TCF7: Difference between revisions

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Revision as of 11:41, 15 September 2017

Transcription factor 7 is a protein that in humans is encoded by the TCF7 gene.^[1]

References

↑ "Entrez Gene: TCF7 transcription factor 7 (T-cell specific, HMG-box)".

van de Wetering M, Oosterwegel M, Holstege F, et al. (1992). "The human T cell transcription factor-1 gene. Structure, localization, and promoter characterization". J. Biol. Chem. 267 (12): 8530–6. PMID 1569101.
van de Wetering M, Oosterwegel M, Dooijes D, Clevers H (1991). "Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box". EMBO J. 10 (1): 123–32. PMC 452620. PMID 1989880.
Castrop J, van Wichen D, Koomans-Bitter M, et al. (1995). "The human TCF-1 gene encodes a nuclear DNA-binding protein uniquely expressed in normal and neoplastic T-lineage lymphocytes". Blood. 86 (8): 3050–9. PMID 7579399.
Mayer K, Wolff E, Clevers H, Ballhausen WG (1995). "The human high mobility group (HMG)-box transcription factor TCF-1: novel isoforms due to alternative splicing and usage of a new exon IXA". Biochim. Biophys. Acta. 1263 (2): 169–72. doi:10.1016/0167-4781(95)00108-s. PMID 7640309.
Van de Wetering M, Castrop J, Korinek V, Clevers H (1996). "Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control properties". Mol. Cell. Biol. 16 (3): 745–52. PMC 231054. PMID 8622675.
Korinek V, Barker N, Willert K, et al. (1998). "Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse". Mol. Cell. Biol. 18 (3): 1248–56. PMC 108837. PMID 9488439.
Roose J, Molenaar M, Peterson J, et al. (1998). "The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors". Nature. 395 (6702): 608–12. doi:10.1038/26989. PMID 9783587.
Roose J, Huls G, van Beest M, et al. (1999). "Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1". Science. 285 (5435): 1923–6. doi:10.1126/science.285.5435.1923. PMID 10489374.
Brantjes H, Roose J, van De Wetering M, Clevers H (2001). "All Tcf HMG box transcription factors interact with Groucho-related co-repressors". Nucleic Acids Res. 29 (7): 1410–9. doi:10.1093/nar/29.7.1410. PMC 31284. PMID 11266540.
Batlle E, Henderson JT, Beghtel H, et al. (2002). "Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB". Cell. 111 (2): 251–63. doi:10.1016/S0092-8674(02)01015-2. PMID 12408869.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Noble JA, White AM, Lazzeroni LC, et al. (2003). "A polymorphism in the TCF7 gene, C883A, is associated with type 1 diabetes". Diabetes. 52 (6): 1579–82. doi:10.2337/diabetes.52.6.1579. PMID 12765974.
Ioannidis V, Kunz B, Tanamachi DM, et al. (2003). "Initiation and limitation of Ly-49A NK cell receptor acquisition by T cell factor-1". J. Immunol. 171 (2): 769–75. doi:10.4049/jimmunol.171.2.769. PMID 12847244.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Smit L, Baas A, Kuipers J, et al. (2004). "Wnt activates the Tak1/Nemo-like kinase pathway". J. Biol. Chem. 279 (17): 17232–40. doi:10.1074/jbc.M307801200. PMID 14960582.
Smith SS, Patterson T, Pauza ME (2005). "Transgenic Ly-49A inhibits antigen-driven T cell activation and delays diabetes". J. Immunol. 174 (7): 3897–905. doi:10.4049/jimmunol.174.7.3897. PMID 15778344.
Willinger T, Freeman T, Herbert M, et al. (2006). "Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo". J. Immunol. 176 (3): 1439–46. doi:10.4049/jimmunol.176.3.1439. PMID 16424171.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

[entrez-1] "Entrez Gene: TCF7 transcription factor 7 (T-cell specific, HMG-box)".

