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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Protein SSXT''' is a [[protein]] that in humans is encoded by the ''SS18'' [[gene]].<ref name="pmid8152806">{{cite journal | vauthors = Shipley JM, Clark J, Crew AJ, Birdsall S, Rocques PJ, Gill S, Chelly J, Monaco AP, Abe S, Gusterson BA | title = The t(X;18)(p11.2;q11.2) translocation found in human synovial sarcomas involves two distinct loci on the X chromosome | journal = Oncogene | volume = 9 | issue = 5 | pages = 1447–53 | date = May 1994 | pmid = 8152806 | doi =  }}</ref><ref name="pmid7951320">{{cite journal | vauthors = Clark J, Rocques PJ, Crew AJ, Gill S, Shipley J, Chan AM, Gusterson BA, Cooper CS | title = Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma | journal = Nature Genetics | volume = 7 | issue = 4 | pages = 502–8 | date = Aug 1994 | pmid = 7951320 | pmc =  | doi = 10.1038/ng0894-502 }}</ref><ref name="pmid16484776">{{cite journal | vauthors = de Bruijn DR, Geurts van Kessel A | title = Common origin of the human synovial sarcoma associated SS18 and SS18L1 gene loci | journal = Cytogenetic and Genome Research | volume = 112 | issue = 3-4 | pages = 222–6 | year = 2006 | pmid = 16484776 | doi = 10.1159/000089874 }}</ref>
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| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Synovial sarcoma translocation, chromosome 18
| HGNCid = 11340
| Symbol = SS18
| AltSymbols =; MGC116875; SSXT; SYT
| OMIM = 600192
| ECnumber = 
| Homologene = 38080
| MGIid = 107708
| GeneAtlas_image1 = PBB_GE_SS18_202816_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SS18_202817_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_SS18_209954_x_at_tn.png
| Function =  
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6760
    | Hs_Ensembl = ENSG00000141380
    | Hs_RefseqProtein = NP_001007560
    | Hs_RefseqmRNA = NM_001007559
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 18
    | Hs_GenLoc_start = 21850217
    | Hs_GenLoc_end = 21924609
    | Hs_Uniprot = Q15532
    | Mm_EntrezGene = 268996
    | Mm_Ensembl = ENSMUSG00000037013
    | Mm_RefseqmRNA = NM_009280
    | Mm_RefseqProtein = NP_033306
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 18
    | Mm_GenLoc_start = 14767216
    | Mm_GenLoc_end = 14825932
    | Mm_Uniprot = Q3TM96
  }}
}}
'''Synovial sarcoma translocation, chromosome 18''', also known as '''SS18''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SS18 synovial sarcoma translocation, chromosome 18| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6760| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
SS18 is a member of the human [[SWI/SNF]] chromatin remodeling complex.<ref name="pmid22442726">{{cite journal | vauthors = Middeljans E, Wan X, Jansen PW, Sharma V, Stunnenberg HG, Logie C | title = SS18 together with animal-specific factors defines human BAF-type SWI/SNF complexes | journal = PLOS ONE | volume = 7 | issue = 3 | pages = e33834 | year = 2012 | pmid = 22442726 | pmc = 3307773 | doi = 10.1371/journal.pone.0033834 }}</ref><ref name=pmid11734557 /><ref name=pmid14603256 />
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== Clinical significance ==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Fligman I, Lonardo F, Jhanwar SC, ''et al.'' |title=Molecular diagnosis of synovial sarcoma and characterization of a variant SYT-SSX2 fusion transcript. |journal=Am. J. Pathol. |volume=147 |issue= 6 |pages= 1592-9 |year= 1996 |pmid= 7495284 |doi=  }}
*{{cite journal  | author=Clark J, Rocques PJ, Crew AJ, ''et al.'' |title=Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma. |journal=Nat. Genet. |volume=7 |issue= 4 |pages= 502-8 |year= 1994 |pmid= 7951320 |doi= 10.1038/ng0894-502 }}
*{{cite journal  | author=Shipley JM, Clark J, Crew AJ, ''et al.'' |title=The t(X;18)(p11.2;q11.2) translocation found in human synovial sarcomas involves two distinct loci on the X chromosome. |journal=Oncogene |volume=9 |issue= 5 |pages= 1447-53 |year= 1994 |pmid= 8152806 |doi=  }}
*{{cite journal  | author=Brett D, Whitehouse S, Antonson P, ''et al.'' |title=The SYT protein involved in the t(X;18) synovial sarcoma translocation is a transcriptional activator localised in nuclear bodies. |journal=Hum. Mol. Genet. |volume=6 |issue= 9 |pages= 1559-64 |year= 1998 |pmid= 9285794 |doi=  }}
