SUMO4: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Small ubiquitin-related modifier 4''' is a [[protein]] that in humans is encoded by the ''SUMO4'' [[gene]].<ref name="pmid15123604">{{cite journal | vauthors = Bohren KM, Nadkarni V, Song JH, Gabbay KH, Owerbach D | title = A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription factors and is associated with susceptibility to type I diabetes mellitus | journal = The Journal of Biological Chemistry | volume = 279 | issue = 26 | pages = 27233–8 | date = Jun 2004 | pmid = 15123604 | pmc =  | doi = 10.1074/jbc.M402273200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SUMO4 SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=387082| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae)
| HGNCid = 21181
| Symbol = SUMO4
| AltSymbols =; IDDM5; SMT3H4; SUMO-4; dJ281H8.4
| OMIM = 608829
| ECnumber = 
| Homologene = 88399
| MGIid = 
| GeneAtlas_image1 = PBB_GE_SUMO4_215452_x_at_tn.png
| Function =  
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 387082
    | Hs_Ensembl = ENSG00000177688
    | Hs_RefseqProtein = NP_001002255
    | Hs_RefseqmRNA = NM_001002255
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 149763056
    | Hs_GenLoc_end = 149764121
    | Hs_Uniprot = Q6EEV6
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae)''', also known as '''SUMO4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SUMO4 SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=387082| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the [[Interleukin_12_subunit_beta|IL12B]] gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism.<ref name="entrez">{{cite web | title = Entrez Gene: SUMO4 SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=387082| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
SUMO4 has been shown to [[Protein-protein interaction|interact]] with [[IκBα]].<ref name=pmid15247916>{{cite journal | vauthors = Guo D, Li M, Zhang Y, Yang P, Eckenrode S, Hopkins D, Zheng W, Purohit S, Podolsky RH, Muir A, Wang J, Dong Z, Brusko T, Atkinson M, Pozzilli P, Zeidler A, Raffel LJ, Jacob CO, Park Y, Serrano-Rios M, Larrad MT, Zhang Z, Garchon HJ, Bach JF, Rotter JI, She JX, Wang CY | title = A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes | journal = Nature Genetics | volume = 36 | issue = 8 | pages = 837–41 | date = Aug 2004 | pmid = 15247916 | doi = 10.1038/ng1391 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Wang CY, Podolsky R, She JX | title = Genetic and functional evidence supporting SUMO4 as a type 1 diabetes susceptibility gene | journal = Annals of the New York Academy of Sciences | volume = 1079 | issue = 1 | pages = 257–67 | date = Oct 2006 | pmid = 17130563 | doi = 10.1196/annals.1375.039 | bibcode = 2006NYASA1079..257W }}
| citations =
* {{cite journal | vauthors = Davies JL, Kawaguchi Y, Bennett ST, Copeman JB, Cordell HJ, Pritchard LE, Reed PW, Gough SC, Jenkins SC, Palmer SM | title = A genome-wide search for human type 1 diabetes susceptibility genes | journal = Nature | volume = 371 | issue = 6493 | pages = 130–6 | date = Sep 1994 | pmid = 8072542 | doi = 10.1038/371130a0 | bibcode = 1994Natur.371..130D }}
*{{cite journal | author=Wang CY, Podolsky R, She JX |title=Genetic and functional evidence supporting SUMO4 as a type 1 diabetes susceptibility gene. |journal=Ann. N. Y. Acad. Sci. |volume=1079 |issue= |pages= 257-67 |year= 2007 |pmid= 17130563 |doi= 10.1196/annals.1375.039 }}
* {{cite journal | vauthors = Luo DF, Buzzetti R, Rotter JI, Maclaren NK, Raffel LJ, Nisticò L, Giovannini C, Pozzilli P, Thomson G, She JX | title = Confirmation of three susceptibility genes to insulin-dependent diabetes mellitus: IDDM4, IDDM5 and IDDM8 | journal = Human Molecular Genetics | volume = 5 | issue = 5 | pages = 693–8 | date = May 1996 | pmid = 8733139 | doi = 10.1093/hmg/5.5.693 }}
*{{cite journal | author=Davies JL, Kawaguchi Y, Bennett ST, ''et al.'' |title=A genome-wide search for human type 1 diabetes susceptibility genes. |journal=Nature |volume=371 |issue= 6493 |pages= 130-6 |year= 1994 |pmid= 8072542 |doi= 10.1038/371130a0 }}
