TGS1: Difference between revisions

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Latest revision as of 11:49, 15 September 2017

Trimethylguanosine synthase is an enzyme that in humans is encoded by the TGS1 gene.^[1]^[2]^[3]

Interactions

TGS1 has been shown to interact with:

References

↑ ^1.0 ^1.1 Zhu Y, Qi C, Cao WQ, Yeldandi AV, Rao MS, Reddy JK (Aug 2001). "Cloning and characterization of PIMT, a protein with a methyltransferase domain, which interacts with and enhances nuclear receptor coactivator PRIP function". Proc Natl Acad Sci U S A. 98 (18): 10380–5. doi:10.1073/pnas.181347498. PMC 56969. PMID 11517327.
↑ Mouaikel J, Verheggen C, Bertrand E, Tazi J, Bordonné R (May 2002). "Hypermethylation of the cap structure of both yeast snRNAs and snoRNAs requires a conserved methyltransferase that is localized to the nucleolus". Mol Cell. 9 (4): 891–901. doi:10.1016/S1097-2765(02)00484-7. PMID 11983179.
↑ "Entrez Gene: TGS1 trimethylguanosine synthase homolog (S. cerevisiae)".
↑ ^4.0 ^4.1 ^4.2 ^4.3 Misra P, Qi C, Yu S, Shah SH, Cao WQ, Rao MS, Thimmapaya B, Zhu Y, Reddy JK (May 2002). "Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation". J. Biol. Chem. 277 (22): 20011–9. doi:10.1074/jbc.M201739200. PMID 11912212.
↑ Enünlü I, Pápai G, Cserpán I, Udvardy A, Jeang KT, Boros I (Sep 2003). "Different isoforms of PRIP-interacting protein with methyltransferase domain/trimethylguanosine synthase localizes to the cytoplasm and nucleus". Biochem. Biophys. Res. Commun. 309 (1): 44–51. doi:10.1016/s0006-291x(03)01514-6. PMID 12943661.

Misra P, Qi C, Yu S, Shah SH, Cao WQ, Rao MS, Thimmapaya B, Zhu Y, Reddy JK (2002). "Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation". J. Biol. Chem. 277 (22): 20011–9. doi:10.1074/jbc.M201739200. PMID 11912212.
Verheggen C, Lafontaine DL, Samarsky D, Mouaikel J, Blanchard JM, Bordonné R, Bertrand E (2002). "Mammalian and yeast U3 snoRNPs are matured in specific and related nuclear compartments". EMBO J. 21 (11): 2736–45. doi:10.1093/emboj/21.11.2736. PMC 126019. PMID 12032086.
Wang Y, Han KJ, Pang XW, Vaughan HA, Qu W, Dong XY, Peng JR, Zhao HT, Rui JA, Leng XS, Cebon J, Burgess AW, Chen WF (2002). "Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies". J. Immunol. 169 (2): 1102–9. doi:10.4049/jimmunol.169.2.1102. PMID 12097419.
Surapureddi S, Yu S, Bu H, Hashimoto T, Yeldandi AV, Kashireddy P, Cherkaoui-Malki M, Qi C, Zhu YJ, Rao MS, Reddy JK (2002). "Identification of a transcriptionally active peroxisome proliferator-activated receptor α-interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator". Proc. Natl. Acad. Sci. U.S.A. 99 (18): 11836–41. doi:10.1073/pnas.182426699. PMC 129355. PMID 12189208.
Krackhardt AM, Witzens M, Harig S, Hodi FS, Zauls AJ, Chessia M, Barrett P, Gribben JG (2002). "Identification of tumor-associated antigens in chronic lymphocytic leukemia by SEREX". Blood. 100 (6): 2123–31. doi:10.1182/blood-2002-02-0513. PMID 12200376.
Mouaikel J, Narayanan U, Verheggen C, Matera AG, Bertrand E, Tazi J, Bordonné R (2004). "Interaction between the small-nuclear-RNA cap hypermethylase and the spinal muscular atrophy protein, survival of motor neuron". EMBO Rep. 4 (6): 616–22. doi:10.1038/sj.embor.embor863. PMC 1319203. PMID 12776181.
Enünlü I, Pápai G, Cserpán I, Udvardy A, Jeang KT, Boros I (2003). "Different isoforms of PRIP-interacting protein with methyltransferase domain/trimethylguanosine synthase localizes to the cytoplasm and nucleus". Biochem. Biophys. Res. Commun. 309 (1): 44–51. doi:10.1016/S0006-291X(03)01514-6. PMID 12943661.
Watkins NJ, Lemm I, Ingelfinger D, Schneider C, Hossbach M, Urlaub H, Lührmann R (2005). "Assembly and maturation of the U3 snoRNP in the nucleoplasm in a large dynamic multiprotein complex". Mol. Cell. 16 (5): 789–98. doi:10.1016/j.molcel.2004.11.012. PMID 15574333.
Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.

