TNIP2: Difference between revisions

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Revision as of 12:05, 15 September 2017

TNFAIP3-interacting protein 2 is a protein that in humans is encoded by the TNIP2 gene.^[1]^[2]^[3]

References

↑ Van Huffel S, Delaei F, Heyninck K, De Valck D, Beyaert R (Aug 2001). "Identification of a novel A20-binding inhibitor of nuclear factor-kappa B activation termed ABIN-2". J Biol Chem. 276 (32): 30216–23. doi:10.1074/jbc.M100048200. PMID 11390377.
↑ Tadros A, Hughes DP, Dunmore BJ, Brindle NP (Dec 2003). "ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1". Blood. 102 (13): 4407–9. doi:10.1182/blood-2003-05-1602. PMID 12933576.
↑ "Entrez Gene: TNIP2 TNFAIP3 interacting protein 2".

Heyninck K, De Valck D, Vanden Berghe W, et al. (1999). "The Zinc Finger Protein A20 Inhibits TNF-induced NF-κB–dependent Gene Expression by Interfering with an RIP- or TRAF2-mediated Transactivation Signal and Directly Binds to a Novel NF-κB–inhibiting Protein ABIN". J. Cell Biol. 145 (7): 1471–82. doi:10.1083/jcb.145.7.1471. PMC 2133159. PMID 10385526.
Klinkenberg M, Van Huffel S, Heyninck K, Beyaert R (2001). "Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein-protein interactions". FEBS Lett. 498 (1): 93–7. doi:10.1016/S0014-5793(01)02504-2. PMID 11389905.
Wu WS, Xu ZX, Chang KS (2002). "The promyelocytic leukemia protein represses A20-mediated transcription". J. Biol. Chem. 277 (35): 31734–9. doi:10.1074/jbc.M201648200. PMID 12080044.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Liu WK, Chien CY, Chou CK, Su JY (2003). "An LKB1-interacting protein negatively regulates TNFalpha-induced NF-kappaB activation". J. Biomed. Sci. 10 (2): 242–52. doi:10.1159/000068708. PMID 12595760.
Hughes DP, Marron MB, Brindle NP (2003). "The antiinflammatory endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-kappaB inhibitor ABIN-2". Circ. Res. 92 (6): 630–6. doi:10.1161/01.RES.0000063422.38690.DC. PMID 12609966.
Chien CY, Liu WK, Chou CK, Su JY (2003). "The A20-binding protein ABIN-2 exerts unexpected function in mediating transcriptional coactivation". FEBS Lett. 543 (1–3): 55–60. doi:10.1016/S0014-5793(03)00401-0. PMID 12753905.
Liu WK, Yen PF, Chien CY, et al. (2004). "The inhibitor ABIN-2 disrupts the interaction of receptor-interacting protein with the kinase subunit IKKgamma to block activation of the transcription factor NF-kappaB and potentiate apoptosis". Biochem. J. 378 (Pt 3): 867–76. doi:10.1042/BJ20031736. PMC 1224013. PMID 14653779.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
Lang V, Symons A, Watton SJ, et al. (2004). "ABIN-2 Forms a Ternary Complex with TPL-2 and NF-κB1 p105 and Is Essential for TPL-2 Protein Stability". Mol. Cell. Biol. 24 (12): 5235–48. doi:10.1128/MCB.24.12.5235-5248.2004. PMC 419892. PMID 15169888.
Li CC, Chou CK, Wang MH, Tsai TF (2006). "Overexpression of ABIN-2, a negative regulator of NF-kappaB, delays liver regeneration in the ABIN-2 transgenic mice". Biochem. Biophys. Res. Commun. 342 (1): 300–9. doi:10.1016/j.bbrc.2006.01.114. PMID 16480954.
Greenberg H, Ye X, Wilson D, et al. (2006). "Chronic intermittent hypoxia activates nuclear factor-kappaB in cardiovascular tissues in vivo". Biochem. Biophys. Res. Commun. 343 (2): 591–6. doi:10.1016/j.bbrc.2006.03.015. PMID 16554025.
Liu Y, Nakahara T, Miyakoshi J, et al. (2007). "Nuclear accumulation and activation of nuclear factor kappaB after split-dose irradiation in LS174T cells". J. Radiat. Res. 48 (1): 13–20. doi:10.1269/jrr.0615. PMID 17038805.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

[pmid11390377-1] Van Huffel S, Delaei F, Heyninck K, De Valck D, Beyaert R (Aug 2001). "Identification of a novel A20-binding inhibitor of nuclear factor-kappa B activation termed ABIN-2". J Biol Chem. 276 (32): 30216–23. doi:10.1074/jbc.M100048200. PMID 11390377.

