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{{Infobox_gene}}
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'''Son of sevenless homolog 1''' is a [[protein]] that in humans is encoded by the ''SOS1'' [[gene]].<ref name="pmid8276400">{{cite journal | vauthors = Webb GC, Jenkins NA, Largaespada DA, Copeland NG, Fernandez CS, Bowtell DD | title = Mammalian homologues of the Drosophila Son of sevenless gene map to murine chromosomes 17 and 12 and to human chromosomes 2 and 14, respectively | journal = Genomics | volume = 18 | issue = 1 | pages = 14–9 | date = February 1994 | pmid = 8276400 | pmc =  | doi = 10.1006/geno.1993.1421 }}</ref><ref name="pmid10995566">{{cite journal | vauthors = Xiao S, Wang X, Qu B, Yang M, Liu G, Bu L, Wang Y, Zhu L, Lei H, Hu L, Zhang X, Liu J, Zhao G, Kong X | title = Refinement of the locus for autosomal dominant hereditary gingival fibromatosis (GINGF) to a 3.8-cM region on 2p21 | journal = Genomics | volume = 68 | issue = 3 | pages = 247–52 | date = November 2000 | pmid = 10995566 | pmc = | doi = 10.1006/geno.2000.6285 }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_SOS1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1awe.
| PDB = {{PDB2|1awe}}, {{PDB2|1bkd}}, {{PDB2|1dbh}}, {{PDB2|1nvu}}, {{PDB2|1nvv}}, {{PDB2|1nvw}}, {{PDB2|1nvx}}, {{PDB2|1pms}}, {{PDB2|1q9c}}, {{PDB2|1xd2}}, {{PDB2|1xd4}}, {{PDB2|1xdv}}, {{PDB2|2ii0}}
| Name = Son of sevenless homolog 1 (Drosophila)
| HGNCid = 11187
| Symbol = SOS1
| AltSymbols =; GF1; HGF; GGF1; GINGF; NS4
| OMIM = 182530
| ECnumber = 
| Homologene = 4117
| MGIid = 98354
| GeneAtlas_image1 = PBB_GE_SOS1_212777_at_tn.png
| GeneAtlas_image2 = PBB_GE_SOS1_212780_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0005085 |text = guanyl-nucleotide exchange factor activity}} {{GNF_GO|id=GO:0005089 |text = Rho guanyl-nucleotide exchange factor activity}} {{GNF_GO|id=GO:0005100 |text = Rho GTPase activator activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0000786 |text = nucleosome}} {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005694 |text = chromosome}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007265 |text = Ras protein signal transduction}} {{GNF_GO|id=GO:0035023 |text = regulation of Rho protein signal transduction}} {{GNF_GO|id=GO:0051056 |text = regulation of small GTPase mediated signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6654
    | Hs_Ensembl = ENSG00000115904
    | Hs_RefseqProtein = NP_005624
    | Hs_RefseqmRNA = NM_005633
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 39066469
    | Hs_GenLoc_end = 39201067
    | Hs_Uniprot = Q07889
    | Mm_EntrezGene = 20662
    | Mm_Ensembl = ENSMUSG00000024241
    | Mm_RefseqmRNA = NM_009231
    | Mm_RefseqProtein = NP_033257
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 80306507
    | Mm_GenLoc_end = 80388261
    | Mm_Uniprot = Q2M4G6
  }}
}}
'''Son of sevenless homolog 1 (Drosophila)''', also known as '''SOS1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = RAS genes (e.g., MIM 190020) encode membrane-bound guanine nucleotide-binding proteins that function in the transduction of signals that control cell growth and differentiation. Binding of GTP activates RAS proteins, and subsequent hydrolysis of the bound GTP to GDP and phosphate inactivates signaling by these proteins. GTP binding can be catalyzed by guanine nucleotide exchange factors for RAS, and GTP hydrolysis can be accelerated by GTPase-activating proteins (GAPs). The first exchange factor to be identified for RAS was the S. cerevisiae CDC25 gene product. Genetic analysis indicated that CDC25 is essential for activation of RAS proteins. In Drosophila, the protein encoded by the 'son of sevenless' gene (Sos) contains a domain that shows sequence similarity with the catalytic domain of CDC25. Sos may act as a positive regulator of RAS by promoting guanine nucleotide exchange.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: SOS1 son of sevenless homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6654| accessdate = }}</ref>
}}
Recent studies also show that mutations in Sos1 can cause [[Noonan syndrome]].


==See also==
RAS genes (e.g., MIM 190020) encode membrane-bound guanine nucleotide-binding proteins that function in the transduction of signals that control cell growth and differentiation. Binding of GTP activates RAS proteins, and subsequent hydrolysis of the bound GTP to GDP and phosphate inactivates signaling by these proteins. GTP binding can be catalyzed by [[guanine nucleotide exchange factor]]s for RAS, and GTP hydrolysis can be accelerated by GTPase-activating proteins (GAPs). The first exchange factor to be identified for RAS was the S. cerevisiae CDC25 gene product. Genetic analysis indicated that CDC25 is essential for activation of RAS proteins. In Drosophila, the protein encoded by the 'son of sevenless' gene (Sos) contains a domain that shows sequence similarity with the catalytic domain of CDC25. Sos may act as a positive regulator of RAS by promoting guanine nucleotide exchange.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: SOS1 son of sevenless homolog 1 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6654| accessdate = }}</ref>
 
== Clinical significance ==
 
Recent studies also show that mutations in Sos1 can cause [[Noonan syndrome]]<ref name="pmid17143285">{{cite journal | vauthors = Roberts AE, Araki T, Swanson KD, Montgomery KT, Schiripo TA, Joshi VA, Li L, Yassin Y, Tamburino AM, Neel BG, Kucherlapati RS | title = Germline gain-of-function mutations in SOS1 cause Noonan syndrome | journal = Nat. Genet. | volume = 39 | issue = 1 | pages = 70–4 | date = January 2007 | pmid = 17143285 | doi = 10.1038/ng1926 | url =  | issn =  }}</ref> and hereditary gingival fibromatosis type 1.<ref name="pmid11868160">{{cite journal | vauthors = Hart TC, Zhang Y, Gorry MC, Hart PS, Cooper M, Marazita ML, Marks JM, Cortelli JR, Pallos D | title = A mutation in the SOS1 gene causes hereditary gingival fibromatosis type 1 | journal = Am. J. Hum. Genet. | volume = 70 | issue = 4 | pages = 943–54 | date = April 2002 | pmid = 11868160 | pmc = 379122 | doi = 10.1086/339689 | url =  | issn =  }}</ref> Noonan syndrome has also been shown to be caused by mutations in [[KRAS]] and [[PTPN11]] genes.<ref name="pmid11704759">{{cite journal | vauthors = Tartaglia M, Mehler EL, Goldberg R, Zampino G, Brunner HG, Kremer H, van der Burgt I, Crosby AH, Ion A, Jeffery S, Kalidas K, Patton MA, Kucherlapati RS, Gelb BD | title = Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome | journal = Nat. Genet. | volume = 29 | issue = 4 | pages = 465–8 | date = December 2001 | pmid = 11704759 | doi = 10.1038/ng772 | url =  | issn =  }}</ref> activators of the MAP kinase pathway.
 