[pmid11517327-1] 1.0 ^1.1 Zhu Y, Qi C, Cao WQ, Yeldandi AV, Rao MS, Reddy JK (Aug 2001). "Cloning and characterization of PIMT, a protein with a methyltransferase domain, which interacts with and enhances nuclear receptor coactivator PRIP function". Proc Natl Acad Sci U S A. 98 (18): 10380–5. doi:10.1073/pnas.181347498. PMC 56969. PMID 11517327.

[pmid11983179-2] Mouaikel J, Verheggen C, Bertrand E, Tazi J, Bordonné R (May 2002). "Hypermethylation of the cap structure of both yeast snRNAs and snoRNAs requires a conserved methyltransferase that is localized to the nucleolus". Mol Cell. 9 (4): 891–901. doi:10.1016/S1097-2765(02)00484-7. PMID 11983179.

[entrez-3] "Entrez Gene: TGS1 trimethylguanosine synthase homolog (S. cerevisiae)".

[pmid11912212-4] 4.0 ^4.1 ^4.2 ^4.3 Misra P, Qi C, Yu S, Shah SH, Cao WQ, Rao MS, Thimmapaya B, Zhu Y, Reddy JK (May 2002). "Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation". J. Biol. Chem. 277 (22): 20011–9. doi:10.1074/jbc.M201739200. PMID 11912212.

[pmid12943661-5] Enünlü I, Pápai G, Cserpán I, Udvardy A, Jeang KT, Boros I (Sep 2003). "Different isoforms of PRIP-interacting protein with methyltransferase domain/trimethylguanosine synthase localizes to the cytoplasm and nucleus". Biochem. Biophys. Res. Commun. 309 (1): 44–51. doi:10.1016/s0006-291x(03)01514-6. PMID 12943661.