* {{cite journal | vauthors = Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, Horton R, Hunt SE, Scott CE, Gilbert JG, Clamp ME, Bethel G, Milne S, Ainscough R, Almeida JP, Ambrose KD, Andrews TD, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beare DM, Beasley H, Beasley O, Bird CP, Blakey S, Bray-Allen S, Brook J, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY, Clark G, Clee CM, Clegg S, Cobley V, Collier RE, Collins JE, Colman LK, Corby NR, Coville GJ, Culley KM, Dhami P, Davies J, Dunn M, Earthrowl ME, Ellington AE, Evans KA, Faulkner L, Francis MD, Frankish A, Frankland J, French L, Garner P, Garnett J, Ghori MJ, Gilby LM, Gillson CJ, Glithero RJ, Grafham DV, Grant M, Gribble S, Griffiths C, Griffiths M, Hall R, Halls KS, Hammond S, Harley JL, Hart EA, Heath PD, Heathcott R, Holmes SJ, Howden PJ, Howe KL, Howell GR, Huckle E, Humphray SJ, Humphries MD, Hunt AR, Johnson CM, Joy AA, Kay M, Keenan SJ, Kimberley AM, King A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd CR, Lloyd DM, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, Maslen GL, Matthews L, McCann OT, McLaren SJ, McLay K, McMurray A, Moore MJ, Mullikin JC, Niblett D, Nickerson T, Novik KL, Oliver K, Overton-Larty EK, Parker A, Patel R, Pearce AV, Peck AI, Phillimore B, Phillips S, Plumb RW, Porter KM, Ramsey Y, Ranby SA, Rice CM, Ross MT, Searle SM, Sehra HK, Sheridan E, Skuce CD, Smith S, Smith M, Spraggon L, Squares SL, Steward CA, Sycamore N, Tamlyn-Hall G, Tester J, Theaker AJ, Thomas DW, Thorpe A, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, White SS, Whitehead SL, Whittaker H, Wild A, Willey DJ, Wilmer TE, Wood JM, Wray PW, Wyatt JC, Young L, Younger RM, Bentley DR, Coulson A, Durbin R, Hubbard T, Sulston JE, Dunham I, Rogers J, Beck S | title = The DNA sequence and analysis of human chromosome 6 | journal = Nature | volume = 425 | issue = 6960 | pages = 805–11 | date = Oct 2003 | pmid = 14574404 | doi = 10.1038/nature02055 }}
*{{cite journal | author=Luo DF, Buzzetti R, Rotter JI, ''et al.'' |title=Confirmation of three susceptibility genes to insulin-dependent diabetes mellitus: IDDM4, IDDM5 and IDDM8. |journal=Hum. Mol. Genet. |volume=5 |issue= 5 |pages= 693-8 |year= 1997 |pmid= 8733139 |doi= }}
* {{cite journal | vauthors = Guo D, Li M, Zhang Y, Yang P, Eckenrode S, Hopkins D, Zheng W, Purohit S, Podolsky RH, Muir A, Wang J, Dong Z, Brusko T, Atkinson M, Pozzilli P, Zeidler A, Raffel LJ, Jacob CO, Park Y, Serrano-Rios M, Larrad MT, Zhang Z, Garchon HJ, Bach JF, Rotter JI, She JX, Wang CY | title = A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes | journal = Nature Genetics | volume = 36 | issue = 8 | pages = 837–41 | date = Aug 2004 | pmid = 15247916 | doi = 10.1038/ng1391 }}
*{{cite journal | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
* {{cite journal | vauthors = Smyth DJ, Howson JM, Lowe CE, Walker NM, Lam AC, Nutland S, Hutchings J, Tuomilehto-Wolf E, Tuomilehto J, Guja C, Ionescu-Tîrgoviste C, Undlien DE, Rønningen KS, Savage D, Dunger DB, Twells RC, McArdle WL, Strachan DP, Todd JA | title = Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes | journal = Nature Genetics | volume = 37 | issue = 2 | pages = 110–1; author reply 112-3 | date = Feb 2005 | pmid = 15678134 | doi = 10.1038/ng0205-110 }}
*{{cite journal  | author=Bohren KM, Nadkarni V, Song JH, ''et al.'' |title=A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription factors and is associated with susceptibility to type I diabetes mellitus. |journal=J. Biol. Chem. |volume=279 |issue= 26 |pages= 27233-8 |year= 2004 |pmid= 15123604 |doi= 10.1074/jbc.M402273200 }}
* {{cite journal | vauthors = Qu H, Bharaj B, Liu XQ, Curtis JA, Newhook LA, Paterson AD, Hudson TJ, Polychronakos C | title = Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes | journal = Nature Genetics | volume = 37 | issue = 2 | pages = 111–2; author reply 112-3 | date = Feb 2005 | pmid = 15678135 | doi = 10.1038/ng0205-111 }}