== Interactions ==
 
SOS1 has been shown to [[Protein-protein interaction|interact]] with:
{{div col|colwidth=20em}}
* [[ABI1]],<ref name = pmid10499589/>
* [[BCR gene]],<ref name = pmid8112292/><ref name = pmid7529874>{{cite journal | vauthors = Maru Y, Peters KL, Afar DE, Shibuya M, Witte ON, Smithgall TE | title = Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOS | journal = Mol. Cell. Biol. | volume = 15 | issue = 2 | pages = 835–42 | date = February 1995 | pmid = 7529874 | pmc = 231961 | doi =  }}</ref>
* [[CRK (gene)|CRK]],<ref name = pmid8810325/>
* [[EPS8]],<ref name = pmid10499589>{{cite journal | vauthors = Scita G, Nordstrom J, Carbone R, Tenca P, Giardina G, Gutkind S, Bjarnegård M, Betsholtz C, Di Fiore PP | title = EPS8 and E3B1 transduce signals from Ras to Rac | journal = Nature | volume = 401 | issue = 6750 | pages = 290–3 | date = September 1999 | pmid = 10499589 | doi = 10.1038/45822 }}</ref><ref name = pmid14565974>{{cite journal | vauthors = Offenhäuser N, Borgonovo A, Disanza A, Romano P, Ponzanelli I, Iannolo G, Di Fiore PP, Scita G | title = The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway | journal = Mol. Biol. Cell | volume = 15 | issue = 1 | pages = 91–8 | date = January 2004 | pmid = 14565974 | pmc = 307530 | doi = 10.1091/mbc.E03-06-0427 }}</ref>
* [[Epidermal growth factor receptor]],<ref name = pmid7510700/><ref name = pmid10675333>{{cite journal | vauthors = Qian X, Esteban L, Vass WC, Upadhyaya C, Papageorge AG, Yienger K, Ward JM, Lowy DR, Santos E | title = The Sos1 and Sos2 Ras-specific exchange factors: differences in placental expression and signaling properties | journal = EMBO J. | volume = 19 | issue = 4 | pages = 642–54 | date = February 2000 | pmid = 10675333 | pmc = 305602 | doi = 10.1093/emboj/19.4.642 }}</ref><ref name = pmid9447973>{{cite journal | vauthors = Qian X, Vass WC, Papageorge AG, Anborgh PH, Lowy DR | title = N terminus of Sos1 Ras exchange factor: critical roles for the Dbl and pleckstrin homology domains | journal = Mol. Cell. Biol. | volume = 18 | issue = 2 | pages = 771–8 | date = February 1998 | pmid = 9447973 | pmc = 108788 | doi =  10.1128/mcb.18.2.771}}</ref>
* [[FRS2]],<ref name = pmid11997436/><ref name = pmid10783152>{{cite journal | vauthors = Foehr ED, Tatavos A, Tanabe E, Raffioni S, Goetz S, Dimarco E, De Luca M, Bradshaw RA | title = Discoidin domain receptor 1 (DDR1) signaling in PC12 cells: activation of juxtamembrane domains in PDGFR/DDR/TrkA chimeric receptors | journal = FASEB J. | volume = 14 | issue = 7 | pages = 973–81 | date = May 2000 | pmid = 10783152 | doi =  }}</ref><ref name = pmid9182757>{{cite journal | vauthors = Kouhara H, Hadari YR, Spivak-Kroizman T, Schilling J, Bar-Sagi D, Lax I, Schlessinger J | title = A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway | journal = Cell | volume = 89 | issue = 5 | pages = 693–702 | date = May 1997 | pmid = 9182757 | doi =  10.1016/s0092-8674(00)80252-4}}</ref>
* [[Grb2]],<ref name = pmid8112292>{{cite journal | vauthors = Puil L, Liu J, Gish G, Mbamalu G, Bowtell D, Pelicci PG, Arlinghaus R, Pawson T | title = Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway | journal = EMBO J. | volume = 13 | issue = 4 | pages = 764–73 | date = February 1994 | pmid = 8112292 | pmc = 394874 | doi =  }}</ref><ref name = pmid8810325/><ref name = pmid7510700>{{cite journal | vauthors = Buday L, Egan SE, Rodriguez Viciana P, Cantrell DA, Downward J | title = A complex of Grb2 adaptor protein, Sos exchange factor, and a 36-kDa membrane-bound tyrosine phosphoprotein is implicated in ras activation in T cells | journal = J. Biol. Chem. | volume = 269 | issue = 12 | pages = 9019–23 | date = March 1994 | pmid = 7510700 | doi =  }}</ref><ref name = pmid11997436>{{cite journal | vauthors = Wong A, Lamothe B, Lee A, Schlessinger J, Lax I, Li A | title = FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 10 | pages = 6684–9 | date = May 2002 | pmid = 11997436 | pmc = 124463 | doi = 10.1073/pnas.052138899 }}</ref><ref name = pmid9344843/><ref name = pmid7664271/><ref name = pmid12577067>{{cite journal | vauthors = Blagoev B, Kratchmarova I, Ong SE, Nielsen M, Foster LJ, Mann M | title = A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling | journal = Nat. Biotechnol. | volume = 21 | issue = 3 | pages = 315–8 | date = March 2003 | pmid = 12577067 | doi = 10.1038/nbt790 }}</ref><ref name = pmid9872323>{{cite journal | vauthors = Liu SK, McGlade CJ | title = Gads is a novel SH2 and SH3 domain-containing adaptor protein that binds to tyrosine-phosphorylated Shc | journal = Oncogene | volume = 17 | issue = 24 | pages = 3073–82 | date = Dec 1998 | pmid = 9872323 | doi = 10.1038/sj.onc.1202337 }}</ref><ref name = pmid11960376>{{cite journal | vauthors = Oneyama C, Nakano H, Sharma SV | title = UCS15A, a novel small molecule, SH3 domain-mediated protein-protein interaction