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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Telomerase protein component 1''' is an [[enzyme]] that in humans is encoded by the ''TEP1'' [[gene]].<ref name="pmid9403057">{{cite journal | vauthors = Saito T, Matsuda Y, Suzuki T, Hayashi A, Yuan X, Saito M, Nakayama J, Hori T, Ishikawa F | title = Comparative gene mapping of the human and mouse TEP1 genes, which encode one protein component of telomerases | journal = Genomics | volume = 46 | issue = 1 | pages = 46–50 | date = November 1997 | pmid = 9403057 | pmc =  | doi = 10.1006/geno.1997.5005 }}</ref><ref name="entrez">{{cite web |title=Entrez Gene: TEP1 telomerase-associated protein 1|url=https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7011|accessdate=}}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Telomerase-associated protein 1
| HGNCid = 11726
| Symbol = TEP1
| AltSymbols =; TLP1; TP1; TROVE1; VAULT2; p240
| OMIM = 601686
| ECnumber = 
| Homologene = 5157
| MGIid = 109573
| GeneAtlas_image1 = PBB_GE_TEP1_205727_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003720 |text = telomerase activity}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}}
| Component = {{GNF_GO|id=GO:0000781 |text = chromosome, telomeric region}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005694 |text = chromosome}} {{GNF_GO|id=GO:0005697 |text = telomerase holoenzyme complex}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0016363 |text = nuclear matrix}}
| Process = {{GNF_GO|id=GO:0000722 |text = telomere maintenance via recombination}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7011
    | Hs_Ensembl = ENSG00000129566
    | Hs_RefseqProtein = NP_009041
    | Hs_RefseqmRNA = NM_007110
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 14
    | Hs_GenLoc_start = 19905755
    | Hs_GenLoc_end = 19951426
    | Hs_Uniprot = Q99973
    | Mm_EntrezGene = 21745
    | Mm_Ensembl = ENSMUSG00000006281
    | Mm_RefseqmRNA = XM_985651
    | Mm_RefseqProtein = XP_990745
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 49746013
    | Mm_GenLoc_end = 49792511
    | Mm_Uniprot = Q3UZN7
  }}
}}
'''Telomerase-associated protein 1''', also known as '''TEP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TEP1 telomerase-associated protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7011| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene product is a component of the [[ribonucleoprotein]] complex responsible for [[telomerase]] activity which catalyzes the addition of new [[telomeres]] on the chromosome ends. The telomerase-associated proteins are conserved from [[ciliates]] to humans.<ref name="entrez" /> It is also a minor vault protein.
{{PBB_Summary
| section_title =
| summary_text = This gene product is a component of the ribonucleoprotein complex responsible for telomerase activity which catalyzes the addition of new telomeres on the chromosome ends. The telomerase-associated proteins are conserved from ciliates to humans.<ref name="entrez">{{cite web | title = Entrez Gene: TEP1 telomerase-associated protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7011| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
{{refbegin | 2}}
== Further reading ==
{{PBB_Further_reading
{{refbegin |2}}
| citations =
* {{cite journal | vauthors = Joly EC, Tremblay E, Tanguay RM, Wu Y, Bibor-Hardy V | title = TRiC-P5, a novel TCP1-related protein, is localized in the cytoplasm and in the nuclear matrix | journal = Journal of Cell Science | volume = 107 ( Pt 10) | issue = 10 | pages = 2851–9 | date = October 1994 | pmid = 7876352 | doi =  }}