[pmid12933576-2] Tadros A, Hughes DP, Dunmore BJ, Brindle NP (Dec 2003). "ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1". Blood. 102 (13): 4407–9. doi:10.1182/blood-2003-05-1602. PMID 12933576.

[entrez-3] "Entrez Gene: TNIP2 TNFAIP3 interacting protein 2".

[1]

[2]

[3]

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+{{Underlinked|date=March 2014}}
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+{{Infobox_gene}}
-| update_page = yes
+'''TNFAIP3-interacting protein 2''' is a [[protein]] that in humans is encoded by the ''TNIP2'' [[gene]].<ref name="pmid11390377">{{cite journal |vauthors=Van Huffel S, Delaei F, Heyninck K, De Valck D, Beyaert R | title = Identification of a novel A20-binding inhibitor of nuclear factor-kappa B activation termed ABIN-2 | journal = J Biol Chem | volume = 276 | issue = 32 | pages = 30216–23 |date=Aug 2001 | pmid = 11390377 | pmc =  | doi = 10.1074/jbc.M100048200 }}</ref><ref name="pmid12933576">{{cite journal |vauthors=Tadros A, Hughes DP, Dunmore BJ, Brindle NP | title = ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1 | journal = Blood | volume = 102 | issue = 13 | pages = 4407–9 |date=Dec 2003 | pmid = 12933576 | pmc =  | doi = 10.1182/blood-2003-05-1602 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TNIP2 TNFAIP3 interacting protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79155| accessdate = }}</ref>
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- | image =
- | image_source =
- | PDB =
- | Name = TNFAIP3 interacting protein 2
- | HGNCid = 19118
- | Symbol = TNIP2
- | AltSymbols =; ABIN-2; ABIN2; FLIP1; KLIP; MGC4289
- | OMIM = 610669
- | ECnumber =
- | Homologene = 11515
- | MGIid = 2386643
- | GeneAtlas_image1 = PBB_GE_TNIP2_218335_x_at_tn.png
-  | GeneAtlas_image2 = PBB_GE_TNIP2_48531_at_tn.png
- | GeneAtlas_image3 = PBB_GE_TNIP2_gnf1h09307_at_tn.png
- | Function =
- | Component =
- | Process =
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 79155
-    | Hs_Ensembl = ENSG00000168884
-    | Hs_RefseqProtein = NP_077285
-    | Hs_RefseqmRNA = NM_024309
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 4
-    | Hs_GenLoc_start = 2713185
-    | Hs_GenLoc_end = 2727901
-    | Hs_Uniprot =
-    | Mm_EntrezGene = 231130
-    | Mm_Ensembl = ENSMUSG00000059866
-    | Mm_RefseqmRNA = NM_139064
-    | Mm_RefseqProtein = NP_620703
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 5
-    | Mm_GenLoc_start = 34812944
-    | Mm_GenLoc_end = 34830836
-    | Mm_Uniprot =
-  }}
-}}
-'''TNFAIP3 interacting protein 2''', also known as '''TNIP2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TNIP2 TNFAIP3 interacting protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79155| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
@@ Line 57: / Line 10: @@
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Heyninck K, De Valck D, Vanden Berghe W, ''et al.'' |title=The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN. |journal=J. Cell Biol. |volume=145 |issue= 7 |pages= 1471-82 |year= 1999 |pmid= 10385526 |doi=  }}
+*{{cite journal  | author=Heyninck K |title=The Zinc Finger Protein A20 Inhibits TNF-induced NF-κB–dependent Gene Expression by Interfering with an RIP- or TRAF2-mediated Transactivation Signal and Directly Binds to a Novel NF-κB–inhibiting Protein ABIN |journal=J. Cell Biol. |volume=145 |issue= 7 |pages= 1471–82 |year= 1999 |pmid= 10385526 |doi=10.1083/jcb.145.7.1471  | pmc=2133159  |name-list-format=vanc| author2=De Valck D  | author3=Vanden Berghe W  | display-authors=3  | last4=Van Criekinge  | first4=W  | last5=Contreras  | first5=R  | last6=Fiers  | first6=W  | last7=Haegeman  | first7=G  | last8=Beyaert  | first8=R  }}
-*{{cite journal  | author=Klinkenberg M, Van Huffel S, Heyninck K, Beyaert R |title=Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein-protein interactions. |journal=FEBS Lett. |volume=498 |issue= 1 |pages= 93-7 |year= 2001 |pmid= 11389905 |doi=  }}