[1]

@@ Line 1: / Line 1: @@
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+{{Underlinked|date=June 2016}}
-{{PBB_Controls
+{{Infobox_gene}}
-| update_page = yes
+'''Transcription factor 7''' is a [[protein]] that in humans is encoded by the ''TCF7'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TCF7 transcription factor 7 (T-cell specific, HMG-box)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6932| accessdate = }}</ref>
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-{{GNF_Protein_box
- | image = PBB_Protein_TCF7_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 2lef.
- | PDB = {{PDB2|2lef}}
- | Name = Transcription factor 7 (T-cell specific, HMG-box)
- | HGNCid = 11639
- | Symbol = TCF7
- | AltSymbols =; MGC47735; TCF-1
- | OMIM = 189908
- | ECnumber =
- | Homologene = 2410
- | MGIid = 98507
- | GeneAtlas_image1 = PBB_GE_TCF7_205254_x_at_tn.png
- | GeneAtlas_image2 = PBB_GE_TCF7_205255_x_at_tn.png
- | Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}}
- | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
- | Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0016055 |text = Wnt receptor signaling pathway}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 6932
-    | Hs_Ensembl = ENSG00000081059
-    | Hs_RefseqProtein = NP_003193
-    | Hs_RefseqmRNA = NM_003202
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 5
-    | Hs_GenLoc_start = 133478301
-    | Hs_GenLoc_end = 133511826
-    | Hs_Uniprot = P36402
-    | Mm_EntrezGene = 21414
-    | Mm_Ensembl = ENSMUSG00000000782
-    | Mm_RefseqmRNA = NM_009331
-    | Mm_RefseqProtein = NP_033357
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 11
-    | Mm_GenLoc_start = 52096027
-    | Mm_GenLoc_end = 52126602
-    | Mm_Uniprot = Q80UF1
-  }}
-}}
-'''Transcription factor 7 (T-cell specific, HMG-box)''', also known as '''TCF7''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TCF7 transcription factor 7 (T-cell specific, HMG-box)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6932| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
@@ Line 56: / Line 10: @@
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=van de Wetering M, Oosterwegel M, Holstege F, ''et al.'' |title=The human T cell transcription factor-1 gene. Structure, localization, and promoter characterization. |journal=J. Biol. Chem. |volume=267 |issue= 12 |pages= 8530-6 |year= 1992 |pmid= 1569101 |doi=  }}
+*{{cite journal   |vauthors=van de Wetering M, Oosterwegel M, Holstege F, etal |title=The human T cell transcription factor-1 gene. Structure, localization, and promoter characterization. |journal=J. Biol. Chem. |volume=267 |issue= 12 |pages= 8530–6 |year= 1992 |pmid= 1569101 |doi=  }}
-*{{cite journal  | author=van de Wetering M, Oosterwegel M, Dooijes D, Clevers H |title=Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box. |journal=EMBO J. |volume=10 |issue= 1 |pages= 123-32 |year= 1991 |pmid= 1989880 |doi=  }}
+*{{cite journal  | vauthors=van de Wetering M, Oosterwegel M, Dooijes D, Clevers H |title=Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box. |journal=EMBO J. |volume=10 |issue= 1 |pages= 123–32 |year= 1991 |pmid= 1989880 |doi=  | pmc=452620  }}
-*{{cite journal  | author=Castrop J, van Wichen D, Koomans-Bitter M, ''et al.'' |title=The human TCF-1 gene encodes a nuclear DNA-binding protein uniquely expressed in normal and neoplastic T-lineage lymphocytes. |journal=Blood |volume=86 |issue= 8 |pages= 3050-9 |year= 1995 |pmid= 7579399 |doi=  }}