*{{cite journal | author=Joly EC, Tremblay E, Tanguay RM, ''et al.'' |title=TRiC-P5, a novel TCP1-related protein, is localized in the cytoplasm and in the nuclear matrix. |journal=J. Cell. Sci. |volume=107 ( Pt 10) |issue= |pages= 2851-9 |year= 1995 |pmid= 7876352 |doi=  }}
* {{cite journal | vauthors = Harrington L, McPhail T, Mar V, Zhou W, Oulton R, Bass MB, Arruda I, Robinson MO | title = A mammalian telomerase-associated protein | journal = Science | volume = 275 | issue = 5302 | pages = 973–7 | date = February 1997 | pmid = 9020079 | doi = 10.1126/science.275.5302.973 }}
*{{cite journal | author=Harrington L, McPhail T, Mar V, ''et al.'' |title=A mammalian telomerase-associated protein. |journal=Science |volume=275 |issue= 5302 |pages= 973-7 |year= 1997 |pmid= 9020079 |doi= }}
* {{cite journal | vauthors = Harrington L, Zhou W, McPhail T, Oulton R, Yeung DS, Mar V, Bass MB, Robinson MO | title = Human telomerase contains evolutionarily conserved catalytic and structural subunits | journal = Genes & Development | volume = 11 | issue = 23 | pages = 3109–15 | date = December 1997 | pmid = 9389643 | pmc = 316744 | doi = 10.1101/gad.11.23.3109 }}
*{{cite journal | author=Harrington L, Zhou W, McPhail T, ''et al.'' |title=Human telomerase contains evolutionarily conserved catalytic and structural subunits. |journal=Genes Dev. |volume=11 |issue= 23 |pages= 3109-15 |year= 1998 |pmid= 9389643 |doi= }}
* {{cite journal | vauthors = Li H, Zhao L, Yang Z, Funder JW, Liu JP | title = Telomerase is controlled by protein kinase Calpha in human breast cancer cells | journal = The Journal of Biological Chemistry | volume = 273 | issue = 50 | pages = 33436–42 | date = December 1998 | pmid = 9837921 | doi = 10.1074/jbc.273.50.33436 }}
*{{cite journal  | author=Saito T, Matsuda Y, Suzuki T, ''et al.'' |title=Comparative gene mapping of the human and mouse TEP1 genes, which encode one protein component of telomerases. |journal=Genomics |volume=46 |issue= 1 |pages= 46-50 |year= 1998 |pmid= 9403057 |doi=  }}
* {{cite journal | vauthors = Kickhoefer VA, Stephen AG, Harrington L, Robinson MO, Rome LH | title = Vaults and telomerase share a common subunit, TEP1 | journal = The Journal of Biological Chemistry | volume = 274 | issue = 46 | pages = 32712–7 | date = November 1999 | pmid = 10551828 | doi = 10.1074/jbc.274.46.32712 }}
*{{cite journal | author=Li H, Zhao L, Yang Z, ''et al.'' |title=Telomerase is controlled by protein kinase Calpha in human breast cancer cells. |journal=J. Biol. Chem. |volume=273 |issue= 50 |pages= 33436-42 |year= 1999 |pmid= 9837921 |doi= }}
* {{cite journal | vauthors = Li H, Cao Y, Berndt MC, Funder JW, Liu JP | title = Molecular interactions between telomerase and the tumor suppressor protein p53 in vitro | journal = Oncogene | volume = 18 | issue = 48 | pages = 6785–94 | date = November 1999 | pmid = 10597287 | doi = 10.1038/sj.onc.1203061 }}
*{{cite journal | author=Kickhoefer VA, Stephen AG, Harrington L, ''et al.'' |title=Vaults and telomerase share a common subunit, TEP1. |journal=J. Biol. Chem. |volume=274 |issue= 46 |pages= 32712-7 |year= 2000 |pmid= 10551828 |doi= }}
* {{cite journal | vauthors = Koyanagi Y, Kobayashi D, Yajima T, Asanuma K, Kimura T, Sato T, Kida T, Yagihashi A, Kameshima H, Watanabe N | title = Telomerase activity is down regulated via decreases in hTERT mRNA but not TEP1 mRNA or hTERC during the differentiation of leukemic cells | journal = Anticancer Research | volume = 20 | issue = 2A | pages = 773–8 | year = 2000 | pmid = 10810353 | doi =  }}
*{{cite journal | author=Li H, Cao Y, Berndt MC, ''et al.'' |title=Molecular interactions between telomerase and the tumor suppressor protein p53 in vitro. |journal=Oncogene |volume=18 |issue= 48 |pages= 6785-94 |year= 2000 |pmid= 10597287 |doi= 10.1038/sj.onc.1203061 }}