*{{cite journal  | author=Thaete C, Brett D, Monaghan P, ''et al.'' |title=Functional domains of the SYT and SYT-SSX synovial sarcoma translocation proteins and co-localization with the SNF protein BRM in the nucleus. |journal=Hum. Mol. Genet. |volume=8 |issue= 4 |pages= 585-91 |year= 1999 |pmid= 10072425 |doi=  }}
*{{cite journal  | author=Eid JE, Kung AL, Scully R, Livingston DM |title=p300 interacts with the nuclear proto-oncoprotein SYT as part of the active control of cell adhesion. |journal=Cell |volume=102 |issue= 6 |pages= 839-48 |year= 2000 |pmid= 11030627 |doi=  }}
*{{cite journal  | author=Tamborini E, Agus V, Mezzelani A, ''et al.'' |title=Identification of a novel spliced variant of the SYT gene expressed in normal tissues and in synovial sarcoma. |journal=Br. J. Cancer |volume=84 |issue= 8 |pages= 1087-94 |year= 2001 |pmid= 11308259 |doi= 10.1054/bjoc.2000.1710 }}
*{{cite journal  | author=Brodin B, Haslam K, Yang K, ''et al.'' |title=Cloning and characterization of spliced fusion transcript variants of synovial sarcoma: SYT/SSX4, SYT/SSX4v, and SYT/SSX2v. Possible regulatory role of the fusion gene product in wild type SYT expression. |journal=Gene |volume=268 |issue= 1-2 |pages= 173-82 |year= 2001 |pmid= 11368913 |doi=  }}
*{{cite journal  | author=de Bruijn DR, dos Santos NR, Thijssen J, ''et al.'' |title=The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10. |journal=Oncogene |volume=20 |issue= 25 |pages= 3281-9 |year= 2001 |pmid= 11423977 |doi= 10.1038/sj.onc.1204419 }}
*{{cite journal  | author=Suzuki H, Fukunishi Y, Kagawa I, ''et al.'' |title=Protein-protein interaction panel using mouse full-length cDNAs. |journal=Genome Res. |volume=11 |issue= 10 |pages= 1758-65 |year= 2001 |pmid= 11591653 |doi= 10.1101/gr.180101 }}
*{{cite journal  | author=Kato H, Tjernberg A, Zhang W, ''et al.'' |title=SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones. |journal=J. Biol. Chem. |volume=277 |issue= 7 |pages= 5498-505 |year= 2002 |pmid= 11734557 |doi= 10.1074/jbc.M108702200 }}
*{{cite journal  | author=Yang K, Lui WO, Xie Y, ''et al.'' |title=Co-existence of SYT-SSX1 and SYT-SSX2 fusions in synovial sarcomas. |journal=Oncogene |volume=21 |issue= 26 |pages= 4181-90 |year= 2002 |pmid= 12037676 |doi= 10.1038/sj.onc.1205569 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Imabayashi H, Mori T, Gojo S, ''et al.'' |title=Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis. |journal=Exp. Cell Res. |volume=288 |issue= 1 |pages= 35-50 |year= 2003 |pmid= 12878157 |doi=  }}
*{{cite journal  | author=Perani M, Ingram CJ, Cooper CS, ''et al.'' |title=Conserved SNH domain of the proto-oncoprotein SYT interacts with components of the human chromatin remodelling complexes, while the QPGY repeat domain forms homo-oligomers. |journal=Oncogene |volume=22 |issue= 50 |pages= 8156-67 |year= 2003 |pmid= 14603256 |doi= 10.1038/sj.onc.1207031 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Iwasaki T, Koibuchi N, Chin WW |title=Synovial sarcoma translocation (SYT) encodes a nuclear receptor coactivator. |journal=Endocrinology |volume=146 |issue= 9 |pages= 3892-9 |year= 2005 |pmid= 15919756 |doi= 10.1210/en.2004-1513 }}
*{{cite journal  | author=Fernebro J, Francis P, Edén P, ''et al.'' |title=Gene expression profiles relate to SS18/SSX fusion type in synovial sarcoma. |journal=Int. J. Cancer |volume=118 |issue= 5 |pages= 1165-72 |year= 2006 |pmid= 16152617 |doi= 10.1002/ijc.21475 }}
*{{cite journal  | author=Perani M, Antonson P, Hamoudi R, ''et al.'' |title=The proto-oncoprotein SYT interacts with SYT-interacting protein/co-activator activator (SIP/CoAA), a human nuclear receptor co-activator with similarity to EWS and TLS/FUS family of proteins. |journal=J. Biol. Chem. |volume=280 |issue= 52 |pages= 42863-76 |year= 2006 |pmid= 16227627 |doi= 10.1074/jbc.M502963200 }}
*{{cite journal  | author=Sun Y, Gao D, Liu Y, ''et al.'' |title=IGF2 is critical for tumorigenesis by synovial sarcoma oncoprotein SYT-SSX1. |journal=Oncogene |volume=25 |issue= 7 |pages= 1042-52 |year= 2006 |pmid= 16247461 |doi= 10.1038/sj.onc.1209143 }}
}}
{{refend}}


