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{{Underlinked|date=June 2016}}
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{{Infobox_gene}}
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'''Transcription elongation factor SPT4''' is a [[protein]] that in humans is encoded by the ''SUPT4H1'' [[gene]].<ref name="pmid8786137">{{cite journal | vauthors = Chiang PW, Wang SQ, Smithivas P, Song WJ, Crombez E, Akhtar A, Im R, Greenfield J, Ramamoorthy S, Van Keuren M, Blackburn CC, Tsai CH, Kurnit DM | title = Isolation and characterization of the human and mouse homologues (SUPT4H and Supt4h) of the yeast SPT4 gene | journal = Genomics | volume = 34 | issue = 3 | pages = 368–75 |date=Sep 1996 | pmid = 8786137 | pmc =  | doi = 10.1006/geno.1996.0299 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SUPT4H1 suppressor of Ty 4 homolog 1 (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6827| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Suppressor of Ty 4 homolog 1 (S. cerevisiae)
| HGNCid = 11467
| Symbol = SUPT4H1
| AltSymbols =; SPT4H; SUPT4H
| OMIM = 603555
| ECnumber = 
| Homologene = 68303
| MGIid = 107416
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0008148 |text = negative transcription elongation factor activity}} {{GNF_GO|id=GO:0008159 |text = positive transcription elongation factor activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}} {{GNF_GO|id=GO:0046982 |text = protein heterodimerization activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006338 |text = chromatin remodeling}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006368 |text = RNA elongation from RNA polymerase II promoter}} {{GNF_GO|id=GO:0045941 |text = positive regulation of transcription}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6827
    | Hs_Ensembl =
    | Hs_RefseqProtein = NP_003159
    | Hs_RefseqmRNA = NM_003168
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr =
    | Hs_GenLoc_start =   
    | Hs_GenLoc_end =
    | Hs_Uniprot = 
    | Mm_EntrezGene = 20922
    | Mm_Ensembl = ENSMUSG00000020485
    | Mm_RefseqmRNA = NM_009296
    | Mm_RefseqProtein = NP_033322
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 87553748
    | Mm_GenLoc_end = 87559809
    | Mm_Uniprot = P63271
  }}
}}
'''Suppressor of Ty 4 homolog 1 (S. cerevisiae)''', also known as '''SUPT4H1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SUPT4H1 suppressor of Ty 4 homolog 1 (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6827| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
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| citations =  
| citations =  
*{{cite journal | author=Hartzog GA, Basrai MA, Ricupero-Hovasse SL, ''et al.'' |title=Identification and analysis of a functional human homolog of the SPT4 gene of Saccharomyces cerevisiae. |journal=Mol. Cell. Biol. |volume=16 |issue= 6 |pages= 2848-56 |year= 1996 |pmid= 8649394 |doi=  }}
*{{cite journal   |vauthors=Hartzog GA, Basrai MA, Ricupero-Hovasse SL, etal |title=Identification and analysis of a functional human homolog of the SPT4 gene of Saccharomyces cerevisiae |journal=Mol. Cell. Biol. |volume=16 |issue= 6 |pages= 2848–56 |year= 1996 |pmid= 8649394 |doi= | pmc=231277 }}
