TAOK2: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Serine/threonine-protein kinase TAO2''' is an [[enzyme]] that in humans is encoded by the ''TAOK2'' [[gene]].<ref name="pmid10048485">{{cite journal | vauthors = Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res. | volume = 5 | issue = 6 | pages = 355–64 | year = 1998 | date = May 1999 | pmid = 10048485 | pmc =  | doi = 10.1093/dnares/5.6.355 }}</ref><ref name="pmid9786855">{{cite journal | vauthors = Hutchison M, Berman KS, Cobb MH | title = Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades | journal = J. Biol. Chem. | volume = 273 | issue = 44 | pages = 28625–32  | date = Dec 1998 | pmid = 9786855 | pmc = | doi = 10.1074/jbc.273.44.28625 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TAOK2 TAO kinase 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9344| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image = PBB_Protein_TAOK2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1u5q.
| PDB = {{PDB2|1u5q}}, {{PDB2|1u5r}}, {{PDB2|2gcd}}
| Name = TAO kinase 2
| HGNCid = 16835
| Symbol = TAOK2
| AltSymbols =; KIAA0881; MAP3K17; PSK; PSK1; TAO1; TAO2
| OMIM = 
| ECnumber = 
| Homologene = 74531
| MGIid = 
| GeneAtlas_image1 = PBB_GE_TAOK2_204878_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_TAOK2_204877_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_TAOK2_204986_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0016023 |text = cytoplasmic membrane-bound vesicle}}
| Process = {{GNF_GO|id=GO:0000186 |text = activation of MAPKK activity}} {{GNF_GO|id=GO:0001558 |text = regulation of cell growth}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006612 |text = protein targeting to membrane}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006950 |text = response to stress}} {{GNF_GO|id=GO:0008360 |text = regulation of cell shape}} {{GNF_GO|id=GO:0016477 |text = cell migration}} {{GNF_GO|id=GO:0030036 |text = actin cytoskeleton organization and biogenesis}} {{GNF_GO|id=GO:0046330 |text = positive regulation of JNK cascade}} {{GNF_GO|id=GO:0048041 |text = focal adhesion formation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9344
    | Hs_Ensembl = ENSG00000149930
    | Hs_RefseqProtein = NP_004774
    | Hs_RefseqmRNA = NM_004783
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 29892723
    | Hs_GenLoc_end = 29911082
    | Hs_Uniprot = Q9UL54
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''TAO kinase 2''', also known as '''TAOK2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TAOK2 TAO kinase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9344| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
TAOK2 has been shown to [[Protein-protein interaction|interact]] with [[MAP2K6]]<ref name=pmid11279118>{{cite journal | vauthors = Chen Z, Cobb MH | title = Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2 | journal = J. Biol. Chem. | volume = 276 | issue = 19 | pages = 16070–5 | date = May 2001 | pmid = 11279118 | doi = 10.1074/jbc.M100681200 }}</ref> and [[MAP2K3]].<ref name=pmid11279118/>
{{PBB_Summary
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| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{Reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Hutchison M, Berman KS, Cobb MH |title=Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades. |journal=J. Biol. Chem. |volume=273 |issue= 44 |pages= 28625-32 |year= 1998 |pmid= 9786855 |doi=  }}
*{{cite journal  | author=Nagase T, Ishikawa K, Suyama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 6 |pages= 355-64 |year= 1999 |pmid= 10048485 |doi=  }}
*{{cite journal  | author=Chen Z, Hutchison M, Cobb MH |title=Isolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domain. |journal=J. Biol. Chem. |volume=274 |issue= 40 |pages= 28803-7 |year= 1999 |pmid= 10497253 |doi=  }}
*{{cite journal  | author=Moore TM, Garg R, Johnson C, ''et al.'' |title=PSK, a novel STE20-like kinase derived from prostatic carcinoma that activates the c-Jun N-terminal kinase mitogen-activated protein kinase pathway and regulates actin cytoskeletal organization. |journal=J. Biol. Chem. |volume=275 |issue= 6 |pages= 4311-22 |year= 2000 |pmid= 10660600 |doi=  }}
*{{cite journal  | author=Chen Z, Cobb MH |title=Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2. |journal=J. Biol. Chem. |volume=276 |issue= 19 |pages= 16070-5 |year= 2001 |pmid= 11279118 |doi= 10.1074/jbc.M100681200 }}
*{{cite journal  | author=Nakayama M, Kikuno R, Ohara O |title=Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. |journal=Genome Res. |volume=12 |issue= 11 |pages= 1773-84 |year= 2003 |pmid= 12421765 |doi= 10.1101/gr.406902 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Mitsopoulos C, Zihni C, Garg R, ''et al.'' |title=The prostate-derived sterile 20-like kinase (PSK) regulates microtubule organization and stability. |journal=J. Biol. Chem. |volume=278 |issue= 20 |pages= 18085-91 |year= 2003 |pmid= 12639963 |doi= 10.1074/jbc.M213064200 }}
*{{cite journal  | author=Chen Z, Raman M, Chen L, ''et al.'' |title=TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors. |journal=J. Biol. Chem. |volume=278 |issue= 25 |pages= 22278-83 |year= 2003 |pmid= 12665513 |doi= 10.1074/jbc.M301173200 }}
*{{cite journal  | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
*{{cite journal  | author=Yustein JT, Xia L, Kahlenburg JM, ''et al.'' |title=Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38. |journal=Oncogene |volume=22 |issue= 40 |pages= 6129-41 |year= 2003 |pmid= 13679851 |doi= 10.1038/sj.onc.1206605 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Huangfu WC, Omori E, Akira S, ''et al.'' |title=Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways. |journal=J. Biol. Chem. |volume=281 |issue= 39 |pages= 28802-10 |year= 2006 |pmid= 16893890 |doi= 10.1074/jbc.M603627200 }}
*{{cite journal  | author=Zihni C, Mitsopoulos C, Tavares IA, ''et al.'' |title=Prostate-derived sterile 20-like kinase 1-alpha induces apoptosis. JNK- and caspase-dependent nuclear localization is a requirement for membrane blebbing. |journal=J. Biol. Chem. |volume=282 |issue= 9 |pages= 6484-93 |year= 2007 |pmid= 17158878 |doi= 10.1074/jbc.M608336200 }}
}}
{{refend}}