*{{cite journal  | author=Guo D, Li M, Zhang Y, ''et al.'' |title=A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes. |journal=Nat. Genet. |volume=36 |issue= 8 |pages= 837-41 |year= 2004 |pmid= 15247916 |doi= 10.1038/ng1391 }}
* {{cite journal | vauthors = Park Y, Park S, Kang J, Yang S, Kim D | title = Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes | journal = Nature Genetics | volume = 37 | issue = 2 | pages = 112; author reply 112-3 | date = Feb 2005 | pmid = 15678137 | doi = 10.1038/ng0205-112a }}
*{{cite journal  | author=Smyth DJ, Howson JM, Lowe CE, ''et al.'' |title=Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes. |journal=Nat. Genet. |volume=37 |issue= 2 |pages= 110-1; author reply 112-3 |year= 2005 |pmid= 15678134 |doi= 10.1038/ng0205-110 }}
* {{cite journal | vauthors = Owerbach D, McKay EM, Yeh ET, Gabbay KH, Bohren KM | title = A proline-90 residue unique to SUMO-4 prevents maturation and sumoylation | journal = Biochemical and Biophysical Research Communications | volume = 337 | issue = 2 | pages = 517–20 | date = Nov 2005 | pmid = 16198310 | doi = 10.1016/j.bbrc.2005.09.090 }}
*{{cite journal  | author=Qu H, Bharaj B, Liu XQ, ''et al.'' |title=Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes. |journal=Nat. Genet. |volume=37 |issue= 2 |pages= 111-2; author reply 112-3 |year= 2005 |pmid= 15678135 |doi= 10.1038/ng0205-111 }}
* {{cite journal | vauthors = Guo D, Han J, Adam BL, Colburn NH, Wang MH, Dong Z, Eizirik DL, She JX, Wang CY | title = Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress | journal = Biochemical and Biophysical Research Communications | volume = 337 | issue = 4 | pages = 1308–18 | date = Dec 2005 | pmid = 16236267 | doi = 10.1016/j.bbrc.2005.09.191 }}
*{{cite journal | author=Park Y, Park S, Kang J, ''et al.'' |title=Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes. |journal=Nat. Genet. |volume=37 |issue= 2 |pages= 112; author reply 112-3 |year= 2005 |pmid= 15678137 |doi= 10.1038/ng0205-112a }}
* {{cite journal | vauthors = Noso S, Ikegami H, Fujisawa T, Kawabata Y, Asano K, Hiromine Y, Tsurumaru M, Sugihara S, Lee I, Kawasaki E, Awata T, Ogihara T | title = Genetic heterogeneity in association of the SUMO4 M55V variant with susceptibility to type 1 diabetes | journal = Diabetes | volume = 54 | issue = 12 | pages = 3582–6 | date = Dec 2005 | pmid = 16306380 | doi = 10.2337/diabetes.54.12.3582 }}
*{{cite journal | author=Owerbach D, McKay EM, Yeh ET, ''et al.'' |title=A proline-90 residue unique to SUMO-4 prevents maturation and sumoylation. |journal=Biochem. Biophys. Res. Commun. |volume=337 |issue= 2 |pages= 517-20 |year= 2005 |pmid= 16198310 |doi= 10.1016/j.bbrc.2005.09.090 }}
* {{cite journal | vauthors = Tsurumaru M, Kawasaki E, Ida H, Migita K, Moriuchi A, Fukushima K, Fukushima T, Abiru N, Yamasaki H, Noso S, Ikegami H, Awata T, Sasaki H, Eguchi K | title = Evidence for the role of small ubiquitin-like modifier 4 as a general autoimmunity locus in the Japanese population | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 91 | issue = 8 | pages = 3138–43 | date = Aug 2006 | pmid = 16735488 | doi = 10.1210/jc.2006-0206 }}
*{{cite journal | author=Guo D, Han J, Adam BL, ''et al.'' |title=Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress. |journal=Biochem. Biophys. Res. Commun. |volume=337 |issue= 4 |pages= 1308-18 |year= 2005 |pmid= 16236267 |doi= 10.1016/j.bbrc.2005.09.191 }}
* {{cite journal | vauthors = Costas J, Perez-Pampin E, Ferreiros-Vidal I, Torres M, Phillips C, Vicario JL, Pablos JL, Carracedo A, Gomez-Reino JJ, Gonzalez A | title = SUMO4 and MAP3K7IP2 single nucleotide polymorphisms and susceptibility to rheumatoid arthritis | journal = The Journal of Rheumatology | volume = 33 | issue = 6 | pages = 1048–51 | date = Jun 2006 | pmid = 16755651 | doi = }}
*{{cite journal | author=Noso S, Ikegami H, Fujisawa T, ''et al.'' |title=Genetic heterogeneity in association of the SUMO4 M55V variant with susceptibility to type 1 diabetes. |journal=Diabetes |volume=54 |issue= 12 |pages= 3582-6 |year= 2006 |pmid= 16306380 |doi= }}
