SSR4: Difference between revisions

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'''Translocon-associated protein subunit delta''' is a [[protein]] that in humans is encoded by the ''SSR4'' [[gene]].<ref name="pmid9286695">{{cite journal | vauthors = Brenner V, Nyakatura G, Rosenthal A, Platzer M | title = Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse | journal = Genomics | volume = 44 | issue = 1 | pages = 8–14 |date=Nov 1997 | pmid = 9286695 | pmc =  | doi = 10.1006/geno.1997.4822 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SSR4 signal sequence receptor, delta (translocon-associated protein delta)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6748| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Signal sequence receptor, delta (translocon-associated protein delta)
| HGNCid = 11326
| Symbol = SSR4
| AltSymbols =; TRAPD
| OMIM = 300090
| ECnumber = 
| Homologene = 4573
| MGIid = 1099464
| GeneAtlas_image1 = PBB_GE_SSR4_201004_at_tn.png
| Function = {{GNF_GO|id=GO:0005509 |text = calcium ion binding}}
| Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005784 |text = translocon complex}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006886 |text = intracellular protein transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6748
    | Hs_Ensembl = ENSG00000180879
    | Hs_RefseqProtein = NP_006271
    | Hs_RefseqmRNA = NM_006280
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 152712165
    | Hs_GenLoc_end = 152717154
    | Hs_Uniprot = P51571
    | Mm_EntrezGene = 20832
    | Mm_Ensembl = ENSMUSG00000002014
    | Mm_RefseqmRNA = NM_009279
    | Mm_RefseqProtein = NP_033305
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 70039782
    | Mm_GenLoc_end = 70043542
    | Mm_Uniprot = Q3TVJ8
  }}
}}
'''Signal sequence receptor, delta (translocon-associated protein delta)''', also known as '''SSR4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SSR4 signal sequence receptor, delta (translocon-associated protein delta)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6748| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = SSR4, also called TRAPD, is assumed to be involved in protein secretion. It is located in the Xq28 region, arranged in a compact head-to-head manner with the IDH3G gene. These two genes are driven by a bidirectional promoter located between them, and encode proteins involved in unrelated biochemical pathways located in different compartments of the cell. The nontranscribed intergenic region represents only 133 bp and is embedded in a CpG island. The CpG island functions as a bidirectional promoter to initiate the transcription of both functionally unrelated genes with distinct expression patterns. SSR4 consists of six exons and is approximately 70 kb telomeric to the ALD gene. Although alternative splicing of exon 5 has not been detected in human SSR4, transcript variants missing the region homologous to human exon 5 have been detected in both Xenopus laevis and Mus musculus.<ref name="entrez">{{cite web | title = Entrez Gene: SSR4 signal sequence receptor, delta (translocon-associated protein delta)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6748| accessdate = }}</ref>
| summary_text = SSR4, also called TRAPD, is assumed to be involved in protein secretion. It is located in the Xq28 region, arranged in a compact head-to-head manner with the IDH3G gene. These two genes are driven by a bidirectional promoter located between them, and encode proteins involved in unrelated biochemical pathways located in different compartments of the cell. The nontranscribed intergenic region represents only 133 bp and is embedded in a CpG island. The CpG island functions as a bidirectional promoter to initiate the transcription of both functionally unrelated genes with distinct expression patterns. SSR4 consists of six exons and is approximately 70 kb telomeric to the ALD gene. Although alternative splicing of exon 5 has not been detected in human SSR4, transcript variants missing the region homologous to human exon 5 have been detected in both Xenopus laevis and Mus musculus.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Holthuis JC, van Riel MC, Martens GJ |title=Translocon-associated protein TRAP delta and a novel TRAP-like protein are coordinately expressed with pro-opiomelanocortin in Xenopus intermediate pituitary. |journal=Biochem. J. |volume=312 ( Pt 1) |issue=  |pages= 205-13 |year= 1996 |pmid= 7492314 |doi=  }}
*{{cite journal  | vauthors=Holthuis JC, van Riel MC, Martens GJ |title=Translocon-associated protein TRAP delta and a novel TRAP-like protein are coordinately expressed with pro-opiomelanocortin in Xenopus intermediate pituitary |journal=Biochem. J. |volume=312 ( Pt 1) |issue=  Pt 1|pages= 205–13 |year= 1996 |pmid= 7492314 |doi= | pmc=1136246 }}
