SYCP3: Difference between revisions

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{{Infobox_gene}}
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'''Synaptonemal complex protein 3''' is a [[protein]] that in humans is encoded by the ''SYCP3'' [[gene]].<ref name="pmid12213195">{{cite journal | vauthors = Martinez-Garay I, Jablonka S, Sutajova M, Steuernagel P, Gal A, Kutsche K | title = A new gene family (FAM9) of low-copy repeats in Xp22.3 expressed exclusively in testis: implications for recombinations in this region | journal = Genomics | volume = 80 | issue = 3 | pages = 259–67 | date = September 2002 | pmid = 12213195 | pmc =  | doi = 10.1006/geno.2002.6834 }}</ref><ref name="pmid10854409">{{cite journal | vauthors = Mallon AM, Platzer M, Bate R, Gloeckner G, Botcherby MR, Nordsiek G, Strivens MA, Kioschis P, Dangel A, Cunningham D, Straw RN, Weston P, Gilbert M, Fernando S, Goodall K, Hunter G, Greystrong JS, Clarke D, Kimberley C, Goerdes M, Blechschmidt K, Rump A, Hinzmann B, Mundy CR, Miller W, Poustka A, Herman GE, Rhodes M, Denny P, Rosenthal A, Brown SD | title = Comparative genome sequence analysis of the Bpa/Str region in mouse and Man | journal = Genome Research | volume = 10 | issue = 6 | pages = 758–75 | date = June 2000 | pmid = 10854409 | pmc = 310879 | doi = 10.1101/gr.10.6.758 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SYCP3 synaptonemal complex protein 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50511| accessdate = }}</ref> It is a component of the [[synaptonemal complex]] formed between homologous chromosomes during the [[prophase]] of [[meiosis]].<ref name="pmid24950965">{{cite journal | vauthors = Syrjänen JL, Pellegrini L, Davies OR | title = A molecular model for the role of SYCP3 in meiotic chromosome organisation | journal = eLife | volume = 3 | issue = | pages = | year = 2014 | pmid = 24950965 | pmc = 4102245 | doi = 10.7554/eLife.02963 }}</ref>
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== References ==
{{GNF_Protein_box
{{reflist}}
| image = 
| image_source = 
| PDB =
| Name = Synaptonemal complex protein 3
| HGNCid = 18130
| Symbol = SYCP3
| AltSymbols =; SCP3; COR1; MGC71888
| OMIM = 604759
| ECnumber = 
| Homologene = 7964
| MGIid = 109542
| GeneAtlas_image1 = PBB_GE_SYCP3_gnf1h02670_at_tn.png
| GeneAtlas_image2 = PBB_GE_SYCP3_gnf1h02671_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0000793 |text = condensed chromosome}} {{GNF_GO|id=GO:0000800 |text = lateral element}} {{GNF_GO|id=GO:0000802 |text = transverse filament}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0000705 |text = achiasmate meiosis I}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007066 |text = female meiosis sister chromatid cohesion}} {{GNF_GO|id=GO:0007067 |text = mitosis}} {{GNF_GO|id=GO:0007126 |text = meiosis}} {{GNF_GO|id=GO:0007130 |text = synaptonemal complex assembly}} {{GNF_GO|id=GO:0007141 |text = male meiosis I}} {{GNF_GO|id=GO:0007283 |text = spermatogenesis}} {{GNF_GO|id=GO:0035093 |text = spermatogenesis, exchange of chromosomal proteins}} {{GNF_GO|id=GO:0043066 |text = negative regulation of apoptosis}} {{GNF_GO|id=GO:0051301 |text = cell division}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 50511
    | Hs_Ensembl = ENSG00000139351
    | Hs_RefseqProtein = NP_710161
    | Hs_RefseqmRNA = NM_153694
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 100646558
    | Hs_GenLoc_end = 100655844
    | Hs_Uniprot = Q8IZU3
    | Mm_EntrezGene = 20962
    | Mm_Ensembl = ENSMUSG00000020059
    | Mm_RefseqmRNA = NM_011517
    | Mm_RefseqProtein = NP_035647
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 87889386
    | Mm_GenLoc_end = 87903034
    | Mm_Uniprot = P70281
  }}
}}
'''Synaptonemal complex protein 3''', also known as '''SYCP3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SYCP3 synaptonemal complex protein 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50511| accessdate = }}</ref>