{{protein-stub}}
SS18 is involved in a [[chromosomal translocation]] commonly found in [[synovial sarcoma]].<ref name="pmid12037676">{{cite journal | vauthors = Yang K, Lui WO, Xie Y, Zhang A, Skytting B, Mandahl N, Larsson C, Larsson O | title = Co-existence of SYT-SSX1 and SYT-SSX2 fusions in synovial sarcomas | journal = Oncogene | volume = 21 | issue = 26 | pages = 4181–90 | date = Jun 2002 | pmid = 12037676 | doi = 10.1038/sj.onc.1205569 }}</ref>
{{WikiDoc Sources}}
 
== Interactions ==
 
SS18 has been shown to [[Protein-protein interaction|interact]] with:
{{div col|colwidth=20em}}
* [[EP300]],<ref name = pmid11030627>{{cite journal | vauthors = Eid JE, Kung AL, Scully R, Livingston DM | title = p300 interacts with the nuclear proto-oncoprotein SYT as part of the active control of cell adhesion | journal = Cell | volume = 102 | issue = 6 | pages = 839–48 | date = Sep 2000 | pmid = 11030627 | doi = 10.1016/S0092-8674(00)00072-6 }}</ref>
* [[MLLT10]],<ref name = pmid11423977>{{cite journal | vauthors = de Bruijn DR, dos Santos NR, Thijssen J, Balemans M, Debernardi S, Linder B, Young BD, Geurts van Kessel A | title = The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10 | journal = Oncogene | volume = 20 | issue = 25 | pages = 3281–9 | date = May 2001 | pmid = 11423977 | doi = 10.1038/sj.onc.1204419 }}</ref>
* [[SMARCA2]],<ref name = pmid14603256>{{cite journal | vauthors = Perani M, Ingram CJ, Cooper CS, Garrett MD, Goodwin GH | title = Conserved SNH domain of the proto-oncoprotein SYT interacts with components of the human chromatin remodelling complexes, while the QPGY repeat domain forms homo-oligomers | journal = Oncogene | volume = 22 | issue = 50 | pages = 8156–67 | date = Nov 2003 | pmid = 14603256 | doi = 10.1038/sj.onc.1207031 }}</ref> and
* [[SMARCB1]].<ref name = pmid11734557>{{cite journal | vauthors = Kato H, Tjernberg A, Zhang W, Krutchinsky AN, An W, Takeuchi T, Ohtsuki Y, Sugano S, de Bruijn DR, Chait BT, Roeder RG | title = SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones | journal = The Journal of Biological Chemistry | volume = 277 | issue = 7 | pages = 5498–505 | date = Feb 2002 | pmid = 11734557 | doi = 10.1074/jbc.M108702200 }}</ref>
{{Div col end}}
 