blocking drug | journal = Oncogene | volume = 21 | issue = 13 | pages = 2037–50 | date = March 2002 | pmid = 11960376 | doi = 10.1038/sj.onc.1205271 }}</ref><ref name = pmid8695800>{{cite journal | vauthors = Robinson A, Gibbins J, Rodríguez-Liñares B, Finan PM, Wilson L, Kellie S, Findell P, Watson SP | title = Characterization of Grb2-binding proteins in human platelets activated by Fc gamma RIIA cross-linking | journal = Blood | volume = 88 | issue = 2 | pages = 522–30 | date = July 1996 | pmid = 8695800 | doi =  }}</ref><ref name = pmid8479541>{{cite journal | vauthors = Li N, Batzer A, Daly R, Yajnik V, Skolnik E, Chardin P, Bar-Sagi D, Margolis B, Schlessinger J | title = Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling | journal = Nature | volume = 363 | issue = 6424 | pages = 85–8 | date = May 1993 | pmid = 8479541 | doi = 10.1038/363085a0 }}</ref><ref name = pmid8188688>{{cite journal | vauthors = Reif K, Buday L, Downward J, Cantrell DA | title = SH3 domains of the adapter molecule Grb2 complex with two proteins in T cells: the guanine nucleotide exchange protein Sos and a 75-kDa protein that is a substrate for T cell antigen receptor-activated tyrosine kinases | journal = J. Biol. Chem. | volume = 269 | issue = 19 | pages = 14081–7 | date = May 1994 | pmid = 8188688 | doi =  }}</ref><ref name = pmid10319320>{{cite journal | vauthors = D'Angelo G, Martini JF, Iiri T, Fantl WJ, Martial J, Weiner RI | title = 16K human prolactin inhibits vascular endothelial growth factor-induced activation of Ras in capillary endothelial cells | journal = Mol. Endocrinol. | volume = 13 | issue = 5 | pages = 692–704 | date = May 1999 | pmid = 10319320 | doi = 10.1210/mend.13.5.0280 }}</ref><ref name = pmid7629168>{{cite journal | vauthors = Nel AE, Gupta S, Lee L, Ledbetter JA, Kanner SB | title = Ligation of the T-cell antigen receptor (TCR) induces association of hSos1, ZAP-70, phospholipase C-gamma 1, and other phosphoproteins with Grb2 and the zeta-chain of the TCR | journal = J. Biol. Chem. | volume = 270 | issue = 31 | pages = 18428–36 | date = August 1995 | pmid = 7629168 | doi =  10.1074/jbc.270.31.18428}}</ref><ref name = pmid10716926>{{cite journal | vauthors = Tong XK, Hussain NK, de Heuvel E, Kurakin A, Abi-Jaoude E, Quinn CC, Olson MF, Marais R, Baranes D, Kay BK, McPherson PS | title = The endocytic protein intersectin is a major binding partner for the Ras exchange factor mSos1 in rat brain | journal = EMBO J. | volume = 19 | issue = 6 | pages = 1263–71 | date = March 2000 | pmid = 10716926 | pmc = 305667 | doi = 10.1093/emboj/19.6.1263 }}</ref><ref name = pmid10477741>{{cite journal | vauthors = Park RK, Izadi KD, Deo YM, Durden DL | title = Role of Src in the modulation of multiple adaptor proteins in FcalphaRI oxidant signaling | journal = Blood | volume = 94 | issue = 6 | pages = 2112–20 | date = September 1999 | pmid = 10477741 | doi =  }}</ref><ref name = pmid10207103>{{cite journal | vauthors = Germani A, Romero F, Houlard M, Camonis J, Gisselbrecht S, Fischer S, Varin-Blank N | title = hSiah2 is a new Vav binding protein which inhibits Vav-mediated signaling pathways | journal = Mol. Cell. Biol. | volume = 19 | issue = 5 | pages = 3798–807 | date = May 1999 | pmid = 10207103 | pmc = 84217 | doi =  }}</ref><ref name = pmid10570290>{{cite journal | vauthors = Park RK, Erdreich-Epstein A, Liu M, Izadi KD, Durden DL | title = High affinity IgG receptor activation of Src family kinases is required for modulation of the Shc-Grb2-Sos complex and the downstream activation of the nicotinamide adenine dinucleotide phosphate (reduced) oxidase | journal = J. Immunol. | volume = 163 | issue = 11 | pages = 6023–34 | date = Dec 1999 | pmid = 10570290 | doi =  }}</ref><ref name = pmid11964172>{{cite journal | vauthors = Saci A, Liu WQ, Vidal M, Garbay C, Rendu F, Bachelot-Loza C | title = Differential effect of the inhibition of Grb2-SH3 interactions in platelet activation induced by thrombin and by Fc receptor engagement | journal = Biochem. J. | volume = 363 | issue = Pt 3 | pages = 717–25 | date = May 2002 | pmid = 11964172 | pmc = 1222524 | doi =  10.1042/0264-6021:3630717}}</ref><ref name = pmid9009162>{{cite journal | vauthors = Sastry L, Cao T, King CR | title = Multiple Grb2-protein complexes in human cancer cells | journal = Int. J. Cancer | volume = 70 | issue = 2 | pages = 208–13 | date = January 1997 | pmid = 9009162 | doi =  10.1002/(sici)1097-0215(19970117)70:2<208::aid-ijc12>3.0.co;2-e}}</ref><ref name = pmid7514169>{{cite journal | vauthors = Spivak-Kroizman T, Mohammadi M, Hu P, Jaye M, Schlessinger J, Lax I | title = Point mutation in the fibroblast growth factor receptor eliminates phosphatidylinositol hydrolysis without affecting neuronal differentiation of PC12 cells | journal = J. Biol. Chem. | volume = 269 | issue = 20 | pages = 14419–23 | date = May 1994 | pmid = 7514169 | doi =  }}</ref>