* {{cite journal | vauthors = Sedimbi SK, Shastry A, Park Y, Rumba I, Sanjeevi CB | title = Association of SUMO4 M55V polymorphism with autoimmune diabetes in Latvian patients | journal = Annals of the New York Academy of Sciences | volume = 1079 | issue = 1 | pages = 273–7 | date = Oct 2006 | pmid = 17130565 | doi = 10.1196/annals.1375.041 | bibcode = 2006NYASA1079..273S }}
*{{cite journal | author=Tsurumaru M, Kawasaki E, Ida H, ''et al.'' |title=Evidence for the role of small ubiquitin-like modifier 4 as a general autoimmunity locus in the Japanese population. |journal=J. Clin. Endocrinol. Metab. |volume=91 |issue= 8 |pages= 3138-43 |year= 2006 |pmid= 16735488 |doi= 10.1210/jc.2006-0206 }}
* {{cite journal | vauthors = Lin HY, Wang CL, Hsiao PJ, Lu YC, Chen SY, Lin KD, Hsin SC, Hsieh MC, Shin SJ | title = SUMO4 M55V variant is associated with diabetic nephropathy in type 2 diabetes | journal = Diabetes | volume = 56 | issue = 4 | pages = 1177–80 | date = Apr 2007 | pmid = 17229939 | doi = 10.2337/db06-1283 }}
*{{cite journal | author=Costas J, Perez-Pampin E, Ferreiros-Vidal I, ''et al.'' |title=SUMO4 and MAP3K7IP2 single nucleotide polymorphisms and susceptibility to rheumatoid arthritis. |journal=J. Rheumatol. |volume=33 |issue= 6 |pages= 1048-51 |year= 2006 |pmid= 16755651 |doi= }}
* {{cite journal | vauthors = Sedimbi SK, Kanungo A, Shastry A, Park Y, Sanjeevi CB | title = No association of SUMO4 M55V with autoimmune diabetes in Asian-Indian patients | journal = International Journal of Immunogenetics | volume = 34 | issue = 2 | pages = 137–42 | date = Apr 2007 | pmid = 17373940 | doi = 10.1111/j.1744-313X.2007.00668.x }}
*{{cite journal | author=Sedimbi SK, Shastry A, Park Y, ''et al.'' |title=Association of SUMO4 M55V polymorphism with autoimmune diabetes in Latvian patients. |journal=Ann. N. Y. Acad. Sci. |volume=1079 |issue= |pages= 273-7 |year= 2007 |pmid= 17130565 |doi= 10.1196/annals.1375.041 }}
* {{cite journal | vauthors = Noso S, Fujisawa T, Kawabata Y, Asano K, Hiromine Y, Fukai A, Ogihara T, Ikegami H | title = Association of small ubiquitin-like modifier 4 (SUMO4) variant, located in IDDM5 locus, with type 2 diabetes in the Japanese population | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 92 | issue = 6 | pages = 2358–62 | date = Jun 2007 | pmid = 17374705 | doi = 10.1210/jc.2007-0031 }}
*{{cite journal | author=Lin HY, Wang CL, Hsiao PJ, ''et al.'' |title=SUMO4 M55V variant is associated with diabetic nephropathy in type 2 diabetes. |journal=Diabetes |volume=56 |issue= 4 |pages= 1177-80 |year= 2007 |pmid= 17229939 |doi= 10.2337/db06-1283 }}
* {{cite journal | vauthors = Bohren KM, Gabbay KH, Owerbach D | title = Affinity chromatography of native SUMO proteins using His-tagged recombinant UBC9 bound to Co2+-charged talon resin | journal = Protein Expression and Purification | volume = 54 | issue = 2 | pages = 289–94 | date = Aug 2007 | pmid = 17459725 | doi = 10.1016/j.pep.2007.03.013 }}
*{{cite journal | author=Sedimbi SK, Kanungo A, Shastry A, ''et al.'' |title=No association of SUMO4 M55V with autoimmune diabetes in Asian-Indian patients. |journal=Int. J. Immunogenet. |volume=34 |issue= 2 |pages= 137-42 |year= 2007 |pmid= 17373940 |doi= 10.1111/j.1744-313X.2007.00668.x }}
*{{cite journal | author=Noso S, Fujisawa T, Kawabata Y, ''et al.'' |title=Association of small ubiquitin-like modifier 4 (SUMO4) variant, located in IDDM5 locus, with type 2 diabetes in the Japanese population. |journal=J. Clin. Endocrinol. Metab. |volume=92 |issue= 6 |pages= 2358-62 |year= 2007 |pmid= 17374705 |doi= 10.1210/jc.2007-0031 }}
*{{cite journal | author=Bohren KM, Gabbay KH, Owerbach D |title=Affinity chromatography of native SUMO proteins using His-tagged recombinant UBC9 bound to Co2+-charged talon resin. |journal=Protein Expr. Purif. |volume=54 |issue= 2 |pages= 289-94 |year= 2007 |pmid= 17459725 |doi= 10.1016/j.pep.2007.03.013 }}
}}
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Latest revision as of 02:08, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