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== Further reading ==
{{PBB_Summary
| section_title =
| summary_text =
}}
 
==References==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Yuan L, Liu JG, Zhao J, Brundell E, Daneholt B, Höög C | title = The murine SCP3 gene is required for synaptonemal complex assembly, chromosome synapsis, and male fertility | journal = Molecular Cell | volume = 5 | issue = 1 | pages = 73–83 | date = January 2000 | pmid = 10678170 | doi = 10.1016/S1097-2765(00)80404-9 }}
| citations =
* {{cite journal | vauthors = Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y | title = Protein-protein interaction panel using mouse full-length cDNAs | journal = Genome Research | volume = 11 | issue = 10 | pages = 1758–65 | date = October 2001 | pmid = 11591653 | pmc = 311163 | doi = 10.1101/gr.180101 }}
*{{cite journal | author=Yuan L, Liu JG, Zhao J, ''et al.'' |title=The murine SCP3 gene is required for synaptonemal complex assembly, chromosome synapsis, and male fertility. |journal=Mol. Cell |volume=5 |issue= 1 |pages= 73-83 |year= 2000 |pmid= 10678170 |doi= }}
* {{cite journal | vauthors = Lee J, Iwai T, Yokota T, Yamashita M | title = Temporally and spatially selective loss of Rec8 protein from meiotic chromosomes during mammalian meiosis | journal = Journal of Cell Science | volume = 116 | issue = Pt 13 | pages = 2781–90 | date = July 2003 | pmid = 12759374 | doi = 10.1242/jcs.00495 }}
*{{cite journal  | author=Mallon AM, Platzer M, Bate R, ''et al.'' |title=Comparative genome sequence analysis of the Bpa/Str region in mouse and Man. |journal=Genome Res. |volume=10 |issue= 6 |pages= 758-75 |year= 2000 |pmid= 10854409 |doi=  }}
* {{cite journal | vauthors = Miyamoto T, Hasuike S, Yogev L, Maduro MR, Ishikawa M, Westphal H, Lamb DJ | title = Azoospermia in patients heterozygous for a mutation in SYCP3 | journal = Lancet | volume = 362 | issue = 9397 | pages = 1714–9 | date = November 2003 | pmid = 14643120 | doi = 10.1016/S0140-6736(03)14845-3 }}
*{{cite journal | author=Suzuki H, Fukunishi Y, Kagawa I, ''et al.'' |title=Protein-protein interaction panel using mouse full-length cDNAs. |journal=Genome Res. |volume=11 |issue= 10 |pages= 1758-65 |year= 2001 |pmid= 11591653 |doi= 10.1101/gr.180101 }}
* {{cite journal | vauthors = de Boer P, Giele M, Lock MT, de Rooij DG, Giltay J, Hochstenbach R, te Velde ER | title = Kinetics of meiosis in azoospermic males: a joint histological and cytological approach | journal = Cytogenetic and Genome Research | volume = 105 | issue = 1 | pages = 36–46 | year = 2004 | pmid = 15218256 | doi = 10.1159/000078007 }}
*{{cite journal | author=Martinez-Garay I, Jablonka S, Sutajova M, ''et al.'' |title=A new gene family (FAM9) of low-copy repeats in Xp22.3 expressed exclusively in testis: implications for recombinations in this region. |journal=Genomics |volume=80 |issue= 3 |pages= 259-67 |year= 2003 |pmid= 12213195 |doi=  }}
* {{cite journal | vauthors = Stouffs K, Lissens W, Tournaye H, Van Steirteghem A, Liebaers I | title = SYCP3 mutations are uncommon in patients with azoospermia | journal = Fertility and Sterility | volume = 84 | issue = 4 | pages = 1019–20 | date = October 2005 | pmid = 16213863 | doi = 10.1016/j.fertnstert.2005.04.033 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Aarabi M, Modarressi MH, Soltanghoraee H, Behjati R, Amirjannati N, Akhondi MM | title = Testicular expression of synaptonemal complex protein 3 (SYCP3) messenger ribonucleic acid in 110 patients with nonobstructive azoospermia | journal = Fertility and Sterility | volume = 86 | issue = 2 | pages = 325–31 | date = August 2006 | pmid = 16824523 | doi = 10.1016/j.fertnstert.2005.12.070 }}