* [[HRAS]],<ref name = pmid12628188>{{cite journal | vauthors = Margarit SM, Sondermann H, Hall BE, Nagar B, Hoelz A, Pirruccello M, Bar-Sagi D, Kuriyan J | title = Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS | journal = Cell | volume = 112 | issue = 5 | pages = 685–95 | date = March 2003 | pmid = 12628188 | doi =  10.1016/s0092-8674(03)00149-1}}</ref><ref name = pmid9690470>{{cite journal | vauthors = Boriack-Sjodin PA, Margarit SM, Bar-Sagi D, Kuriyan J | title = The structural basis of the activation of Ras by Sos | journal = Nature | volume = 394 | issue = 6691 | pages = 337–43 | date = July 1998 | pmid = 9690470 | doi = 10.1038/28548 }}</ref>
* [[ITSN1]],<ref name = pmid10716926/>
* [[MUC1]],<ref name = pmid7664271>{{cite journal | vauthors = Pandey P, Kharbanda S, Kufe D | title = Association of the DF3/MUC1 breast cancer antigen with Grb2 and the Sos/Ras exchange protein | journal = Cancer Res. | volume = 55 | issue = 18 | pages = 4000–3 | date = September 1995 | pmid = 7664271 | doi =  }}</ref><ref name = pmid11278868>{{cite journal | vauthors = Schroeder JA, Thompson MC, Gardner MM, Gendler SJ | title = Transgenic MUC1 interacts with epidermal growth factor receptor and correlates with mitogen-activated protein kinase activation in the mouse mammary gland | journal = J. Biol. Chem. | volume = 276 | issue = 16 | pages = 13057–64 | date = April 2001 | pmid = 11278868 | doi = 10.1074/jbc.M011248200 }}</ref>
* [[NCK1]],<ref name = pmid8810325>{{cite journal | vauthors = Okada S, Pessin JE | title = Interactions between Src homology (SH) 2/SH3 adapter proteins and the guanylnucleotide exchange factor SOS are differentially regulated by insulin and epidermal growth factor | journal = J. Biol. Chem. | volume = 271 | issue = 41 | pages = 25533–8 | date = October 1996 | pmid = 8810325 | doi =  10.1074/jbc.271.41.25533}}</ref><ref name = pmid10206341>{{cite journal | vauthors = Wunderlich L, Faragó A, Buday L | title = Characterization of interactions of Nck with Sos and dynamin | journal = Cell. Signal. | volume = 11 | issue = 1 | pages = 25–9 | date = January 1999 | pmid = 10206341 | doi =  10.1016/s0898-6568(98)00027-8}}</ref><ref name = pmid7862111>{{cite journal | vauthors = Hu Q, Milfay D, Williams LT | title = Binding of NCK to SOS and activation of ras-dependent gene expression | journal = Mol. Cell. Biol. | volume = 15 | issue = 3 | pages = 1169–74 | date = March 1995 | pmid = 7862111 | pmc = 230339 | doi =  }}</ref><ref name = pmid10026169>{{cite journal | vauthors = Braverman LE, Quilliam LA | title = Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck | journal = J. Biol. Chem. | volume = 274 | issue = 9 | pages = 5542–9 | date = February 1999 | pmid = 10026169 | doi =  10.1074/jbc.274.9.5542}}</ref>
* [[PLCG1]],<ref name = pmid10913276>{{cite journal | vauthors = Kim MJ, Chang JS, Park SK, Hwang JI, Ryu SH, Suh PG | title = Direct interaction of SOS1 Ras exchange protein with the SH3 domain of phospholipase C-gamma1 | journal = Biochemistry | volume = 39 | issue = 29 | pages = 8674–82 | date = July 2000 | pmid = 10913276 | doi =  10.1021/bi992558t}}</ref><ref name = pmid10940929>{{cite journal | vauthors = Scholler JK, Perez-Villar JJ, O'Day K, Kanner SB | title = Engagement of the T lymphocyte antigen receptor regulates association of son-of-sevenless homologues with the SH3 domain of phospholipase Cgamma1 | journal = Eur. J. Immunol. | volume = 30 | issue = 8 | pages = 2378–87 | date = August 2000 | pmid = 10940929 | doi = 10.1002/1521-4141(2000)30:8<2378::AID-IMMU2378>3.0.CO;2-E }}</ref>
* [[PTPN11]],<ref name = pmid9344843>{{cite journal | vauthors = Chin H, Saito T, Arai A, Yamamoto K, Kamiyama R, Miyasaka N, Miura O | title = Erythropoietin and IL-3 induce tyrosine phosphorylation of CrkL and its association with Shc, SHP-2, and Cbl in hematopoietic cells | journal = Biochem. Biophys. Res. Commun. | volume = 239 | issue = 2 | pages = 412–7 | date = October 1997 | pmid = 9344843 | doi = 10.1006/bbrc.1997.7480 }}</ref><ref name = pmid9632781>{{cite journal | vauthors = Hadari YR, Kouhara H, Lax I, Schlessinger J | title = Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation | journal = Mol. Cell. Biol. | volume = 18 | issue = 7 | pages = 3966–73 | date = July 1998 | pmid = 9632781 | pmc = 108981 | doi =  }}</ref>
* [[SH3KBP1]],<ref name = pmid11071869>{{cite journal | vauthors = Watanabe S, Take H, Takeda K, Yu ZX, Iwata N, Kajigaya S | title = Characterization of the CIN85 adaptor protein and identification of components involved in CIN85 complexes | journal = Biochem. Biophys. Res. Commun. | volume = 278 | issue = 1 | pages = 167–74 | date = November 2000 | pmid = 11071869 | doi = 10.1006/bbrc.2000.3760 }}</ref>  and
* [[SHC1]].<ref name = pmid10675333/><ref name = pmid10783152/><ref name = pmid9344843/><ref name = pmid10570290/> and
{{Div col end}}
 