== References ==
{{Reflist}}
 
== Further reading ==
{{Refbegin | 2}}
* {{cite journal | vauthors = Fligman I, Lonardo F, Jhanwar SC, Gerald WL, Woodruff J, Ladanyi M | title = Molecular diagnosis of synovial sarcoma and characterization of a variant SYT-SSX2 fusion transcript | journal = The American Journal of Pathology | volume = 147 | issue = 6 | pages = 1592–9 | date = Dec 1995 | pmid = 7495284 | pmc = 1869933 | doi =  }}
* {{cite journal | vauthors = Brett D, Whitehouse S, Antonson P, Shipley J, Cooper C, Goodwin G | title = The SYT protein involved in the t(X;18) synovial sarcoma translocation is a transcriptional activator localised in nuclear bodies | journal = Human Molecular Genetics | volume = 6 | issue = 9 | pages = 1559–64 | date = Sep 1997 | pmid = 9285794 | doi = 10.1093/hmg/6.9.1559 }}
* {{cite journal | vauthors = Thaete C, Brett D, Monaghan P, Whitehouse S, Rennie G, Rayner E, Cooper CS, Goodwin G | title = Functional domains of the SYT and SYT-SSX synovial sarcoma translocation proteins and co-localization with the SNF protein BRM in the nucleus | journal = Human Molecular Genetics | volume = 8 | issue = 4 | pages = 585–91 | date = Apr 1999 | pmid = 10072425 | doi = 10.1093/hmg/8.4.585 }}
* {{cite journal | vauthors = Eid JE, Kung AL, Scully R, Livingston DM | title = p300 interacts with the nuclear proto-oncoprotein SYT as part of the active control of cell adhesion | journal = Cell | volume = 102 | issue = 6 | pages = 839–48 | date = Sep 2000 | pmid = 11030627 | doi = 10.1016/S0092-8674(00)00072-6 }}
* {{cite journal | vauthors = Tamborini E, Agus V, Mezzelani A, Riva C, Sozzi G, Azzarelli A, Pierotti MA, Pilotti S | title = Identification of a novel spliced variant of the SYT gene expressed in normal tissues and in synovial sarcoma | journal = British Journal of Cancer | volume = 84 | issue = 8 | pages = 1087–94 | date = Apr 2001 | pmid = 11308259 | pmc = 2363857 | doi = 10.1054/bjoc.2000.1710 }}
* {{cite journal | vauthors = Brodin B, Haslam K, Yang K, Bartolazzi A, Xie Y, Starborg M, Lundeberg J, Larsson O | title = Cloning and characterization of spliced fusion transcript variants of synovial sarcoma: SYT/SSX4, SYT/SSX4v, and SYT/SSX2v. Possible regulatory role of the fusion gene product in wild type SYT expression | journal = Gene | volume = 268 | issue = 1-2 | pages = 173–82 | date = May 2001 | pmid = 11368913 | doi = 10.1016/S0378-1119(01)00412-7 }}
* {{cite journal | vauthors = de Bruijn DR, dos Santos NR, Thijssen J, Balemans M, Debernardi S, Linder B, Young BD, Geurts van Kessel A | title = The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10 | journal = Oncogene | volume = 20 | issue = 25 | pages = 3281–9 | date = May 2001 | pmid = 11423977 | doi = 10.1038/sj.onc.1204419 }}
* {{cite journal | vauthors = Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y | title = Protein-protein interaction panel using mouse full-length cDNAs | journal = Genome Research | volume = 11 | issue = 10 | pages = 1758–65 | date = Oct 2001 | pmid = 11591653 | pmc = 311163 | doi = 10.1101/gr.180101 }}