+*{{cite journal   |vauthors=Castrop J, van Wichen D, Koomans-Bitter M, etal |title=The human TCF-1 gene encodes a nuclear DNA-binding protein uniquely expressed in normal and neoplastic T-lineage lymphocytes. |journal=Blood |volume=86 |issue= 8 |pages= 3050–9 |year= 1995 |pmid= 7579399 |doi=  }}
-*{{cite journal  | author=Mayer K, Wolff E, Clevers H, Ballhausen WG |title=The human high mobility group (HMG)-box transcription factor TCF-1: novel isoforms due to alternative splicing and usage of a new exon IXA. |journal=Biochim. Biophys. Acta |volume=1263 |issue= 2 |pages= 169-72 |year= 1995 |pmid= 7640309 |doi=  }}
+*{{cite journal  | vauthors=Mayer K, Wolff E, Clevers H, Ballhausen WG |title=The human high mobility group (HMG)-box transcription factor TCF-1: novel isoforms due to alternative splicing and usage of a new exon IXA. |journal=Biochim. Biophys. Acta |volume=1263 |issue= 2 |pages= 169–72 |year= 1995 |pmid= 7640309 |doi=  10.1016/0167-4781(95)00108-s}}
-*{{cite journal  | author=Van de Wetering M, Castrop J, Korinek V, Clevers H |title=Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control properties. |journal=Mol. Cell. Biol. |volume=16 |issue= 3 |pages= 745-52 |year= 1996 |pmid= 8622675 |doi=  }}
+*{{cite journal  | vauthors=Van de Wetering M, Castrop J, Korinek V, Clevers H |title=Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control properties. |journal=Mol. Cell. Biol. |volume=16 |issue= 3 |pages= 745–52 |year= 1996 |pmid= 8622675 |doi=  | pmc=231054  }}
-*{{cite journal  | author=Korinek V, Barker N, Willert K, ''et al.'' |title=Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse. |journal=Mol. Cell. Biol. |volume=18 |issue= 3 |pages= 1248-56 |year= 1998 |pmid= 9488439 |doi=  }}
+*{{cite journal   |vauthors=Korinek V, Barker N, Willert K, etal |title=Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse. |journal=Mol. Cell. Biol. |volume=18 |issue= 3 |pages= 1248–56 |year= 1998 |pmid= 9488439 |doi=  | pmc=108837  }}
-*{{cite journal  | author=Roose J, Molenaar M, Peterson J, ''et al.'' |title=The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors. |journal=Nature |volume=395 |issue= 6702 |pages= 608-12 |year= 1998 |pmid= 9783587 |doi= 10.1038/26989 }}
+*{{cite journal   |vauthors=Roose J, Molenaar M, Peterson J, etal |title=The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors. |journal=Nature |volume=395 |issue= 6702 |pages= 608–12 |year= 1998 |pmid= 9783587 |doi= 10.1038/26989 }}
-*{{cite journal  | author=Roose J, Huls G, van Beest M, ''et al.'' |title=Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1. |journal=Science |volume=285 |issue= 5435 |pages= 1923-6 |year= 1999 |pmid= 10489374 |doi=  }}
+*{{cite journal   |vauthors=Roose J, Huls G, van Beest M, etal |title=Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1. |journal=Science |volume=285 |issue= 5435 |pages= 1923–6 |year= 1999 |pmid= 10489374 |doi=10.1126/science.285.5435.1923  }}
-*{{cite journal  | author=Brantjes H, Roose J, van De Wetering M, Clevers H |title=All Tcf HMG box transcription factors interact with Groucho-related co-repressors. |journal=Nucleic Acids Res. |volume=29 |issue= 7 |pages= 1410-9 |year= 2001 |pmid= 11266540 |doi=  }}
+*{{cite journal  | vauthors=Brantjes H, Roose J, van De Wetering M, Clevers H |title=All Tcf HMG box transcription factors interact with Groucho-related co-repressors. |journal=Nucleic Acids Res. |volume=29 |issue= 7 |pages= 1410–9 |year= 2001 |pmid= 11266540 |doi=10.1093/nar/29.7.1410  | pmc=31284  }}