== See also ==
* [[Son of Sevenless]]
* [[Son of Sevenless]]
{{Clear}}
== References ==
{{Reflist|35em}}


==References==
== Further reading ==
{{reflist|2}}
{{Refbegin|35em}}
* {{cite journal | vauthors = Lioubin MN, Myles GM, Carlberg K, Bowtell D, Rohrschneider LR | title = Shc, Grb2, Sos1, and a 150-kilodalton tyrosine-phosphorylated protein form complexes with Fms in hematopoietic cells. | journal = Mol. Cell. Biol. | volume = 14 | issue = 9 | pages = 5682–91 | year = 1994 | pmid = 7520523 | pmc = 359093 | doi = 10.1128/mcb.14.9.5682 }}
* {{cite journal | vauthors = Nel AE, Gupta S, Lee L, Ledbetter JA, Kanner SB | title = Ligation of the T-cell antigen receptor (TCR) induces association of hSos1, ZAP-70, phospholipase C-gamma 1, and other phosphoproteins with Grb2 and the zeta-chain of the TCR. | journal = J. Biol. Chem. | volume = 270 | issue = 31 | pages = 18428–36 | year = 1995 | pmid = 7629168 | doi = 10.1074/jbc.270.31.18428 }}
* {{cite journal | vauthors = Pandey P, Kharbanda S, Kufe D | title = Association of the DF3/MUC1 breast cancer antigen with Grb2 and the Sos/Ras exchange protein. | journal = Cancer Res. | volume = 55 | issue = 18 | pages = 4000–3 | year = 1995 | pmid = 7664271 | doi =  }}
* {{cite journal | vauthors = Hu Q, Milfay D, Williams LT | title = Binding of NCK to SOS and activation of ras-dependent gene expression. | journal = Mol. Cell. Biol. | volume = 15 | issue = 3 | pages = 1169–74 | year = 1995 | pmid = 7862111 | pmc = 230339 | doi =  }}
* {{cite journal | vauthors = Puil L, Liu J, Gish G, Mbamalu G, Bowtell D, Pelicci PG, Arlinghaus R, Pawson T | title = Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway. | journal = EMBO J. | volume = 13 | issue = 4 | pages = 764–73 | year = 1994 | pmid = 8112292 | pmc = 394874 | doi =  }}
* {{cite journal | vauthors = Li N, Batzer A, Daly R, Yajnik V, Skolnik E, Chardin P, Bar-Sagi D, Margolis B, Schlessinger J | title = Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling. | journal = Nature | volume = 363 | issue = 6424 | pages = 85–8 | year = 1993 | pmid = 8479541 | doi = 10.1038/363085a0 }}
* {{cite journal | vauthors = Chardin P, Camonis JH, Gale NW, van Aelst L, Schlessinger J, Wigler MH, Bar-Sagi D | title = Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. | journal = Science | volume = 260 | issue = 5112 | pages = 1338–43 | year = 1993 | pmid = 8493579 | doi = 10.1126/science.8493579 }}
* {{cite journal | vauthors = Sadoshima J, Izumo S | title = The heterotrimeric G q protein-coupled angiotensin II receptor activates p21 ras via the tyrosine kinase-Shc-Grb2-Sos pathway in cardiac myocytes. | journal = EMBO J. | volume = 15 | issue = 4 | pages = 775–87 | year = 1996 | pmid = 8631299 | pmc = 450276 | doi =  }}
* {{cite journal | vauthors = Feng GS, Ouyang YB, Hu DP, Shi ZQ, Gentz R, Ni J | title = Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway. | journal = J. Biol. Chem. | volume = 271 | issue = 21 | pages = 12129–32 | year = 1996 | pmid = 8647802 | doi = 10.1074/jbc.271.21.12129 }}
* {{cite journal | vauthors = Okada S, Pessin JE | title = Interactions between Src homology (SH) 2/SH3 adapter proteins and the guanylnucleotide exchange factor SOS are differentially regulated by insulin and epidermal growth factor. | journal = J. Biol. Chem. | volume = 271 | issue = 41 | pages = 25533–8 | year = 1996 | pmid = 8810325 | doi = 10.1074/jbc.271.41.25533 }}
* {{cite journal | vauthors = Corbalan-Garcia S, Yang SS, Degenhardt KR, Bar-Sagi D | title = Identification of the mitogen-activated protein kinase phosphorylation sites on human Sos1 that regulate interaction with Grb2. | journal = Mol. Cell. Biol. | volume = 16 | issue = 10 | pages = 5674–82 | year = 1996 | pmid = 8816480 | pmc = 231567 | doi =  }}
* {{cite journal | vauthors = Sattler M, Salgia R, Shrikhande G, Verma S, Uemura N, Law SF, Golemis EA, Griffin JD | title = Differential signaling after beta1 integrin ligation is mediated through binding of CRKL to p120(CBL) and p110(HEF1). | journal = J. Biol. Chem. | volume = 272 | issue = 22 | pages = 14320–6 | year = 1997 | pmid = 9162067 | doi = 10.1074/jbc.272.22.14320 }}
* {{cite journal | vauthors = Leprince C, Romero F, Cussac D, Vayssiere B, Berger R, Tavitian A, Camonis JH | title = A new member of the amphiphysin family connecting endocytosis and signal transduction pathways. | journal = J. Biol. Chem. | volume = 272 | issue = 24 | pages = 15101–5 | year = 1997 | pmid = 9182529 | doi = 10.1074/jbc.272.24.15101 }}
* {{cite journal | vauthors = Kouhara H, Hadari YR, Spivak-Kroizman T, Schilling J, Bar-Sagi D, Lax I, Schlessinger J | title = A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway. | journal = Cell | volume = 89 | issue = 5 | pages = 693–702 | year = 1997 | pmid = 9182757 | doi = 10.1016/S0092-8674(00)80252-4 }}
* {{cite journal | vauthors = Chin H, Saito T, Arai A, Yamamoto K, Kamiyama R, Miyasaka N, Miura O | title = Erythropoietin and IL-3 induce tyrosine phosphorylation of CrkL and its association with Shc, SHP-2, and Cbl in hematopoietic cells. | journal = Biochem. Biophys. Res. Commun. | volume = 239 | issue = 2 | pages = 412–7 | year = 1997 | pmid = 9344843 | doi = 10.1006/bbrc.1997.7480 }}
* {{cite journal | vauthors = Zheng J, Chen RH, Corblan-Garcia S, Cahill SM, Bar-Sagi D, Cowburn D | title = The solution structure of the pleckstrin homology domain of human SOS1. A possible structural role for the sequential association of diffuse B cell lymphoma and pleckstrin homology domains. | journal = J. Biol. Chem. | volume = 272 | issue = 48 | pages = 30340–4 | year = 1997 | pmid = 9374522 | doi = 10.1074/jbc.272.48.30340 }}
* {{cite journal | vauthors = Li S, Kim M, Hu YL, Jalali S, Schlaepfer DD, Hunter T, Chien S, Shyy JY | title = Fluid shear stress activation of focal adhesion kinase. Linking to mitogen-activated protein kinases. | journal = J. Biol. Chem. | volume = 272 | issue = 48 | pages = 30455–62 | year = 1997 | pmid = 9374537 | doi = 10.1074/jbc.272.48.30455 }}
* {{cite journal | vauthors = Qian X, Vass WC, Papageorge AG, Anborgh PH, Lowy DR | title = N terminus of Sos1 Ras exchange factor: critical roles for the Dbl and pleckstrin homology domains. | journal = Mol. Cell. Biol. | volume = 18 | issue = 2 | pages = 771–8 | year = 1998 | pmid = 9447973 | pmc = 108788 | doi =  10.1128/mcb.18.2.771}}
* {{cite journal | vauthors = Curto M, Frankel P, Carrero A, Foster DA | title = Novel recruitment of Shc, Grb2, and Sos by fibroblast growth factor receptor-1 in v-Src-transformed cells. | journal = Biochem. Biophys. Res. Commun. | volume = 243 | issue = 2 | pages = 555–60 | year = 1998 | pmid = 9480847 | doi = 10.1006/bbrc.1997.7982 }}
{{Refend}}


==External links==
== External links ==
* [https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=noonan  GeneReviews/NCBI/NIH/UW entry on Noonan syndrome]
* http://www.noonansyndrome.org
* http://www.noonansyndrome.org
* http://ghr.nlm.nih.gov/gene=sos1
* http://ghr.nlm.nih.gov/gene=sos1


