |title=Vinexin beta interacts with the non-phosphorylated AF-1 domain of retinoid receptor gamma (RARgamma) and represses RARgamma-mediated transcription. |journal=J. Biol. Chem. |volume=280 |issue= 17 |pages= 17027–37 |year= 2005 |pmid= 15734736 |doi= 10.1074/jbc.M501344200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Bour G, Plassat JL, Bauer A, ''et al.'' |title=Vinexin beta interacts with the non-phosphorylated AF-1 domain of retinoid receptor gamma (RARgamma) and represses RARgamma-mediated transcription. |journal=J. Biol. Chem. |volume=280 |issue= 17 |pages= 17027-37 |year= 2005 |pmid= 15734736 |doi= 10.1074/jbc.M501344200 }}
*{{cite journal  |author1=Mitsushima M |author2=Ueda K |author3=Kioka N |title=Vinexin beta regulates the phosphorylation of epidermal growth factor receptor on the cell surface. |journal=Genes Cells |volume=11 |issue= 9 |pages= 971–82 |year= 2006 |pmid= 16923119 |doi= 10.1111/j.1365-2443.2006.00995.x }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Beausoleil SA, Villén J, Gerber SA, etal |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal  | author=Mitsushima M, Ueda K, Kioka N |title=Vinexin beta regulates the phosphorylation of epidermal growth factor receptor on the cell surface. |journal=Genes Cells |volume=11 |issue= 9 |pages= 971-82 |year= 2006 |pmid= 16923119 |doi= 10.1111/j.1365-2443.2006.00995.x }}
*{{cite journal   |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285-92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal   |vauthors=Mizutani K, Ito H, Iwamoto I, etal |title=Essential roles of ERK-mediated phosphorylation of vinexin in cell spreading, migration and anchorage-independent growth. |journal=Oncogene |volume=26 |issue= 50 |pages= 7122–31 |year= 2007 |pmid= 17486060 |doi= 10.1038/sj.onc.1210512 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Mizutani K, Ito H, Iwamoto I, ''et al.'' |title=Essential roles of ERK-mediated phosphorylation of vinexin in cell spreading, migration and anchorage-independent growth. |journal=Oncogene |volume=26 |issue= 50 |pages= 7122-31 |year= 2007 |pmid= 17486060 |doi= 10.1038/sj.onc.1210512 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* {{UCSC genome browser|SORBS3}}
* {{UCSC gene details|SORBS3}}
 
{{PDB Gallery|geneid=10174}}
 
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Revision as of 06:50, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Vinexin is a protein that in humans is encoded by the SORBS3 gene.[1][2][3]


Interactions

SORBS3 has been shown to interact with DLG5[4] and MAPK1.[5]

References

  1. ↑ Kioka N; Sakata S; Kawauchi T; Amachi T; Akiyama SK; Okazaki K; Yaen C; Yamada KM; Aota S (Mar 1999). "Vinexin: a novel vinculin-binding protein with multiple SH3 domains enhances actin cytoskeletal organization". J Cell Biol. 144 (1): 59–69. doi:10.1083/jcb.144.1.59. PMC 2148117. PMID 9885244.
  2. ↑ Kioka N (Jan 2003). "[A novel adaptor protein family regulating cytoskeletal organization and signal transduction--Vinexin, CAP/ponsin, ArgBP2]". Seikagaku. 74 (11): 1356–60. PMID 12510380.
  3. ↑ "Entrez Gene: SORBS3 sorbin and SH3 domain containing 3".
  4. ↑ Wakabayashi, Makoto; Ito Takuya; Mitsushima Masaru; Aizawa Sanae; Ueda Kazumitsu; Amachi Teruo; Kioka Noriyuki (Jun 2003). "Interaction of lp-dlg/KIAA0583, a membrane-associated guanylate kinase family protein, with vinexin and beta-catenin at sites of cell-cell contact". J. Biol. Chem. United States. 278 (24): 21709–14. doi:10.1074/jbc.M211004200. ISSN 0021-9258. PMID 12657639.
  5. ↑ Mitsushima, Masaru; Suwa Akira; Amachi Teruo; Ueda Kazumitsu; Kioka Noriyuki (Aug 2004). "Extracellular signal-regulated kinase activated by epidermal growth factor and cell adhesion interacts with and phosphorylates vinexin". J. Biol. Chem. United States. 279 (33): 34570–7. doi:10.1074/jbc.M402304200. ISSN 0021-9258. PMID 15184391.

Further reading

External links



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