-*{{cite journal  | author=Batlle E, Henderson JT, Beghtel H, ''et al.'' |title=Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB. |journal=Cell |volume=111 |issue= 2 |pages= 251-63 |year= 2002 |pmid= 12408869 |doi=  }}
+*{{cite journal   |vauthors=Batlle E, Henderson JT, Beghtel H, etal |title=Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB. |journal=Cell |volume=111 |issue= 2 |pages= 251–63 |year= 2002 |pmid= 12408869 |doi=10.1016/S0092-8674(02)01015-2  }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Noble JA, White AM, Lazzeroni LC, ''et al.'' |title=A polymorphism in the TCF7 gene, C883A, is associated with type 1 diabetes. |journal=Diabetes |volume=52 |issue= 6 |pages= 1579-82 |year= 2003 |pmid= 12765974 |doi=  }}
+*{{cite journal   |vauthors=Noble JA, White AM, Lazzeroni LC, etal |title=A polymorphism in the TCF7 gene, C883A, is associated with type 1 diabetes. |journal=Diabetes |volume=52 |issue= 6 |pages= 1579–82 |year= 2003 |pmid= 12765974 |doi=10.2337/diabetes.52.6.1579  }}
-*{{cite journal  | author=Ioannidis V, Kunz B, Tanamachi DM, ''et al.'' |title=Initiation and limitation of Ly-49A NK cell receptor acquisition by T cell factor-1. |journal=J. Immunol. |volume=171 |issue= 2 |pages= 769-75 |year= 2003 |pmid= 12847244 |doi=  }}
+*{{cite journal   |vauthors=Ioannidis V, Kunz B, Tanamachi DM, etal |title=Initiation and limitation of Ly-49A NK cell receptor acquisition by T cell factor-1. |journal=J. Immunol. |volume=171 |issue= 2 |pages= 769–75 |year= 2003 |pmid= 12847244 |doi=  10.4049/jimmunol.171.2.769}}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
-*{{cite journal  | author=Smit L, Baas A, Kuipers J, ''et al.'' |title=Wnt activates the Tak1/Nemo-like kinase pathway. |journal=J. Biol. Chem. |volume=279 |issue= 17 |pages= 17232-40 |year= 2004 |pmid= 14960582 |doi= 10.1074/jbc.M307801200 }}
+*{{cite journal   |vauthors=Smit L, Baas A, Kuipers J, etal |title=Wnt activates the Tak1/Nemo-like kinase pathway. |journal=J. Biol. Chem. |volume=279 |issue= 17 |pages= 17232–40 |year= 2004 |pmid= 14960582 |doi= 10.1074/jbc.M307801200 }}
-*{{cite journal  | author=Smith SS, Patterson T, Pauza ME |title=Transgenic Ly-49A inhibits antigen-driven T cell activation and delays diabetes. |journal=J. Immunol. |volume=174 |issue= 7 |pages= 3897-905 |year= 2005 |pmid= 15778344 |doi=  }}
+*{{cite journal  | vauthors=Smith SS, Patterson T, Pauza ME |title=Transgenic Ly-49A inhibits antigen-driven T cell activation and delays diabetes. |journal=J. Immunol. |volume=174 |issue= 7 |pages= 3897–905 |year= 2005 |pmid= 15778344 |doi=  10.4049/jimmunol.174.7.3897}}
-*{{cite journal  | author=Willinger T, Freeman T, Herbert M, ''et al.'' |title=Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo. |journal=J. Immunol. |volume=176 |issue= 3 |pages= 1439-46 |year= 2006 |pmid= 16424171 |doi=  }}
+*{{cite journal   |vauthors=Willinger T, Freeman T, Herbert M, etal |title=Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo. |journal=J. Immunol. |volume=176 |issue= 3 |pages= 1439–46 |year= 2006 |pmid= 16424171 |doi=  10.4049/jimmunol.176.3.1439}}
 }}
 {{refend}}
+{{PDB Gallery|geneid=6932}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
-{{protein-stub}}
+{{gene-5-stub}}
-{{WikiDoc Sources}}

TCF7: Difference between revisions

Revision as of 11:41, 15 September 2017

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