==Further reading==
{{PDB Gallery|geneid=6654}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Lioubin MN, Myles GM, Carlberg K, ''et al.'' |title=Shc, Grb2, Sos1, and a 150-kilodalton tyrosine-phosphorylated protein form complexes with Fms in hematopoietic cells. |journal=Mol. Cell. Biol. |volume=14 |issue= 9 |pages= 5682-91 |year= 1994 |pmid= 7520523 |doi=  }}
*{{cite journal  | author=Nel AE, Gupta S, Lee L, ''et al.'' |title=Ligation of the T-cell antigen receptor (TCR) induces association of hSos1, ZAP-70, phospholipase C-gamma 1, and other phosphoproteins with Grb2 and the zeta-chain of the TCR. |journal=J. Biol. Chem. |volume=270 |issue= 31 |pages= 18428-36 |year= 1995 |pmid= 7629168 |doi=  }}
*{{cite journal  | author=Pandey P, Kharbanda S, Kufe D |title=Association of the DF3/MUC1 breast cancer antigen with Grb2 and the Sos/Ras exchange protein. |journal=Cancer Res. |volume=55 |issue= 18 |pages= 4000-3 |year= 1995 |pmid= 7664271 |doi=  }}
*{{cite journal  | author=Hu Q, Milfay D, Williams LT |title=Binding of NCK to SOS and activation of ras-dependent gene expression. |journal=Mol. Cell. Biol. |volume=15 |issue= 3 |pages= 1169-74 |year= 1995 |pmid= 7862111 |doi=  }}
*{{cite journal  | author=Puil L, Liu J, Gish G, ''et al.'' |title=Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway. |journal=EMBO J. |volume=13 |issue= 4 |pages= 764-73 |year= 1994 |pmid= 8112292 |doi=  }}
*{{cite journal  | author=Webb GC, Jenkins NA, Largaespada DA, ''et al.'' |title=Mammalian homologues of the Drosophila Son of sevenless gene map to murine chromosomes 17 and 12 and to human chromosomes 2 and 14, respectively. |journal=Genomics |volume=18 |issue= 1 |pages= 14-9 |year= 1994 |pmid= 8276400 |doi= 10.1006/geno.1993.1421 }}
*{{cite journal  | author=Li N, Batzer A, Daly R, ''et al.'' |title=Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling. |journal=Nature |volume=363 |issue= 6424 |pages= 85-8 |year= 1993 |pmid= 8479541 |doi= 10.1038/363085a0 }}
*{{cite journal  | author=Chardin P, Camonis JH, Gale NW, ''et al.'' |title=Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. |journal=Science |volume=260 |issue= 5112 |pages= 1338-43 |year= 1993 |pmid= 8493579 |doi=  }}
*{{cite journal  | author=Sadoshima J, Izumo S |title=The heterotrimeric G q protein-coupled angiotensin II receptor activates p21 ras via the tyrosine kinase-Shc-Grb2-Sos pathway in cardiac myocytes. |journal=EMBO J. |volume=15 |issue= 4 |pages= 775-87 |year= 1996 |pmid= 8631299 |doi=  }}
*{{cite journal  | author=Feng GS, Ouyang YB, Hu DP, ''et al.'' |title=Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway. |journal=J. Biol. Chem. |volume=271 |issue= 21 |pages= 12129-32 |year= 1996 |pmid= 8647802 |doi=  }}
*{{cite journal  | author=Okada S, Pessin JE |title=Interactions between Src homology (SH) 2/SH3 adapter proteins and the guanylnucleotide exchange factor SOS are differentially regulated by insulin and epidermal growth factor. |journal=J. Biol. Chem. |volume=271 |issue= 41 |pages= 25533-8 |year= 1996 |pmid= 8810325 |doi=  }}
*{{cite journal  | author=Corbalan-Garcia S, Yang SS, Degenhardt KR, Bar-Sagi D |title=Identification of the mitogen-activated protein kinase phosphorylation sites on human Sos1 that regulate interaction with Grb2. |journal=Mol. Cell. Biol. |volume=16 |issue= 10 |pages= 5674-82 |year= 1996 |pmid= 8816480 |doi=  }}
*{{cite journal  | author=Sattler M, Salgia R, Shrikhande G, ''et al.'' |title=Differential signaling after beta1 integrin ligation is mediated through binding of CRKL to p120(CBL) and p110(HEF1). |journal=J. Biol. Chem. |volume=272 |issue= 22 |pages= 14320-6 |year= 1997 |pmid= 9162067 |doi=  }}
*{{cite journal  | author=Leprince C, Romero F, Cussac D, ''et al.'' |title=A new member of the amphiphysin family connecting endocytosis and signal transduction pathways. |journal=J. Biol. Chem. |volume=272 |issue= 24 |pages= 15101-5 |year= 1997 |pmid= 9182529 |doi=  }}
*{{cite journal  | author=Kouhara H, Hadari YR, Spivak-Kroizman T, ''et al.'' |title=A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway. |journal=Cell |volume=89 |issue= 5 |pages= 693-702 |year= 1997 |pmid= 9182757 |doi=  }}
*{{cite journal  | author=Chin H, Saito T, Arai A, ''et al.'' |title=Erythropoietin and IL-3 induce tyrosine phosphorylation of CrkL and its association with Shc, SHP-2, and Cbl in hematopoietic cells. |journal=Biochem. Biophys. Res. Commun. |volume=239 |issue= 2 |pages= 412-7 |year= 1997 |pmid= 9344843 |doi= 10.1006/bbrc.1997.7480 }}
*{{cite journal  | author=Zheng J, Chen RH, Corblan-Garcia S, ''et al.'' |title=The solution structure of the pleckstrin homology domain of human SOS1. A possible structural role for the sequential association of diffuse B cell lymphoma and pleckstrin homology domains. |journal=J. Biol. Chem. |volume=272 |issue= 48 |pages= 30340-4 |year= 1997 |pmid= 9374522 |doi=  }}
*{{cite journal  | author=Li S, Kim M, Hu YL, ''et al.'' |title=Fluid shear stress activation of focal adhesion kinase. Linking to mitogen-activated protein kinases. |journal=J. Biol. Chem. |volume=272 |issue= 48 |pages= 30455-62 |year= 1997 |pmid= 9374537 |doi=  }}
*{{cite journal  | author=Qian X, Vass WC, Papageorge AG, ''et al.'' |title=N terminus of Sos1 Ras exchange factor: critical roles for the Dbl and pleckstrin homology domains. |journal=Mol. Cell. Biol. |volume=18 |issue= 2 |pages= 771-8 |year= 1998 |pmid= 9447973 |doi=  }}
*{{cite journal  | author=Curto M, Frankel P, Carrero A, Foster DA |title=Novel recruitment of Shc, Grb2, and Sos by fibroblast growth factor receptor-1 in v-Src-transformed cells. |journal=Biochem. Biophys. Res. Commun. |volume=243 |issue= 2 |pages= 555-60 |year= 1998 |pmid= 9480847 |doi= 10.1006/bbrc.1997.7982 }}
}}
{{refend}}


{{protein-stub}}
{{NLM content}}
{{NLM content}}
{{WikiDoc Sources}}

Latest revision as of 06:50, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
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View/Edit Human

Son of sevenless homolog 1 is a protein that in humans is encoded by the SOS1 gene.[1][2]

