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{{Infobox_gene}}
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'''Bax inhibitor 1''' is a [[protein]] that in humans is encoded by the ''TMBIM6'' [[gene]].<ref name="pmid8530040">{{cite journal | vauthors = Walter L, Marynen P, Szpirer J, Levan G, Gunther E | title = Identification of a novel conserved human gene, TEGT | journal = Genomics | volume = 28 | issue = 2 | pages = 301–4 |date=Feb 1996 | pmid = 8530040 | pmc =  | doi = 10.1006/geno.1995.1145 }}</ref><ref name="pmid9660918">{{cite journal | vauthors = Xu Q, Reed JC | title = Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast | journal = Mol Cell | volume = 1 | issue = 3 | pages = 337–46 |date=Jul 1998 | pmid = 9660918 | pmc =  | doi =10.1016/S1097-2765(00)80034-9 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TEGT testis enhanced gene transcript (BAX inhibitor 1)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7009| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Testis enhanced gene transcript (BAX inhibitor 1)
| HGNCid = 11723
| Symbol = TEGT
| AltSymbols =; BI-1; TMBIM6
| OMIM = 600748
| ECnumber =
| Homologene = 2419
| MGIid = 99682
  | GeneAtlas_image1 = PBB_GE_TEGT_200804_at_tn.png
| GeneAtlas_image2 = PBB_GE_TEGT_200803_s_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0005626 |text = insoluble fraction}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0043066 |text = negative regulation of apoptosis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7009
    | Hs_Ensembl = ENSG00000139644
    | Hs_RefseqProtein = NP_003208
    | Hs_RefseqmRNA = NM_003217
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 48421607
    | Hs_GenLoc_end = 48444984
    | Hs_Uniprot = P55061
    | Mm_EntrezGene = 110213
    | Mm_Ensembl = ENSMUSG00000023010
    | Mm_RefseqmRNA = NM_026669
    | Mm_RefseqProtein = NP_080945
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 99229642
    | Mm_GenLoc_end = 99235377
    | Mm_Uniprot = Q4KKX5
  }}
}}
'''Testis enhanced gene transcript (BAX inhibitor 1)''', also known as '''TEGT''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TEGT testis enhanced gene transcript (BAX inhibitor 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7009| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
*{{cite journal  | author=Walter L, Marynen P, Szpirer J, ''et al.'' |title=Identification of a novel conserved human gene, TEGT. |journal=Genomics |volume=28 |issue= 2 |pages= 301-4 |year= 1996 |pmid= 8530040 |doi= 10.1006/geno.1995.1145 }}
*{{cite journal   |vauthors=Hillier LD, Lennon G, Becker M, etal |title=Generation and analysis of 280,000 human expressed sequence tags |journal=Genome Res. |volume=6 |issue= 9 |pages= 807–28 |year= 1997 |pmid= 8889549 |doi=10.1101/gr.6.9.807 }}
*{{cite journal | author=Hillier LD, Lennon G, Becker M, ''et al.'' |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807-28 |year= 1997 |pmid= 8889549 |doi=  }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal  | vauthors=Cowling RT, Birnboim HC |title=Preliminary characterization of the protein encoded by human testis-enhanced gene transcript (TEGT) |journal=Mol. Membr. Biol. |volume=15 |issue= 4 |pages= 177–87 |year= 1999 |pmid= 10087504 |doi=10.3109/09687689709044319 }}
*{{cite journal  | author=Xu Q, Reed JC |title=Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast. |journal=Mol. Cell |volume=1 |issue= 3 |pages= 337-46 |year= 1998 |pmid= 9660918 |doi= }}
*{{cite journal  | vauthors=Jean JC, Oakes SM, Joyce-Brady M |title=The Bax inhibitor-1 gene is differentially regulated in adult testis and developing lung by two alternative TATA-less promoters |journal=Genomics |volume=57 |issue= 2 |pages= 201–8 |year= 1999 |pmid= 10198159 |doi= 10.1006/geno.1999.5761 }}
*{{cite journal  | author=Cowling RT, Birnboim HC |title=Preliminary characterization of the protein encoded by human testis-enhanced gene transcript (TEGT). |journal=Mol. Membr. Biol. |volume=15 |issue= 4 |pages= 177-87 |year= 1999 |pmid= 10087504 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Jean JC, Oakes SM, Joyce-Brady M |title=The Bax inhibitor-1 gene is differentially regulated in adult testis and developing lung by two alternative TATA-less promoters. |journal=Genomics |volume=57 |issue= 2 |pages= 201-8 |year= 1999 |pmid= 10198159 |doi= 10.1006/geno.1999.5761 }}
*{{cite journal   |vauthors=Grzmil M, Thelen P, Hemmerlein B, etal |title=Bax inhibitor-1 is overexpressed in prostate cancer and its specific down-regulation by RNA interference leads to cell death in human prostate carcinoma cells |journal=Am. J. Pathol. |volume=163 |issue= 2 |pages= 543–52 |year= 2003 |pmid= 12875974 |doi= 10.1016/S0002-9440(10)63682-6| pmc=1868227 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Grzmil M, Thelen P, Hemmerlein B, ''et al.'' |title=Bax inhibitor-1 is overexpressed in prostate cancer and its specific down-regulation by RNA interference leads to cell death in human prostate carcinoma cells. |journal=Am. J. Pathol. |volume=163 |issue= 2 |pages= 543-52 |year= 2003 |pmid= 12875974 |doi=  }}
*{{cite journal   |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Tanaka R, Ishiyama T, Uchihara T, etal |title=Expression of the Bax inhibitor-1 gene in pulmonary adenocarcinoma |journal=Cancer |volume=106 |issue= 3 |pages= 648–53 |year= 2006 |pmid= 16353209 |doi= 10.1002/cncr.21639 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal   |vauthors=Lee GH, Kim HK, Chae SW, etal |title=Bax inhibitor-1 regulates endoplasmic reticulum stress-associated reactive oxygen species and heme oxygenase-1 expression |journal=J. Biol. Chem. |volume=282 |issue= 30 |pages= 21618–28 |year= 2007 |pmid= 17526500 |doi= 10.1074/jbc.M700053200 }}
*{{cite journal | author=Tanaka R, Ishiyama T, Uchihara T, ''et al.'' |title=Expression of the Bax inhibitor-1 gene in pulmonary adenocarcinoma. |journal=Cancer |volume=106 |issue= 3 |pages= 648-53 |year= 2006 |pmid= 16353209 |doi= 10.1002/cncr.21639 }}
*{{cite journal | author=Lee GH, Kim HK, Chae SW, ''et al.'' |title=Bax inhibitor-1 regulates endoplasmic reticulum stress-associated reactive oxygen species and heme oxygenase-1 expression. |journal=J. Biol. Chem. |volume=282 |issue= 30 |pages= 21618-28 |year= 2007 |pmid= 17526500 |doi= 10.1074/jbc.M700053200 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 11:45, 15 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Bax inhibitor 1 is a protein that in humans is encoded by the TMBIM6 gene.[1][2][3]


References

  1. ↑ Walter L, Marynen P, Szpirer J, Levan G, Gunther E (Feb 1996). "Identification of a novel conserved human gene, TEGT". Genomics. 28 (2): 301–4. doi:10.1006/geno.1995.1145. PMID 8530040.
  2. ↑ Xu Q, Reed JC (Jul 1998). "Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast". Mol Cell. 1 (3): 337–46. doi:10.1016/S1097-2765(00)80034-9. PMID 9660918.
  3. ↑ "Entrez Gene: TEGT testis enhanced gene transcript (BAX inhibitor 1)".

Further reading



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