* {{cite journal | vauthors = Beattie TL, Zhou W, Robinson MO, Harrington L | title = Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding | journal = Molecular Biology of the Cell | volume = 11 | issue = 10 | pages = 3329–40 | date = October 2000 | pmid = 11029039 | pmc = 14995 | doi = 10.1091/mbc.11.10.3329 }}
*{{cite journal | author=Koyanagi Y, Kobayashi D, Yajima T, ''et al.'' |title=Telomerase activity is down regulated via decreases in hTERT mRNA but not TEP1 mRNA or hTERC during the differentiation of leukemic cells. |journal=Anticancer Res. |volume=20 |issue= 2A |pages= 773-8 |year= 2000 |pmid= 10810353 |doi=  }}
* {{cite journal | vauthors = Zhang RG, Zhang RP, Wang XW, Xie H | title = Effects of cisplatin on telomerase activity and telomere length in BEL-7404 human hepatoma cells | journal = Cell Research | volume = 12 | issue = 1 | pages = 55–62 | date = March 2002 | pmid = 11942411 | doi = 10.1038/sj.cr.7290110 }}
*{{cite journal | author=Beattie TL, Zhou W, Robinson MO, Harrington L |title=Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding. |journal=Mol. Biol. Cell |volume=11 |issue= 10 |pages= 3329-40 |year= 2000 |pmid= 11029039 |doi= }}
* {{cite journal | vauthors = Chang JT, Chen YL, Yang HT, Chen CY, Cheng AJ | title = Differential regulation of telomerase activity by six telomerase subunits | journal = European Journal of Biochemistry | volume = 269 | issue = 14 | pages = 3442–50 | date = July 2002 | pmid = 12135483 | doi = 10.1046/j.1432-1033.2002.03025.x }}
*{{cite journal | author=Zhang RG, Zhang RP, Wang XW, Xie H |title=Effects of cisplatin on telomerase activity and telomere length in BEL-7404 human hepatoma cells. |journal=Cell Res. |volume=12 |issue= 1 |pages= 55-62 |year= 2004 |pmid= 11942411 |doi= 10.1038/sj.cr.7290110 }}
* {{cite journal | vauthors = Zhou JH, Zhang HM, Chen Q, Han DD, Pei F, Zhang LS, Yang DT | title = Relationship between telomerase activity and its subunit expression and inhibitory effect of antisense hTR on pancreatic carcinoma | journal = World Journal of Gastroenterology | volume = 9 | issue = 8 | pages = 1808–14 | date = August 2003 | pmid = 12918126 | doi =  }}
*{{cite journal | author=Chang JT, Chen YL, Yang HT, ''et al.'' |title=Differential regulation of telomerase activity by six telomerase subunits. |journal=Eur. J. Biochem. |volume=269 |issue= 14 |pages= 3442-50 |year= 2002 |pmid= 12135483 |doi= }}
* {{cite journal | vauthors = Li C, Wu MY, Liang YR, Wu XY | title = Correlation between expression of human telomerase subunits and telomerase activity in esophageal squamous cell carcinoma | journal = World Journal of Gastroenterology | volume = 9 | issue = 11 | pages = 2395–9 | date = November 2003 | pmid = 14606063 | doi =  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY | title = A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration | journal = Cell | volume = 125 | issue = 4 | pages = 801–14 | date = May 2006 | pmid = 16713569 | doi = 10.1016/j.cell.2006.03.032 }}
*{{cite journal | author=Zhou JH, Zhang HM, Chen Q, ''et al.'' |title=Relationship between telomerase activity and its subunit expression and inhibitory effect of antisense hTR on pancreatic carcinoma. |journal=World J. Gastroenterol. |volume=9 |issue= 8 |pages= 1808-14 |year= 2003 |pmid= 12918126 |doi=  }}
*{{cite journal | author=Li C, Wu MY, Liang YR, Wu XY |title=Correlation between expression of human telomerase subunits and telomerase activity in esophageal squamous cell carcinoma. |journal=World J. Gastroenterol. |volume=9 |issue= 11 |pages= 2395-9 |year= 2003 |pmid= 14606063 |doi=  }}
*{{cite journal | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
}}
{{refend}}
{{refend}}


