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{{expert needed|1=Genetics|date=July 2013}}
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{{Infobox_gene}}
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'''Translocon-associated protein subunit beta''' also known as '''TRAP-beta''' is a [[protein]] that in humans is encoded by the ''SSR2'' [[gene]].<ref name="pmid7789174">{{cite journal | vauthors = Chinen K, Sudo K, Takahashi E, Nakamura Y | title = Isolation and mapping of the human beta-signal sequence receptor gene (SSR2) | journal = Cytogenetics and Cell Genetics | volume = 70 | issue = 3-4 | pages = 215–7 | date = Jul 1995 | pmid = 7789174 | pmc =  | doi = 10.1159/000134036 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SSR2 signal sequence receptor, beta (translocon-associated protein beta)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6746| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Signal sequence receptor, beta (translocon-associated protein beta)
| HGNCid = 11324
| Symbol = SSR2
| AltSymbols =; DKFZp686F19123; HSD25; TLAP; TRAPB
| OMIM = 600867
| ECnumber = 
| Homologene = 2369
| MGIid = 1913506
| GeneAtlas_image1 = PBB_GE_SSR2_200652_at_tn.png
| Function = {{GNF_GO|id=GO:0005048 |text = signal sequence binding}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006613 |text = cotranslational protein targeting to membrane}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6746
    | Hs_Ensembl = ENSG00000163479
    | Hs_RefseqProtein = XP_001128341
    | Hs_RefseqmRNA = XM_001128341
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 154245463
    | Hs_GenLoc_end = 154257374
    | Hs_Uniprot = P43308
    | Mm_EntrezGene = 66256
    | Mm_Ensembl = ENSMUSG00000041355
    | Mm_RefseqmRNA = NM_025448
    | Mm_RefseqProtein = NP_079724
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 88665807
    | Mm_GenLoc_end = 88673918
    | Mm_Uniprot = Q9CPW5
  }}
}}
'''Signal sequence receptor, beta (translocon-associated protein beta)''', also known as '''SSR2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SSR2 signal sequence receptor, beta (translocon-associated protein beta)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6746| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The signal sequence receptor (SSR) is a [[glycosylated]] [[endoplasmic reticulum]] (ER) membrane receptor associated with [[protein translocation]] across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein (alpha-SSR or [[SSR1]]) and a 22-kD glycoprotein (beta-SSR or SSR2). The human beta-signal sequence receptor gene (SSR2) maps to chromosome bands 1q21-q23.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein (alpha-SSR or SSR1) and a 22-kD glycoprotein (beta-SSR or SSR2). The human beta-signal sequence receptor gene (SSR2) maps to chromosome bands 1q21-q23.<ref name="entrez">{{cite web | title = Entrez Gene: SSR2 signal sequence receptor, beta (translocon-associated protein beta)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6746| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Tajima S, Lauffer L, Rath VL, Walter P | title = The signal recognition particle receptor is a complex that contains two distinct polypeptide chains | journal = The Journal of Cell Biology | volume = 103 | issue = 4 | pages = 1167–78 | date = October 1986 | pmid = 3021779 | pmc = 2114348 | doi = 10.1083/jcb.103.4.1167 }}
| citations =
* {{cite journal | vauthors = Hartmann E, Görlich D, Kostka S, Otto A, Kraft R, Knespel S, Bürger E, Rapoport TA, Prehn S | title = A tetrameric complex of membrane proteins in the endoplasmic reticulum | journal = European Journal of Biochemistry / FEBS | volume = 214 | issue = 2 | pages = 375–81 | date = June 1993 | pmid = 7916687 | doi = 10.1111/j.1432-1033.1993.tb17933.x }}
*{{cite journal | author=Tajima S, Lauffer L, Rath VL, Walter P |title=The signal recognition particle receptor is a complex that contains two distinct polypeptide chains. |journal=J. Cell Biol. |volume=103 |issue= 4 |pages= 1167-78 |year= 1986 |pmid= 3021779 |doi= }}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Chinen K, Sudo K, Takahashi E, Nakamura Y |title=Isolation and mapping of the human beta-signal sequence receptor gene (SSR2). |journal=Cytogenet. Cell Genet. |volume=70 |issue= 3-4 |pages= 215-7 |year= 1995 |pmid= 7789174 |doi=  }}
* {{cite journal | vauthors = Bodescot M, Brison O | title = Cloning and sequence analysis of the beta subunit of the human translocon-associated protein | journal = Biochimica et Biophysica Acta | volume = 1217 | issue = 1 | pages = 101–2 | date = January 1994 | pmid = 8286409 | doi = 10.1016/0167-4781(94)90131-7 }}
*{{cite journal | author=Hartmann E, Görlich D, Kostka S, ''et al.'' |title=A tetrameric complex of membrane proteins in the endoplasmic reticulum. |journal=Eur. J. Biochem. |volume=214 |issue= 2 |pages= 375-81 |year= 1993 |pmid= 7916687 |doi= }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Wang L, Dobberstein B | title = Oligomeric complexes involved in translocation of proteins across the membrane of the endoplasmic reticulum | journal = FEBS Letters | volume = 457 | issue = 3 | pages = 316–22 | date = September 1999 | pmid = 10471800 | doi = 10.1016/S0014-5793(99)01075-3 }}
*{{cite journal | author=Bodescot M, Brison O |title=Cloning and sequence analysis of the beta subunit of the human translocon-associated protein. |journal=Biochim. Biophys. Acta |volume=1217 |issue= 1 |pages= 101-2 |year= 1994 |pmid= 8286409 |doi= }}
* {{cite journal | vauthors = Zhang H, Li XJ, Martin DB, Aebersold R | title = Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry | journal = Nature Biotechnology | volume = 21 | issue = 6 | pages = 660–6 | date = June 2003 | pmid = 12754519 | doi = 10.1038/nbt827 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S | title = Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions | journal = Genome Research | volume = 14 | issue = 9 | pages = 1711–8 | date = September 2004 | pmid = 15342556 | pmc = 515316 | doi = 10.1101/gr.2435604 }}
*{{cite journal | author=Wang L, Dobberstein B |title=Oligomeric complexes involved in translocation of proteins across the membrane of the endoplasmic reticulum. |journal=FEBS Lett. |volume=457 |issue= 3 |pages= 316-22 |year= 1999 |pmid= 10471800 |doi= }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Zhang H, Li XJ, Martin DB, Aebersold R |title=Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. |journal=Nat. Biotechnol. |volume=21 |issue= 6 |pages= 660-6 |year= 2003 |pmid= 12754519 |doi= 10.1038/nbt827 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Suzuki Y, Yamashita R, Shirota M, ''et al.'' |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711-8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 02:42, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Translocon-associated protein subunit beta also known as TRAP-beta is a protein that in humans is encoded by the SSR2 gene.[1][2]

Function

The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein (alpha-SSR or SSR1) and a 22-kD glycoprotein (beta-SSR or SSR2). The human beta-signal sequence receptor gene (SSR2) maps to chromosome bands 1q21-q23.[2]

References

  1. ↑ Chinen K, Sudo K, Takahashi E, Nakamura Y (Jul 1995). "Isolation and mapping of the human beta-signal sequence receptor gene (SSR2)". Cytogenetics and Cell Genetics. 70 (3–4): 215–7. doi:10.1159/000134036. PMID 7789174.
  2. ↑ 2.0 2.1 "Entrez Gene: SSR2 signal sequence receptor, beta (translocon-associated protein beta)".

Further reading

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