Function

RAS genes (e.g., MIM 190020) encode membrane-bound guanine nucleotide-binding proteins that function in the transduction of signals that control cell growth and differentiation. Binding of GTP activates RAS proteins, and subsequent hydrolysis of the bound GTP to GDP and phosphate inactivates signaling by these proteins. GTP binding can be catalyzed by guanine nucleotide exchange factors for RAS, and GTP hydrolysis can be accelerated by GTPase-activating proteins (GAPs). The first exchange factor to be identified for RAS was the S. cerevisiae CDC25 gene product. Genetic analysis indicated that CDC25 is essential for activation of RAS proteins. In Drosophila, the protein encoded by the 'son of sevenless' gene (Sos) contains a domain that shows sequence similarity with the catalytic domain of CDC25. Sos may act as a positive regulator of RAS by promoting guanine nucleotide exchange.[supplied by OMIM][3]

Clinical significance

Recent studies also show that mutations in Sos1 can cause Noonan syndrome[4] and hereditary gingival fibromatosis type 1.[5] Noonan syndrome has also been shown to be caused by mutations in KRAS and PTPN11 genes.[6] activators of the MAP kinase pathway.

Interactions

SOS1 has been shown to interact with:

See also

References

  1. ↑ Webb GC, Jenkins NA, Largaespada DA, Copeland NG, Fernandez CS, Bowtell DD (February 1994). "Mammalian homologues of the Drosophila Son of sevenless gene map to murine chromosomes 17 and 12 and to human chromosomes 2 and 14, respectively". Genomics. 18 (1): 14–9. doi:10.1006/geno.1993.1421. PMID 8276400.
  2. ↑ Xiao S, Wang X, Qu B, Yang M, Liu G, Bu L, Wang Y, Zhu L, Lei H, Hu L, Zhang X, Liu J, Zhao G, Kong X (November 2000). "Refinement of the locus for autosomal dominant hereditary gingival fibromatosis (GINGF) to a 3.8-cM region on 2p21". Genomics. 68 (3): 247–52. doi:10.1006/geno.2000.6285. PMID 10995566.
  3. ↑ "Entrez Gene: SOS1 son of sevenless homolog 1 (Drosophila)".
  4. ↑ Roberts AE, Araki T, Swanson KD, Montgomery KT, Schiripo TA, Joshi VA, Li L, Yassin Y, Tamburino AM, Neel BG, Kucherlapati RS (January 2007). "Germline gain-of-function mutations in SOS1 cause Noonan syndrome". Nat. Genet. 39 (1): 70–4. doi:10.1038/ng1926. PMID 17143285.
  5. ↑ Hart TC, Zhang Y, Gorry MC, Hart PS, Cooper M, Marazita ML, Marks JM, Cortelli JR, Pallos D (April 2002). "A mutation in the SOS1 gene causes hereditary gingival fibromatosis type 1". Am. J. Hum. Genet. 70 (4): 943–54. doi:10.1086/339689. PMC 379122. PMID 11868160.
  6. ↑ Tartaglia M, Mehler EL, Goldberg R, Zampino G, Brunner HG, Kremer H, van der Burgt I, Crosby AH, Ion A, Jeffery S, Kalidas K, Patton MA, Kucherlapati RS, Gelb BD (December 2001). "Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome". Nat. Genet. 29 (4): 465–8. doi:10.1038/ng772. PMID 11704759.
  7. ↑ 7.0 7.1 Scita G, Nordstrom J, Carbone R, Tenca P, Giardina G, Gutkind S, Bjarnegård M, Betsholtz C, Di Fiore PP (September 1999). "EPS8 and E3B1 transduce signals from Ras to Rac". Nature. 401 (6750): 290–3. doi:10.1038/45822. PMID 10499589.
  8. ↑ 8.0 8.1 Puil L, Liu J, Gish G, Mbamalu G, Bowtell D, Pelicci PG, Arlinghaus R, Pawson T (February 1994). "Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway". EMBO J. 13 (4): 764–73. PMC 394874. PMID 8112292.
  9. ↑ Maru Y, Peters KL, Afar DE, Shibuya M, Witte ON, Smithgall TE (February 1995). "Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOS". Mol. Cell. Biol. 15 (2): 835–42. PMC 231961. PMID 7529874.
  10. ↑ 10.0 10.1 10.2 Okada S, Pessin JE (October 1996). "Interactions between Src homology (SH) 2/SH3 adapter proteins and the guanylnucleotide exchange factor SOS are differentially regulated by insulin and epidermal growth factor". J. Biol. Chem. 271 (41): 25533–8. doi:10.1074/jbc.271.41.25533. PMID 8810325.
  11. ↑ Offenhäuser N, Borgonovo A, Disanza A, Romano P, Ponzanelli I, Iannolo G, Di Fiore PP, Scita G (January 2004). "The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway". Mol. Biol. Cell. 15 (1): 91–8. doi:10.1091/mbc.E03-06-0427. PMC 307530. PMID 14565974.
  12. ↑ 12.0 12.1 Buday L, Egan SE, Rodriguez Viciana P, Cantrell DA, Downward J (March 1994). "A complex of Grb2 adaptor protein, Sos exchange factor, and a 36-kDa membrane-bound tyrosine phosphoprotein is implicated in ras activation in T cells". J. Biol. Chem. 269 (12): 9019–23. PMID 7510700.
  13. ↑ 13.0 13.1 Qian X, Esteban L, Vass WC, Upadhyaya C, Papageorge AG, Yienger K, Ward JM, Lowy DR, Santos E (February 2000). "The Sos1 and Sos2 Ras-specific exchange factors: differences in placental expression and signaling properties". EMBO J. 19 (4): 642–54. doi:10.1093/emboj/19.4.642. PMC 305602. PMID 10675333.
  14. ↑ Qian X, Vass WC, Papageorge AG, Anborgh PH, Lowy DR (February 1998). "N terminus of Sos1 Ras exchange factor: critical roles for the Dbl and pleckstrin homology domains". Mol. Cell. Biol. 18 (2): 771–8. doi:10.1128/mcb.18.2.771. PMC 108788. PMID 9447973.
  15. ↑ 15.0 15.1 Wong A, Lamothe B, Lee A, Schlessinger J, Lax I, Li A (May 2002). "FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl". Proc. Natl. Acad. Sci. U.S.A. 99 (10): 6684–9. doi:10.1073/pnas.052138899. PMC 124463. PMID 11997436.
  16. ↑ 16.0 16.1 Foehr ED, Tatavos A, Tanabe E, Raffioni S, Goetz S, Dimarco E, De Luca M, Bradshaw RA (May 2000). "Discoidin domain receptor 1 (DDR1) signaling in PC12 cells: activation of juxtamembrane domains in PDGFR/DDR/TrkA chimeric receptors". FASEB J. 14 (7): 973–81. PMID 10783152.