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@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Trimethylguanosine synthase''' is an [[enzyme]] that in humans is encoded by the ''TGS1'' [[gene]].<ref name="pmid11517327">{{cite journal | vauthors = Zhu Y, Qi C, Cao WQ, Yeldandi AV, Rao MS, Reddy JK | title = Cloning and characterization of PIMT, a protein with a methyltransferase domain, which interacts with and enhances nuclear receptor coactivator PRIP function | journal = Proc Natl Acad Sci U S A | volume = 98 | issue = 18 | pages = 10380–5 | date = Aug 2001 | pmid = 11517327 | pmc = 56969 | doi = 10.1073/pnas.181347498 }}</ref><ref name="pmid11983179">{{cite journal | vauthors = Mouaikel J, Verheggen C, Bertrand E, Tazi J, Bordonné R | title = Hypermethylation of the cap structure of both yeast snRNAs and snoRNAs requires a conserved methyltransferase that is localized to the nucleolus | journal = Mol Cell | volume = 9 | issue = 4 | pages = 891–901 | date = May 2002 | pmid = 11983179 | pmc =  | doi = 10.1016/S1097-2765(02)00484-7 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TGS1 trimethylguanosine synthase homolog (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=96764| accessdate = }}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Interactions ==
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Trimethylguanosine synthase homolog (S. cerevisiae)
- | HGNCid = 17843
- | Symbol = TGS1
- | AltSymbols =; DKFZp762A163; FLJ22995; NCOA6IP; PIMT; PIPMT
- | OMIM = 606461
- | ECnumber =
- | Homologene = 32608
- | MGIid = 2151797
- | GeneAtlas_image1 = PBB_GE_TGS1_219231_at_tn.png
- | Function = {{GNF_GO|id=GO:0008168 |text = methyltransferase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
- | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
- | Process =
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 96764
-    | Hs_Ensembl = ENSG00000137574
-    | Hs_RefseqProtein = NP_079107
-    | Hs_RefseqmRNA = NM_024831
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 8
-    | Hs_GenLoc_start = 56848255
-    | Hs_GenLoc_end = 56900557
-    | Hs_Uniprot = Q96RS0
-    | Mm_EntrezGene = 116940
-    | Mm_Ensembl = ENSMUSG00000028233
-    | Mm_RefseqmRNA = NM_054089
-    | Mm_RefseqProtein = NP_473430
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 4
-    | Mm_GenLoc_start = 3502022
-    | Mm_GenLoc_end = 3543768
-    | Mm_Uniprot = Q8CCI3
-  }}
-}}
-'''Trimethylguanosine synthase homolog (S. cerevisiae)''', also known as '''TGS1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TGS1 trimethylguanosine synthase homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=96764| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+TGS1 has been shown to [[Protein-protein interaction|interact]] with:
-{{PBB_Summary
+* [[CREB-binding protein]],<ref name = pmid11912212/> and
-| section_title =
+* [[EED (protein)|EED]],<ref name = pmid12943661>{{cite journal | vauthors = Enünlü I, Pápai G, Cserpán I, Udvardy A, Jeang KT, Boros I | title = Different isoforms of PRIP-interacting protein with methyltransferase domain/trimethylguanosine synthase localizes to the cytoplasm and nucleus | journal = Biochem. Biophys. Res. Commun. | volume = 309 | issue = 1 | pages = 44–51 | date = Sep 2003 | pmid = 12943661 | doi =  10.1016/s0006-291x(03)01514-6}}</ref>
-| summary_text =
+* [[EP300]],<ref name = pmid11912212/>
-}}
+* [[MED1]],<ref name = pmid11912212/>  and
+* [[NCOA6]].<ref name = pmid11517327 /><ref name = pmid11912212>{{cite journal | vauthors = Misra P, Qi C, Yu S, Shah SH, Cao WQ, Rao MS, Thimmapaya B, Zhu Y, Reddy JK | title = Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation | journal = J. Biol. Chem. | volume = 277 | issue = 22 | pages = 20011–9 | date = May 2002 | pmid = 11912212 | doi = 10.1074/jbc.M201739200 }}</ref>
-==References==
+== References ==
-{{reflist|2}}
+{{reflist}}
-==Further reading==
+== Further reading ==
 {{refbegin | 2}}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Misra P, Qi C, Yu S, Shah SH, Cao WQ, Rao MS, Thimmapaya B, Zhu Y, Reddy JK | title = Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation | journal = J. Biol. Chem. | volume = 277 | issue = 22 | pages = 20011–9 | year = 2002 | pmid = 11912212 | doi = 10.1074/jbc.M201739200 }}
-| citations =
+* {{cite journal | vauthors = Verheggen C, Lafontaine DL, Samarsky D, Mouaikel J, Blanchard JM, Bordonné R, Bertrand E | title = Mammalian and yeast U3 snoRNPs are matured in specific and related nuclear compartments | journal = EMBO J. | volume = 21 | issue = 11 | pages = 2736–45 | year = 2002 | pmid = 12032086 | pmc = 126019 | doi = 10.1093/emboj/21.11.2736 }}
-*{{cite journal  | author=Zhu Y, Qi C, Cao WQ, ''et al.'' |title=Cloning and characterization of PIMT, a protein with a methyltransferase domain, which interacts with and enhances nuclear receptor coactivator PRIP function. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 18 |pages= 10380-5 |year= 2001 |pmid= 11517327 |doi= 10.1073/pnas.181347498 }}
+* {{cite journal | vauthors = Wang Y, Han KJ, Pang XW, Vaughan HA, Qu W, Dong XY, Peng JR, Zhao HT, Rui JA, Leng XS, Cebon J, Burgess AW, Chen WF | title = Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies | journal = J. Immunol. | volume = 169 | issue = 2 | pages = 1102–9 | year = 2002 | pmid = 12097419 | doi = 10.4049/jimmunol.169.2.1102 }}