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Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Small ubiquitin-related modifier 4 is a protein that in humans is encoded by the SUMO4 gene.[1][2]

Function

This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism.[2]

Interactions

SUMO4 has been shown to interact with IκBα.[3]

References

  1. ↑ Bohren KM, Nadkarni V, Song JH, Gabbay KH, Owerbach D (Jun 2004). "A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription factors and is associated with susceptibility to type I diabetes mellitus". The Journal of Biological Chemistry. 279 (26): 27233–8. doi:10.1074/jbc.M402273200. PMID 15123604.
  2. ↑ 2.0 2.1 "Entrez Gene: SUMO4 SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae)".
  3. ↑ Guo D, Li M, Zhang Y, Yang P, Eckenrode S, Hopkins D, Zheng W, Purohit S, Podolsky RH, Muir A, Wang J, Dong Z, Brusko T, Atkinson M, Pozzilli P, Zeidler A, Raffel LJ, Jacob CO, Park Y, Serrano-Rios M, Larrad MT, Zhang Z, Garchon HJ, Bach JF, Rotter JI, She JX, Wang CY (Aug 2004). "A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes". Nature Genetics. 36 (8): 837–41. doi:10.1038/ng1391. PMID 15247916.

Further reading

  • Wang CY, Podolsky R, She JX (Oct 2006). "Genetic and functional evidence supporting SUMO4 as a type 1 diabetes susceptibility gene". Annals of the New York Academy of Sciences. 1079 (1): 257–67. Bibcode:2006NYASA1079..257W. doi:10.1196/annals.1375.039. PMID 17130563.
  • Davies JL, Kawaguchi Y, Bennett ST, Copeman JB, Cordell HJ, Pritchard LE, Reed PW, Gough SC, Jenkins SC, Palmer SM (Sep 1994). "A genome-wide search for human type 1 diabetes susceptibility genes". Nature. 371 (6493): 130–6. Bibcode:1994Natur.371..130D. doi:10.1038/371130a0. PMID 8072542.
  • Luo DF, Buzzetti R, Rotter JI, Maclaren NK, Raffel LJ, Nisticò L, Giovannini C, Pozzilli P, Thomson G, She JX (May 1996). "Confirmation of three susceptibility genes to insulin-dependent diabetes mellitus: IDDM4, IDDM5 and IDDM8". Human Molecular Genetics. 5 (5): 693–8. doi:10.1093/hmg/5.5.693. PMID 8733139.
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