*{{cite journal | author=Hartmann E, Görlich D, Kostka S, ''et al.'' |title=A tetrameric complex of membrane proteins in the endoplasmic reticulum. |journal=Eur. J. Biochem. |volume=214 |issue= 2 |pages= 375-81 |year= 1993 |pmid= 7916687 |doi= }}
*{{cite journal   |vauthors=Hartmann E, Görlich D, Kostka S, etal |title=A tetrameric complex of membrane proteins in the endoplasmic reticulum |journal=Eur. J. Biochem. |volume=214 |issue= 2 |pages= 375–81 |year= 1993 |pmid= 7916687 |doi=10.1111/j.1432-1033.1993.tb17933.x  }}
*{{cite journal  | author=Brenner V, Nyakatura G, Rosenthal A, Platzer M |title=Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse. |journal=Genomics |volume=44 |issue= 1 |pages= 8-14 |year= 1997 |pmid= 9286695 |doi= 10.1006/geno.1997.4822 }}
*{{cite journal  | vauthors=Wang L, Dobberstein B |title=Oligomeric complexes involved in translocation of proteins across the membrane of the endoplasmic reticulum |journal=FEBS Lett. |volume=457 |issue= 3 |pages= 316–22 |year= 1999 |pmid= 10471800 |doi=10.1016/S0014-5793(99)01075-3 }}
*{{cite journal  | author=Wang L, Dobberstein B |title=Oligomeric complexes involved in translocation of proteins across the membrane of the endoplasmic reticulum. |journal=FEBS Lett. |volume=457 |issue= 3 |pages= 316-22 |year= 1999 |pmid= 10471800 |doi=  }}
*{{cite journal  | vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA Cloning Using In Vitro Site-Specific Recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948 }}
*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Miyazaki K, Fujita T, Ozaki T, etal |title=NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1 |journal=J. Biol. Chem. |volume=279 |issue= 12 |pages= 11327–35 |year= 2004 |pmid= 14684739 |doi= 10.1074/jbc.M312389200 }}
*{{cite journal | author=Miyazaki K, Fujita T, Ozaki T, ''et al.'' |title=NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1. |journal=J. Biol. Chem. |volume=279 |issue= 12 |pages= 11327-35 |year= 2004 |pmid= 14684739 |doi= 10.1074/jbc.M312389200 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Wang Z, VandeBerg JL |title=Cloning and molecular characterization of a human ortholog of Monodelphis TRAPD in ultraviolet B-induced melanoma |journal=Melanoma Res. |volume=14 |issue= 2 |pages= 107–14 |year= 2005 |pmid= 15057039 |doi=10.1097/00008390-200404000-00005 }}
*{{cite journal  | author=Wang Z, VandeBerg JL |title=Cloning and molecular characterization of a human ortholog of Monodelphis TRAPD in ultraviolet B-induced melanoma. |journal=Melanoma Res. |volume=14 |issue= 2 |pages= 107-14 |year= 2005 |pmid= 15057039 |doi=  }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Wiemann S, Arlt D, Huber W, etal |title=From ORFeome to Biology: A Functional Genomics Pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 | pmc=528930 }}
*{{cite journal | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal   |vauthors=Mehrle A, Rosenfelder H, Schupp I, etal |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 | pmc=1347501 }}
*{{cite journal | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
*{{cite journal   |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein–protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
}}
{{refend}}
{{refend}}


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Revision as of 07:06, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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View/Edit Human

Translocon-associated protein subunit delta is a protein that in humans is encoded by the SSR4 gene.[1][2]

SSR4, also called TRAPD, is assumed to be involved in protein secretion. It is located in the Xq28 region, arranged in a compact head-to-head manner with the IDH3G gene. These two genes are driven by a bidirectional promoter located between them, and encode proteins involved in unrelated biochemical pathways located in different compartments of the cell. The nontranscribed intergenic region represents only 133 bp and is embedded in a CpG island. The CpG island functions as a bidirectional promoter to initiate the transcription of both functionally unrelated genes with distinct expression patterns. SSR4 consists of six exons and is approximately 70 kb telomeric to the ALD gene. Although alternative splicing of exon 5 has not been detected in human SSR4, transcript variants missing the region homologous to human exon 5 have been detected in both Xenopus laevis and Mus musculus.[2]

References

  1. ↑ Brenner V, Nyakatura G, Rosenthal A, Platzer M (Nov 1997). "Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse". Genomics. 44 (1): 8–14. doi:10.1006/geno.1997.4822. PMID 9286695.
  2. ↑ 2.0 2.1 "Entrez Gene: SSR4 signal sequence receptor, delta (translocon-associated protein delta)".

Further reading



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