* {{cite journal | vauthors = Kato H, Tjernberg A, Zhang W, Krutchinsky AN, An W, Takeuchi T, Ohtsuki Y, Sugano S, de Bruijn DR, Chait BT, Roeder RG | title = SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones | journal = The Journal of Biological Chemistry | volume = 277 | issue = 7 | pages = 5498–505 | date = Feb 2002 | pmid = 11734557 | doi = 10.1074/jbc.M108702200 }}
* {{cite journal | vauthors = Yang K, Lui WO, Xie Y, Zhang A, Skytting B, Mandahl N, Larsson C, Larsson O | title = Co-existence of SYT-SSX1 and SYT-SSX2 fusions in synovial sarcomas | journal = Oncogene | volume = 21 | issue = 26 | pages = 4181–90 | date = Jun 2002 | pmid = 12037676 | doi = 10.1038/sj.onc.1205569 }}
* {{cite journal | vauthors = Imabayashi H, Mori T, Gojo S, Kiyono T, Sugiyama T, Irie R, Isogai T, Hata J, Toyama Y, Umezawa A | title = Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis | journal = Experimental Cell Research | volume = 288 | issue = 1 | pages = 35–50 | date = Aug 2003 | pmid = 12878157 | doi = 10.1016/S0014-4827(03)00130-7 }}
* {{cite journal | vauthors = Perani M, Ingram CJ, Cooper CS, Garrett MD, Goodwin GH | title = Conserved SNH domain of the proto-oncoprotein SYT interacts with components of the human chromatin remodelling complexes, while the QPGY repeat domain forms homo-oligomers | journal = Oncogene | volume = 22 | issue = 50 | pages = 8156–67 | date = Nov 2003 | pmid = 14603256 | doi = 10.1038/sj.onc.1207031 }}
* {{cite journal | vauthors = Iwasaki T, Koibuchi N, Chin WW | title = Synovial sarcoma translocation (SYT) encodes a nuclear receptor coactivator | journal = Endocrinology | volume = 146 | issue = 9 | pages = 3892–9 | date = Sep 2005 | pmid = 15919756 | doi = 10.1210/en.2004-1513 }}
* {{cite journal | vauthors = Fernebro J, Francis P, Edén P, Borg A, Panagopoulos I, Mertens F, Vallon-Christersson J, Akerman M, Rydholm A, Bauer HC, Mandahl N, Nilbert M | title = Gene expression profiles relate to SS18/SSX fusion type in synovial sarcoma | journal = International Journal of Cancer | volume = 118 | issue = 5 | pages = 1165–72 | date = Mar 2006 | pmid = 16152617 | doi = 10.1002/ijc.21475 }}
* {{cite journal | vauthors = Perani M, Antonson P, Hamoudi R, Ingram CJ, Cooper CS, Garrett MD, Goodwin GH | title = The proto-oncoprotein SYT interacts with SYT-interacting protein/co-activator activator (SIP/CoAA), a human nuclear receptor co-activator with similarity to EWS and TLS/FUS family of proteins | journal = The Journal of Biological Chemistry | volume = 280 | issue = 52 | pages = 42863–76 | date = Dec 2005 | pmid = 16227627 | doi = 10.1074/jbc.M502963200 }}
* {{cite journal | vauthors = Sun Y, Gao D, Liu Y, Huang J, Lessnick S, Tanaka S | title = IGF2 is critical for tumorigenesis by synovial sarcoma oncoprotein SYT-SSX1 | journal = Oncogene | volume = 25 | issue = 7 | pages = 1042–52 | date = Feb 2006 | pmid = 16247461 | doi = 10.1038/sj.onc.1209143 }}
{{Refend}}