+*{{cite journal  |vauthors=Klinkenberg M, Van Huffel S, Heyninck K, Beyaert R |title=Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein-protein interactions |journal=FEBS Lett. |volume=498 |issue= 1 |pages= 93–7 |year= 2001 |pmid= 11389905 |doi=10.1016/S0014-5793(01)02504-2  }}
-*{{cite journal  | author=Van Huffel S, Delaei F, Heyninck K, ''et al.'' |title=Identification of a novel A20-binding inhibitor of nuclear factor-kappa B activation termed ABIN-2. |journal=J. Biol. Chem. |volume=276 |issue= 32 |pages= 30216-23 |year= 2001 |pmid= 11390377 |doi= 10.1074/jbc.M100048200 }}
+*{{cite journal  |vauthors=Wu WS, Xu ZX, Chang KS |title=The promyelocytic leukemia protein represses A20-mediated transcription |journal=J. Biol. Chem. |volume=277 |issue= 35 |pages= 31734–9 |year= 2002 |pmid= 12080044 |doi= 10.1074/jbc.M201648200 }}
-*{{cite journal  | author=Wu WS, Xu ZX, Chang KS |title=The promyelocytic leukemia protein represses A20-mediated transcription. |journal=J. Biol. Chem. |volume=277 |issue= 35 |pages= 31734-9 |year= 2002 |pmid= 12080044 |doi= 10.1074/jbc.M201648200 }}
+*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  |vauthors=Liu WK, Chien CY, Chou CK, Su JY |title=An LKB1-interacting protein negatively regulates TNFalpha-induced NF-kappaB activation |journal=J. Biomed. Sci. |volume=10 |issue= 2 |pages= 242–52 |year= 2003 |pmid= 12595760 |doi= 10.1159/000068708 }}
-*{{cite journal  | author=Liu WK, Chien CY, Chou CK, Su JY |title=An LKB1-interacting protein negatively regulates TNFalpha-induced NF-kappaB activation. |journal=J. Biomed. Sci. |volume=10 |issue= 2 |pages= 242-52 |year= 2003 |pmid= 12595760 |doi= 10.1159/000068708 }}
+*{{cite journal  |vauthors=Hughes DP, Marron MB, Brindle NP |title=The antiinflammatory endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-kappaB inhibitor ABIN-2 |journal=Circ. Res. |volume=92 |issue= 6 |pages= 630–6 |year= 2003 |pmid= 12609966 |doi= 10.1161/01.RES.0000063422.38690.DC }}
-*{{cite journal  | author=Hughes DP, Marron MB, Brindle NP |title=The antiinflammatory endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-kappaB inhibitor ABIN-2. |journal=Circ. Res. |volume=92 |issue= 6 |pages= 630-6 |year= 2003 |pmid= 12609966 |doi= 10.1161/01.RES.0000063422.38690.DC }}
+*{{cite journal  |vauthors=Chien CY, Liu WK, Chou CK, Su JY |title=The A20-binding protein ABIN-2 exerts unexpected function in mediating transcriptional coactivation |journal=FEBS Lett. |volume=543 |issue= 1–3 |pages= 55–60 |year= 2003 |pmid= 12753905 |doi=10.1016/S0014-5793(03)00401-0  }}
-*{{cite journal  | author=Chien CY, Liu WK, Chou CK, Su JY |title=The A20-binding protein ABIN-2 exerts unexpected function in mediating transcriptional coactivation. |journal=FEBS Lett. |volume=543 |issue= 1-3 |pages= 55-60 |year= 2003 |pmid= 12753905 |doi=  }}
+*{{cite journal  | author=Liu WK |title=The inhibitor ABIN-2 disrupts the interaction of receptor-interacting protein with the kinase subunit IKKgamma to block activation of the transcription factor NF-kappaB and potentiate apoptosis |journal=Biochem. J. |volume=378 |issue= Pt 3 |pages= 867–76 |year= 2004 |pmid= 14653779 |doi= 10.1042/BJ20031736  | pmc=1224013  |name-list-format=vanc| author2=Yen PF  | author3=Chien CY  | display-authors=3  | last4=Fann  | first4=Ming-Ji  | last5=Su  | first5=Jin-Yuan  | last6=Chou  | first6=Chen-Kung }}
-*{{cite journal  | author=Tadros A, Hughes DP, Dunmore BJ, Brindle NP |title=ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1. |journal=Blood |volume=102 |issue= 13 |pages= 4407-9 |year= 2004 |pmid= 12933576 |doi= 10.1182/blood-2003-05-1602 }}
+*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285  |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
-*{{cite journal  | author=Liu WK, Yen PF, Chien CY, ''et al.'' |title=The inhibitor ABIN-2 disrupts the interaction of receptor-interacting protein with the kinase subunit IKKgamma to block activation of the transcription factor NF-kappaB and potentiate apoptosis. |journal=Biochem. J. |volume=378 |issue= Pt 3 |pages= 867-76 |year= 2004 |pmid= 14653779 |doi= 10.1042/BJ20031736 }}