{{protein-stub}}
== Further reading ==
{{WikiDoc Sources}}
{{Refbegin | 2}}
* {{cite journal | vauthors = Chen Z, Hutchison M, Cobb MH | title = Isolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domain | journal = J. Biol. Chem. | volume = 274 | issue = 40 | pages = 28803–7 | year = 1999 | pmid = 10497253 | doi = 10.1074/jbc.274.40.28803 }}
* {{cite journal | vauthors = Moore TM, Garg R, Johnson C, Coptcoat MJ, Ridley AJ, Morris JD | title = PSK, a novel STE20-like kinase derived from prostatic carcinoma that activates the c-Jun N-terminal kinase mitogen-activated protein kinase pathway and regulates actin cytoskeletal organization | journal = J. Biol. Chem. | volume = 275 | issue = 6 | pages = 4311–22 | year = 2000 | pmid = 10660600 | doi = 10.1074/jbc.275.6.4311 }}
* {{cite journal | vauthors = Chen Z, Cobb MH | title = Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2 | journal = J. Biol. Chem. | volume = 276 | issue = 19 | pages = 16070–5 | year = 2001 | pmid = 11279118 | doi = 10.1074/jbc.M100681200 }}
* {{cite journal | vauthors = Nakayama M, Kikuno R, Ohara O | title = Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs | journal = Genome Res. | volume = 12 | issue = 11 | pages = 1773–84 | year = 2002 | pmid = 12421765 | pmc = 187542 | doi = 10.1101/gr.406902 }}
* {{cite journal | vauthors = Mitsopoulos C, Zihni C, Garg R, Ridley AJ, Morris JD | title = The prostate-derived sterile 20-like kinase (PSK) regulates microtubule organization and stability | journal = J. Biol. Chem. | volume = 278 | issue = 20 | pages = 18085–91 | year = 2003 | pmid = 12639963 | doi = 10.1074/jbc.M213064200 }}
* {{cite journal | vauthors = Chen Z, Raman M, Chen L, Lee SF, Gilman AG, Cobb MH | title = TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors | journal = J. Biol. Chem. | volume = 278 | issue = 25 | pages = 22278–83 | year = 2003 | pmid = 12665513 | doi = 10.1074/jbc.M301173200 }}
* {{cite journal | vauthors = Yustein JT, Xia L, Kahlenburg JM, Robinson D, Templeton D, Kung HJ | title = Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38 | journal = Oncogene | volume = 22 | issue = 40 | pages = 6129–41 | year = 2003 | pmid = 13679851 | doi = 10.1038/sj.onc.1206605 }}
* {{cite journal | vauthors = Huangfu WC, Omori E, Akira S, Matsumoto K, Ninomiya-Tsuji J | title = Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways | journal = J. Biol. Chem. | volume = 281 | issue = 39 | pages = 28802–10 | year = 2006 | pmid = 16893890 | pmc = 1797068 | doi = 10.1074/jbc.M603627200 }}
* {{cite journal | vauthors = Zihni C, Mitsopoulos C, Tavares IA, Baum B, Ridley AJ, Morris JD | title = Prostate-derived sterile 20-like kinase 1-alpha induces apoptosis. JNK- and caspase-dependent nuclear localization is a requirement for membrane blebbing | journal = J. Biol. Chem. | volume = 282 | issue = 9 | pages = 6484–93 | year = 2007 | pmid = 17158878 | doi = 10.1074/jbc.M608336200 }}
{{Refend}}
 
{{PDB Gallery|geneid=9344}}
 
 
{{Gene-16-stub}}

Revision as of 02:31, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Serine/threonine-protein kinase TAO2 is an enzyme that in humans is encoded by the TAOK2 gene.[1][2][3]

Interactions

TAOK2 has been shown to interact with MAP2K6[4] and MAP2K3.[4]

References

  1. ↑ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485. Check date values in: |year= / |date= mismatch (help)
  2. ↑ Hutchison M, Berman KS, Cobb MH (Dec 1998). "Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades". J. Biol. Chem. 273 (44): 28625–32. doi:10.1074/jbc.273.44.28625. PMID 9786855.
  3. ↑ "Entrez Gene: TAOK2 TAO kinase 2".
  4. ↑ 4.0 4.1 Chen Z, Cobb MH (May 2001). "Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2". J. Biol. Chem. 276 (19): 16070–5. doi:10.1074/jbc.M100681200. PMID 11279118.

Further reading


Retrieved from "https://www.wikidoc.org/index.php?title=TAOK2&oldid=1417435"