*{{cite journal | author=Chiang PW, Wang SQ, Smithivas P, ''et al.'' |title=Isolation and characterization of the human and mouse homologues (SUPT4H and Supt4h) of the yeast SPT4 gene. |journal=Genomics |volume=34 |issue= 3 |pages= 368-75 |year= 1996 |pmid= 8786137 |doi= 10.1006/geno.1996.0299 }}
*{{cite journal   |vauthors=Wada T, Takagi T, Yamaguchi Y, etal |title=DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs |journal=Genes Dev. |volume=12 |issue= 3 |pages= 343–56 |year= 1998 |pmid= 9450929 |doi=10.1101/gad.12.3.343  | pmc=316480  }}
*{{cite journal | author=Wada T, Takagi T, Yamaguchi Y, ''et al.'' |title=DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs. |journal=Genes Dev. |volume=12 |issue= 3 |pages= 343-56 |year= 1998 |pmid= 9450929 |doi= }}
*{{cite journal   |vauthors=Wada T, Takagi T, Yamaguchi Y, etal |title=Evidence that P-TEFb alleviates the negative effect of DSIF on RNA polymerase II-dependent transcription in vitro |journal=EMBO J. |volume=17 |issue= 24 |pages= 7395–403 |year= 1999 |pmid= 9857195 |doi= 10.1093/emboj/17.24.7395  | pmc=1171084 }}
*{{cite journal | author=Wada T, Takagi T, Yamaguchi Y, ''et al.'' |title=Evidence that P-TEFb alleviates the negative effect of DSIF on RNA polymerase II-dependent transcription in vitro. |journal=EMBO J. |volume=17 |issue= 24 |pages= 7395-403 |year= 1999 |pmid= 9857195 |doi= 10.1093/emboj/17.24.7395 }}
*{{cite journal   |vauthors=Yamaguchi Y, Wada T, Watanabe D, etal |title=Structure and function of the human transcription elongation factor DSIF |journal=J. Biol. Chem. |volume=274 |issue= 12 |pages= 8085–92 |year= 1999 |pmid= 10075709 |doi=10.1074/jbc.274.12.8085  }}
*{{cite journal | author=Yamaguchi Y, Wada T, Watanabe D, ''et al.'' |title=Structure and function of the human transcription elongation factor DSIF. |journal=J. Biol. Chem. |volume=274 |issue= 12 |pages= 8085-92 |year= 1999 |pmid= 10075709 |doi= }}
*{{cite journal   |vauthors=Yamaguchi Y, Takagi T, Wada T, etal |title=NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation |journal=Cell |volume=97 |issue= 1 |pages= 41–51 |year= 1999 |pmid= 10199401 |doi=10.1016/S0092-8674(00)80713-8  }}
*{{cite journal | author=Yamaguchi Y, Takagi T, Wada T, ''et al.'' |title=NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation. |journal=Cell |volume=97 |issue= 1 |pages= 41-51 |year= 1999 |pmid= 10199401 |doi=  }}
*{{cite journal   |vauthors=Kim JB, Yamaguchi Y, Wada T, etal |title=Tat-SF1 Protein Associates with RAP30 and Human SPT5 Proteins |journal=Mol. Cell. Biol. |volume=19 |issue= 9 |pages= 5960–8 |year= 1999 |pmid= 10454543 |doi= 10.1128/mcb.19.9.5960| pmc=84462 }}
*{{cite journal  | author=Kim JB, Yamaguchi Y, Wada T, ''et al.'' |title=Tat-SF1 protein associates with RAP30 and human SPT5 proteins. |journal=Mol. Cell. Biol. |volume=19 |issue= 9 |pages= 5960-8 |year= 1999 |pmid= 10454543 |doi= }}
*{{cite journal  | vauthors=Ivanov D, Kwak YT, Guo J, Gaynor RB |title=Domains in the SPT5 Protein That Modulate Its Transcriptional Regulatory Properties |journal=Mol. Cell. Biol. |volume=20 |issue= 9 |pages= 2970–83 |year= 2000 |pmid= 10757782 |doi=10.1128/MCB.20.9.2970-2983.2000  | pmc=85557  }}
*{{cite journal | author=Ivanov D, Kwak YT, Guo J, Gaynor RB |title=Domains in the SPT5 protein that modulate its transcriptional regulatory properties. |journal=Mol. Cell. Biol. |volume=20 |issue= 9 |pages= 2970-83 |year= 2000 |pmid= 10757782 |doi= }}