+*{{cite journal  | author=Bouwmeester T |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086  |name-list-format=vanc| author2=Bauch A  | author3=Ruffner H  | display-authors=3  | last4=Angrand  | first4=Pierre-Olivier  | last5=Bergamini  | first5=Giovanna  | last6=Croughton  | first6=Karen  | last7=Cruciat  | first7=Cristina  | last8=Eberhard  | first8=Dirk  | last9=Gagneur  | first9=Julien }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal  | author=Lang V |title=ABIN-2 Forms a Ternary Complex with TPL-2 and NF-κB1 p105 and Is Essential for TPL-2 Protein Stability |journal=Mol. Cell. Biol. |volume=24 |issue= 12 |pages= 5235–48 |year= 2004 |pmid= 15169888 |doi= 10.1128/MCB.24.12.5235-5248.2004  | pmc=419892  |name-list-format=vanc| author2=Symons A  | author3=Watton SJ  | display-authors=3  | last4=Janzen  | first4=J.  | last5=Soneji  | first5=Y.  | last6=Beinke  | first6=S.  | last7=Howell  | first7=S.  | last8=Ley  | first8=S. C. }}
-*{{cite journal  | author=Bouwmeester T, Bauch A, Ruffner H, ''et al.'' |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97-105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 }}
+*{{cite journal  |vauthors=Li CC, Chou CK, Wang MH, Tsai TF |title=Overexpression of ABIN-2, a negative regulator of NF-kappaB, delays liver regeneration in the ABIN-2 transgenic mice |journal=Biochem. Biophys. Res. Commun. |volume=342 |issue= 1 |pages= 300–9 |year= 2006 |pmid= 16480954 |doi= 10.1016/j.bbrc.2006.01.114 }}
-*{{cite journal  | author=Lang V, Symons A, Watton SJ, ''et al.'' |title=ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability. |journal=Mol. Cell. Biol. |volume=24 |issue= 12 |pages= 5235-48 |year= 2004 |pmid= 15169888 |doi= 10.1128/MCB.24.12.5235-5248.2004 }}
+*{{cite journal  | author=Greenberg H |title=Chronic intermittent hypoxia activates nuclear factor-kappaB in cardiovascular tissues in vivo |journal=Biochem. Biophys. Res. Commun. |volume=343 |issue= 2 |pages= 591–6 |year= 2006 |pmid= 16554025 |doi= 10.1016/j.bbrc.2006.03.015  |name-list-format=vanc| author2=Ye X  | author3=Wilson D  | display-authors=3  | last4=Htoo  | first4=Aung K.  | last5=Hendersen  | first5=Todd  | last6=Liu  | first6=Shu Fang }}
-*{{cite journal  | author=Li CC, Chou CK, Wang MH, Tsai TF |title=Overexpression of ABIN-2, a negative regulator of NF-kappaB, delays liver regeneration in the ABIN-2 transgenic mice. |journal=Biochem. Biophys. Res. Commun. |volume=342 |issue= 1 |pages= 300-9 |year= 2006 |pmid= 16480954 |doi= 10.1016/j.bbrc.2006.01.114 }}
+*{{cite journal  | author=Liu Y |title=Nuclear accumulation and activation of nuclear factor kappaB after split-dose irradiation in LS174T cells |journal=J. Radiat. Res. |volume=48 |issue= 1 |pages= 13–20 |year= 2007 |pmid= 17038805 |doi=10.1269/jrr.0615  |name-list-format=vanc| author2=Nakahara T  | author3=Miyakoshi J  | display-authors=3  | last4=Hu  | first4=Dong-Liang  | last5=Nakane  | first5=Akio  | last6=Abe  | first6=Yoshinao  }}
-*{{cite journal  | author=Greenberg H, Ye X, Wilson D, ''et al.'' |title=Chronic intermittent hypoxia activates nuclear factor-kappaB in cardiovascular tissues in vivo. |journal=Biochem. Biophys. Res. Commun. |volume=343 |issue= 2 |pages= 591-6 |year= 2006 |pmid= 16554025 |doi= 10.1016/j.bbrc.2006.03.015 }}
-*{{cite journal  | author=Liu Y, Nakahara T, Miyakoshi J, ''et al.'' |title=Nuclear accumulation and activation of nuclear factor kappaB after split-dose irradiation in LS174T cells. |journal=J. Radiat. Res. |volume=48 |issue= 1 |pages= 13-20 |year= 2007 |pmid= 17038805 |doi=  }}
 }}
 {{refend}}
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TNIP2: Difference between revisions

Revision as of 12:05, 15 September 2017

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