*{{cite journal  | author=Lee J, Iwai T, Yokota T, Yamashita M |title=Temporally and spatially selective loss of Rec8 protein from meiotic chromosomes during mammalian meiosis. |journal=J. Cell. Sci. |volume=116 |issue= Pt 13 |pages= 2781-90 |year= 2004 |pmid= 12759374 |doi= 10.1242/jcs.00495 }}
* {{cite journal | vauthors = Sapkota G, Knockaert M, Alarcón C, Montalvo E, Brivanlou AH, Massagué J | title = Dephosphorylation of the linker regions of Smad1 and Smad2/3 by small C-terminal domain phosphatases has distinct outcomes for bone morphogenetic protein and transforming growth factor-beta pathways | journal = The Journal of Biological Chemistry | volume = 281 | issue = 52 | pages = 40412–9 | date = December 2006 | pmid = 17085434 | doi = 10.1074/jbc.M610172200 }}
*{{cite journal | author=Miyamoto T, Hasuike S, Yogev L, ''et al.'' |title=Azoospermia in patients heterozygous for a mutation in SYCP3. |journal=Lancet |volume=362 |issue= 9397 |pages= 1714-9 |year= 2004 |pmid= 14643120 |doi= }}
* {{cite journal | vauthors = Martínez J, Bonache S, Carvajal A, Bassas L, Larriba S | title = Mutations of SYCP3 are rare in infertile Spanish men with meiotic arrest | journal = Fertility and Sterility | volume = 88 | issue = 4 | pages = 988–9 | date = October 2007 | pmid = 17434513 | doi = 10.1016/j.fertnstert.2006.11.163 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=de Boer P, Giele M, Lock MT, ''et al.'' |title=Kinetics of meiosis in azoospermic males: a joint histological and cytological approach. |journal=Cytogenet. Genome Res. |volume=105 |issue= 1 |pages= 36-46 |year= 2004 |pmid= 15218256 |doi= 10.1159/000078007 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Stouffs K, Lissens W, Tournaye H, ''et al.'' |title=SYCP3 mutations are uncommon in patients with azoospermia. |journal=Fertil. Steril. |volume=84 |issue= 4 |pages= 1019-20 |year= 2006 |pmid= 16213863 |doi= 10.1016/j.fertnstert.2005.04.033 }}
*{{cite journal | author=Aarabi M, Modarressi MH, Soltanghoraee H, ''et al.'' |title=Testicular expression of synaptonemal complex protein 3 (SYCP3) messenger ribonucleic acid in 110 patients with nonobstructive azoospermia. |journal=Fertil. Steril. |volume=86 |issue= 2 |pages= 325-31 |year= 2006 |pmid= 16824523 |doi= 10.1016/j.fertnstert.2005.12.070 }}
*{{cite journal | author=Sapkota G, Knockaert M, Alarcón C, ''et al.'' |title=Dephosphorylation of the linker regions of Smad1 and Smad2/3 by small C-terminal domain phosphatases has distinct outcomes for bone morphogenetic protein and transforming growth factor-beta pathways. |journal=J. Biol. Chem. |volume=281 |issue= 52 |pages= 40412-9 |year= 2007 |pmid= 17085434 |doi= 10.1074/jbc.M610172200 }}
*{{cite journal | author=Martínez J, Bonache S, Carvajal A, ''et al.'' |title=Mutations of SYCP3 are rare in infertile Spanish men with meiotic arrest. |journal=Fertil. Steril. |volume=88 |issue= 4 |pages= 988-9 |year= 2007 |pmid= 17434513 |doi= 10.1016/j.fertnstert.2006.11.163 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
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{{WikiDoc Sources}}