*{{cite journal   |vauthors=Wada T, Orphanides G, Hasegawa J, etal |title=FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional differences between P-TEFb and TFIIH |journal=Mol. Cell |volume=5 |issue= 6 |pages= 1067–72 |year= 2000 |pmid= 10912001 |doi=10.1016/S1097-2765(00)80272-5  }}
*{{cite journal  | author=Wada T, Orphanides G, Hasegawa J, ''et al.'' |title=FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional differences between P-TEFb and TFIIH. |journal=Mol. Cell |volume=5 |issue= 6 |pages= 1067-72 |year= 2000 |pmid= 10912001 |doi= }}
*{{cite journal  | vauthors=Ping YH, Rana TM |title=DSIF and NELF interact with RNA polymerase II elongation complex and HIV-1 Tat stimulates P-TEFb-mediated phosphorylation of RNA polymerase II and DSIF during transcription elongation |journal=J. Biol. Chem. |volume=276 |issue= 16 |pages= 12951–8 |year= 2001 |pmid= 11112772 |doi= 10.1074/jbc.M006130200 }}
*{{cite journal | author=Ping YH, Rana TM |title=DSIF and NELF interact with RNA polymerase II elongation complex and HIV-1 Tat stimulates P-TEFb-mediated phosphorylation of RNA polymerase II and DSIF during transcription elongation. |journal=J. Biol. Chem. |volume=276 |issue= 16 |pages= 12951-8 |year= 2001 |pmid= 11112772 |doi= 10.1074/jbc.M006130200 }}
*{{cite journal   |vauthors=Renner DB, Yamaguchi Y, Wada T, etal |title=A highly purified RNA polymerase II elongation control system |journal=J. Biol. Chem. |volume=276 |issue= 45 |pages= 42601–9 |year= 2001 |pmid= 11553615 |doi= 10.1074/jbc.M104967200 }}
*{{cite journal  | author=Renner DB, Yamaguchi Y, Wada T, ''et al.'' |title=A highly purified RNA polymerase II elongation control system. |journal=J. Biol. Chem. |volume=276 |issue= 45 |pages= 42601-9 |year= 2001 |pmid= 11553615 |doi= 10.1074/jbc.M104967200 }}
*{{cite journal  | vauthors=Mo X, Dynan WS |title=Subnuclear Localization of Ku Protein: Functional Association with RNA Polymerase II Elongation Sites |journal=Mol. Cell. Biol. |volume=22 |issue= 22 |pages= 8088–99 |year= 2002 |pmid= 12391174 |doi=10.1128/MCB.22.22.8088-8099.2002  | pmc=134733  }}
*{{cite journal | author=Mo X, Dynan WS |title=Subnuclear localization of Ku protein: functional association with RNA polymerase II elongation sites. |journal=Mol. Cell. Biol. |volume=22 |issue= 22 |pages= 8088-99 |year= 2002 |pmid= 12391174 |doi= }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Narita T, Yamaguchi Y, Yano K, etal |title=Human Transcription Elongation Factor NELF: Identification of Novel Subunits and Reconstitution of the Functionally Active Complex |journal=Mol. Cell. Biol. |volume=23 |issue= 6 |pages= 1863–73 |year= 2003 |pmid= 12612062 |doi=10.1128/MCB.23.6.1863-1873.2003  | pmc=149481  }}
*{{cite journal | author=Narita T, Yamaguchi Y, Yano K, ''et al.'' |title=Human transcription elongation factor NELF: identification of novel subunits and reconstitution of the functionally active complex. |journal=Mol. Cell. Biol. |volume=23 |issue= 6 |pages= 1863-73 |year= 2003 |pmid= 12612062 |doi= }}
*{{cite journal   |vauthors=Kim DK, Inukai N, Yamada T, etal |title=Structure-function analysis of human Spt4: evidence that hSpt4 and hSpt5 exert their roles in transcriptional elongation as parts of the DSIF complex |journal=Genes Cells |volume=8 |issue= 4 |pages= 371–8 |year= 2004 |pmid= 12653964 |doi=10.1046/j.1365-2443.2003.00638.x  }}