-*{{cite journal  | author=Misra P, Qi C, Yu S, ''et al.'' |title=Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation. |journal=J. Biol. Chem. |volume=277 |issue= 22 |pages= 20011-9 |year= 2002 |pmid= 11912212 |doi= 10.1074/jbc.M201739200 }}
+* {{cite journal | vauthors = Surapureddi S, Yu S, Bu H, Hashimoto T, Yeldandi AV, Kashireddy P, Cherkaoui-Malki M, Qi C, Zhu YJ, Rao MS, Reddy JK | title = Identification of a transcriptionally active peroxisome proliferator-activated receptor α-interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 18 | pages = 11836–41 | year = 2002 | pmid = 12189208 | pmc = 129355 | doi = 10.1073/pnas.182426699 }}
-*{{cite journal  | author=Mouaikel J, Verheggen C, Bertrand E, ''et al.'' |title=Hypermethylation of the cap structure of both yeast snRNAs and snoRNAs requires a conserved methyltransferase that is localized to the nucleolus. |journal=Mol. Cell |volume=9 |issue= 4 |pages= 891-901 |year= 2002 |pmid= 11983179 |doi=  }}
+* {{cite journal | vauthors = Krackhardt AM, Witzens M, Harig S, Hodi FS, Zauls AJ, Chessia M, Barrett P, Gribben JG | title = Identification of tumor-associated antigens in chronic lymphocytic leukemia by SEREX | journal = Blood | volume = 100 | issue = 6 | pages = 2123–31 | year = 2002 | pmid = 12200376 | doi = 10.1182/blood-2002-02-0513 }}
-*{{cite journal  | author=Verheggen C, Lafontaine DL, Samarsky D, ''et al.'' |title=Mammalian and yeast U3 snoRNPs are matured in specific and related nuclear compartments. |journal=EMBO J. |volume=21 |issue= 11 |pages= 2736-45 |year= 2002 |pmid= 12032086 |doi= 10.1093/emboj/21.11.2736 }}
+* {{cite journal | vauthors = Mouaikel J, Narayanan U, Verheggen C, Matera AG, Bertrand E, Tazi J, Bordonné R | title = Interaction between the small-nuclear-RNA cap hypermethylase and the spinal muscular atrophy protein, survival of motor neuron | journal = EMBO Rep. | volume = 4 | issue = 6 | pages = 616–22 | year = 2004 | pmid = 12776181 | pmc = 1319203 | doi = 10.1038/sj.embor.embor863 }}
-*{{cite journal  | author=Wang Y, Han KJ, Pang XW, ''et al.'' |title=Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies. |journal=J. Immunol. |volume=169 |issue= 2 |pages= 1102-9 |year= 2002 |pmid= 12097419 |doi=  }}
+* {{cite journal | vauthors = Enünlü I, Pápai G, Cserpán I, Udvardy A, Jeang KT, Boros I | title = Different isoforms of PRIP-interacting protein with methyltransferase domain/trimethylguanosine synthase localizes to the cytoplasm and nucleus | journal = Biochem. Biophys. Res. Commun. | volume = 309 | issue = 1 | pages = 44–51 | year = 2003 | pmid = 12943661 | doi = 10.1016/S0006-291X(03)01514-6 }}
-*{{cite journal  | author=Surapureddi S, Yu S, Bu H, ''et al.'' |title=Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 18 |pages= 11836-41 |year= 2002 |pmid= 12189208 |doi= 10.1073/pnas.182426699 }}
+* {{cite journal | vauthors = Watkins NJ, Lemm I, Ingelfinger D, Schneider C, Hossbach M, Urlaub H, Lührmann R | title = Assembly and maturation of the U3 snoRNP in the nucleoplasm in a large dynamic multiprotein complex | journal = Mol. Cell | volume = 16 | issue = 5 | pages = 789–98 | year = 2005 | pmid = 15574333 | doi = 10.1016/j.molcel.2004.11.012 }}
-*{{cite journal  | author=Krackhardt AM, Witzens M, Harig S, ''et al.'' |title=Identification of tumor-associated antigens in chronic lymphocytic leukemia by SEREX. |journal=Blood |volume=100 |issue= 6 |pages= 2123-31 |year= 2002 |pmid= 12200376 |doi= 10.1182/blood-2002-02-0513 }}
+* {{cite journal | vauthors = Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS | title = Transcriptome analysis of human gastric cancer | journal = Mamm. Genome | volume = 16 | issue = 12 | pages = 942–54 | year = 2006 | pmid = 16341674 | doi = 10.1007/s00335-005-0075-2 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
-*{{cite journal  | author=Mouaikel J, Narayanan U, Verheggen C, ''et al.'' |title=Interaction between the small-nuclear-RNA cap hypermethylase and the spinal muscular atrophy protein, survival of motor neuron. |journal=EMBO Rep. |volume=4 |issue= 6 |pages= 616-22 |year= 2004 |pmid= 12776181 |doi= 10.1038/sj.embor.embor863 }}
-*{{cite journal  | author=Enünlü I, Pápai G, Cserpán I, ''et al.'' |title=Different isoforms of PRIP-interacting protein with methyltransferase domain/trimethylguanosine synthase localizes to the cytoplasm and nucleus. |journal=Biochem. Biophys. Res. Commun. |volume=309 |issue= 1 |pages= 44-51 |year= 2003 |pmid= 12943661 |doi=  }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
-*{{cite journal  | author=Watkins NJ, Lemm I, Ingelfinger D, ''et al.'' |title=Assembly and maturation of the U3 snoRNP in the nucleoplasm in a large dynamic multiprotein complex. |journal=Mol. Cell |volume=16 |issue= 5 |pages= 789-98 |year= 2005 |pmid= 15574333 |doi= 10.1016/j.molcel.2004.11.012 }}
-*{{cite journal  | author=Oh JH, Yang JO, Hahn Y, ''et al.'' |title=Transcriptome analysis of human gastric cancer. |journal=Mamm. Genome |volume=16 |issue= 12 |pages= 942-54 |year= 2006 |pmid= 16341674 |doi= 10.1007/s00335-005-0075-2 }}
-*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
-}}
 {{refend}}
-{{protein-stub}}
-{{WikiDoc Sources}}
+{{gene-8-stub}}

TGS1: Difference between revisions

Latest revision as of 11:49, 15 September 2017

Interactions

References

Further reading

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