Latest revision as of 04:59, 16 November 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Synaptonemal complex protein 3 is a protein that in humans is encoded by the SYCP3 gene.[1][2][3] It is a component of the synaptonemal complex formed between homologous chromosomes during the prophase of meiosis.[4]

References

  1. ↑ Martinez-Garay I, Jablonka S, Sutajova M, Steuernagel P, Gal A, Kutsche K (September 2002). "A new gene family (FAM9) of low-copy repeats in Xp22.3 expressed exclusively in testis: implications for recombinations in this region". Genomics. 80 (3): 259–67. doi:10.1006/geno.2002.6834. PMID 12213195.
  2. ↑ Mallon AM, Platzer M, Bate R, Gloeckner G, Botcherby MR, Nordsiek G, Strivens MA, Kioschis P, Dangel A, Cunningham D, Straw RN, Weston P, Gilbert M, Fernando S, Goodall K, Hunter G, Greystrong JS, Clarke D, Kimberley C, Goerdes M, Blechschmidt K, Rump A, Hinzmann B, Mundy CR, Miller W, Poustka A, Herman GE, Rhodes M, Denny P, Rosenthal A, Brown SD (June 2000). "Comparative genome sequence analysis of the Bpa/Str region in mouse and Man". Genome Research. 10 (6): 758–75. doi:10.1101/gr.10.6.758. PMC 310879. PMID 10854409.
  3. ↑ "Entrez Gene: SYCP3 synaptonemal complex protein 3".
  4. ↑ Syrjänen JL, Pellegrini L, Davies OR (2014). "A molecular model for the role of SYCP3 in meiotic chromosome organisation". eLife. 3. doi:10.7554/eLife.02963. PMC 4102245. PMID 24950965.

Further reading

  • Yuan L, Liu JG, Zhao J, Brundell E, Daneholt B, Höög C (January 2000). "The murine SCP3 gene is required for synaptonemal complex assembly, chromosome synapsis, and male fertility". Molecular Cell. 5 (1): 73–83. doi:10.1016/S1097-2765(00)80404-9. PMID 10678170.
  • Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y (October 2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Research. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653.
  • Lee J, Iwai T, Yokota T, Yamashita M (July 2003). "Temporally and spatially selective loss of Rec8 protein from meiotic chromosomes during mammalian meiosis". Journal of Cell Science. 116 (Pt 13): 2781–90. doi:10.1242/jcs.00495. PMID 12759374.
  • Miyamoto T, Hasuike S, Yogev L, Maduro MR, Ishikawa M, Westphal H, Lamb DJ (November 2003). "Azoospermia in patients heterozygous for a mutation in SYCP3". Lancet. 362 (9397): 1714–9. doi:10.1016/S0140-6736(03)14845-3. PMID 14643120.
  • de Boer P, Giele M, Lock MT, de Rooij DG, Giltay J, Hochstenbach R, te Velde ER (2004). "Kinetics of meiosis in azoospermic males: a joint histological and cytological approach". Cytogenetic and Genome Research. 105 (1): 36–46. doi:10.1159/000078007. PMID 15218256.
  • Stouffs K, Lissens W, Tournaye H, Van Steirteghem A, Liebaers I (October 2005). "SYCP3 mutations are uncommon in patients with azoospermia". Fertility and Sterility. 84 (4): 1019–20. doi:10.1016/j.fertnstert.2005.04.033. PMID 16213863.
  • Aarabi M, Modarressi MH, Soltanghoraee H, Behjati R, Amirjannati N, Akhondi MM (August 2006). "Testicular expression of synaptonemal complex protein 3 (SYCP3) messenger ribonucleic acid in 110 patients with nonobstructive azoospermia". Fertility and Sterility. 86 (2): 325–31. doi:10.1016/j.fertnstert.2005.12.070. PMID 16824523.
  • Sapkota G, Knockaert M, Alarcón C, Montalvo E, Brivanlou AH, Massagué J (December 2006). "Dephosphorylation of the linker regions of Smad1 and Smad2/3 by small C-terminal domain phosphatases has distinct outcomes for bone morphogenetic protein and transforming growth factor-beta pathways". The Journal of Biological Chemistry. 281 (52): 40412–9. doi:10.1074/jbc.M610172200. PMID 17085434.
  • Martínez J, Bonache S, Carvajal A, Bassas L, Larriba S (October 2007). "Mutations of SYCP3 are rare in infertile Spanish men with meiotic arrest". Fertility and Sterility. 88 (4): 988–9. doi:10.1016/j.fertnstert.2006.11.163. PMID 17434513.
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