Revision as of 22:06, 25 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Protein SSXT is a protein that in humans is encoded by the SS18 gene.[1][2][3]

Function

SS18 is a member of the human SWI/SNF chromatin remodeling complex.[4][5][6]

Clinical significance

SS18 is involved in a chromosomal translocation commonly found in synovial sarcoma.[7]

Interactions

SS18 has been shown to interact with:

References

  1. ↑ Shipley JM, Clark J, Crew AJ, Birdsall S, Rocques PJ, Gill S, Chelly J, Monaco AP, Abe S, Gusterson BA (May 1994). "The t(X;18)(p11.2;q11.2) translocation found in human synovial sarcomas involves two distinct loci on the X chromosome". Oncogene. 9 (5): 1447–53. PMID 8152806.
  2. ↑ Clark J, Rocques PJ, Crew AJ, Gill S, Shipley J, Chan AM, Gusterson BA, Cooper CS (Aug 1994). "Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma". Nature Genetics. 7 (4): 502–8. doi:10.1038/ng0894-502. PMID 7951320.
  3. ↑ de Bruijn DR, Geurts van Kessel A (2006). "Common origin of the human synovial sarcoma associated SS18 and SS18L1 gene loci". Cytogenetic and Genome Research. 112 (3–4): 222–6. doi:10.1159/000089874. PMID 16484776.
  4. ↑ Middeljans E, Wan X, Jansen PW, Sharma V, Stunnenberg HG, Logie C (2012). "SS18 together with animal-specific factors defines human BAF-type SWI/SNF complexes". PLOS ONE. 7 (3): e33834. doi:10.1371/journal.pone.0033834. PMC 3307773. PMID 22442726.
  5. ↑ 5.0 5.1 Kato H, Tjernberg A, Zhang W, Krutchinsky AN, An W, Takeuchi T, Ohtsuki Y, Sugano S, de Bruijn DR, Chait BT, Roeder RG (Feb 2002). "SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones". The Journal of Biological Chemistry. 277 (7): 5498–505. doi:10.1074/jbc.M108702200. PMID 11734557.
  6. ↑ 6.0 6.1 Perani M, Ingram CJ, Cooper CS, Garrett MD, Goodwin GH (Nov 2003). "Conserved SNH domain of the proto-oncoprotein SYT interacts with components of the human chromatin remodelling complexes, while the QPGY repeat domain forms homo-oligomers". Oncogene. 22 (50): 8156–67. doi:10.1038/sj.onc.1207031. PMID 14603256.
  7. ↑ Yang K, Lui WO, Xie Y, Zhang A, Skytting B, Mandahl N, Larsson C, Larsson O (Jun 2002). "Co-existence of SYT-SSX1 and SYT-SSX2 fusions in synovial sarcomas". Oncogene. 21 (26): 4181–90. doi:10.1038/sj.onc.1205569. PMID 12037676.
  8. ↑ Eid JE, Kung AL, Scully R, Livingston DM (Sep 2000). "p300 interacts with the nuclear proto-oncoprotein SYT as part of the active control of cell adhesion". Cell. 102 (6): 839–48. doi:10.1016/S0092-8674(00)00072-6. PMID 11030627.
  9. ↑ de Bruijn DR, dos Santos NR, Thijssen J, Balemans M, Debernardi S, Linder B, Young BD, Geurts van Kessel A (May 2001). "The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10". Oncogene. 20 (25): 3281–9. doi:10.1038/sj.onc.1204419. PMID 11423977.

Further reading

  • Fligman I, Lonardo F, Jhanwar SC, Gerald WL, Woodruff J, Ladanyi M (Dec 1995). "Molecular diagnosis of synovial sarcoma and characterization of a variant SYT-SSX2 fusion transcript". The American Journal of Pathology. 147 (6): 1592–9. PMC 1869933. PMID 7495284.
  • Brett D, Whitehouse S, Antonson P, Shipley J, Cooper C, Goodwin G (Sep 1997). "The SYT protein involved in the t(X;18) synovial sarcoma translocation is a transcriptional activator localised in nuclear bodies". Human Molecular Genetics. 6 (9): 1559–64. doi:10.1093/hmg/6.9.1559. PMID 9285794.
  • Thaete C, Brett D, Monaghan P, Whitehouse S, Rennie G, Rayner E, Cooper CS, Goodwin G (Apr 1999). "Functional domains of the SYT and SYT-SSX synovial sarcoma translocation proteins and co-localization with the SNF protein BRM in the nucleus". Human Molecular Genetics. 8 (4): 585–91. doi:10.1093/hmg/8.4.585. PMID 10072425.
  • Eid JE, Kung AL, Scully R, Livingston DM (Sep 2000). "p300 interacts with the nuclear proto-oncoprotein SYT as part of the active control of cell adhesion". Cell. 102 (6): 839–48. doi:10.1016/S0092-8674(00)00072-6. PMID 11030627.
  • Tamborini E, Agus V, Mezzelani A, Riva C, Sozzi G, Azzarelli A, Pierotti MA, Pilotti S (Apr 2001). "Identification of a novel spliced variant of the SYT gene expressed in normal tissues and in synovial sarcoma". British Journal of Cancer. 84 (8): 1087–94. doi:10.1054/bjoc.2000.1710. PMC 2363857. PMID 11308259.
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