  17. ↑ Kouhara H, Hadari YR, Spivak-Kroizman T, Schilling J, Bar-Sagi D, Lax I, Schlessinger J (May 1997). "A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway". Cell. 89 (5): 693–702. doi:10.1016/s0092-8674(00)80252-4. PMID 9182757.
  18. ↑ 18.0 18.1 18.2 Chin H, Saito T, Arai A, Yamamoto K, Kamiyama R, Miyasaka N, Miura O (October 1997). "Erythropoietin and IL-3 induce tyrosine phosphorylation of CrkL and its association with Shc, SHP-2, and Cbl in hematopoietic cells". Biochem. Biophys. Res. Commun. 239 (2): 412–7. doi:10.1006/bbrc.1997.7480. PMID 9344843.
  19. ↑ 19.0 19.1 Pandey P, Kharbanda S, Kufe D (September 1995). "Association of the DF3/MUC1 breast cancer antigen with Grb2 and the Sos/Ras exchange protein". Cancer Res. 55 (18): 4000–3. PMID 7664271.
  20. ↑ Blagoev B, Kratchmarova I, Ong SE, Nielsen M, Foster LJ, Mann M (March 2003). "A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling". Nat. Biotechnol. 21 (3): 315–8. doi:10.1038/nbt790. PMID 12577067.
  21. ↑ Liu SK, McGlade CJ (Dec 1998). "Gads is a novel SH2 and SH3 domain-containing adaptor protein that binds to tyrosine-phosphorylated Shc". Oncogene. 17 (24): 3073–82. doi:10.1038/sj.onc.1202337. PMID 9872323.
  22. ↑ Oneyama C, Nakano H, Sharma SV (March 2002). "UCS15A, a novel small molecule, SH3 domain-mediated protein-protein interaction blocking drug". Oncogene. 21 (13): 2037–50. doi:10.1038/sj.onc.1205271. PMID 11960376.
  23. ↑ Robinson A, Gibbins J, Rodríguez-Liñares B, Finan PM, Wilson L, Kellie S, Findell P, Watson SP (July 1996). "Characterization of Grb2-binding proteins in human platelets activated by Fc gamma RIIA cross-linking". Blood. 88 (2): 522–30. PMID 8695800.
  24. ↑ Li N, Batzer A, Daly R, Yajnik V, Skolnik E, Chardin P, Bar-Sagi D, Margolis B, Schlessinger J (May 1993). "Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling". Nature. 363 (6424): 85–8. doi:10.1038/363085a0. PMID 8479541.
  25. ↑ Reif K, Buday L, Downward J, Cantrell DA (May 1994). "SH3 domains of the adapter molecule Grb2 complex with two proteins in T cells: the guanine nucleotide exchange protein Sos and a 75-kDa protein that is a substrate for T cell antigen receptor-activated tyrosine kinases". J. Biol. Chem. 269 (19): 14081–7. PMID 8188688.
  26. ↑ D'Angelo G, Martini JF, Iiri T, Fantl WJ, Martial J, Weiner RI (May 1999). "16K human prolactin inhibits vascular endothelial growth factor-induced activation of Ras in capillary endothelial cells". Mol. Endocrinol. 13 (5): 692–704. doi:10.1210/mend.13.5.0280. PMID 10319320.
  27. ↑ Nel AE, Gupta S, Lee L, Ledbetter JA, Kanner SB (August 1995). "Ligation of the T-cell antigen receptor (TCR) induces association of hSos1, ZAP-70, phospholipase C-gamma 1, and other phosphoproteins with Grb2 and the zeta-chain of the TCR". J. Biol. Chem. 270 (31): 18428–36. doi:10.1074/jbc.270.31.18428. PMID 7629168.
  28. ↑ 28.0 28.1 Tong XK, Hussain NK, de Heuvel E, Kurakin A, Abi-Jaoude E, Quinn CC, Olson MF, Marais R, Baranes D, Kay BK, McPherson PS (March 2000). "The endocytic protein intersectin is a major binding partner for the Ras exchange factor mSos1 in rat brain". EMBO J. 19 (6): 1263–71. doi:10.1093/emboj/19.6.1263. PMC 305667. PMID 10716926.
  29. ↑ Park RK, Izadi KD, Deo YM, Durden DL (September 1999). "Role of Src in the modulation of multiple adaptor proteins in FcalphaRI oxidant signaling". Blood. 94 (6): 2112–20. PMID 10477741.
  30. ↑ Germani A, Romero F, Houlard M, Camonis J, Gisselbrecht S, Fischer S, Varin-Blank N (May 1999). "hSiah2 is a new Vav binding protein which inhibits Vav-mediated signaling pathways". Mol. Cell. Biol. 19 (5): 3798–807. PMC 84217. PMID 10207103.
  31. ↑ 31.0 31.1 Park RK, Erdreich-Epstein A, Liu M, Izadi KD, Durden DL (Dec 1999). "High affinity IgG receptor activation of Src family kinases is required for modulation of the Shc-Grb2-Sos complex and the downstream activation of the nicotinamide adenine dinucleotide phosphate (reduced) oxidase". J. Immunol. 163 (11): 6023–34. PMID 10570290.
  32. ↑ Saci A, Liu WQ, Vidal M, Garbay C, Rendu F, Bachelot-Loza C (May 2002). "Differential effect of the inhibition of Grb2-SH3 interactions in platelet activation induced by thrombin and by Fc receptor engagement". Biochem. J. 363 (Pt 3): 717–25. doi:10.1042/0264-6021:3630717. PMC 1222524. PMID 11964172.
  33. ↑ Sastry L, Cao T, King CR (January 1997). "Multiple Grb2-protein complexes in human cancer cells". Int. J. Cancer. 70 (2): 208–13. doi:10.1002/(sici)1097-0215(19970117)70:2<208::aid-ijc12>3.0.co;2-e. PMID 9009162.
  34. ↑ Spivak-Kroizman T, Mohammadi M, Hu P, Jaye M, Schlessinger J, Lax I (May 1994). "Point mutation in the fibroblast growth factor receptor eliminates phosphatidylinositol hydrolysis without affecting neuronal differentiation of PC12 cells". J. Biol. Chem. 269 (20): 14419–23. PMID 7514169.
  35. ↑ Margarit SM, Sondermann H, Hall BE, Nagar B, Hoelz A, Pirruccello M, Bar-Sagi D, Kuriyan J (March 2003). "Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS". Cell. 112 (5): 685–95. doi:10.1016/s0092-8674(03)00149-1. PMID 12628188.
  36. ↑ Boriack-Sjodin PA, Margarit SM, Bar-Sagi D, Kuriyan J (July 1998). "The structural basis of the activation of Ras by Sos". Nature. 394 (6691): 337–43. doi:10.1038/28548. PMID 9690470.
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