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Revision as of 20:58, 18 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Telomerase protein component 1 is an enzyme that in humans is encoded by the TEP1 gene.[1][2]

Function

This gene product is a component of the ribonucleoprotein complex responsible for telomerase activity which catalyzes the addition of new telomeres on the chromosome ends. The telomerase-associated proteins are conserved from ciliates to humans.[2] It is also a minor vault protein.

References

  1. ↑ Saito T, Matsuda Y, Suzuki T, Hayashi A, Yuan X, Saito M, Nakayama J, Hori T, Ishikawa F (November 1997). "Comparative gene mapping of the human and mouse TEP1 genes, which encode one protein component of telomerases". Genomics. 46 (1): 46–50. doi:10.1006/geno.1997.5005. PMID 9403057.
  2. ↑ 2.0 2.1 "Entrez Gene: TEP1 telomerase-associated protein 1".

Further reading

  • Joly EC, Tremblay E, Tanguay RM, Wu Y, Bibor-Hardy V (October 1994). "TRiC-P5, a novel TCP1-related protein, is localized in the cytoplasm and in the nuclear matrix". Journal of Cell Science. 107 ( Pt 10) (10): 2851–9. PMID 7876352.
  • Harrington L, McPhail T, Mar V, Zhou W, Oulton R, Bass MB, Arruda I, Robinson MO (February 1997). "A mammalian telomerase-associated protein". Science. 275 (5302): 973–7. doi:10.1126/science.275.5302.973. PMID 9020079.
  • Harrington L, Zhou W, McPhail T, Oulton R, Yeung DS, Mar V, Bass MB, Robinson MO (December 1997). "Human telomerase contains evolutionarily conserved catalytic and structural subunits". Genes & Development. 11 (23): 3109–15. doi:10.1101/gad.11.23.3109. PMC 316744. PMID 9389643.
  • Li H, Zhao L, Yang Z, Funder JW, Liu JP (December 1998). "Telomerase is controlled by protein kinase Calpha in human breast cancer cells". The Journal of Biological Chemistry. 273 (50): 33436–42. doi:10.1074/jbc.273.50.33436. PMID 9837921.
  • Kickhoefer VA, Stephen AG, Harrington L, Robinson MO, Rome LH (November 1999). "Vaults and telomerase share a common subunit, TEP1". The Journal of Biological Chemistry. 274 (46): 32712–7. doi:10.1074/jbc.274.46.32712. PMID 10551828.
  • Li H, Cao Y, Berndt MC, Funder JW, Liu JP (November 1999). "Molecular interactions between telomerase and the tumor suppressor protein p53 in vitro". Oncogene. 18 (48): 6785–94. doi:10.1038/sj.onc.1203061. PMID 10597287.
  • Koyanagi Y, Kobayashi D, Yajima T, Asanuma K, Kimura T, Sato T, Kida T, Yagihashi A, Kameshima H, Watanabe N (2000). "Telomerase activity is down regulated via decreases in hTERT mRNA but not TEP1 mRNA or hTERC during the differentiation of leukemic cells". Anticancer Research. 20 (2A): 773–8. PMID 10810353.
  • Beattie TL, Zhou W, Robinson MO, Harrington L (October 2000). "Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding". Molecular Biology of the Cell. 11 (10): 3329–40. doi:10.1091/mbc.11.10.3329. PMC 14995. PMID 11029039.
  • Zhang RG, Zhang RP, Wang XW, Xie H (March 2002). "Effects of cisplatin on telomerase activity and telomere length in BEL-7404 human hepatoma cells". Cell Research. 12 (1): 55–62. doi:10.1038/sj.cr.7290110. PMID 11942411.
  • Chang JT, Chen YL, Yang HT, Chen CY, Cheng AJ (July 2002). "Differential regulation of telomerase activity by six telomerase subunits". European Journal of Biochemistry. 269 (14): 3442–50. doi:10.1046/j.1432-1033.2002.03025.x. PMID 12135483.
  • Zhou JH, Zhang HM, Chen Q, Han DD, Pei F, Zhang LS, Yang DT (August 2003). "Relationship between telomerase activity and its subunit expression and inhibitory effect of antisense hTR on pancreatic carcinoma". World Journal of Gastroenterology. 9 (8): 1808–14. PMID 12918126.
  • Li C, Wu MY, Liang YR, Wu XY (November 2003). "Correlation between expression of human telomerase subunits and telomerase activity in esophageal squamous cell carcinoma". World Journal of Gastroenterology. 9 (11): 2395–9. PMID 14606063.
  • Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.


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