*{{cite journal | author=Kim DK, Inukai N, Yamada T, ''et al.'' |title=Structure-function analysis of human Spt4: evidence that hSpt4 and hSpt5 exert their roles in transcriptional elongation as parts of the DSIF complex. |journal=Genes Cells |volume=8 |issue= 4 |pages= 371-8 |year= 2004 |pmid= 12653964 |doi= }}
*{{cite journal   |vauthors=Kwak YT, Guo J, Prajapati S, etal |title=Methylation of SPT5 regulates its interaction with RNA polymerase II and transcriptional elongation properties |journal=Mol. Cell |volume=11 |issue= 4 |pages= 1055–66 |year= 2003 |pmid= 12718890 |doi=10.1016/S1097-2765(03)00101-1  }}
*{{cite journal | author=Kwak YT, Guo J, Prajapati S, ''et al.'' |title=Methylation of SPT5 regulates its interaction with RNA polymerase II and transcriptional elongation properties. |journal=Mol. Cell |volume=11 |issue= 4 |pages= 1055-66 |year= 2003 |pmid= 12718890 |doi= }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Endoh M, Zhu W, Hasegawa J, etal |title=Human Spt6 Stimulates Transcription Elongation by RNA Polymerase II In Vitro |journal=Mol. Cell. Biol. |volume=24 |issue= 8 |pages= 3324–36 |year= 2004 |pmid= 15060154 |doi=10.1128/MCB.24.8.3324-3336.2004  | pmc=381665  }}
*{{cite journal | author=Endoh M, Zhu W, Hasegawa J, ''et al.'' |title=Human Spt6 stimulates transcription elongation by RNA polymerase II in vitro. |journal=Mol. Cell. Biol. |volume=24 |issue= 8 |pages= 3324-36 |year= 2004 |pmid= 15060154 |doi=  }}
*{{cite journal   |vauthors=Mandal SS, Chu C, Wada T, etal |title=Functional interactions of RNA-capping enzyme with factors that positively and negatively regulate promoter escape by RNA polymerase II |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 20 |pages= 7572–7 |year= 2004 |pmid= 15136722 |doi= 10.1073/pnas.0401493101 | pmc=419647 }}
*{{cite journal  | author=Mandal SS, Chu C, Wada T, ''et al.'' |title=Functional interactions of RNA-capping enzyme with factors that positively and negatively regulate promoter escape by RNA polymerase II. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 20 |pages= 7572-7 |year= 2004 |pmid= 15136722 |doi= 10.1073/pnas.0401493101 }}
*{{cite journal   |vauthors=Jennings BH, Shah S, Yamaguchi Y, etal |title=Locus-specific requirements for Spt5 in transcriptional activation and repression in Drosophila |journal=Curr. Biol. |volume=14 |issue= 18 |pages= 1680–4 |year= 2005 |pmid= 15380072 |doi= 10.1016/j.cub.2004.08.066 }}
*{{cite journal | author=Jennings BH, Shah S, Yamaguchi Y, ''et al.'' |title=Locus-specific requirements for Spt5 in transcriptional activation and repression in Drosophila. |journal=Curr. Biol. |volume=14 |issue= 18 |pages= 1680-4 |year= 2005 |pmid= 15380072 |doi= 10.1016/j.cub.2004.08.066 }}
}}
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Latest revision as of 07:18, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Transcription elongation factor SPT4 is a protein that in humans is encoded by the SUPT4H1 gene.[1][2]


References

  1. ↑ Chiang PW, Wang SQ, Smithivas P, Song WJ, Crombez E, Akhtar A, Im R, Greenfield J, Ramamoorthy S, Van Keuren M, Blackburn CC, Tsai CH, Kurnit DM (Sep 1996). "Isolation and characterization of the human and mouse homologues (SUPT4H and Supt4h) of the yeast SPT4 gene". Genomics. 34 (3): 368–75. doi:10.1006/geno.1996.0299. PMID 8786137.
  2. ↑ "Entrez Gene: SUPT4H1 suppressor of Ty 4 homolog 1 (S. cerevisiae)".

Further reading



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